Cholecystitis

Common Name(s)

Cholecystitis

In general, gallbladder disease (GBD) is one of the major digestive diseases. GBD prevalence is particularly high in some minority populations in the United States, including Native and Mexican Americans. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations of GBD in western countries, including the United States. Most people with gallstones remain asymptomatic through their lifetimes; however, it is estimated that approximately 10 to 50% of individuals eventually develop symptoms. Significant risk factors associated with GBD are age, female sex, obesity (especially central obesity), lipids, diet, parity, type 2 diabetes ({125853}), medications, and Mexican American ethnicity. GBD appears to be strongly related to the metabolic syndrome ({605552}) and/or its major components, such as hyperinsulinism, dyslipidemia, and abdominal adiposity ({2:Boland et al., 2002}; {17:Tsai et al., 2004}). Infection, specifically by Helicobacter, has been implicated in cholelithiasis and cholecystitis ({16:Silva et al., 2003}; {10:Maurer et al., 2005}). Low phospholipid-associated cholelithiasis is a specific form of gallbladder disease characterized by young-adult onset of chronic cholestasis with intrahepatic sludge and cholesterol cholelithiasis. Affected individuals have recurrence of the disorder after cholecystectomy and show a favorable response to treatment with ursodeoxycholic acid (UDCA) (summary by {11:Pasmant et al., 2012}). Mutation in the ABCB4 gene can cause a spectrum of related diseases, including the more severe progressive familial intrahepatic cholestasis-3 (PFIC3; {602347}), intrahepatic cholestasis of pregnancy-3 (ICP3; {614972}), andoral contraceptive-induced cholestasis (OCIC; see {614972}). Genetic Heterogeneity of Gallbladder Disease Two major susceptibility loci for symptomatic gallbladder disease have been identified on chromosome 1p in Mexican Americans (GBD2, {609918}; GBD3, {609919}). In addition, variations in the ABCG8 gene ({605460}) on chromosome 2p21 confer susceptibility to gallbladder disease (GBD4; {611465}).
 

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Condition Specific Organizations

Following organizations serve the condition "Cholecystitis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholecystitis" returned 395 free, full-text research articles on human participants. First 3 results:

Does ultrasonography accurately diagnose acute cholecystitis? Improving diagnostic accuracy based on a review at a regional hospital.
 

Author(s): Hamish Hwang, Ian Marsh, Jason Doyle

Journal: Can J Surg. 2014 Jun;57(3):162-8.

 

Acute cholecystitis is one of the most common diseases requiring emergency surgery. Ultrasonography is an accurate test for cholelithiasis but has a high false-negative rate for acute cholecystitis. The Murphy sign and laboratory tests performed independently are also not particularly ...

Last Updated: 29 May 2014

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Candida famata-induced fulminating cholecystitis.
 

Author(s): Paulo Sergio Ramos de Araujo, Zulma Medeiros, Fabio Lopes de Melo, Maria Amélia Maciel, Heloisa Ramos Lacerda de Melo

Journal: Rev. Soc. Bras. Med. Trop.. ;46(6):795-6.

 

Lithiasic cholecystitis is classically associated with the presence of enterobacteria, such as Escherichia coli, Enterococcus, Klebsiella, and Enterobacter, in the gallbladder. Cholecystitis associated with fungal infections is a rare event related to underlying conditions such as ...

Last Updated: 29 Jan 2014

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Percutaneous cholecystostomy is appropriate as definitive treatment for acute cholecystitis in critically ill patients: a single center, cross-sectional study.
 

Author(s): Byung Hyo Cha, Ha Hun Song, Young Nam Kim, Won Jung Jeon, Sang Jin Lee, Jin Dong Kim, Hak Hyun Lee, Ban Seok Lee, Sang Hyub Lee

Journal: Korean J Gastroenterol. 2014 Jan;63(1):32-8.

 

Percutaneous cholecystostomy (PC) is an effective treatment for cholecystitis in high-risk surgical patients. However, there is no definitive agreement on the need for additional cholecystectomy in these patients.

Last Updated: 27 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholecystitis" returned 19 free, full-text review articles on human participants. First 3 results:

Uncomplicated acute cholecystitis: early or delayed laparoscopic cholecystectomy?
 

Author(s): Ajith Sankarankutty, Luis Teodoro da Luz, Tercio De Campos, Sandro Rizoli, Gustavo Pereira Fraga, Bartolomeu Nascimento,

Journal: Rev Col Bras Cir. ;39(5):436-40.

 

Recent meta-analyses suggested that early laparoscopic cholecystectomy (within 1 week of symptom onset) for uncomplicated acute gallbladder disease is safe and feasible. However, surveys on surgical practices indicated that early laparoscopic cholecystectomy is performed by only a ...

Last Updated: 23 Nov 2012

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Treatment of cholecystitis with Chinese herbal medicines: a systematic review of the literature.
 

Author(s): Zhi-Yong Dong, Guan-Liang Wang, Xing Liu, Jia Liu, De-Zeng Zhu, Chang-Quan Ling

Journal: World J. Gastroenterol.. 2012 Apr;18(14):1689-94.

 

To analyze the literature on the use of Chinese herbal medicines for the treatment of cholecystitis.

Last Updated: 24 Apr 2012

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Acute acalculus cholecystitis and hepatitis caused by Brucella melitensis.
 

Author(s): Fawzia E Al-Otaibi

Journal:

 

Acute cholecystitis is a very rare presentation of brucellosis. A case of acalculous cholecystitis caused by Brucella melitensis is reported with a review of previously reported cases.

Last Updated: 6 Sep 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Functional MRC With Eovist for Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 26 Mar 2014

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Last Updated: 1 May 2014

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Last Updated: 10 Feb 2014

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