Chromosome 18

Common Name(s)

Chromosome 18

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chromosome 18" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

Last Updated: 24 Jul 2015

View Details
The Chromosome 18 Registry & Research Society

Our mission is to help individuals with chromosome 18 abnormalities overcome the obstacles they face so they might lead happy, healthy, and productive lives.

Last Updated: 11 Apr 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chromosome 18" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

http://www.trisomy18.org

Last Updated: 24 Jul 2015

View Details
The Chromosome 18 Registry & Research Society

Our mission is to help individuals with chromosome 18 abnormalities overcome the obstacles they face so they might lead happy, healthy, and productive lives.

http://www.chromosome18.org

Last Updated: 11 Apr 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

Trisomy 18 Foundation Facebook Page

Over 43,000 Fans (as of 12/23/14) connecting with T18F news and updates and establishing peer connections to share information about Trisomy 18 and the children they love impacted with Trisomy 18.

Uploaded By: Trisomy 18 Foundation

Updated 23 Dec 2014

Go To URL
Great NonProfits Top Rated NonProfit 2015

Based on public reviews by people served by the Foundation, the Foundation is again awarded a 2015 Top NonProfit Award by Great NonProfits associated with Guidestar. The Foundation was also awarded this same award in 2014, 2013 and 2012.

Uploaded By: Trisomy 18 Foundation

Updated 24 Jul 2015

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chromosome 18" returned 139 free, full-text research articles on human participants. First 3 results:

Molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome derived from chromosome 8 or r(8)(::p11.22→q11.21::) in an 18-year-old female with short stature, obesity, attention deficit hyperactivity disorder, and intellectual disability.
 

Author(s): Chih-Ping Chen, Shuan-Pei Lin, Schu-Rern Chern, Peih-Shan Wu, Yen-Ni Chen, Shin-Wen Chen, Chien-Wen Yang, Meng-Shan Lee, Wayseen Wang

Journal: Taiwan J Obstet Gynecol. 2016 Dec;55(6):856-860.

 

We present molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome (sSMC) derived from chromosome 8.

Last Updated: 1 Jan 2017

Go To URL
Breakpoints and deleted genes identification of ring chromosome 18 in a Chinese girl by whole-genome low-coverage sequencing: a case report study.
 

Author(s): Hui Yao, Chuanchun Yang, Xiaoli Huang, Luhong Yang, Wei Zhao, Dan Yin, Yuan Qin, Feng Mu, Lin Liu, Ping Tian, Zhisheng Liu, Yun Yang

Journal:

 

Ring chromosome 18 [r(18)] is formed by 18p- and 18q- partial deletion and generates a ring chromosome. Loss of critical genes on each arm of chromosome 18 may contribute to the specific phenotype, and the clinical spectrum varieties may heavily depend on the extent of the genomic ...

Last Updated: 25 Jul 2016

Go To URL
An 18.3-Mb Duplication on Chromosome 14q With Multiple Cardiac Anomalies and Clubfoot Was Identified by Microarray Analysis.
 

Author(s): Jihoon G Yoon, Saeam Shin, Jo Won Jung, Seung-Tae Lee, Jong Rak Choi

Journal: Ann Lab Med. 2016 Mar;36(2):194-6.

 

Last Updated: 28 Dec 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chromosome 18" returned 4 free, full-text review articles on human participants. First 3 results:

Epilepsy and chromosome 18 abnormalities: A review.
 

Author(s): Alberto Verrotti, Alessia Carelli, Lorenza di Genova, Pasquale Striano

Journal: Seizure. 2015 Nov;32():78-83.

 

To analyze the various types of epilepsy in subjects with chromosome 18 aberrations in order to define epilepsy and its main clinical, electroclinical and prognostic aspects in chromosome 18 anomalies.

Last Updated: 10 Nov 2015

Go To URL
t(8;14;18): a 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia.
 

Author(s): Delong Liu, Josif Shimonov, Suneeta Primanneni, Yongrong Lai, Tauseef Ahmed, Karen Seiter

Journal:

 

Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) ...

Last Updated: 29 Jun 2007

Go To URL
Clinical and molecular evaluation of four patients with partial duplications of the long arm of chromosome 18.
 

Author(s): R Mewar, A D Kline, W Harrison, K Rojas, F Greenberg, J Overhauser

Journal: Am. J. Hum. Genet.. 1993 Dec;53(6):1269-78.

 

Four individuals with partial duplications of the long arm of chromosome 18 were analyzed at the clinical, cytogenetic, and molecular levels. Two of the individuals had duplications of the long arm from 18q21.1-qter because of inheritance of an unbalanced translocation. Both of these ...

Last Updated: 30 Dec 1993

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Chromosome 18 Clinical Research Center
 

Status: Recruiting

Condition Summary: Chromosome Aberrations; Growth Hormone Deficiency; Hypomyelination

 

Last Updated: 26 Sep 2016

Go to URL
A Phase III Randomized Trial of the Reduction of Chemotherapy in Philadelphia Chromosome-positive ALL of Young Adults
 

Status: Recruiting

Condition Summary: Philadelphia Chromosome Positive Adult Acute Lymphoblastic Leukemia

 

Last Updated: 18 Nov 2016

Go to URL
Multicenter Trial Treatment of Philadelphia Chromosome Negative B-cell Acute Lymphoblastic Leukemia of Young Adults
 

Status: Recruiting

Condition Summary: Philadelphia Chromosome Negative Adult B-cell Acute Lymphoblastic Leukemia

 

Last Updated: 18 Nov 2016

Go to URL