Cholecystitis

Common Name(s)

Cholecystitis

In general, gallbladder disease (GBD) is one of the major digestive diseases. GBD prevalence is particularly high in some minority populations in the United States, including Native and Mexican Americans. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations of GBD in western countries, including the United States. Most people with gallstones remain asymptomatic through their lifetimes; however, it is estimated that approximately 10 to 50% of individuals eventually develop symptoms. Significant risk factors associated with GBD are age, female sex, obesity (especially central obesity), lipids, diet, parity, type 2 diabetes ({125853}), medications, and Mexican American ethnicity. GBD appears to be strongly related to the metabolic syndrome ({605552}) and/or its major components, such as hyperinsulinism, dyslipidemia, and abdominal adiposity ({2:Boland et al., 2002}; {17:Tsai et al., 2004}). Infection, specifically by Helicobacter, has been implicated in cholelithiasis and cholecystitis ({16:Silva et al., 2003}; {10:Maurer et al., 2005}). Low phospholipid-associated cholelithiasis is a specific form of gallbladder disease characterized by young-adult onset of chronic cholestasis with intrahepatic sludge and cholesterol cholelithiasis. Affected individuals have recurrence of the disorder after cholecystectomy and show a favorable response to treatment with ursodeoxycholic acid (UDCA) (summary by {11:Pasmant et al., 2012}). Mutation in the ABCB4 gene can cause a spectrum of related diseases, including the more severe progressive familial intrahepatic cholestasis-3 (PFIC3; {602347}), intrahepatic cholestasis of pregnancy-3 (ICP3; {614972}), andoral contraceptive-induced cholestasis (OCIC; see {614972}). Genetic Heterogeneity of Gallbladder Disease Two major susceptibility loci for symptomatic gallbladder disease have been identified on chromosome 1p in Mexican Americans (GBD2, {609918}; GBD3, {609919}). In addition, variations in the ABCG8 gene ({605460}) on chromosome 2p21 confer susceptibility to gallbladder disease (GBD4; {611465}).
 

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Condition Specific Organizations

Following organizations serve the condition "Cholecystitis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholecystitis" returned 523 free, full-text research articles on human participants. First 3 results:

Q Fever Manifested as Acalculous Cholecystitis.
 

Author(s): Moshe Simons, Samuel N Heyman, Michael Bursztyn, Oded Shalev, Nurith Hiller, Sarah Israel

Journal: Isr. Med. Assoc. J.. 2015 Nov;17(11):714-6.

 

Last Updated: 13 Jan 2016

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The Efficacy of Percutaneous Transhepatic Gallbladder Drainage on Acute Cholecystitis in High-Risk Elderly Patients Based on the Tokyo Guidelines: A Retrospective Case-Control Study.
 

Author(s): Qingqiang Ni, Dongbo Chen, Rui Xu, Dong Shang

Journal: Medicine (Baltimore). 2015 Aug;94(34):e1442.

 

To evaluate the efficacy of percutaneous transhepatic gallbladder drainage (PTGD) for high-risk elderly patients with acute cholecystitis.Retrospective analysis of 159 acute cholecystitis patients who were admitted to General Surgery Division III of the First Affiliated Hospital of ...

Last Updated: 28 Aug 2015

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Localized IgG4-related Cholecystitis Mimicking Gallbladder Cancer.
 

Author(s): Tadahisa Inoue, Fumihiro Okumura, Takashi Mizushima, Hirotada Nishie, Hiroyasu Iwasaki, Kaiki Anbe, Takanori Ozeki, Kenta Kachi, Shigeki Fukusada, Yuta Suzuki, Kazuko Watanabe, Hitoshi Sano

Journal: Intern. Med.. 2015 ;54(15):1869-74.

 

We encountered a case of localized IgG4-cholecystitis mimicking gallbladder cancer with focal/segmental type1 autoimmune pancreatitis (AIP). In this case, we were unable to exclude a diagnosis of gallbladder cancer and thus performed radical cholecystectomy. Type1 AIP is often associated ...

Last Updated: 3 Aug 2015

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Reviews from the PubMed Database

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The terms "Cholecystitis" returned 34 free, full-text review articles on human participants. First 3 results:

Cholecystectomy vs. percutaneous cholecystostomy for the management of critically ill patients with acute cholecystitis: a protocol for a systematic review.
 

Author(s): Peter C Ambe, Sarantos Kaptanis, Marios Papadakis, Sebastian A Weber, Hubert Zirngibl

Journal:

 

Acute cholecystitis is a common diagnosis. However, the heterogeneity of presentation makes it difficult to standardize management. Although surgery is the mainstay of treatment, critically ill patients have been managed via percutaneous cholecystostomy. However, the role of percutaneous ...

Last Updated: 6 Jun 2015

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[Endoscopic gallbladder stenting for acute cholecystitis].
 

Author(s): Satoshi Maekawa, Ryosuke Nomura, Takayuki Murase, Yasuyoshi Ann, Masayuki Oeholm, Masaru Harada

Journal: J. UOEH. 2014 Dec;36(4):265-72.

 

Acute cholecystitis is an inflammatory disease of the gallbladder. Inflammation often remains in the gallbladder, but some patients may take a fatal course with exacerbation of inflammation. Although laparoscopic cholecystectomy is recommended for moderate and severe acute cystitis, ...

Last Updated: 16 Dec 2014

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Acute acalculous cholecystitis determining Mirizzi syndrome: case report and literature review.
 

Author(s): Marco Milone, Mario Musella, Paola Maietta, Dario Guadioso, Anna Pisapia, Guido Coretti, Giovanni De Palma, Francesco Milone

Journal:

 

Although Mirizzi syndrome is widely reported in literature, little is known about acute acalcholous cholecystitis determinig the findings of a Mirizzi syndrome.

Last Updated: 22 Nov 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 7 Apr 2015

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Functional MRC With Eovist for Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 1 Dec 2015

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Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 16 Dec 2015

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