Cholestasis

Common Name(s)

Cholestasis

Cholestasis is a rare disease where a person’s liver can not move the bile it makes to the small intestine. The liver, an organ in the abdomen (belly), is responsible for producing bile, which is a compound that helps people digest fats. Once the bile has been made, it is supposed to enter the small intestine where fat is digested. However, in people with cholestasis, the bile can not move to the small intestine because of a blockage and becomes backed up in the liver. This can be caused by a number of things such as gallstones, scars from prior surgery, or certain cancers. Symptoms of cholestasis are itchiness, jaundice (yellowing of the skin), pale stool, and dark urine. Talk with your doctor to find the best treatment for you if you have been diagnosed with cholestasis.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholestasis" returned 442 free, full-text research articles on human participants. First 3 results:

[Protective effect of emodin pretreatment in young rats with intrahepatic cholestasis].
 

Author(s): Xiao-Li Xiong, Su-Qi Yan, Huan Qin, Li-Shan Zhou, Ling-Ling Zhang, Zhi-Xia Jiang, Yan Ding

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2016 Feb;18(2):165-71.

 

To investigate the protective effect of emodin in young rats with intrahepatic cholestasis.

Last Updated: 23 Feb 2016

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Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.
 

Author(s): Natalia Gomez-Ospina, Carol J Potter, Rui Xiao, Kandamurugu Manickam, Mi-Sun Kim, Kang Ho Kim, Benjamin L Shneider, Jennifer L Picarsic, Theodora A Jacobson, Jing Zhang, Weimin He, Pengfei Liu, A S Knisely, Milton J Finegold, Donna M Muzny, Eric Boerwinkle, James R Lupski, Sharon E Plon, Richard A Gibbs, Christine M Eng, Yaping Yang, Gabriel C Washington, Matthew H Porteus, William E Berquist, Neeraja Kambham, Ravinder J Singh, Fan Xia, Gregory M Enns, David D Moore

Journal:

 

Neonatal cholestasis is a potentially life-threatening condition requiring prompt diagnosis. Mutations in several different genes can cause progressive familial intrahepatic cholestasis, but known genes cannot account for all familial cases. Here we report four individuals from two ...

Last Updated: 18 Feb 2016

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Cholestasis Reveals Severe Cortisol Deficiency in Neonatal Pituitary Stalk Interruption Syndrome.
 

Author(s): Francois-Xavier Mauvais, Emmanuel Gonzales, Anne Davit-Spraul, Emmanuel Jacquemin, Raja Brauner

Journal:

 

Cholestasis has been reported during the course of congenital hypothalamic-pituitary deficiency, but crucial information is lacking regarding both its origin and prognosis. We aimed to characterize the course of cholestasis and factors contributing to it in patients with deficiency ...

Last Updated: 2 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholestasis" returned 62 free, full-text review articles on human participants. First 3 results:

Italian guidelines for the management and treatment of neonatal cholestasis.
 

Author(s): Carlo Dani, Simone Pratesi, Francesco Raimondi, Costantino Romagnoli,

Journal:

 

Hyperbilirubinemia is a frequent condition affecting newborns during the first two weeks of life and when it lasts more than 14 days it is defined as prolonged jaundice. This condition requires differential diagnosis between the usually benign unconjugated hyperbilirubinemia and the ...

Last Updated: 2 Oct 2015

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Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer.
 

Author(s): Tiangang Li, Udayan Apte

Journal: Adv. Pharmacol.. 2015 ;74():263-302.

 

Bile acids are synthesized from cholesterol in the liver. Some cytochrome P450 (CYP) enzymes play key roles in bile acid synthesis. Bile acids are physiological detergent molecules, so are highly cytotoxic. They undergo enterohepatic circulation and play important roles in generating ...

Last Updated: 3 Aug 2015

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Review of a challenging clinical issue: Intrahepatic cholestasis of pregnancy.
 

Author(s): Sebiha Ozkan, Yasin Ceylan, Orhan Veli Ozkan, Sule Yildirim

Journal: World J. Gastroenterol.. 2015 Jun;21(23):7134-41.

 

Intrahepatic cholestasis of pregnancy (ICP) is a reversible pregnancy-specific cholestatic condition characterized by pruritus, elevated liver enzymes, and increased serum bile acids. It commences usually in the late second or third trimester, and quickly resolves after delivery. ...

Last Updated: 25 Jun 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Serum Autotaxin Levels in Cholestasis of Pregnancy
 

Status: Recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 19 Apr 2016

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Il-17 Levels in Intrahepatic Cholestasis of Pregnancy
 

Status: Recruiting

Condition Summary: Intrahepatic Cholestasis of Pregnancy

 

Last Updated: 16 Mar 2014

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Retrospective Review of CT and MR in Pediatric Patients With Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis; Children

 

Last Updated: 30 Nov 2010

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