Cholecystitis

Common Name(s)

Cholecystitis

In general, gallbladder disease (GBD) is one of the major digestive diseases. GBD prevalence is particularly high in some minority populations in the United States, including Native and Mexican Americans. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations of GBD in western countries, including the United States. Most people with gallstones remain asymptomatic through their lifetimes; however, it is estimated that approximately 10 to 50% of individuals eventually develop symptoms. Significant risk factors associated with GBD are age, female sex, obesity (especially central obesity), lipids, diet, parity, type 2 diabetes ({125853}), medications, and Mexican American ethnicity. GBD appears to be strongly related to the metabolic syndrome ({605552}) and/or its major components, such as hyperinsulinism, dyslipidemia, and abdominal adiposity ({2:Boland et al., 2002}; {17:Tsai et al., 2004}). Infection, specifically by Helicobacter, has been implicated in cholelithiasis and cholecystitis ({16:Silva et al., 2003}; {10:Maurer et al., 2005}). Low phospholipid-associated cholelithiasis is a specific form of gallbladder disease characterized by young-adult onset of chronic cholestasis with intrahepatic sludge and cholesterol cholelithiasis. Affected individuals have recurrence of the disorder after cholecystectomy and show a favorable response to treatment with ursodeoxycholic acid (UDCA) (summary by {11:Pasmant et al., 2012}). Mutation in the ABCB4 gene can cause a spectrum of related diseases, including the more severe progressive familial intrahepatic cholestasis-3 (PFIC3; {602347}), intrahepatic cholestasis of pregnancy-3 (ICP3; {614972}), andoral contraceptive-induced cholestasis (OCIC; see {614972}). Genetic Heterogeneity of Gallbladder Disease Two major susceptibility loci for symptomatic gallbladder disease have been identified on chromosome 1p in Mexican Americans (GBD2, {609918}; GBD3, {609919}). In addition, variations in the ABCG8 gene ({605460}) on chromosome 2p21 confer susceptibility to gallbladder disease (GBD4; {611465}).
 

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Condition Specific Organizations

Following organizations serve the condition "Cholecystitis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholecystitis" returned 583 free, full-text research articles on human participants. First 3 results:

A case of acalculous cholecystitis in the course of dengue fever in a traveller returned from Brazil.
 

Author(s): Anna Kuna, Agnieszka Wroczyńska, Michał Gajewski, Iwona Felczak-Korzybska, Wacław L Nahorski

Journal: Int Marit Health. 2016 ;67(1):38-41.

 

Dengue is the second cause of fever after malaria in travellers returning from the tropics. The infection may be asymptomatic or it may manifest itself with fever only, some patients, however, may develop haemorrhagic symptoms and shock.

Last Updated: 31 Mar 2016

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Individualized nomogram improves diagnostic accuracy of stage I-II gallbladder cancer in chronic cholecystitis patients with gallbladder wall thickening.
 

Author(s): Di Zhou, Jian-Dong Wang, Yong Yang, Wen-Long Yu, Yong-Jie Zhang, Zhi-Wei Quan

Journal: HBPD INT. 2016 Apr;15(2):180-8.

 

Early diagnosis of gallbladder cancer (GBC) can remarkably improve the prognosis of patients. This study aimed to develop a nomogram for individualized diagnosis of stage I-II GBC in chronic cholecystitis patients with gallbladder wall thickening.

Last Updated: 29 Mar 2016

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Xanthogranulomatous cholecystitis: contrast-enhanced ultrasound features and differential diagnosis from wall-thickening gallbladder carcinoma.
 

Author(s): Hai-Xia Yuan, Wen-Ping Wang, Jie-Xian Wen, Zheng-Biao Ji, Hong Ding, Bei-Jian Huang, Chao-Lun Li

Journal: Discov Med. 2016 Feb;21(114):89-98.

 

The purpose of this study is to evaluate the value of contrast-enhanced ultrasound (CEUS) in differential diagnosis of Xanthogranulomatous cholecystitis (XGC).

Last Updated: 25 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholecystitis" returned 39 free, full-text review articles on human participants. First 3 results:

[Toxocarosis and acalculous acute cholecystitis: Consequence or coincidence?].
 

Author(s): Alexis Strickler, Natalia Vásquez, Leonardo Maggi, Juvenal Hernández, Ximena Hidalgo

Journal: Rev Chilena Infectol. 2016 Jun;33(3):346-51.

 

Human toxocarosis is a chronic larval parasitosis listed as one of the five most important neglected diseases by the CDC. The larvae can spread systemically and migrate to different tissues including liver and gallbladder. Acalculous acute cholecystitis (AAC) is a rare disease in ...

Last Updated: 7 Sep 2016

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Emphysematous cholecystitis presenting as gas-forming liver abscess and pneumoperitoneum in a dialysis patient: a case report and review of the literature.
 

Author(s): Chen-Yi Liao, Chi-Chang Tsai, Wu-Hsien Kuo, Ren-Jy Ben, Ho-Cheng Lin, Ching-Chang Lee, Kuan-Jen Su, Han-En Wang, Chih-Chiang Wang, I-Hung Chen, Shang-Tao Chien, Ming-Kai Tsai

Journal:

 

Emphysematous cholecystitis is a rare variant of acute cholecystitis with a high mortality rate. The combination of emphysematous cholecystitis, liver abscess and pneumoperitoneum are even rarer. Herein we present a case of emphysematous cholecystitis in a senile diabetic lady who ...

Last Updated: 2 Mar 2016

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Massive pneumoretroperitoneum arising from emphysematous cholecystitis: a case report and the literature review.
 

Author(s): Yasumichi Yagi, Shozo Sasaki, Itsuro Terada, Akemi Yoshikawa, Wataru Fukushima, Hirohisa Kitagawa, Takashi Fujimura, Ryohei Izumi, Katsuhiko Saito

Journal:

 

Emphysematous cholecystitis is a severe variant of acute cholecystitis caused by anaerobic bacteria. Although intraperitoneal air as a complication has been described in association with emphysematous cholecystitis, pneumoretroperitoneum arising from emphysematous cholecystitis is ...

Last Updated: 14 Oct 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 16 Dec 2015

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Last Updated: 7 Apr 2015

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A Randomized Controlled Trial on EGBD vs PC for Acute Cholecystitis.
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 16 Nov 2016

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