Chromophobe renal cell carcinoma

Common Name(s)

Chromophobe renal cell carcinoma

Chromophobe renal cell carcinoma is a rare type of kidney cancer that develops in cells that are involved in the production of urine. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis).

Chromophobe renal cell carcinoma usually occurs in adults between the ages of 40 and 60, although it can appear in all age groups. This type of carcinoma is associated with Birt-Hogg-Dubé syndrome, an inherited disorder caused by a mutation in the FLCN gene. The FLCN gene is involved in regulating cell growth, and a mutation in this gene can cause cells to grow out of control. This situation places affected individuals at higher risk of developing chromophobe renal cell carcinoma as well as noncancerous growths in the kidneys, lungs, and hair follicles.

Common symptoms include the presence of blood in the urine, pain in the back or side of the abdomen, and fatigue. Other signs include abdominal swelling or the presence of a lump in the abdominal area, which may or may not be painful. Diagnosis is usually made with a combination of a physical exam, imaging studies, blood tests, and other laboratory studies. Diagnosis may require a doctor to take a biopsy, or sample, of the tissue to look at under a microscope in order to determine if the cells are growing in an abnormal way.

Treatment may involve surgery, but treatment plans will vary based on many factors such as how large the tumor is and if it has spread to other structures. If you or a family member has been diagnosed with chromophobe renal cell carcinoma, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information. Meeting with a genetic counselor may also be helpful to better understand the inherited causes of this condition.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chromophobe renal cell carcinoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chromophobe renal cell carcinoma" returned 57 free, full-text research articles on human participants. First 3 results:

Chromophobe renal cell carcinoma occurring in the renal allograft of a transplant recipient presenting with weight loss.
 

Author(s): Mohammed Mahdi Althaf, Mohammed S Al-Sunaid, Mohamed Said Abdelsalam, Lutfi A Alkorbi, Turki O Al-Hussain, Mohammed Anas Dababo, Naveed Haq

Journal: Saudi J Kidney Dis Transpl. 2016 Jan;27(1):139-43.

 

The incidence of renal cell carcinomas (RCCs) in renal transplant recipients is reported as 1.1-1.5% in the native kidneys and 0.22-0.25% in the renal allograft. There are no data to support routine surveillance for tumors in transplant recipients. Most reported cases of RCCs occurring ...

Last Updated: 20 Jan 2016

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Robot-assisted heminephrectomy for chromophobe renal cell carcinoma in L-shaped fused crossed ectopia: Surgical challenge.
 

Author(s): Santosh Kumar, Shivanshu Singh, Siddharth Jain, Girdhar Singh Bora, Shrawan Kumar Singh

Journal: Korean J Urol. 2015 Oct;56(10):729-32.

 

Renal cell carcinoma associated with fused ectopic kidneys has rarely been reported in the literature. Here we report the first case of robot-assisted heminephrectomy for chromophobe renal cell carcinoma in an L-shaped fused ectopic kidney. The present case report highlights the importance ...

Last Updated: 23 Oct 2015

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BSND and ATP6V1G3: Novel Immunohistochemical Markers for Chromophobe Renal Cell Carcinoma.
 

Author(s): Kazuya Shinmura, Hisaki Igarashi, Hisami Kato, Kenji Koda, Hiroshi Ogawa, Seishiro Takahashi, Yoshiro Otsuki, Tatsuaki Yoneda, Yuichi Kawanishi, Kazuhito Funai, Tatsuya Takayama, Seiichiro Ozono, Haruhiko Sugimura

Journal: Medicine (Baltimore). 2015 Jun;94(24):e989.

 

Differentiating between chromophobe renal cell carcinoma (RCC) and other RCC subtypes can be problematic using routine light microscopy. This study aimed to identify novel immunohistochemical markers useful for a differential diagnosis between chromophobe RCC and other RCC subtypes. ...

Last Updated: 20 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chromophobe renal cell carcinoma" returned 6 free, full-text review articles on human participants. First 3 results:

[Chromophobe renal cell carcinoma: about four cases and review of the literature].
 

Author(s): Yddoussalah Othmane, Lahyani Mounir, Karmouni Tarik, Elkhader Khalid, Koutani Abdellatif, Ibn Attya Andaloussi Ahmed

Journal:

 

Last Updated: 18 Feb 2016

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Chromophobe renal cell carcinoma: a review of an uncommon entity.
 

Author(s): Francisco Emilio Vera-Badillo, Esther Conde, Ignacio Duran

Journal: Int. J. Urol.. 2012 Oct;19(10):894-900.

 

Renal cell carcinoma is the most common neoplasm of the kidney. It is a heterogeneous disease, comprised of different histological variants with a distinct clinical course, genetics and response to treatment. The various subtypes identified include clear cell, papillary and chromophobe, ...

Last Updated: 24 Sep 2012

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Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review.
 

Author(s): César Augusto Alvarenga, José Manuel Lopes, João Vinagre, Paula Itagyba Paravidino, Marcelo Alvarenga, Adilson Prando, Lísias Nogueira Castilho, Paula Soares, Athanase Billis

Journal: Sao Paulo Med J. 2012 ;130(1):57-60.

 

Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina.

Last Updated: 20 Feb 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer
 

Status: Recruiting

Condition Summary: Carcinoma of the Collecting Ducts of Bellini; Chromophobe Renal Cell Carcinoma; Kidney Medullary Carcinoma; Kidney Oncocytoma; Papillary Renal Cell Carcinoma; Recurrent Renal Cell Carcinoma; Sarcomatoid Renal Cell Carcinoma; Stage IV Renal Cell Cancer

 

Last Updated: 18 Apr 2016

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Everolimus Therapy in People With Birt-Hogg-Dube Syndrome (BHD)-Associated Kidney Cancer or Sporadic Chromophobe Renal Cancer
 

Status: Recruiting

Condition Summary: Renal Cancer; Chromophobe Renal Cell Carcinoma; Birt-Hogg-Dube Syndrome

 

Last Updated: 27 Sep 2016

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