Cholestasis

Common Name(s)

Cholestasis

Cholestasis is a rare disease where a person’s liver can not move the bile it makes to the small intestine. The liver, an organ in the abdomen (belly), is responsible for producing bile, which is a compound that helps people digest fats. Once the bile has been made, it is supposed to enter the small intestine where fat is digested. However, in people with cholestasis, the bile can not move to the small intestine because of a blockage and becomes backed up in the liver. This can be caused by a number of things such as gallstones, scars from prior surgery, or certain cancers. Symptoms of cholestasis are itchiness, jaundice (yellowing of the skin), pale stool, and dark urine. Talk with your doctor to find the best treatment for you if you have been diagnosed with cholestasis.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholestasis" returned 357 free, full-text research articles on human participants. First 3 results:

Cholestasis caused by Fasciola gigantica.
 

Author(s): Remzi Beştaş, Kendal Yalçin, Muttalip Çiçek

Journal: Turkiye Parazitol Derg. 2014 ;38(3):201-4.

 

Fascioliasis is an infectious disease caused by the hepatic trematodes Fasciola hepatica and Fasciola gigantica. Here, we report the case of Fasciola gigantica presenting with biliary obstruction and abdominal pain that was diagnosed and treated by endoscopic retrograde cholangiography ...

Last Updated: 13 Oct 2014

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[Risk factors for parenteral nutrition-associated cholestasis in neonates].
 

Author(s): Qi Feng

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Jul;16(7):670-3.

 

Parenteral nutrition (PN) is a life saving and support therapy for critical newborn infants. Parenteral nutrition-associated cholestasis (PNAC) is one of its common complications. This article focuses on the risk factors for PNAC in newborn infants in both non-nutrient and nutrient ...

Last Updated: 10 Jul 2014

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Small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis.
 

Author(s): Aleksandra Lisowska, Natalia Kobelska-Dubiel, Irena Jankowska, Joanna Pawłowska, Jerzy Moczko, Jarosław Walkowiak

Journal: Acta Biochim. Pol.. 2014 ;61(1):103-7.

 

To date, no studies concerning the presence of small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis were published. Based upon characteristic of progressive familial intrahepatic cholestasis one can expect the coexistence of small intestinal ...

Last Updated: 2 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholestasis" returned 44 free, full-text review articles on human participants. First 3 results:

Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis.
 

Author(s): Anabel Brandoni, María Herminia Hazelhoff, Romina Paula Bulacio, Adriana Mónica Torres

Journal: World J. Gastroenterol.. 2012 Nov;18(44):6387-97.

 

Obstructive jaundice occurs in patients suffering from cholelithiasis and from neoplasms affecting the pancreas and the common bile duct. The absorption, distribution and elimination of drugs are impaired during this pathology. Prolonged cholestasis may alter both liver and kidney ...

Last Updated: 30 Nov 2012

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Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications.
 

Author(s): Marcelo G Roma, Flavia D Toledo, Andrea C Boaglio, Cecilia L Basiglio, Fernando A Crocenzi, Enrique J Sánchez Pozzi

Journal: Clin. Sci.. 2011 Dec;121(12):523-44.

 

UDCA (ursodeoxycholic acid) is the therapeutic agent most widely used for the treatment of cholestatic hepatopathies. Its use has expanded to other kinds of hepatic diseases, and even to extrahepatic ones. Such versatility is the result of its multiple mechanisms of action. UDCA stabilizes ...

Last Updated: 22 Aug 2011

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Drug-induced cholestasis.
 

Author(s): Manmeet S Padda, Mayra Sanchez, Abbasi J Akhtar, James L Boyer

Journal: Hepatology. 2011 Apr;53(4):1377-87.

 

Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug-induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic ...

Last Updated: 11 Apr 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Preventing Cholestasis Using SMOFLipid®
 

Status: Recruiting

Condition Summary: Cholestasis; Psychomotor Disorders, Developmental

 

Last Updated: 10 May 2014

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Ursodeoxycholic Acid And Cholestasis Of Pregnancy
 

Status: Not yet recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 21 Oct 2010

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The Metabolic Profile of Obstetric Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis of Pregnancy

 

Last Updated: 12 Sep 2012

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