Choriocarcinoma

Common Name(s)

Choriocarcinoma, Chorioblastoma

Choriocarcinoma is an rare, fast-growing form of cancer that occurs in a woman's uterus (womb). The abnormal cells start in the tissue that would normally become the placenta. the organ that develops during pregnancy that feeds the growing baby. This form of cancer can quickly spread to the lungs through the blood stream. Early symptoms include increased hormone levels and abnormal vaginal bleeding. If it progresses or spreads, symptoms may include difficulty breathing, coughing up blood, and chest pain. Choriocarcinoma is one type of gestational trophoblastic disease.

Choriocarcinoma most commonly occurs after a molar pregnancy (placenta develops abnormally and the tissue continues to grow into cancer), but can also occur after a miscarriage, embryo implantation outside the uterus where it is supposed to implant (ectopic), and extreme cases of dehydration and nausea during pregnancy. It can also occur after a normal pregnancy. Very rarely, a choriocarcinoma starts in a location other than the placenta such as in the ovary or testis in men and in both cases, the outlook is poor. In females with choriocarcinoma of the placenta, testing will include hormone level checks, blood tests, pelvic exam to detect a mass, CT scans and MRI. Treatment is generally chemotherapy. Hysterectomy and radiation are not usually needed. Future normal pregnancies are possible. If cancer has spread, other treatments may be necessary. Outlook is variable and depends upon multiple factors. Recurrence is possible. In order to best treat your case of choriocarcinoma, it is important to consult your doctor. There are also support groups to provide additional guidance.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Choriocarcinoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Choriocarcinoma" returned 381 free, full-text research articles on human participants. First 3 results:

Cytomorphology of lung metastasis of pure choriocarcinoma of testis in a 58-year-old male.
 

Author(s): Shailja Puri, Shivani Sood, Shobha Mohindroo, Vijay Kaushal

Journal: J Cancer Res Ther. ;11(4):1035.

 

Choriocarcinoma is malignancy arising from the trophoblastic tissue. Pure choriocarcinoma is rare in testis. Choriocarcinoma of testis is more commonly associated with other germ cell tumors. The usual age of presentation is 2nd-3rd decade. Distant metastasis is known to occur in ...

Last Updated: 17 Feb 2016

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Primary choriocarcinoma of appendix mimicking acute appendicitis.
 

Author(s): Enam Murshed Khan, Amrita Chakrabarti, Amit Dutt Dwary

Journal: J Cancer Res Ther. ;11(4):1031.

 

Choriocarcinoma is a malignant trophoblastic cancer, the incidence of primary choriocarcinoma (PCC) of the gastrointestinal tract (GIT) being extremely rare, with only 14 cases being reported in worldwide literature. Here we present an extremely rare case of PCCof the appendix in ...

Last Updated: 17 Feb 2016

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Placental site trophoblastic tumor and choriocarcinoma: an unusual presentation.
 

Author(s): Abdulrahim Gari

Journal:

 

Mixed trophoblastic tumor composed of choriocarcinoma and placental site trophoblastic tumor was diagnosed on histopathology slides review, is a very rare mixed tumor and cured after adjuvant chemotherapy.

Last Updated: 24 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Choriocarcinoma" returned 18 free, full-text review articles on human participants. First 3 results:

Epithelioid trophoblastic tumor after induced abortion with previous broad choriocarcinoma: a case report and review of literature.
 

Author(s): Xiaofei Zhang, Haiyan Shi, Xiaoduan Chen

Journal:

 

Epithelioid trophoblastic tumor (ETT) is a rare trophoblastic tumor originating from chorionic-type intermediate trophoblasts (ITs). It is usually associated with a prior gestational event. We present a 44-year-old woman who had unusual pregnancy related history. The patient received ...

Last Updated: 31 Dec 2014

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Caesarean scar choriocarcinoma: a case report and review of the literature.
 

Author(s): Zhi-Da Qian, Xiao-Ming Zhu

Journal:

 

To report the clinical characteristics, pathologic findings and treatments of a patient with a Caesarean scar choriocarcinoma.

Last Updated: 6 Jun 2014

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Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma.
 

Author(s): Kazuhiro Takahashi, Shigeki Tsukamoto, Ken Saito, Nobuhiro Ohkohchi, Katsu Hirayama

Journal: World J. Gastroenterol.. 2013 Aug;19(31):5187-94.

 

Primary gastric choriocarcinoma is a rapidly growing neoplasm with an average survival of several months in untreated patients. Gastrectomy with lymph node dissection followed by chemotherapy is the treatment of choice. Regimens used for gastric adenocarcinoma are usually selected. ...

Last Updated: 21 Aug 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)
 

Status: Recruiting

Condition Summary: Gestational Trophoblastic Neoplasia; Choriocarcinoma; Placental Site Trophoblastic Tumor; Epithelioid Trophoblastic Tumor

 

Last Updated: 1 Nov 2016

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Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia
 

Status: Recruiting

Condition Summary: Choriocarcinoma; FIGO Stage I Gestational Trophoblastic Tumor; FIGO Stage II Gestational Trophoblastic Tumor; FIGO Stage III Gestational Trophoblastic Tumor; Hydatidiform Mole

 

Last Updated: 9 Feb 2016

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DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
 

Status: Recruiting

Condition Summary: Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Mixed Germ Cell Tumor; Ovarian Teratoma; Ovarian Yolk Sac Tumor; Testicular Choriocarcinoma; Testicular Embryonal Carcinoma; Testicular Seminoma; Testicular Teratoma; Testicular Yolk Sac Tumor

 

Last Updated: 5 Oct 2016

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