Cholestasis

Common Name(s)

Cholestasis

Cholestasis is a rare disease where a person’s liver can not move the bile it makes to the small intestine. The liver, an organ in the abdomen (belly), is responsible for producing bile, which is a compound that helps people digest fats. Once the bile has been made, it is supposed to enter the small intestine where fat is digested. However, in people with cholestasis, the bile can not move to the small intestine because of a blockage and becomes backed up in the liver. This can be caused by a number of things such as gallstones, scars from prior surgery, or certain cancers. Symptoms of cholestasis are itchiness, jaundice (yellowing of the skin), pale stool, and dark urine. Talk with your doctor to find the best treatment for you if you have been diagnosed with cholestasis.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholestasis" returned 434 free, full-text research articles on human participants. First 3 results:

[Protective effect of emodin pretreatment in young rats with intrahepatic cholestasis].
 

Author(s): Xiao-Li Xiong, Su-Qi Yan, Huan Qin, Li-Shan Zhou, Ling-Ling Zhang, Zhi-Xia Jiang, Yan Ding

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2016 Feb;18(2):165-71.

 

To investigate the protective effect of emodin in young rats with intrahepatic cholestasis.

Last Updated: 23 Feb 2016

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Oxidative stress markers in intrahepatic cholestasis of pregnancy: a prospective controlled study.
 

Author(s): Y-Y Hu, J-C Liu, A-Y Xing

Journal: Eur Rev Med Pharmacol Sci. 2015 Sep;19(17):3181-6.

 

Intrahepatic cholestasis of pregnancy (ICP), characterized by skin pruritus and elevation of serum aminotransferase activity and bile acid concentration in the mother, is one of the most common liver disorders in pregnancy. It was proved that ICP might lead to fetal distress by triggering ...

Last Updated: 24 Sep 2015

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Blood Glucose Homeostasis in the Course of Partial Pancreatectomy--Evidence for Surgically Reversible Diabetes Induced by Cholestasis.
 

Author(s): Florian Ehehalt, Dorothée Sturm, Manuela Rösler, Marius Distler, Jürgen Weitz, Stephan Kersting, Barbara Ludwig, Uta Schwanebeck, Hans-Detlev Saeger, Michele Solimena, Robert Grützmann

Journal:

 

Partial pancreatic resection is accompanied not only by a reduction in the islet cell mass but also by a variety of other factors that are likely to interfere with glucose metabolism. The aim of this work was to characterize the patient dynamics of blood glucose homeostasis during ...

Last Updated: 7 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholestasis" returned 61 free, full-text review articles on human participants. First 3 results:

Italian guidelines for the management and treatment of neonatal cholestasis.
 

Author(s): Carlo Dani, Simone Pratesi, Francesco Raimondi, Costantino Romagnoli,

Journal:

 

Hyperbilirubinemia is a frequent condition affecting newborns during the first two weeks of life and when it lasts more than 14 days it is defined as prolonged jaundice. This condition requires differential diagnosis between the usually benign unconjugated hyperbilirubinemia and the ...

Last Updated: 2 Oct 2015

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Review of a challenging clinical issue: Intrahepatic cholestasis of pregnancy.
 

Author(s): Sebiha Ozkan, Yasin Ceylan, Orhan Veli Ozkan, Sule Yildirim

Journal: World J. Gastroenterol.. 2015 Jun;21(23):7134-41.

 

Intrahepatic cholestasis of pregnancy (ICP) is a reversible pregnancy-specific cholestatic condition characterized by pruritus, elevated liver enzymes, and increased serum bile acids. It commences usually in the late second or third trimester, and quickly resolves after delivery. ...

Last Updated: 25 Jun 2015

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New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond.
 

Author(s): Ulrich Beuers, Michael Trauner, Peter Jansen, Raoul Poupon

Journal: J. Hepatol.. 2015 Apr;62(1 Suppl):S25-37.

 

Cholestasis is an impairment of bile formation/flow at the level of the hepatocyte and/or cholangiocyte. The first, and for the moment, most established medical treatment is the natural bile acid (BA) ursodeoxycholic acid (UDCA). This secretagogue improves, e.g. in intrahepatic cholestasis ...

Last Updated: 29 Apr 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Serum Autotaxin Levels in Cholestasis of Pregnancy
 

Status: Recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 19 Apr 2016

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Il-17 Levels in Intrahepatic Cholestasis of Pregnancy
 

Status: Recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 16 Mar 2014

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Retrospective Review of CT and MR in Pediatric Patients With Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis; Children

 

Last Updated: 30 Nov 2010

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