Cholestasis

Common Name(s)

Cholestasis

Cholestasis is a rare disease where a person’s liver can not move the bile it makes to the small intestine. The liver, an organ in the abdomen (belly), is responsible for producing bile, which is a compound that helps people digest fats. Once the bile has been made, it is supposed to enter the small intestine where fat is digested. However, in people with cholestasis, the bile can not move to the small intestine because of a blockage and becomes backed up in the liver. This can be caused by a number of things such as gallstones, scars from prior surgery, or certain cancers. Symptoms of cholestasis are itchiness, jaundice (yellowing of the skin), pale stool, and dark urine. Talk with your doctor to find the best treatment for you if you have been diagnosed with cholestasis.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholestasis" returned 483 free, full-text research articles on human participants. First 3 results:

Liver transplantation for decompensated liver cirrhosis caused by progressive familial intrahepatic cholestasis type 3: A case report.
 

Author(s): Deng Xiang, Jiannan He, Hongmei Wang, Fangfang Xiong, Hao Cheng, Junhua Ai, Renfeng Shan, Renhua Wan, Lunli Zhang, Jun Shi

Journal: Medicine (Baltimore). 2017 Dec;96(50):e9158.

 

Progressive familial intrahepatic cholestasis (PFIC) type 3, characterized by high gamma glutamyl transferase (GGT), is an autosomal recessive genetic disease. It often occurs in patients' first years of age. However, high GGT type PFIC is still rare.

Last Updated: 31 Dec 1969

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Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic cholestasis: A case report.
 

Author(s): Baoshi Han, Yan Sheng, Li Wang, Hao Feng, Xianzeng Hou, Yan Li

Journal: Medicine (Baltimore). 2017 Dec;96(52):e9346.

 

Azithromycin-induced liver injury has been rarely reported in adult individuals, let alone in a pregnant woman. Here, we describe the clinical features and outcomes of azithromycin-induced liver injury in a pregnant woman.

Last Updated: 31 Dec 1969

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Cholestasis and hypercalcemia secondary to panhypopituitarism in a newborn.
 

Author(s): Fatma Dursun, Nelgin Gerenli, Heves Kırmızıbekmez

Journal: Turk. J. Pediatr.. 2017 ;59(1):100-103.

 

Dursun F, Gerenli N, Kırmızıbekmez H. Cholestasis and hypercalcemia secondary to panhypopituitarism in a newborn. Turk J Pediatr 2017; 59: 100-103. Cholestatic hepatitis and hypercalcemia are rare features of hypopituitarism in newborns. So diagnosis of hypopituitarism is frequently ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholestasis" returned 68 free, full-text review articles on human participants. First 3 results:

Progressive familial intrahepatic cholestasis: A comprehensive review of a challenging liver disease.
 

Author(s): Kavita Gaur, Puja Sakhuja

Journal: Indian J Pathol Microbiol. ;60(1):2-7.

 

Cholestatic liver disease in children represents a diagnostic and therapeutic challenge. The requirement of a multidisciplinary approach, high levels of professional expertise, and the costs of genetic testing are a few of the reasons why such patients may suffer for want of an accurate ...

Last Updated: 31 Dec 1969

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Evaluating the effectiveness and safety of ursodeoxycholic acid in treatment of intrahepatic cholestasis of pregnancy: A meta-analysis (a prisma-compliant study).
 

Author(s): Xiang Kong, Yan Kong, Fangyuan Zhang, Tingting Wang, Jin Yan

Journal: Medicine (Baltimore). 2016 Oct;95(40):e4949.

 

Intrahepatic cholestasis of pregnancy (ICP) is a specific pregnancy-related disorder without standard medical therapies. Ursodeoxycholic acid (UDCA) is the most used medicine, but the efficacy and safety of UDCA remain uncertain. Several meta-analyses had been made to assess the effects ...

Last Updated: 31 Dec 1969

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Recovery from LCDD-associated Severe Liver Cholestasis: a Case Report and Literature Review.
 

Author(s): Benoit Brilland, Johnny Sayegh, Anne Croue, Frank Bridoux, Jean-François Subra, Jean-François Augusto

Journal: J Gastrointestin Liver Dis. 2016 Mar;25(1):99-103.

 

Light chain deposition disease (LCDD) is a rare multisystemic disorder associated with plasma cell proliferation. It mainly affects the kidney, but liver and heart involvement may occur, sometimes mimicking the picture of systemic amyloidosis. Liver disease in LCDD is usually asymptomatic ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Use of Omega 3 Oil Emulsion for Parenteral Nutrition Associated Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis

 

Last Updated: 1 May 2017

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Compassionate Use of Omegaven to Reverse Parenteral Nutrition Induced Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis

 

Last Updated: 25 Jan 2018

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