Cholestasis

Common Name(s)

Cholestasis

Cholestasis is a rare disease where a person’s liver can not move the bile it makes to the small intestine. The liver, an organ in the abdomen (belly), is responsible for producing bile, which is a compound that helps people digest fats. Once the bile has been made, it is supposed to enter the small intestine where fat is digested. However, in people with cholestasis, the bile can not move to the small intestine because of a blockage and becomes backed up in the liver. This can be caused by a number of things such as gallstones, scars from prior surgery, or certain cancers. Symptoms of cholestasis are itchiness, jaundice (yellowing of the skin), pale stool, and dark urine. Talk with your doctor to find the best treatment for you if you have been diagnosed with cholestasis.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholestasis" returned 444 free, full-text research articles on human participants. First 3 results:

[Protective effect of emodin pretreatment in young rats with intrahepatic cholestasis].
 

Author(s): Xiao-Li Xiong, Su-Qi Yan, Huan Qin, Li-Shan Zhou, Ling-Ling Zhang, Zhi-Xia Jiang, Yan Ding

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2016 Feb;18(2):165-71.

 

To investigate the protective effect of emodin in young rats with intrahepatic cholestasis.

Last Updated: 23 Feb 2016

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Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.
 

Author(s): Natalia Gomez-Ospina, Carol J Potter, Rui Xiao, Kandamurugu Manickam, Mi-Sun Kim, Kang Ho Kim, Benjamin L Shneider, Jennifer L Picarsic, Theodora A Jacobson, Jing Zhang, Weimin He, Pengfei Liu, A S Knisely, Milton J Finegold, Donna M Muzny, Eric Boerwinkle, James R Lupski, Sharon E Plon, Richard A Gibbs, Christine M Eng, Yaping Yang, Gabriel C Washington, Matthew H Porteus, William E Berquist, Neeraja Kambham, Ravinder J Singh, Fan Xia, Gregory M Enns, David D Moore

Journal:

 

Neonatal cholestasis is a potentially life-threatening condition requiring prompt diagnosis. Mutations in several different genes can cause progressive familial intrahepatic cholestasis, but known genes cannot account for all familial cases. Here we report four individuals from two ...

Last Updated: 18 Feb 2016

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Cholestasis Reveals Severe Cortisol Deficiency in Neonatal Pituitary Stalk Interruption Syndrome.
 

Author(s): Francois-Xavier Mauvais, Emmanuel Gonzales, Anne Davit-Spraul, Emmanuel Jacquemin, Raja Brauner

Journal:

 

Cholestasis has been reported during the course of congenital hypothalamic-pituitary deficiency, but crucial information is lacking regarding both its origin and prognosis. We aimed to characterize the course of cholestasis and factors contributing to it in patients with deficiency ...

Last Updated: 2 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholestasis" returned 65 free, full-text review articles on human participants. First 3 results:

The role of steroid hormones in the development of intrahepatic cholestasis of pregnancy.
 

Author(s): A Pařízek, M Dušková, L Vítek, M Šrámková, M Hill, K Adamcová, P Šimják, A Černý, Z Kordová, H Vráblíková, B Boudová, M Koucký, K Malíčková, L Stárka

Journal: Physiol Res. 2015 ;64 Suppl 2():S203-9.

 

Intrahepatic cholestasis of pregnancy (ICP) is a disorder of liver function, commonly occurring in the third trimester but sometimes also as soon as the end of the second trimester of pregnancy. Symptoms of this disorder include pruritus, plus abnormal values of bile acids and hepatic ...

Last Updated: 18 Dec 2015

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The Immunogenetics of Autoimmune Cholestasis.
 

Author(s): Palak J Trivedi, Gideon M Hirschfield

Journal: Clin Liver Dis. 2016 Feb;20(1):15-31.

 

The immune-mediated hepatobiliary diseases, primary biliary cirrhosis and primary sclerosing cholangitis are relatively rare, albeit and account for a significant amount of liver transplant activity and liver-related mortality globally. Precise disease mechanisms are yet to be described ...

Last Updated: 23 Nov 2015

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Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: A review.
 

Author(s): Giuseppina Palladini, Andrea Ferrigno, Plinio Richelmi, Stefano Perlini, Mariapia Vairetti

Journal: World J. Gastroenterol.. 2015 Nov;21(42):12114-24.

 

Matrix metalloproteinases (MMPs) are a family of proteases using zinc-dependent catalysis to break down extracellular matrix (ECM) components, allowing cell movement and tissue reorganization. Like many other proteases, MMPs are produced as zymogens, an inactive form, which are activated ...

Last Updated: 20 Nov 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Compassionate Use of Omegaven to Reverse Parenteral Nutrition Induced Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis

 

Last Updated: 28 Sep 2016

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Serum Autotaxin Levels in Cholestasis of Pregnancy
 

Status: Recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 19 Apr 2016

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Last Updated: 24 Oct 2016

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