Cholesteatoma

Common Name(s)

Cholesteatoma

Cholesteatoma is a type of skin cyst located in the middle ear. It can be congenital (present from birth), but it more commonly occurs as a complication of chronic ear infection. The hallmark symptom is a painless discharge from the ear. Hearing loss, dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth.  Surgery can stop infections and prevent complications.   
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholesteatoma" for support, advocacy or research.

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Vestibular Disorders Association

VEDA's mission is to serve people with vestibular (inner ear balance) disorders by providing access to information, offering a support network, and elevating awareness of the challenges associated with these conditions.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholesteatoma" for support, advocacy or research.

Logo
Vestibular Disorders Association

VEDA's mission is to serve people with vestibular (inner ear balance) disorders by providing access to information, offering a support network, and elevating awareness of the challenges associated with these conditions.

https://vestibular.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholesteatoma" returned 87 free, full-text research articles on human participants. First 3 results:

Neuroendocrine adenoma of the middle ear confused with congenital cholesteatoma.
 

Author(s): Yee Hyuk Kim, Sang Heun Lee, Da Jung Jung

Journal: Braz J Otorhinolaryngol. 2014 Apr;80(2):180-1.

 

Last Updated: 16 May 2014

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Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium.
 

Author(s): Wei Liu, Shumin Xie, Xing Chen, Xingwang Rao, Hongmiao Ren, Bing Hu, Tuanfang Yin, Yuyan Xiang, Jihao Ren

Journal:

 

Interleukin-6 (IL-6) is one of the most important cytokines which has been shown to play a critical role in the pathogenesis of cholesteatoma. In this study, we aimed to investigate the expression of interleukin-6 (IL-6) and phosphorylated signal transducer and activator of transcription ...

Last Updated: 19 Feb 2014

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[Cholesteatoma of the external auditory canal: seven cases].
 

Author(s): Rim Zainine, Majdi Ben Salah, Mohamed Ennaili, Najeh Beltaief, Ghazi Besbes

Journal: Tunis Med. 2013 Nov;91(11):677-8.

 

Last Updated: 17 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholesteatoma" returned 12 free, full-text review articles on human participants. First 3 results:

Imaging of non-operated cholesteatoma: clinical practice guidelines.
 

Author(s): D Ayache, V Darrouzet, F Dubrulle, C Vincent, S Bobin, M Williams, C Martin,

Journal: Eur Ann Otorhinolaryngol Head Neck Dis. 2012 Jun;129(3):148-52.

 

Middle ear cholesteatoma is an aggressive form of chronic otitis media requiring surgical therapy. The surgical strategy depends on the location of the lesion, its extensions to the middle ear and mastoid, the anatomical conformation of the tympanomastoid cavities and the health status ...

Last Updated: 5 Jun 2012

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TNF-R2 expression in acquired middle ear cholesteatoma.
 

Author(s): Rodrigo Faller Vitale, Celina Siqueira Barbosa Pereira, Adriana Leal Alves, Jose Humberto Tavares Guerreiro Fregnani, Fernando Quintanilha Ribeiro

Journal: Braz J Otorhinolaryngol. ;77(4):531-6.

 

Acquired middle ear cholesteatoma is a disease which promotes bone erosion resulting in potentially serious complications. The tumor necrosis factor alpha (TNF-α) is present in cholesteatoma and it is related to bone erosion, as shown by different authors. To understand the aggressiveness ...

Last Updated: 23 Aug 2011

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Cholesteatoma of the frontal sinus.
 

Author(s): B Hammami, M Mnejja, A Chakroun, I Achour, A Chakroun, I Charfeddine, A Ghorbel

Journal: Eur Ann Otorhinolaryngol Head Neck Dis. 2010 Dec;127(6):213-6.

 

Cholesteatoma of the paranasal sinuses is a rare pathology. A review of the literature reported less than 30 cases. These lesions mainly involve the frontal sinus.

Last Updated: 14 Dec 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comprehensive Wide Bandwidth Test Battery of Auditory Function in Veterans
 

Status: Not yet recruiting

Condition Summary: Hearing Loss, Sensorineural; Hearing Loss, Conductive; Hearing Loss, Mixed Conductive-Sensorineural; Otosclerosis; Tympanic Membrane Perforation; Otitis Media With Effusion; Cholesteatoma

 

Last Updated: 21 May 2014

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