Choriocarcinoma

Common Name(s)

Choriocarcinoma, Chorioblastoma

Choriocarcinoma is an rare, fast-growing form of cancer that occurs in a woman's uterus (womb). The abnormal cells start in the tissue that would normally become the placenta. the organ that develops during pregnancy that feeds the growing baby. This form of cancer can quickly spread to the lungs through the blood stream. Early symptoms include increased hormone levels and abnormal vaginal bleeding. If it progresses or spreads, symptoms may include difficulty breathing, coughing up blood, and chest pain. Choriocarcinoma is one type of gestational trophoblastic disease.

Choriocarcinoma most commonly occurs after a molar pregnancy (placenta develops abnormally and the tissue continues to grow into cancer), but can also occur after a miscarriage, embryo implantation outside the uterus where it is supposed to implant (ectopic), and extreme cases of dehydration and nausea during pregnancy. It can also occur after a normal pregnancy. Very rarely, a choriocarcinoma starts in a location other than the placenta such as in the ovary or testis in men and in both cases, the outlook is poor. In females with choriocarcinoma of the placenta, testing will include hormone level checks, blood tests, pelvic exam to detect a mass, CT scans and MRI. Treatment is generally chemotherapy. Hysterectomy and radiation are not usually needed. Future normal pregnancies are possible. If cancer has spread, other treatments may be necessary. Outlook is variable and depends upon multiple factors. Recurrence is possible. In order to best treat your case of choriocarcinoma, it is important to consult your doctor. There are also support groups to provide additional guidance.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Choriocarcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Choriocarcinoma" returned 367 free, full-text research articles on human participants. First 3 results:

Role of chemotherapy and thrombolysis in treatment of choriocarcinoma accompanied with pulmonary embolism: A case report with literature review.
 

Author(s): Mei Yang, Li Peng

Journal: Medicine (Baltimore). 2017 Sep;96(36):e7866.

 

Choriocarcinoma accompanied with pulmonary embolism (PE) is rare and difficult to diagnose and treat. There are about 25 cases reported in literature, which presented variable clinical characteristics and prognosis.

Last Updated: 31 Dec 1969

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Hemoptysis as primary manifestation in three women with choriocarcinoma with pulmonary metastasis: a case series.
 

Author(s): Wenping Zhang, Bao Liu, Jizhen Wu, Beibei Sun

Journal:

 

Gestational choriocarcinoma is the most common gestational trophoblastic neoplasia; it is often secondary to hydatidiform mole, as well as to abortion, ectopic pregnancy, premature delivery, or term delivery. Approximately 60% of patients with choriocarcinoma develop pulmonary metastases, ...

Last Updated: 31 Dec 1969

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Vulva choriocarcinoma.
 

Author(s): Houssine Boufettal

Journal:

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Choriocarcinoma" returned 22 free, full-text review articles on human participants. First 3 results:

Unusual clinical presentations of choriocarcinoma: A systematic review of case reports.
 

Author(s): Mishu Mangla, Deepak Singla, Harpreet Kaur, Sushmita Sharma

Journal: Taiwan J Obstet Gynecol. 2017 Feb;56(1):1-8.

 

Choriocarcinoma (CC) is a highly malignant tumor originating in the trophoblastic tissue. The clinical presentation of CC is so much varied that every case may be one of its kinds and thus can be a diagnostic challenge. Numerous case reports have been published in various journals ...

Last Updated: 31 Dec 1969

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Primary pulmonary choriocarcinoma in a male that was successfully diagnosed and treated: A case report and review of the literature.
 

Author(s): Ran Zhu, Congwei Jia, Jie Yan, Yufeng Luo, Zhen Huo

Journal: Medicine (Baltimore). 2016 Dec;95(52):e5693.

 

Primary pulmonary choriocarcinoma (PPC) is extremely rare, especially in males. It is characterized by a poor response to therapy and shortened survival times. Here, we report a successful diagnosis and modified treatment for PPC in a male and a review of the literature.

Last Updated: 31 Dec 1969

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Epithelioid trophoblastic tumor after induced abortion with previous broad choriocarcinoma: a case report and review of literature.
 

Author(s): Xiaofei Zhang, Haiyan Shi, Xiaoduan Chen

Journal:

 

Epithelioid trophoblastic tumor (ETT) is a rare trophoblastic tumor originating from chorionic-type intermediate trophoblasts (ITs). It is usually associated with a prior gestational event. We present a 44-year-old woman who had unusual pregnancy related history. The patient received ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)
 

Status: Recruiting

Condition Summary: Gestational Trophoblastic Neoplasia; Choriocarcinoma; Placental Site Trophoblastic Tumor; Epithelioid Trophoblastic Tumor

 

Last Updated: 1 Nov 2016

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Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Adult Germ Cell Tumor; Childhood Extracranial Germ Cell Tumor; Childhood Germ Cell Tumor; Extragonadal Embryonal Carcinoma; Grade 2 Immature Ovarian Teratoma; Grade 3 Immature Ovarian Teratoma; Malignant Germ Cell Tumor; Stage I Ovarian Choriocarcinoma; Stage I Ovarian Embryonal Carcinoma; Stage I Ovarian Teratoma; Stage I Ovarian Yolk Sac Tumor; Stage I Testicular Choriocarcinoma; Stage I Testicular Embryonal Carcinoma; Stage I Testicular Yolk Sac Tumor; Stage II Ovarian Choriocarcinoma; Stage II Ovarian Embryonal Carcinoma; Stage II Ovarian Yolk Sac Tumor; Stage II Testicular Choriocarcinoma; Stage II Testicular Embryonal Carcinoma; Stage II Testicular Yolk Sac Tumor; Stage III Ovarian Choriocarcinoma; Stage III Ovarian Embryonal Carcinoma; Stage III Ovarian Yolk Sac Tumor; Stage III Testicular Choriocarcinoma; Stage III Testicular Embryonal Carcinoma; Stage III Testicular Yolk Sac Tumor; Stage IV Ovarian Choriocarcinoma; Stage IV Ovarian Embryonal Carcinoma; Stage IV Ovarian Yolk Sac Tumor; Testicular Mixed Choriocarcinoma and Embryonal Carcinoma; Testicular Mixed Choriocarcinoma and Teratoma; Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

 

Last Updated: 2 Jun 2017

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DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
 

Status: Recruiting

Condition Summary: Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Mixed Germ Cell Tumor; Ovarian Teratoma; Ovarian Yolk Sac Tumor; Testicular Choriocarcinoma; Testicular Embryonal Carcinoma; Testicular Seminoma; Testicular Teratoma; Testicular Yolk Sac Tumor

 

Last Updated: 5 Oct 2017

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