Cholestasis

Common Name(s)

Cholestasis

Cholestasis is a rare disease where a person’s liver can not move the bile it makes to the small intestine. The liver, an organ in the abdomen (belly), is responsible for producing bile, which is a compound that helps people digest fats. Once the bile has been made, it is supposed to enter the small intestine where fat is digested. However, in people with cholestasis, the bile can not move to the small intestine because of a blockage and becomes backed up in the liver. This can be caused by a number of things such as gallstones, scars from prior surgery, or certain cancers. Symptoms of cholestasis are itchiness, jaundice (yellowing of the skin), pale stool, and dark urine. Talk with your doctor to find the best treatment for you if you have been diagnosed with cholestasis.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholestasis" returned 426 free, full-text research articles on human participants. First 3 results:

Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis.
 

Author(s): Eva Sticova, Alena Lodererova, Evita van de Steeg, Sona Frankova, Marek Kollar, Vera Lanska, Radana Kotalova, Tomas Dedic, Alfred H Schinkel, Milan Jirsa

Journal:

 

Organic anion-transporting polypeptides OATP1B1 and OATP1B3 are sinusoidal membrane transporters mediating liver uptake of a wide range of substrates including conjugated and unconjugated bilirubin, xenobiotics and drugs. Absence of OATP1Bs in the liver causes Rotor syndrome. Our ...

Last Updated: 20 Jul 2015

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Intrahepatic Cholestasis of Pregnancy (ICP) in U.S. Latinas and Chileans: Clinical features, Ancestry Analysis, and Admixture Mapping.
 

Author(s): Laura N Bull, Donglei Hu, Sohela Shah, Luisa Temple, Karla Silva, Scott Huntsman, Jennifer Melgar, Mary T Geiser, Ukina Sanford, Juan A Ortiz, Richard H Lee, Juan P Kusanovic, Elad Ziv, Juan E Vargas

Journal:

 

In the Americas, women with Indigenous American ancestry are at increased risk of intrahepatic cholestasis of pregnancy (ICP), relative to women of other ethnicities. We hypothesized that ancestry-related genetic factors contribute to this increased risk. We collected clinical and ...

Last Updated: 1 Jul 2015

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Composition of parenteral nutrition solution affects the time of occurrence but not the incidence of cholestasis in surgical infants.
 

Author(s): Burak Ardıçlı, İbrahim Karnak, Arbay Özden Çiftçi, Hasan Özen, F Cahit Tanyel, Mehmet Emin Şenocak

Journal: Turk. J. Pediatr.. ;56(5):500-6.

 

Parenteral nutrition-associated cholestasis (PNAC) is one of the most important complications of parenteral nutrition (PN). This study was conducted to define the incidence, characteristics and precipitating factors of PNAC in infants treated with two different PN regimens in the ...

Last Updated: 29 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholestasis" returned 59 free, full-text review articles on human participants. First 3 results:

Review of a challenging clinical issue: Intrahepatic cholestasis of pregnancy.
 

Author(s): Sebiha Ozkan, Yasin Ceylan, Orhan Veli Ozkan, Sule Yildirim

Journal: World J. Gastroenterol.. 2015 Jun;21(23):7134-41.

 

Intrahepatic cholestasis of pregnancy (ICP) is a reversible pregnancy-specific cholestatic condition characterized by pruritus, elevated liver enzymes, and increased serum bile acids. It commences usually in the late second or third trimester, and quickly resolves after delivery. ...

Last Updated: 25 Jun 2015

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New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond.
 

Author(s): Ulrich Beuers, Michael Trauner, Peter Jansen, Raoul Poupon

Journal: J. Hepatol.. 2015 Apr;62(1 Suppl):S25-37.

 

Cholestasis is an impairment of bile formation/flow at the level of the hepatocyte and/or cholangiocyte. The first, and for the moment, most established medical treatment is the natural bile acid (BA) ursodeoxycholic acid (UDCA). This secretagogue improves, e.g. in intrahepatic cholestasis ...

Last Updated: 29 Apr 2015

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Hepatic phenotypes of HNF1B gene mutations: a case of neonatal cholestasis requiring portoenterostomy and literature review.
 

Author(s): Radana Kotalova, Petra Dusatkova, Ondrej Cinek, Lenka Dusatkova, Tomas Dedic, Tomas Seeman, Jan Lebl, Stepanka Pruhova

Journal: World J. Gastroenterol.. 2015 Feb;21(8):2550-7.

 

Hepatocyte nuclear factor 1-β (HNF1B) defects cause renal cysts and diabetes syndrome (RCAD), or HNF1B-maturity-onset diabetes of the young. However, the hepatic phenotype of HNF1B variants is not well studied. We present a female neonate born small for her gestational age [birth ...

Last Updated: 5 Mar 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ursodeoxycholic Acid And Cholestasis Of Pregnancy
 

Status: Not yet recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 21 Oct 2010

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Serum Autotaxin Levels in Cholestasis of Pregnancy
 

Status: Recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 19 Apr 2016

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Il-17 Levels in Intrahepatic Cholestasis of Pregnancy
 

Status: Recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 16 Mar 2014

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