Choriocarcinoma

Common Name(s)

Choriocarcinoma, Chorioblastoma

Choriocarcinoma is an rare, fast-growing form of cancer that occurs in a woman's uterus (womb). The abnormal cells start in the tissue that would normally become the placenta. the organ that develops during pregnancy that feeds the growing baby. This form of cancer can quickly spread to the lungs through the blood stream. Early symptoms include increased hormone levels and abnormal vaginal bleeding. If it progresses or spreads, symptoms may include difficulty breathing, coughing up blood, and chest pain. Choriocarcinoma is one type of gestational trophoblastic disease.

Choriocarcinoma most commonly occurs after a molar pregnancy (placenta develops abnormally and the tissue continues to grow into cancer), but can also occur after a miscarriage, embryo implantation outside the uterus where it is supposed to implant (ectopic), and extreme cases of dehydration and nausea during pregnancy. It can also occur after a normal pregnancy. Very rarely, a choriocarcinoma starts in a location other than the placenta such as in the ovary or testis in men and in both cases, the outlook is poor. In females with choriocarcinoma of the placenta, testing will include hormone level checks, blood tests, pelvic exam to detect a mass, CT scans and MRI. Treatment is generally chemotherapy. Hysterectomy and radiation are not usually needed. Future normal pregnancies are possible. If cancer has spread, other treatments may be necessary. Outlook is variable and depends upon multiple factors. Recurrence is possible. In order to best treat your case of choriocarcinoma, it is important to consult your doctor. There are also support groups to provide additional guidance.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Choriocarcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Choriocarcinoma" returned 385 free, full-text research articles on human participants. First 3 results:

Placental site trophoblastic tumor and choriocarcinoma: an unusual presentation.
 

Author(s): Abdulrahim Gari

Journal:

 

Mixed trophoblastic tumor composed of choriocarcinoma and placental site trophoblastic tumor was diagnosed on histopathology slides review, is a very rare mixed tumor and cured after adjuvant chemotherapy.

Last Updated: 24 Nov 2015

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Choriocarcinoma developed in a tubal pregnancy - a case report.
 

Author(s): Izabella Petre, Elena Bernad, Anca Mureşan, Anca Bordianu, Sandor I Bernad, Onuţ Băcean, Roxana Folescu, Amelia Milulescu, Stelian Pantea

Journal: Rom J Morphol Embryol. 2015 ;56(2 Suppl):871-4.

 

Carcinoma of the Fallopian tube is the least frequent tumor of the female genital tract. The diagnosis is difficult but could be made more frequently if the causes of abnormal bleeding were thoroughly investigated by means of cytology and endometrial curettage. Treatment is by resection ...

Last Updated: 2 Oct 2015

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The role of PPARγ in TBBPA-mediated endocrine disrupting effects in human choriocarcinoma JEG-3 cells.
 

Author(s): Ewelina Honkisz, Anna K Wójtowicz

Journal: Mol. Cell. Biochem.. 2015 Nov;409(1-2):81-91.

 

The goal of the present study was to investigate the action of TBBPA on PPARγ protein expression in vitro in human choriocarcinoma-derived placental JEG-3 cells. We also analyzed TBBPA for its action on placental secretion of progesterone and β-hCG, cell viability, and apoptosis. ...

Last Updated: 1 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Choriocarcinoma" returned 19 free, full-text review articles on human participants. First 3 results:

Epithelioid trophoblastic tumor after induced abortion with previous broad choriocarcinoma: a case report and review of literature.
 

Author(s): Xiaofei Zhang, Haiyan Shi, Xiaoduan Chen

Journal:

 

Epithelioid trophoblastic tumor (ETT) is a rare trophoblastic tumor originating from chorionic-type intermediate trophoblasts (ITs). It is usually associated with a prior gestational event. We present a 44-year-old woman who had unusual pregnancy related history. The patient received ...

Last Updated: 31 Dec 2014

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Caesarean scar choriocarcinoma: a case report and review of the literature.
 

Author(s): Zhi-Da Qian, Xiao-Ming Zhu

Journal:

 

To report the clinical characteristics, pathologic findings and treatments of a patient with a Caesarean scar choriocarcinoma.

Last Updated: 6 Jun 2014

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Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma.
 

Author(s): Kazuhiro Takahashi, Shigeki Tsukamoto, Ken Saito, Nobuhiro Ohkohchi, Katsu Hirayama

Journal: World J. Gastroenterol.. 2013 Aug;19(31):5187-94.

 

Primary gastric choriocarcinoma is a rapidly growing neoplasm with an average survival of several months in untreated patients. Gastrectomy with lymph node dissection followed by chemotherapy is the treatment of choice. Regimens used for gastric adenocarcinoma are usually selected. ...

Last Updated: 21 Aug 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma
 

Status: Not yet recruiting

Condition Summary: Trophoblastic Neoplasms; Choriocarcinoma

 

Last Updated: 17 Feb 2006

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DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
 

Status: Recruiting

Condition Summary: Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Mixed Germ Cell Tumor; Ovarian Teratoma; Ovarian Yolk Sac Tumor; Testicular Choriocarcinoma; Testicular Embryonal Carcinoma; Testicular Seminoma; Testicular Teratoma; Testicular Yolk Sac Tumor

 

Last Updated: 7 Apr 2016

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Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)
 

Status: Not yet recruiting

Condition Summary: Gestational Trophoblastic Neoplasia; Choriocarcinoma; Placental Site Trophoblastic Tumor; Epithelioid Trophoblastic Tumor

 

Last Updated: 22 Jan 2016

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