Cholestasis

Common Name(s)

Cholestasis

Cholestasis is a rare disease where a person’s liver can not move the bile it makes to the small intestine. The liver, an organ in the abdomen (belly), is responsible for producing bile, which is a compound that helps people digest fats. Once the bile has been made, it is supposed to enter the small intestine where fat is digested. However, in people with cholestasis, the bile can not move to the small intestine because of a blockage and becomes backed up in the liver. This can be caused by a number of things such as gallstones, scars from prior surgery, or certain cancers. Symptoms of cholestasis are itchiness, jaundice (yellowing of the skin), pale stool, and dark urine. Talk with your doctor to find the best treatment for you if you have been diagnosed with cholestasis.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholestasis" returned 371 free, full-text research articles on human participants. First 3 results:

Cholestasis caused by Fasciola gigantica.
 

Author(s): Remzi Beştaş, Kendal Yalçin, Muttalip Çiçek

Journal: Turkiye Parazitol Derg. 2014 ;38(3):201-4.

 

Fascioliasis is an infectious disease caused by the hepatic trematodes Fasciola hepatica and Fasciola gigantica. Here, we report the case of Fasciola gigantica presenting with biliary obstruction and abdominal pain that was diagnosed and treated by endoscopic retrograde cholangiography ...

Last Updated: 13 Oct 2014

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Successful management of severe intrahepatic cholestasis of pregnancy: report of a first Japanese case.
 

Author(s): Kenya Kamimura, Hiroyuki Abe, Naomi Kamimura, Masayuki Yamaguchi, Maiko Mamizu, Kanna Ogi, Yoshifumi Takahashi, Ken-Ichi Mizuno, Hiroteru Kamimura, Yuji Kobayashi, Manabu Takeuchi, Kunihiko Yoshida, Kyoko Yamada, Takayuki Enomoto, Koichi Takakuwa, Minoru Nomoto, Miki Obata, Yoshinori Katsuragi, Yukio Mishima, Ryo Kominami, Tomoteru Kamimura, Yutaka Aoyagi

Journal:

 

Intrahepatic cholestasis of pregnancy (ICP) is a cholestasis condition caused by elevated levels of serum bile acids that mainly occurs in the third trimester of pregnancy. Maternal symptoms include pruritus; elevation of transaminases, biliary enzymes, and bilirubin levels; and abnormal ...

Last Updated: 22 Sep 2014

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Intractable itch relieved by 4-phenylbutyrate therapy in patients with progressive familial intrahepatic cholestasis type 1.
 

Author(s): Yasuhiro Hasegawa, Hisamitsu Hayashi, Sotaro Naoi, Hiroki Kondou, Kazuhiko Bessho, Koji Igarashi, Kentaro Hanada, Kie Nakao, Takeshi Kimura, Akiko Konishi, Hironori Nagasaka, Yoko Miyoshi, Keiichi Ozono, Hiroyuki Kusuhara

Journal:

 

Progressive familial intrahepatic cholestasis type 1 (PFIC1), an inherited liver disease caused by mutations in ATP8B1, progresses to severe cholestasis with a sustained intractable itch. Currently, no effective therapy has been established for PFIC1. Decreased function of the bile ...

Last Updated: 23 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholestasis" returned 51 free, full-text review articles on human participants. First 3 results:

Atypical causes of cholestasis.
 

Author(s): Ken D Nguyen, Vinay Sundaram, Walid S Ayoub

Journal: World J. Gastroenterol.. 2014 Jul;20(28):9418-26.

 

Cholestatic liver disease consists of a variety of disorders. Primary sclerosing cholangitis and primary biliary cirrhosis are the most commonly recognized cholestatic liver disease in the adult population, while biliary atresia and Alagille syndrome are commonly recognized in the ...

Last Updated: 29 Jul 2014

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The role of canalicular ABC transporters in cholestasis.
 

Author(s): Frans J C Cuperus, Thierry Claudel, Julien Gautherot, Emina Halilbasic, Michael Trauner

Journal: Drug Metab. Dispos.. 2014 Apr;42(4):546-60.

 

Cholestasis, a hallmark feature of hepatobiliary disease, is characterized by the retention of biliary constituents. Some of these constituents, such as bile acids, inflict damage to hepatocytes and bile duct cells. This damage may lead to inflammation, fibrosis, cirrhosis, and eventually ...

Last Updated: 6 Mar 2014

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Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump.
 

Author(s): A David Rodrigues, Yurong Lai, Mary Ellen Cvijic, Lisa L Elkin, Tatyana Zvyaga, Matthew G Soars

Journal: Drug Metab. Dispos.. 2014 Apr;42(4):566-74.

 

The bile salt export pump (BSEP) is located on the canalicular plasma membrane of hepatocytes and plays an important role in the biliary clearance of bile acids (BAs). Therefore, any drug or new chemical entity that inhibits BSEP has the potential to cause cholestasis and possibly ...

Last Updated: 6 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Preventing Cholestasis Using SMOFLipid®
 

Status: Recruiting

Condition Summary: Cholestasis; Psychomotor Disorders, Developmental

 

Last Updated: 22 Dec 2014

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Ursodeoxycholic Acid And Cholestasis Of Pregnancy
 

Status: Not yet recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 21 Oct 2010

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The Metabolic Profile of Obstetric Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis of Pregnancy

 

Last Updated: 23 Mar 2015

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