Cholestasis

Common Name(s)

Cholestasis

Cholestasis is a rare disease where a person’s liver can not move the bile it makes to the small intestine. The liver, an organ in the abdomen (belly), is responsible for producing bile, which is a compound that helps people digest fats. Once the bile has been made, it is supposed to enter the small intestine where fat is digested. However, in people with cholestasis, the bile can not move to the small intestine because of a blockage and becomes backed up in the liver. This can be caused by a number of things such as gallstones, scars from prior surgery, or certain cancers. Symptoms of cholestasis are itchiness, jaundice (yellowing of the skin), pale stool, and dark urine. Talk with your doctor to find the best treatment for you if you have been diagnosed with cholestasis.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholestasis" returned 344 free, full-text research articles on human participants. First 3 results:

Two novel VPS33B mutations in a patient with arthrogryposis, renal dysfunction and cholestasis syndrome in mainland China.
 

Author(s): Li-Ting Li, Jing Zhao, Rui Chen, Jian-She Wang

Journal: World J. Gastroenterol.. 2014 Jan;20(1):326-9.

 

Arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome is a rare genetic disorder and has not been described in China. We present a female infant with neonatal intrahepatic cholestasis from a Chinese family with ARC syndrome. All 23 coding exons and flanking introns of the ...

Last Updated: 13 Jan 2014

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A comprehensive analysis of common genetic variation around six candidate loci for intrahepatic cholestasis of pregnancy.
 

Author(s): Peter H Dixon, Christopher A Wadsworth, Jennifer Chambers, Jennifer Donnelly, Sharon Cooley, Rebecca Buckley, Ramona Mannino, Sheba Jarvis, Argyro Syngelaki, Victoria Geenes, Priyadarshini Paul, Meera Sothinathan, Ralf Kubitz, Frank Lammert, Rachel M Tribe, Chin Lye Ch'ng, Hanns-Ulrich Marschall, Anna Glantz, Shahid A Khan, Kypros Nicolaides, John Whittaker, Michael Geary, Catherine Williamson

Journal: Am. J. Gastroenterol.. 2014 Jan;109(1):76-84.

 

Intrahepatic cholestasis of pregnancy (ICP) has a complex etiology with a significant genetic component. Heterozygous mutations of canalicular transporters occur in a subset of ICP cases and a population susceptibility allele (p.444A) has been identified in ABCB11. We sought to expand ...

Last Updated: 9 Jan 2014

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Clinical signs and genetic sequencing of benign recurrent intrahepatic cholestasis.
 

Author(s): Xing-Yu Ze, Xin-Yan Zhao, Jun Jiang, Ji-Dong Jia, Tai-Ling Wang, Bao-En Wang

Journal: Chin. Med. J.. 2013 ;126(24):4802-3.

 

Last Updated: 17 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholestasis" returned 44 free, full-text review articles on human participants. First 3 results:

Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis.
 

Author(s): Anabel Brandoni, María Herminia Hazelhoff, Romina Paula Bulacio, Adriana Mónica Torres

Journal: World J. Gastroenterol.. 2012 Nov;18(44):6387-97.

 

Obstructive jaundice occurs in patients suffering from cholelithiasis and from neoplasms affecting the pancreas and the common bile duct. The absorption, distribution and elimination of drugs are impaired during this pathology. Prolonged cholestasis may alter both liver and kidney ...

Last Updated: 30 Nov 2012

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Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications.
 

Author(s): Marcelo G Roma, Flavia D Toledo, Andrea C Boaglio, Cecilia L Basiglio, Fernando A Crocenzi, Enrique J Sánchez Pozzi

Journal: Clin. Sci.. 2011 Dec;121(12):523-44.

 

UDCA (ursodeoxycholic acid) is the therapeutic agent most widely used for the treatment of cholestatic hepatopathies. Its use has expanded to other kinds of hepatic diseases, and even to extrahepatic ones. Such versatility is the result of its multiple mechanisms of action. UDCA stabilizes ...

Last Updated: 22 Aug 2011

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Drug-induced cholestasis.
 

Author(s): Manmeet S Padda, Mayra Sanchez, Abbasi J Akhtar, James L Boyer

Journal: Hepatology. 2011 Apr;53(4):1377-87.

 

Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug-induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic ...

Last Updated: 11 Apr 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Retrospective Review of CT and MR in Pediatric Patients With Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis; Children

 

Last Updated: 30 Nov 2010

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The Metabolic Profile of Obstetric Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis of Pregnancy

 

Last Updated: 12 Sep 2012

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Use of Omega 3 Oil Emulsion for Parenteral Nutrition Associated Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis

 

Last Updated: 22 May 2014

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