Cholestasis

Common Name(s)

Cholestasis

Cholestasis is a rare disease where a person’s liver can not move the bile it makes to the small intestine. The liver, an organ in the abdomen (belly), is responsible for producing bile, which is a compound that helps people digest fats. Once the bile has been made, it is supposed to enter the small intestine where fat is digested. However, in people with cholestasis, the bile can not move to the small intestine because of a blockage and becomes backed up in the liver. This can be caused by a number of things such as gallstones, scars from prior surgery, or certain cancers. Symptoms of cholestasis are itchiness, jaundice (yellowing of the skin), pale stool, and dark urine. Talk with your doctor to find the best treatment for you if you have been diagnosed with cholestasis.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholestasis" returned 474 free, full-text research articles on human participants. First 3 results:

Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis.
 

Author(s): Oladipupo Adeyemi, Anita Alvarez-Laviada, Francisca Schultz, Effendi Ibrahim, Michael Trauner, Catherine Williamson, Alexey V Glukhov, Julia Gorelik

Journal:

 

Increased maternal serum bile acid concentrations in intrahepatic cholestasis of pregnancy (ICP) are associated with fetal cardiac arrhythmias. Ursodeoxycholic acid (UDCA) has been shown to demonstrate anti-arrhythmic properties via preventing ICP-associated cardiac conduction slowing ...

Last Updated: 21 Sep 2017

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Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics.
 

Author(s): Taisuke Kawamoto, Yuichi Ito, Osamu Morita, Hiroshi Honda

Journal: J Toxicol Sci. 2017 ;42(4):427-436.

 

Cholestasis is one of the major causes of drug-induced liver injury (DILI), which can result in withdrawal of approved drugs from the market. Early identification of cholestatic drugs is difficult due to the complex mechanisms involved. In order to develop a strategy for mechanism-based ...

Last Updated: 18 Jul 2017

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Effect of Histone Deacetylase HDAC3 on Cytokines IL-18, IL-12 and TNF-α in Patients with Intrahepatic Cholestasis of Pregnancy.
 

Author(s): Yong Shao, Jing Chen, Jiao Zheng, Cai-Ru Liu

Journal: Cell. Physiol. Biochem.. 2017 ;42(4):1294-1302.

 

The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) is poorly understood.

Last Updated: 11 Jul 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholestasis" returned 71 free, full-text review articles on human participants. First 3 results:

Progressive familial intrahepatic cholestasis: A comprehensive review of a challenging liver disease.
 

Author(s): Kavita Gaur, Puja Sakhuja

Journal: Indian J Pathol Microbiol. ;60(1):2-7.

 

Cholestatic liver disease in children represents a diagnostic and therapeutic challenge. The requirement of a multidisciplinary approach, high levels of professional expertise, and the costs of genetic testing are a few of the reasons why such patients may suffer for want of an accurate ...

Last Updated: 14 Feb 2017

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Evaluating the effectiveness and safety of ursodeoxycholic acid in treatment of intrahepatic cholestasis of pregnancy: A meta-analysis (a prisma-compliant study).
 

Author(s): Xiang Kong, Yan Kong, Fangyuan Zhang, Tingting Wang, Jin Yan

Journal: Medicine (Baltimore). 2016 Oct;95(40):e4949.

 

Intrahepatic cholestasis of pregnancy (ICP) is a specific pregnancy-related disorder without standard medical therapies. Ursodeoxycholic acid (UDCA) is the most used medicine, but the efficacy and safety of UDCA remain uncertain. Several meta-analyses had been made to assess the effects ...

Last Updated: 17 Oct 2016

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Recovery from LCDD-associated Severe Liver Cholestasis: a Case Report and Literature Review.
 

Author(s): Benoit Brilland, Johnny Sayegh, Anne Croue, Frank Bridoux, Jean-François Subra, Jean-François Augusto

Journal: J Gastrointestin Liver Dis. 2016 Mar;25(1):99-103.

 

Light chain deposition disease (LCDD) is a rare multisystemic disorder associated with plasma cell proliferation. It mainly affects the kidney, but liver and heart involvement may occur, sometimes mimicking the picture of systemic amyloidosis. Liver disease in LCDD is usually asymptomatic ...

Last Updated: 25 Mar 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Compassionate Use of Omegaven to Reverse Parenteral Nutrition Induced Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis

 

Last Updated: 26 Apr 2017

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Use of Omega 3 Oil Emulsion for Parenteral Nutrition Associated Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis

 

Last Updated: 1 May 2017

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Serum Autotaxin Levels in Cholestasis of Pregnancy
 

Status: Recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 19 Apr 2016

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