Cholecystitis

Common Name(s)

Cholecystitis

In general, gallbladder disease (GBD) is one of the major digestive diseases. GBD prevalence is particularly high in some minority populations in the United States, including Native and Mexican Americans. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations of GBD in western countries, including the United States. Most people with gallstones remain asymptomatic through their lifetimes; however, it is estimated that approximately 10 to 50% of individuals eventually develop symptoms. Significant risk factors associated with GBD are age, female sex, obesity (especially central obesity), lipids, diet, parity, type 2 diabetes ({125853}), medications, and Mexican American ethnicity. GBD appears to be strongly related to the metabolic syndrome ({605552}) and/or its major components, such as hyperinsulinism, dyslipidemia, and abdominal adiposity ({2:Boland et al., 2002}; {17:Tsai et al., 2004}). Infection, specifically by Helicobacter, has been implicated in cholelithiasis and cholecystitis ({16:Silva et al., 2003}; {10:Maurer et al., 2005}). Low phospholipid-associated cholelithiasis is a specific form of gallbladder disease characterized by young-adult onset of chronic cholestasis with intrahepatic sludge and cholesterol cholelithiasis. Affected individuals have recurrence of the disorder after cholecystectomy and show a favorable response to treatment with ursodeoxycholic acid (UDCA) (summary by {11:Pasmant et al., 2012}). Mutation in the ABCB4 gene can cause a spectrum of related diseases, including the more severe progressive familial intrahepatic cholestasis-3 (PFIC3; {602347}), intrahepatic cholestasis of pregnancy-3 (ICP3; {614972}), andoral contraceptive-induced cholestasis (OCIC; see {614972}). Genetic Heterogeneity of Gallbladder Disease Two major susceptibility loci for symptomatic gallbladder disease have been identified on chromosome 1p in Mexican Americans (GBD2, {609918}; GBD3, {609919}). In addition, variations in the ABCG8 gene ({605460}) on chromosome 2p21 confer susceptibility to gallbladder disease (GBD4; {611465}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholecystitis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholecystitis" returned 438 free, full-text research articles on human participants. First 3 results:

[Emphysematous cholecystitis].
 

Author(s): Matías Migliaro, Laura Marticorena, Vivian Rada, Alejandro Benegas, Mario Ariel Lembo

Journal: Medicina (B Aires). 2014 ;74(6):479.

 

Last Updated: 5 Jan 2015

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Laparoscopic cholecystectomy in the treatment of acute cholecystitis: comparison of outcomes and costs between early and delayed cholecystectomy.
 

Author(s): V Minutolo, A Licciardello, M Arena, A Nicosia, B Di Stefano, G Calì, G Arena

Journal: Eur Rev Med Pharmacol Sci. 2014 Dec;18(2 Suppl):40-6.

 

Several trials showed that early laparoscopic cholecystectomy is superior to delayed laparoscopic cholecystectomy for the treatment of acute cholecystitis. However actual practice does not conform to current evidence. The aim of this study is to compare outcomes and total hospital ...

Last Updated: 23 Dec 2014

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Gastric outlet obstruction induced by a gastric wall abscess after cholecystitis.
 

Author(s): Koichi Soga, Kyoichi Kassai, Kenji Itani, Nobuaki Yagi, Yuji Naito, Yoshito Itoh

Journal: Intern. Med.. 2014 ;53(23):2675-8.

 

In December 2011, an 84-year-old Japanese man was admitted with severe cholecystitis. We treated the cholecystitis using antibiotics, and his symptoms improved. In March 2012, he was readmitted after experiencing a sudden bloating sensation and vomiting. We determined that a gastric ...

Last Updated: 2 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholecystitis" returned 25 free, full-text review articles on human participants. First 3 results:

[Endoscopic gallbladder stenting for acute cholecystitis].
 

Author(s): Satoshi Maekawa, Ryosuke Nomura, Takayuki Murase, Yasuyoshi Ann, Masayuki Oeholm, Masaru Harada

Journal: J. UOEH. 2014 Dec;36(4):265-72.

 

Acute cholecystitis is an inflammatory disease of the gallbladder. Inflammation often remains in the gallbladder, but some patients may take a fatal course with exacerbation of inflammation. Although laparoscopic cholecystectomy is recommended for moderate and severe acute cystitis, ...

Last Updated: 16 Dec 2014

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Acute acalculous cholecystitis determining Mirizzi syndrome: case report and literature review.
 

Author(s): Marco Milone, Mario Musella, Paola Maietta, Dario Guadioso, Anna Pisapia, Guido Coretti, Giovanni De Palma, Francesco Milone

Journal:

 

Although Mirizzi syndrome is widely reported in literature, little is known about acute acalcholous cholecystitis determinig the findings of a Mirizzi syndrome.

Last Updated: 22 Nov 2014

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Acute cholecystitis as a rare presentation of metastatic breast carcinoma of the gallbladder: A case report and review of the literature.
 

Author(s): Belhachmi Abdelilah, Ouazni Mohamed, Rajae Yamoul, Imane Elkhiyat, A Al Bouzidi, Sifeddine Alkandry, Eheirchou Abdelkader

Journal:

 

Breast cancer is usually associated with metastases to lungs, bones and liver. Breast carcinoma metastasizing to the gallbladder is very rare. We report the case of 45-year-old female with clinical presentation of acute Cholecystitis, who underwent cholecystectomy in emergency. The ...

Last Updated: 19 Sep 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 7 Apr 2015

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Functional MRC With Eovist for Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 3 Dec 2014

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Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 19 Mar 2015

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