Choroid plexus carcinoma

Common Name(s)

Choroid plexus carcinoma, Choroid plexus tumor

Choroid plexus carcinoma or choroid plexus tumor is a type of cancerous tumor that occurs in the brain’s choroid plexus tissue and most often occurs in children. The choroid plexus tissue lines the ventricles of the brain and produces cerebrospinal fluid or CSF. CSF circulates around the brain and spinal cord providing cushioning and protection. Because these tumors arise from the tissue involved in the making of CSF, the tumors can spread widely through this fluid. Symptoms of choroid plexus carcinoma are similar to those of other brain tumors including frequent headaches, unusually large head due to excess fluid on the brain, or large “soft spots” found on the baby's head. Other symptoms may include a decrease or loss of appetite and vomiting. The cause behind these tumors is largely unknown.

Treatment is usually surgical removal of the tumor and if removed completely, may be the only treatment necessary. If the recurs, a second surgery along with radiation and/or chemotherapy may be needed. Due to the nature of these tumors, it is critical to see a specialist on a regular basis for follow up and close monitoring. If your baby has been diagnosed with a choroid plexus carcinoma, talk to your baby's doctor and specialists about the most current treatment options. Additionally, there are support groups for people with brain tumors to assist you and your loved ones through this process.

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Condition Specific Organizations

Following organizations serve the condition "Choroid plexus carcinoma" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Choroid plexus carcinoma" returned 28 free, full-text research articles on human participants. First 3 results:

Choroid plexus carcinoma in adults: an extremely rare case.
 

Author(s): Selcuk Ozdogan, Yusuf Emrah Gergin, Sinem Gergin, Ozgur Senol, Mehmet Tiryaki, Necati Tatarli, Tufan Hicdonmez

Journal:

 

Choroid plexus tumors are rare intraventricular papillary neoplasms derived from choroid plexus epithelium, which account for approximately 2% to 4% of intracranial tumors in children and 0.5% in adults. Almost all choroid plexus carcinomas are seen in children and are extremely rare ...

Last Updated: 10 Jul 2015

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Choroid Plexus Neoplasms: Toward a Distinction between Carcinoma and Papilloma Using Arterial Spin-Labeling.
 

Author(s): V Dangouloff-Ros, D Grevent, M Pagès, T Blauwblomme, R Calmon, C Elie, S Puget, C Sainte-Rose, F Brunelle, P Varlet, N Boddaert

Journal: AJNR Am J Neuroradiol. 2015 Sep;36(9):1786-90.

 

Pediatric choroid plexus papillomas and carcinomas are highly vascularized neoplasms, which are difficult to distinguish with conventional imaging. We aimed to analyze the diagnostic accuracy of PWI, by using both pseudocontinuous arterial spin-labeling and DSC-PWI. We reviewed the ...

Last Updated: 11 Sep 2015

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Concurrent Gain of Oncogenes Drives Choroid Plexus Carcinoma.
 

Author(s):

Journal: Cancer Discov. 2015 Jul;5(7):OF26.

 

TAF12, NFYC, and RAD54L are oncogenes required to initiate and maintain choroid plexus carcinoma (CPC).

Last Updated: 8 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Choroid plexus carcinoma" returned 3 free, full-text review articles on human participants. First 3 results:

Second surgery and the prognosis of choroid plexus carcinoma--results of a meta-analysis of individual cases.
 

Author(s): Brigitte Wrede, Ping Liu, Joann Ater, Johannes E A Wolff

Journal: Anticancer Res.. ;25(6C):4429-33.

 

Tumors of the choroid plexus (CPT) are rare. While choroid plexus papillomas (CPP) are regarded as benign, choroid plexus carcinomas (CPC) have a dismal prognosis, and there is limited information available regarding the best treatment. Maximal possible surgery is generally believed ...

Last Updated: 7 Dec 2005

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Single solitary metastasis of the slowly progressive type of renal cell carcinoma to the choroid plexus--case report.
 

Author(s): H Matsumura, T Yoshimine, S Yamamoto, M Maruno, T Hayakawa, Y Ono, N Kondoh, M Namiki

Journal: Neurol. Med. Chir. (Tokyo). 1997 Dec;37(12):916-9.

 

A 68-year-old male developed a solitary metastasis in the choroid plexus of the right lateral ventricle 7 years after left nephrectomy for renal cell carcinoma. The lesion was totally removed and the patient has been free from recurrence for 30 months postoperatively. Pure solitary ...

Last Updated: 5 May 1998

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Choroid plexus carcinoma of childhood.
 

Author(s): R J Packer, G Perilongo, D Johnson, L N Sutton, G Vezina, R A Zimmerman, J Ryan, G Reaman, L Schut

Journal: Cancer. 1992 Jan;69(2):580-5.

 

The presentation, growth patterns, and response to therapy of 11 consecutive children with choroid plexus carcinomas were analyzed, and the results were compared with the outcome reported in other series. Patients were a median of 26 months of age at diagnosis. Two patients had thalamic ...

Last Updated: 4 Feb 1992

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Pediatric Study With Dabrafenib in HGG Patients
 

Status: Not yet recruiting

Condition Summary: Anaplastic Astrocytoma; Glioblastoma; Giant Cell Glioblastoma; Gliosarcoma; Anaplastic Oligodendroglioma; Anaplastic Oligoastrocytoma; Anaplastic Ependymoma; Choroid Plexus Carcinoma; Anaplastic Ganglioglioma; Pineal Parenchymal Tumor; Pineoblastoma; Medulloblastoma; PNET; Rhabdoid Tumor; Perineurioma; MPNST; Malignant Meningloma; Anaplastic Hemangiopericytoma

 

Last Updated: 9 Sep 2016

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Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma
 

Status: Recruiting

Condition Summary: Brain and Central Nervous System Tumors

 

Last Updated: 16 May 2016

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Study of Stored Tumor Samples in Young Patients With Brain Tumors
 

Status: Recruiting

Condition Summary: Brain and Central Nervous System Tumors

 

Last Updated: 19 Aug 2016

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