Cholestasis

Common Name(s)

Cholestasis

Cholestasis is a rare disease where a person’s liver can not move the bile it makes to the small intestine. The liver, an organ in the abdomen (belly), is responsible for producing bile, which is a compound that helps people digest fats. Once the bile has been made, it is supposed to enter the small intestine where fat is digested. However, in people with cholestasis, the bile can not move to the small intestine because of a blockage and becomes backed up in the liver. This can be caused by a number of things such as gallstones, scars from prior surgery, or certain cancers. Symptoms of cholestasis are itchiness, jaundice (yellowing of the skin), pale stool, and dark urine. Talk with your doctor to find the best treatment for you if you have been diagnosed with cholestasis.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholestasis" returned 409 free, full-text research articles on human participants. First 3 results:

Portal hypertension and intrahepatic cholestasis in primary amyloidosis.
 

Author(s): Erkan Çağlar, Gülşen Özbay, Hakan Kalyon, Abdullah Sonsuz

Journal: Turk J Gastroenterol. 2014 Dec;25 Suppl 1():258-9.

 

Last Updated: 27 Apr 2015

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Novel mutation in a Chinese patient with progressive familial intrahepatic cholestasis type 3.
 

Author(s): Hao-Zhe Sun, Hong Shi, Shun-Cai Zhang, Xi-Zhong Shen

Journal: World J. Gastroenterol.. 2015 Jan;21(2):699-703.

 

Genotyping is conclusive for the diagnosis of progressive familial intrahepatic cholestasis type 3 (PFIC3). Here we report a Chinese patient of PFIC3 with compound mutations in the ABCB4 gene. Liver biopsy was performed on a 17-year-old male patient with intrahepatic cholestasis of ...

Last Updated: 16 Jan 2015

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Clinical algorithm to guide the need for endoscopic retrograde cholangiopancreatography to evaluate early postliver transplant cholestasis.
 

Author(s): Satheesh Nair, Shilpa Lingala, Sanjaya K Satapathy, James D Eason, Jason M Vanatta

Journal: Exp Clin Transplant. 2014 Dec;12(6):543-7.

 

Severe cholestasis after liver transplant is common. In this study, our aim was to develop an algorithm to guide biliary intervention in these patients.

Last Updated: 10 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholestasis" returned 57 free, full-text review articles on human participants. First 3 results:

New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond.
 

Author(s): Ulrich Beuers, Michael Trauner, Peter Jansen, Raoul Poupon

Journal: J. Hepatol.. 2015 Apr;62(1 Suppl):S25-37.

 

Cholestasis is an impairment of bile formation/flow at the level of the hepatocyte and/or cholangiocyte. The first, and for the moment, most established medical treatment is the natural bile acid (BA) ursodeoxycholic acid (UDCA). This secretagogue improves, e.g. in intrahepatic cholestasis ...

Last Updated: 29 Apr 2015

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Hepatic phenotypes of HNF1B gene mutations: a case of neonatal cholestasis requiring portoenterostomy and literature review.
 

Author(s): Radana Kotalova, Petra Dusatkova, Ondrej Cinek, Lenka Dusatkova, Tomas Dedic, Tomas Seeman, Jan Lebl, Stepanka Pruhova

Journal: World J. Gastroenterol.. 2015 Feb;21(8):2550-7.

 

Hepatocyte nuclear factor 1-β (HNF1B) defects cause renal cysts and diabetes syndrome (RCAD), or HNF1B-maturity-onset diabetes of the young. However, the hepatic phenotype of HNF1B variants is not well studied. We present a female neonate born small for her gestational age [birth ...

Last Updated: 5 Mar 2015

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Fibrates and cholestasis.
 

Author(s): Nisanne S Ghonem, David N Assis, James L Boyer

Journal: Hepatology. 2015 Aug;62(2):635-43.

 

Cholestasis, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), results from an impairment or disruption of bile production and causes intracellular retention of toxic bile constituents, including bile salts. If left untreated, cholestasis leads to ...

Last Updated: 24 Jul 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ursodeoxycholic Acid And Cholestasis Of Pregnancy
 

Status: Not yet recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 21 Oct 2010

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Serum Autotaxin Levels in Cholestasis of Pregnancy
 

Status: Recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 23 Jun 2015

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Il-17 Levels in Intrahepatic Cholestasis of Pregnancy
 

Status: Recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 16 Mar 2014

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