Cholecystitis

Common Name(s)

Cholecystitis

In general, gallbladder disease (GBD) is one of the major digestive diseases. GBD prevalence is particularly high in some minority populations in the United States, including Native and Mexican Americans. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations of GBD in western countries, including the United States. Most people with gallstones remain asymptomatic through their lifetimes; however, it is estimated that approximately 10 to 50% of individuals eventually develop symptoms. Significant risk factors associated with GBD are age, female sex, obesity (especially central obesity), lipids, diet, parity, type 2 diabetes ({125853}), medications, and Mexican American ethnicity. GBD appears to be strongly related to the metabolic syndrome ({605552}) and/or its major components, such as hyperinsulinism, dyslipidemia, and abdominal adiposity ({2:Boland et al., 2002}; {17:Tsai et al., 2004}). Infection, specifically by Helicobacter, has been implicated in cholelithiasis and cholecystitis ({16:Silva et al., 2003}; {10:Maurer et al., 2005}). Low phospholipid-associated cholelithiasis is a specific form of gallbladder disease characterized by young-adult onset of chronic cholestasis with intrahepatic sludge and cholesterol cholelithiasis. Affected individuals have recurrence of the disorder after cholecystectomy and show a favorable response to treatment with ursodeoxycholic acid (UDCA) (summary by {11:Pasmant et al., 2012}). Mutation in the ABCB4 gene can cause a spectrum of related diseases, including the more severe progressive familial intrahepatic cholestasis-3 (PFIC3; {602347}), intrahepatic cholestasis of pregnancy-3 (ICP3; {614972}), andoral contraceptive-induced cholestasis (OCIC; see {614972}). Genetic Heterogeneity of Gallbladder Disease Two major susceptibility loci for symptomatic gallbladder disease have been identified on chromosome 1p in Mexican Americans (GBD2, {609918}; GBD3, {609919}). In addition, variations in the ABCG8 gene ({605460}) on chromosome 2p21 confer susceptibility to gallbladder disease (GBD4; {611465}).
 

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Condition Specific Organizations

Following organizations serve the condition "Cholecystitis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholecystitis" returned 418 free, full-text research articles on human participants. First 3 results:

Acalculous cholecystitis or biliary dyskinesia for Epstein-Barr virus gallbladder involvement?
 

Author(s): Andrew Fretzayas, Maria Moustaki, Achilleas Attilakos, Triantafillia Brozou, Polyxeni Nicolaidou

Journal: Prague Med Rep. 2014 ;115(1-2):67-72.

 

We present two patients with Epstein-Barr virus (EBV) infection related to gallbladder involvement. Such an association is already known as EBV induced acalculous cholecystitis, diagnosed on the basis of ultrasonographic findings. In our patients, radioisotopic cholescintigraphy was ...

Last Updated: 30 May 2014

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Does ultrasonography accurately diagnose acute cholecystitis? Improving diagnostic accuracy based on a review at a regional hospital.
 

Author(s): Hamish Hwang, Ian Marsh, Jason Doyle

Journal: Can J Surg. 2014 Jun;57(3):162-8.

 

Acute cholecystitis is one of the most common diseases requiring emergency surgery. Ultrasonography is an accurate test for cholelithiasis but has a high false-negative rate for acute cholecystitis. The Murphy sign and laboratory tests performed independently are also not particularly ...

Last Updated: 29 May 2014

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Diagnosis and treatment of xanthogranulomatous cholecystitis.
 

Author(s): H Yabanoglu, C Aydogan, F Karakayali, G Moray, M Haberal

Journal: Eur Rev Med Pharmacol Sci. 2014 ;18(8):1170-5.

 

The aim of this study was to review our case load of the treatment and outcomes of patients with xanthogranulomatous cholecystitis (XGC).

Last Updated: 12 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholecystitis" returned 22 free, full-text review articles on human participants. First 3 results:

[Endoscopic gallbladder stenting for acute cholecystitis].
 

Author(s): Satoshi Maekawa, Ryosuke Nomura, Takayuki Murase, Yasuyoshi Ann, Masayuki Oeholm, Masaru Harada

Journal: J. UOEH. 2014 Dec;36(4):265-72.

 

Acute cholecystitis is an inflammatory disease of the gallbladder. Inflammation often remains in the gallbladder, but some patients may take a fatal course with exacerbation of inflammation. Although laparoscopic cholecystectomy is recommended for moderate and severe acute cystitis, ...

Last Updated: 16 Dec 2014

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Acute acalculous cholecystitis determining Mirizzi syndrome: case report and literature review.
 

Author(s): Marco Milone, Mario Musella, Paola Maietta, Dario Guadioso, Anna Pisapia, Guido Coretti, Giovanni De Palma, Francesco Milone

Journal:

 

Although Mirizzi syndrome is widely reported in literature, little is known about acute acalcholous cholecystitis determinig the findings of a Mirizzi syndrome.

Last Updated: 22 Nov 2014

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Uncomplicated acute cholecystitis: early or delayed laparoscopic cholecystectomy?
 

Author(s): Ajith Sankarankutty, Luis Teodoro da Luz, Tercio De Campos, Sandro Rizoli, Gustavo Pereira Fraga, Bartolomeu Nascimento,

Journal: Rev Col Bras Cir. ;39(5):436-40.

 

Recent meta-analyses suggested that early laparoscopic cholecystectomy (within 1 week of symptom onset) for uncomplicated acute gallbladder disease is safe and feasible. However, surveys on surgical practices indicated that early laparoscopic cholecystectomy is performed by only a ...

Last Updated: 23 Nov 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 7 Apr 2015

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Functional MRC With Eovist for Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 3 Dec 2014

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Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 19 Mar 2015

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