Chromosome 10

Common Name(s)

Chromosome 10

Description for this condition is not yet available.
 

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chromosome 10" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chromosome 10" returned 180 free, full-text research articles on human participants. First 3 results:

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells.
 

Author(s): Aram Ghalali, Zhi-Wei Ye, Johan Högberg, Ulla Stenius

Journal: J. Biol. Chem.. 2014 Apr;289(17):11601-15.

 

Akt kinase controls cell survival, proliferation, and invasive growth and is a critical factor for cancer development. Here we describe a cross-talk between phosphatases that may preserve levels of activated/phosphorylated Akt and confer aggressive growth of cancer cells. In prostatic ...

Last Updated: 28 Apr 2014

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Role of DNA secondary structures in fragile site breakage along human chromosome 10.
 

Author(s): Laura W Dillon, Levi C T Pierce, Maggie C Y Ng, Yuh-Hwa Wang

Journal: Hum. Mol. Genet.. 2013 Apr;22(7):1443-56.

 

The formation of alternative DNA secondary structures can result in DNA breakage leading to cancer and other diseases. Chromosomal fragile sites, which are regions of the genome that exhibit chromosomal breakage under conditions of mild replication stress, are predicted to form stable ...

Last Updated: 15 Mar 2013

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The p17 nonstructural protein of avian reovirus triggers autophagy enhancing virus replication via activation of phosphatase and tensin deleted on chromosome 10 (PTEN) and AMP-activated protein kinase (AMPK), as well as dsRNA-dependent protein kinase (PKR)/eIF2α signaling pathways.
 

Author(s): Pei I Chi, Wei R Huang, I H Lai, Ching Y Cheng, Hung J Liu

Journal: J. Biol. Chem.. 2013 Feb;288(5):3571-84.

 

Autophagy has been shown to facilitate replication or production of avian reovirus (ARV); nevertheless, how ARV induces autophagy remains largely unknown. Here, we demonstrate that the nonstructural protein p17 of ARV functions as an activator of autophagy. ARV-infected or p17-transfected ...

Last Updated: 4 Feb 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chromosome 10" returned 3 free, full-text review articles on human participants. First 3 results:

Pharmacological targeting of the integrated protein kinase B, phosphatase and tensin homolog deleted on chromosome 10, and transforming growth factor-beta pathways in prostate cancer.
 

Author(s): Stephen J Assinder, Qihan Dong, Helena Mangs, Des R Richardson

Journal: Mol. Pharmacol.. 2009 Mar;75(3):429-36.

 

Prostate cancer is a highly heterogenous disease in which a patient-tailored care program is much desired. Central to this goal is the development of novel targeted pharmacological interventions. To develop these treatment strategies, an understanding of the integration of cellular ...

Last Updated: 20 Feb 2009

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Phosphatase and tensin homologue deleted on chromosome 10: extending its PTENtacles.
 

Author(s): Bangyan L Stiles

Journal: Int. J. Biochem. Cell Biol.. 2009 Apr;41(4):757-61.

 

Since its discovery in 1997, phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has become one of the most important molecules in tumor biology. Mutations, deletions or dysregulation of PTEN is found in many human tumors. Recent studies have extended the reach of PTEN ...

Last Updated: 16 Feb 2009

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Hirschsprung's disease associated with a deletion of chromosome 10 (q11.2q21.2): a further link with the neurocristopathies?
 

Author(s): M S Fewtrell, P K Tam, A H Thomson, M Fitchett, J Currie, S M Huson, L M Mulligan

Journal: J. Med. Genet.. 1994 Apr;31(4):325-7.

 

We report a patient with total colonic aganglionosis in association with a deletion of part of the long arm of chromosome 10: (del(10)(q11.2q21.2)). This deletion includes the ret proto-oncogene, which has recently been implicated in multiple endocrine neoplasia type 2A (MEN 2A). ...

Last Updated: 29 Sep 1994

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 17 Apr 2014

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The Effect of Co Enzyme Q10 Together With Fertility Drugs on Pregnancy Outcome of in Vitro Fertilization
 

Status: Recruiting

Condition Summary: Aneuploidy; Pregnancy; Miscarriage

 

Last Updated: 12 Jan 2010

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