Chordoma

Common Name(s)

Chordoma

A chordoma is a rare tumor that develops from cells of the notochord, a structure that is present in the developing embryo and is important for the development of the spine.  The notochord usually disappears before birth, though a few cells may remain embedded in the bones of the spine or at the base of the skull.   A chordoma occurs when these notochord cells start to grow into a tumor and spread into surrounding bone.  Approximately one third of chordomas occur at the base of the skull in a bone called the clivus and the most common symptoms are double vision (diplopia) and headaches.   The average age of diagnosis for chordomas of the skull base is 38 years.    Treatment often begins with surgery to remove as much of the tumor as possible, and radiation therapy may follow surgery to destroy any remaining tumor cells.  Chordomas often grow back in the original location after treatment (known as a recurrence); they do not often spread to distant parts of the body (metastasize).   Though the cause of chordomas is unknown, there is currently a study aimed at identifying a potential genetic predisposition to this disease; more information on this study can be found on the National Cancer Institute's web site.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chordoma" for support, advocacy or research.

Chordoma Foundation

The Chordoma Foundation is a nonprofit organization working to improve the lives of chordoma patients by accelerating research to develop effective treatments for chordoma, and by helping patients to get the best care possible.

Last Updated: 5 Aug 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chordoma" for support, advocacy or research.

Chordoma Foundation

The Chordoma Foundation is a nonprofit organization working to improve the lives of chordoma patients by accelerating research to develop effective treatments for chordoma, and by helping patients to get the best care possible.

http://www.chordomafoundation.org/

Last Updated: 5 Aug 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chordoma" returned 213 free, full-text research articles on human participants. First 3 results:

Diagnostic Clues and Treatment of Intradural Cranial Chordoma.
 

Author(s): Han-Hai Zeng, Xiao-Bo Yu, Lin-Feng Fan, Gao Chen

Journal: Chin. Med. J.. 2016 12;129(23):2895-2896.

 

Last Updated: 30 Nov 2016

Go To URL
Auto-immune thyroid dysfunction induced by tyrosine kinase inhibitors in a patient with recurrent chordoma.
 

Author(s): Juliette Eroukhmanoff, Frederic Castinetti, Nicolas Penel, Sebastien Salas

Journal:

 

While hypothyroidism has frequently been reported with the use of TKIs, the thyroid-stimulating hormone (TSH) suppressing effect of TKIs is rare, except for thyroiditis. We describe a case with progressive recurrent chordoma who initially became hyperthyroid in a context of autoimmunity ...

Last Updated: 25 Aug 2016

Go To URL
Predicting clinical outcomes in chordoma patients receiving immunotherapy: a comparison between volumetric segmentation and RECIST.
 

Author(s): Kathleen E Fenerty, Les R Folio, Nicholas J Patronas, Jennifer L Marté, James L Gulley, Christopher R Heery

Journal:

 

The Response Evaluation Criteria in Solid Tumors (RECIST) are the current standard for evaluating disease progression or therapy response in patients with solid tumors. RECIST 1.1 calls for axial, longest-diameter (or perpendicular short axis of lymph nodes) measurements of a maximum ...

Last Updated: 24 Aug 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chordoma" returned 19 free, full-text review articles on human participants. First 3 results:

Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
 

Author(s): Tamir Ailon, Radmehr Torabi, Charles G Fisher, Laurence D Rhines, Michelle J Clarke, Chetan Bettegowda, Stefano Boriani, Yoshiya J Yamada, Norio Kawahara, Peter P Varga, John H Shin, Arjun Saghal, Ziya L Gokaslan

Journal: Spine. 2016 Oct;41 Suppl 20():S193-S198.

 

Systematic review.

Last Updated: 18 Oct 2016

Go To URL
Safety and Local Control of Radiation Therapy for Chordoma of the Spine and Sacrum: A Systematic Review.
 

Author(s): Brenton Pennicooke, Ilya Laufer, Arjun Sahgal, Peter P Varga, Ziya L Gokaslan, Mark H Bilsky, Yoshiya J Yamada

Journal: Spine. 2016 Oct;41 Suppl 20():S186-S192.

 

Systematic literature review.

Last Updated: 10 Aug 2016

Go To URL
Chordoma dedifferentiation after proton beam therapy: a case report and review of the literature.
 

Author(s): Joseph Frankl, Cassi Grotepas, Baldassare Stea, G Michael Lemole, Alexander Chiu, Rihan Khan

Journal:

 

Chordoma is a rare invasive bone tumor that may occur anywhere along the neuraxis. A total of three primary histological varieties have been identified: conventional, chondroid, and dedifferentiated.

Last Updated: 12 Oct 2016

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Ion Irradiation of Sacrococcygeal Chordoma
 

Status: Recruiting

Condition Summary: Sacral Chordoma

 

Last Updated: 1 May 2017

Go to URL
CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma
 

Status: Not yet recruiting

Condition Summary: Chordoma

 

Last Updated: 11 Apr 2017

Go to URL

Last Updated: 23 Sep 2017

Go to URL