Chromosome 18

Common Name(s)

Chromosome 18

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chromosome 18" for support, advocacy or research.

The Chromosome 18 Registry & Research Society

Our mission is to help individuals with chromosome 18 abnormalities overcome the obstacles they face so they might lead happy, healthy, and productive lives.

Last Updated: 11 Apr 2013

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Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

Last Updated: 29 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chromosome 18" for support, advocacy or research.

The Chromosome 18 Registry & Research Society

Our mission is to help individuals with chromosome 18 abnormalities overcome the obstacles they face so they might lead happy, healthy, and productive lives.

http://www.chromosome18.org

Last Updated: 11 Apr 2013

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Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

http://www.trisomy18.org

Last Updated: 29 Apr 2014

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General Support Organizations

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General Resources

Trisomy 18 YouTube Channel: Tell your Own Story

Playlists featuring the lives of families with their children coping with various aspects of Trisomy 18 -- 100s of videos

Uploaded By: Trisomy 18 Foundation

Updated 4 Jan 2013

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Blogs

Taking on Trisomy 18: News, Analysis and Commentary from the Trisomy 18 Foundation

Blog by CEO Victoria Miller on issues of the day regarding Trisomy 18 and Trisomy 18 community experiences.

Uploaded by: Trisomy 18 Foundation

Updated 4 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chromosome 18" returned 119 free, full-text research articles on human participants. First 3 results:

Gain of 11q by an additional ring chromosome 11 and trisomy 18 in CD5-positive intravascular large B-cell lymphoma.
 

Author(s): Katsuya Yamamoto, Kimikazu Yakushijin, Atsuo Okamura, Yoshitake Hayashi, Hiroshi Matsuoka, Hironobu Minami

Journal: J Clin Exp Hematop. 2013 ;53(2):161-5.

 

Chromosomal abnormalities of intravascular large B-cell lymphoma (IVLBCL), a rare form of extranodal diffuse large B-cell lymphoma, have been described in only a small number of cases. A 59-year-old female presented with pancytopenia and splenomegaly. Bone marrow was normocellular ...

Last Updated: 2 Sep 2013

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A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18.
 

Author(s): Kerttu K Majander, Pia M Villa, Katja Kivinen, Juha Kere, Hannele Laivuori

Journal: Eur. J. Hum. Genet.. 2013 Sep;21(9):1024-6.

 

Pre-eclampsia is a common vascular disorder of pregnancy. It originates in the placenta and targets the maternal endothelium. According to epidemiological research, >50% of the liability to this disorder can be accounted for by genetic factors. Both maternal and fetal genes contribute ...

Last Updated: 16 Aug 2013

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Second-trimester IL-15 and IL-18 levels in the amniotic fluid of fetuses with normal karyotypes and with chromosome abnormalities.
 

Author(s): Dominika Klimkiewicz-Blok, Jerzy Florjański, Jerzy Zalewski, Radosław Blok

Journal: Adv Clin Exp Med. ;21(2):201-5.

 

Little is known about the behavior of interleukin 15 (IL-15) and 18 (IL-18) in the amniotic fluid in the second trimester of gestations complicated by chromosomal defects in the fetus. Likewise, it has not yet been established whether a fetus with chromosome abnormalities creates ...

Last Updated: 10 Dec 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chromosome 18" returned 4 free, full-text review articles on human participants. First 3 results:

t(8;14;18): a 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia.
 

Author(s): Delong Liu, Josif Shimonov, Suneeta Primanneni, Yongrong Lai, Tauseef Ahmed, Karen Seiter

Journal:

 

Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) ...

Last Updated: 29 Jun 2007

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Clinical and molecular evaluation of four patients with partial duplications of the long arm of chromosome 18.
 

Author(s): R Mewar, A D Kline, W Harrison, K Rojas, F Greenberg, J Overhauser

Journal: Am. J. Hum. Genet.. 1993 Dec;53(6):1269-78.

 

Four individuals with partial duplications of the long arm of chromosome 18 were analyzed at the clinical, cytogenetic, and molecular levels. Two of the individuals had duplications of the long arm from 18q21.1-qter because of inheritance of an unbalanced translocation. Both of these ...

Last Updated: 30 Dec 1993

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Interstitial deletion of the long arm of chromosome 18, del(18)(q12.2q21.1): a report of three cases of an autosomal deletion with a mild phenotype.
 

Author(s): A Schinzel, F Binkert, D M Lillington, M Sands, R J Stocks, R H Lindenbaum, H Matthews, H Sheridan

Journal: J. Med. Genet.. 1991 May;28(5):352-5.

 

We describe three unrelated patients with apparently identical interstitial deletions of the segment (18) (q12.2q21.1). They were a short and markedly mentally retarded 5 year old girl, a macrocephalic and obese 2 1/2 year old boy with moderate mental retardation, and a macrocephalic, ...

Last Updated: 6 Sep 1991

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Chromosome 18 Clinical Research Center
 

Status: Recruiting

Condition Summary: Chromosome Aberrations; Growth Hormone Deficiency; Delayed Myelination

 

Last Updated: 26 Feb 2013

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Development of Non-invasive Prenatal Test for Microdeletion/Duplication and Other Genetic Syndromes Based on Fetal DNA Isolated From Maternal Blood
 

Status: Recruiting

Condition Summary: Microdeletion Syndromes; Trisomy 21; Trisomy 18; Trisomy 13; Sex Chromosome Abnormalities

 

Last Updated: 8 Apr 2014

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Non-Invasive Determination of Fetal Chromosome Abnormalities
 

Status: Recruiting

Condition Summary: Down Syndrome (Trisomy 21); Edward's Syndrome (Trisomy 18); Patau Syndrome (Trisomy 13); Klinefelter Syndrome (47, XXY); and Other Chromosome; Abnormalities.

 

Last Updated: 30 Apr 2009

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