Cholestasis

Common Name(s)

Cholestasis

Cholestasis is a rare disease where a person’s liver can not move the bile it makes to the small intestine. The liver, an organ in the abdomen (belly), is responsible for producing bile, which is a compound that helps people digest fats. Once the bile has been made, it is supposed to enter the small intestine where fat is digested. However, in people with cholestasis, the bile can not move to the small intestine because of a blockage and becomes backed up in the liver. This can be caused by a number of things such as gallstones, scars from prior surgery, or certain cancers. Symptoms of cholestasis are itchiness, jaundice (yellowing of the skin), pale stool, and dark urine. Talk with your doctor to find the best treatment for you if you have been diagnosed with cholestasis.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholestasis" returned 372 free, full-text research articles on human participants. First 3 results:

Cholestasis in a neonate with ABO haemolytic disease of newborn following transfusion of ABO group-specific red cells compatible with neonatal serum: inspissated bile syndrome.
 

Author(s): Ashish Jain, Ujjal Poddar, Priti Elhence, Archana Tripathi, Upendra Shava, Surender K Yachha

Journal: Blood Transfus. 2014 Oct;12(4):621-3.

 

Last Updated: 29 Oct 2014

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Cholestasis caused by Fasciola gigantica.
 

Author(s): Remzi Beştaş, Kendal Yalçin, Muttalip Çiçek

Journal: Turkiye Parazitol Derg. 2014 ;38(3):201-4.

 

Fascioliasis is an infectious disease caused by the hepatic trematodes Fasciola hepatica and Fasciola gigantica. Here, we report the case of Fasciola gigantica presenting with biliary obstruction and abdominal pain that was diagnosed and treated by endoscopic retrograde cholangiography ...

Last Updated: 13 Oct 2014

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Total parenteral nutrition-associated cholestasis and risk factors in preterm infants.
 

Author(s): Turki M Alkharfy, Rubana Ba-Abbad, Anjum Hadi, Badr H Sobaih, Khalid M AlFaleh

Journal: Saudi J Gastroenterol. ;20(5):293-6.

 

Development of hepatic dysfunction is a well-recognized complication of total parenteral nutrition in preterm infants. Previous studies reported the incidence of total parenteral nutrition-associated cholestasis and described possible contributing factors to its pathogenesis, but ...

Last Updated: 25 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholestasis" returned 48 free, full-text review articles on human participants. First 3 results:

Atypical causes of cholestasis.
 

Author(s): Ken D Nguyen, Vinay Sundaram, Walid S Ayoub

Journal: World J. Gastroenterol.. 2014 Jul;20(28):9418-26.

 

Cholestatic liver disease consists of a variety of disorders. Primary sclerosing cholangitis and primary biliary cirrhosis are the most commonly recognized cholestatic liver disease in the adult population, while biliary atresia and Alagille syndrome are commonly recognized in the ...

Last Updated: 29 Jul 2014

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The role of canalicular ABC transporters in cholestasis.
 

Author(s): Frans J C Cuperus, Thierry Claudel, Julien Gautherot, Emina Halilbasic, Michael Trauner

Journal: Drug Metab. Dispos.. 2014 Apr;42(4):546-60.

 

Cholestasis, a hallmark feature of hepatobiliary disease, is characterized by the retention of biliary constituents. Some of these constituents, such as bile acids, inflict damage to hepatocytes and bile duct cells. This damage may lead to inflammation, fibrosis, cirrhosis, and eventually ...

Last Updated: 6 Mar 2014

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Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump.
 

Author(s): A David Rodrigues, Yurong Lai, Mary Ellen Cvijic, Lisa L Elkin, Tatyana Zvyaga, Matthew G Soars

Journal: Drug Metab. Dispos.. 2014 Apr;42(4):566-74.

 

The bile salt export pump (BSEP) is located on the canalicular plasma membrane of hepatocytes and plays an important role in the biliary clearance of bile acids (BAs). Therefore, any drug or new chemical entity that inhibits BSEP has the potential to cause cholestasis and possibly ...

Last Updated: 6 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Ursodeoxycholic Acid And Cholestasis Of Pregnancy
 

Status: Not yet recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 21 Oct 2010

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Serum Autotaxin Levels in Cholestasis of Pregnancy
 

Status: Recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 23 Jun 2015

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Il-17 Levels in Intrahepatic Cholestasis of Pregnancy
 

Status: Recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 16 Mar 2014

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