Choriocarcinoma

Common Name(s)

Choriocarcinoma, Chorioblastoma

Choriocarcinoma is an rare, fast-growing form of cancer that occurs in a woman's uterus (womb). The abnormal cells start in the tissue that would normally become the placenta. the organ that develops during pregnancy that feeds the growing baby. This form of cancer can quickly spread to the lungs through the blood stream. Early symptoms include increased hormone levels and abnormal vaginal bleeding. If it progresses or spreads, symptoms may include difficulty breathing, coughing up blood, and chest pain. Choriocarcinoma is one type of gestational trophoblastic disease.

Choriocarcinoma most commonly occurs after a molar pregnancy (placenta develops abnormally and the tissue continues to grow into cancer), but can also occur after a miscarriage, embryo implantation outside the uterus where it is supposed to implant (ectopic), and extreme cases of dehydration and nausea during pregnancy. It can also occur after a normal pregnancy. Very rarely, a choriocarcinoma starts in a location other than the placenta such as in the ovary or testis in men and in both cases, the outlook is poor. In females with choriocarcinoma of the placenta, testing will include hormone level checks, blood tests, pelvic exam to detect a mass, CT scans and MRI. Treatment is generally chemotherapy. Hysterectomy and radiation are not usually needed. Future normal pregnancies are possible. If cancer has spread, other treatments may be necessary. Outlook is variable and depends upon multiple factors. Recurrence is possible. In order to best treat your case of choriocarcinoma, it is important to consult your doctor. There are also support groups to provide additional guidance.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Choriocarcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Choriocarcinoma" returned 304 free, full-text research articles on human participants. First 3 results:

AKR1C3 overexpression mediates methotrexate resistance in choriocarcinoma cells.
 

Author(s): Jing Zhao, Yang Xiang, Changji Xiao, Peng Guo, Dan Wang, Ying Liu, Yun Shen

Journal:

 

Chemotherapy is typically used to treat choriocarcinoma, but a small proportion of tumors develop resistance to chemotherapy. Similarly, methotrexate (MTX) is a first-line chemotherapy used to treat choriocarcinoma; although ~30% of patients are drug-resistant for MTX mono-therapy. ...

Last Updated: 29 Aug 2014

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Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells.
 

Author(s): C Rossmann, A Hammer, C N Koyani, A Kovacevic, M Siwetz, G Desoye, T G Poehlmann, U R Markert, B Huppertz, W Sattler, E Malle

Journal: Placenta. 2014 Aug;35(8):661-4.

 

Trophoblast invasion into uterine tissues represents a hallmark of first trimester placental development. As expression of serum amyloid A4 (SAA4) occurs in tumorigenic and invasive tissues we here investigated whether SAA4 is present in trophoblast-like human AC1-M59/Jeg-3 cells ...

Last Updated: 1 Aug 2014

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Primary hepatic choriocarcinoma in a 49-year-old man: report of a case.
 

Author(s): Ryosuke Sekine, Masanobu Hyodo, Masayuki Kojima, Yoshiyuki Meguro, Akifumi Suzuki, Taku Yokoyama, Alan T Lefor, Norio Hirota

Journal: World J. Gastroenterol.. 2013 Dec;19(48):9485-9.

 

We report a case of hepatic choriocarcinoma in a man diagnosed at autopsy after a rapid downhill clinical course. The patient was a 49-year-old man who presented with acute right-sided abdominal pain. There were no masses palpable on physical examination. Radiographic findings showed ...

Last Updated: 10 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Choriocarcinoma" returned 16 free, full-text review articles on human participants. First 3 results:

Caesarean scar choriocarcinoma: a case report and review of the literature.
 

Author(s): Zhi-Da Qian, Xiao-Ming Zhu

Journal:

 

To report the clinical characteristics, pathologic findings and treatments of a patient with a Caesarean scar choriocarcinoma.

Last Updated: 6 Jun 2014

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Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma.
 

Author(s): Kazuhiro Takahashi, Shigeki Tsukamoto, Ken Saito, Nobuhiro Ohkohchi, Katsu Hirayama

Journal: World J. Gastroenterol.. 2013 Aug;19(31):5187-94.

 

Primary gastric choriocarcinoma is a rapidly growing neoplasm with an average survival of several months in untreated patients. Gastrectomy with lymph node dissection followed by chemotherapy is the treatment of choice. Regimens used for gastric adenocarcinoma are usually selected. ...

Last Updated: 21 Aug 2013

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Primary choriocarcinoma of the colon: a case report and review of the literature.
 

Author(s): Lun Jiang, Jing-Tao Wu, Xin Peng

Journal:

 

Choriocarcinoma usually arises in the uterus and gonads. Primary choriocarcinoma (PCC) in an extragenital organ is rare. When it occurs in the gastrointestinal tract, the stomach is the most common site. Only 12 cases of PCC of the colon have been reported in the world literature. ...

Last Updated: 8 Feb 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma
 

Status: Not yet recruiting

Condition Summary: Trophoblastic Neoplasms; Choriocarcinoma

 

Last Updated: 17 Feb 2006

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DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
 

Status: Recruiting

Condition Summary: Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Mixed Germ Cell Tumor; Ovarian Teratoma; Ovarian Yolk Sac Tumor; Testicular Choriocarcinoma; Testicular Embryonal Carcinoma; Testicular Seminoma; Testicular Teratoma; Testicular Yolk Sac Tumor

 

Last Updated: 11 May 2015

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Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors
 

Status: Not yet recruiting

Condition Summary: Germ Cell Tumor; Teratoma; Choriocarcinoma; Germinoma; Mixed Germ Cell Tumor; Yolk Sac Tumor; Childhood Teratoma; Malignant Germ Cell Neoplasm; Extragonadal Seminoma; Non-seminomatous Germ Cell Tumor; Seminoma

 

Last Updated: 24 Mar 2015

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