Choriocarcinoma

Common Name(s)

Choriocarcinoma, Chorioblastoma

Choriocarcinoma is an rare, fast-growing form of cancer that occurs in a woman's uterus (womb). The abnormal cells start in the tissue that would normally become the placenta. the organ that develops during pregnancy that feeds the growing baby. This form of cancer can quickly spread to the lungs through the blood stream. Early symptoms include increased hormone levels and abnormal vaginal bleeding. If it progresses or spreads, symptoms may include difficulty breathing, coughing up blood, and chest pain. Choriocarcinoma is one type of gestational trophoblastic disease.

Choriocarcinoma most commonly occurs after a molar pregnancy (placenta develops abnormally and the tissue continues to grow into cancer), but can also occur after a miscarriage, embryo implantation outside the uterus where it is supposed to implant (ectopic), and extreme cases of dehydration and nausea during pregnancy. It can also occur after a normal pregnancy. Very rarely, a choriocarcinoma starts in a location other than the placenta such as in the ovary or testis in men and in both cases, the outlook is poor. In females with choriocarcinoma of the placenta, testing will include hormone level checks, blood tests, pelvic exam to detect a mass, CT scans and MRI. Treatment is generally chemotherapy. Hysterectomy and radiation are not usually needed. Future normal pregnancies are possible. If cancer has spread, other treatments may be necessary. Outlook is variable and depends upon multiple factors. Recurrence is possible. In order to best treat your case of choriocarcinoma, it is important to consult your doctor. There are also support groups to provide additional guidance.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Choriocarcinoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Choriocarcinoma" returned 350 free, full-text research articles on human participants. First 3 results:

Short tandem repeat analysis for confirmation of uterine non-gestational choriocarcinoma in a postmenopausal Taiwanese woman.
 

Author(s): Chin-Jui Wu, Hsiao-Lin Hwa, Wen-Chun Chang, Heng-Cheng Hsu, Mu-Zon Wu, Bor-Ching Sheu

Journal: Medicine (Baltimore). 2018 Feb;97(8):e9899.

 

Rare uterine choriocarcinoma can be differentiated gestational from nongestational choriocarcinoma by using short tandem repeats (STRs).

Last Updated: 31 Dec 1969

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Preimplantation Factor (PIF) Promotes HLA-G, -E, -F, -C Expression in JEG-3 Choriocarcinoma Cells and Endogenous Progesterone Activity.
 

Author(s): Miya Soukaina Hakam, Jose Maria Miranda-Sayago, Soren Hayrabedyan, Krassimira Todorova, Patrick Simon Spencer, Asma Jabeen, Eytan R Barnea, Nelson Fernandez

Journal: Cell. Physiol. Biochem.. 2017 ;43(6):2277-2296.

 

Pregnancy success requires mandatory maternal tolerance of the semi/ allogeneic embryo involving embryo-derived signals. Expression levels of PreImplantation Factor (PIF), a novel peptide secreted by viable embryos, correlate with embryo development, and its early detection in circulation ...

Last Updated: 31 Dec 1969

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Role of chemotherapy and thrombolysis in treatment of choriocarcinoma accompanied with pulmonary embolism: A case report with literature review.
 

Author(s): Mei Yang, Li Peng

Journal: Medicine (Baltimore). 2017 Sep;96(36):e7866.

 

Choriocarcinoma accompanied with pulmonary embolism (PE) is rare and difficult to diagnose and treat. There are about 25 cases reported in literature, which presented variable clinical characteristics and prognosis.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Choriocarcinoma" returned 22 free, full-text review articles on human participants. First 3 results:

Intraplacental choriocarcinoma coexisting with fetomaternal hemorrhage: Case report, chemotherapy management, and literature review.
 

Author(s): Qin She, Zhi Cheng, Darine El-Chaar, Feng Luo, Xiaoyan Guo, Shi Wu Wen

Journal: Medicine (Baltimore). 2018 Apr;97(14):e9977.

 

Near-term intraplacental choriocarcinoma (IC) coexisting with massive fetomaternal hemorrhage (FMH) is rare, and its clinical course is poorly understood. Here, we report a new case from our hospital, with detailed discussion and literature review.

Last Updated: 31 Dec 1969

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A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature.
 

Author(s): Nan Jia, Yan Chen, Xiang Tao, Enzhi Ou, Xin Lu, Weiwei Feng

Journal:

 

Choriocarcinoma of the ovary is rare. This tumor can arise from gestational tissue or pure germ cells of the ovary, the former results in gestational choriocarcinoma. The clinical characteristics and histology of both tumor types are identical, differentiation of these tumors is necessary ...

Last Updated: 31 Dec 1969

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Unusual clinical presentations of choriocarcinoma: A systematic review of case reports.
 

Author(s): Mishu Mangla, Deepak Singla, Harpreet Kaur, Sushmita Sharma

Journal: Taiwan J Obstet Gynecol. 2017 Feb;56(1):1-8.

 

Choriocarcinoma (CC) is a highly malignant tumor originating in the trophoblastic tissue. The clinical presentation of CC is so much varied that every case may be one of its kinds and thus can be a diagnostic challenge. Numerous case reports have been published in various journals ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)
 

Status: Recruiting

Condition Summary: Gestational Trophoblastic Neoplasia; Choriocarcinoma; Placental Site Trophoblastic Tumor; Epithelioid Trophoblastic Tumor

 

Last Updated: 1 Nov 2016

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Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Adult Germ Cell Tumor; Childhood Extracranial Germ Cell Tumor; Childhood Germ Cell Tumor; Extragonadal Embryonal Carcinoma; Grade 2 Immature Ovarian Teratoma; Grade 3 Immature Ovarian Teratoma; Malignant Germ Cell Tumor; Stage I Ovarian Choriocarcinoma; Stage I Ovarian Embryonal Carcinoma; Stage I Ovarian Teratoma; Stage I Ovarian Yolk Sac Tumor; Stage I Testicular Choriocarcinoma; Stage I Testicular Embryonal Carcinoma; Stage I Testicular Yolk Sac Tumor; Stage II Ovarian Choriocarcinoma; Stage II Ovarian Embryonal Carcinoma; Stage II Ovarian Yolk Sac Tumor; Stage II Testicular Choriocarcinoma; Stage II Testicular Embryonal Carcinoma; Stage II Testicular Yolk Sac Tumor; Stage III Ovarian Choriocarcinoma; Stage III Ovarian Embryonal Carcinoma; Stage III Ovarian Yolk Sac Tumor; Stage III Testicular Choriocarcinoma; Stage III Testicular Embryonal Carcinoma; Stage III Testicular Yolk Sac Tumor; Stage IV Ovarian Choriocarcinoma; Stage IV Ovarian Embryonal Carcinoma; Stage IV Ovarian Yolk Sac Tumor; Testicular Mixed Choriocarcinoma and Embryonal Carcinoma; Testicular Mixed Choriocarcinoma and Teratoma; Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

 

Last Updated: 2 Jun 2017

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DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
 

Status: Recruiting

Condition Summary: Childhood Malignant Ovarian Germ Cell Tumor; Childhood Malignant Testicular Germ Cell Tumor; Ovarian Choriocarcinoma; Ovarian Embryonal Carcinoma; Ovarian Mixed Germ Cell Tumor; Ovarian Teratoma; Ovarian Yolk Sac Tumor; Testicular Choriocarcinoma; Testicular Embryonal Carcinoma; Testicular Seminoma; Testicular Teratoma; Testicular Yolk Sac Tumor

 

Last Updated: 5 Oct 2017

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