Cholecystitis

Common Name(s)

Cholecystitis

In general, gallbladder disease (GBD) is one of the major digestive diseases. GBD prevalence is particularly high in some minority populations in the United States, including Native and Mexican Americans. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations of GBD in western countries, including the United States. Most people with gallstones remain asymptomatic through their lifetimes; however, it is estimated that approximately 10 to 50% of individuals eventually develop symptoms. Significant risk factors associated with GBD are age, female sex, obesity (especially central obesity), lipids, diet, parity, type 2 diabetes ({125853}), medications, and Mexican American ethnicity. GBD appears to be strongly related to the metabolic syndrome ({605552}) and/or its major components, such as hyperinsulinism, dyslipidemia, and abdominal adiposity ({2:Boland et al., 2002}; {17:Tsai et al., 2004}). Infection, specifically by Helicobacter, has been implicated in cholelithiasis and cholecystitis ({16:Silva et al., 2003}; {10:Maurer et al., 2005}). Low phospholipid-associated cholelithiasis is a specific form of gallbladder disease characterized by young-adult onset of chronic cholestasis with intrahepatic sludge and cholesterol cholelithiasis. Affected individuals have recurrence of the disorder after cholecystectomy and show a favorable response to treatment with ursodeoxycholic acid (UDCA) (summary by {11:Pasmant et al., 2012}). Mutation in the ABCB4 gene can cause a spectrum of related diseases, including the more severe progressive familial intrahepatic cholestasis-3 (PFIC3; {602347}), intrahepatic cholestasis of pregnancy-3 (ICP3; {614972}), andoral contraceptive-induced cholestasis (OCIC; see {614972}). Genetic Heterogeneity of Gallbladder Disease Two major susceptibility loci for symptomatic gallbladder disease have been identified on chromosome 1p in Mexican Americans (GBD2, {609918}; GBD3, {609919}). In addition, variations in the ABCG8 gene ({605460}) on chromosome 2p21 confer susceptibility to gallbladder disease (GBD4; {611465}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholecystitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholecystitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholecystitis" returned 405 free, full-text research articles on human participants. First 3 results:

Acalculous cholecystitis or biliary dyskinesia for Epstein-Barr virus gallbladder involvement?
 

Author(s): Andrew Fretzayas, Maria Moustaki, Achilleas Attilakos, Triantafillia Brozou, Polyxeni Nicolaidou

Journal: Prague Med Rep. 2014 ;115(1-2):67-72.

 

We present two patients with Epstein-Barr virus (EBV) infection related to gallbladder involvement. Such an association is already known as EBV induced acalculous cholecystitis, diagnosed on the basis of ultrasonographic findings. In our patients, radioisotopic cholescintigraphy was ...

Last Updated: 30 May 2014

Go To URL
Does ultrasonography accurately diagnose acute cholecystitis? Improving diagnostic accuracy based on a review at a regional hospital.
 

Author(s): Hamish Hwang, Ian Marsh, Jason Doyle

Journal: Can J Surg. 2014 Jun;57(3):162-8.

 

Acute cholecystitis is one of the most common diseases requiring emergency surgery. Ultrasonography is an accurate test for cholelithiasis but has a high false-negative rate for acute cholecystitis. The Murphy sign and laboratory tests performed independently are also not particularly ...

Last Updated: 29 May 2014

Go To URL
Candida famata-induced fulminating cholecystitis.
 

Author(s): Paulo Sergio Ramos de Araujo, Zulma Medeiros, Fabio Lopes de Melo, Maria Amélia Maciel, Heloisa Ramos Lacerda de Melo

Journal: Rev. Soc. Bras. Med. Trop.. ;46(6):795-6.

 

Lithiasic cholecystitis is classically associated with the presence of enterobacteria, such as Escherichia coli, Enterococcus, Klebsiella, and Enterobacter, in the gallbladder. Cholecystitis associated with fungal infections is a rare event related to underlying conditions such as ...

Last Updated: 29 Jan 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholecystitis" returned 20 free, full-text review articles on human participants. First 3 results:

Uncomplicated acute cholecystitis: early or delayed laparoscopic cholecystectomy?
 

Author(s): Ajith Sankarankutty, Luis Teodoro da Luz, Tercio De Campos, Sandro Rizoli, Gustavo Pereira Fraga, Bartolomeu Nascimento,

Journal: Rev Col Bras Cir. ;39(5):436-40.

 

Recent meta-analyses suggested that early laparoscopic cholecystectomy (within 1 week of symptom onset) for uncomplicated acute gallbladder disease is safe and feasible. However, surveys on surgical practices indicated that early laparoscopic cholecystectomy is performed by only a ...

Last Updated: 23 Nov 2012

Go To URL
Treatment of cholecystitis with Chinese herbal medicines: a systematic review of the literature.
 

Author(s): Zhi-Yong Dong, Guan-Liang Wang, Xing Liu, Jia Liu, De-Zeng Zhu, Chang-Quan Ling

Journal: World J. Gastroenterol.. 2012 Apr;18(14):1689-94.

 

To analyze the literature on the use of Chinese herbal medicines for the treatment of cholecystitis.

Last Updated: 24 Apr 2012

Go To URL
Is early laparoscopic cholecystectomy for acute cholecystitis preferable to delayed surgery?: Best evidence topic (BET).
 

Author(s): Christos Skouras, Omar Jarral, Rahul Deshpande, George Zografos, Nagy Habib, Emmanouil Zacharakis

Journal: Int J Surg. 2012 ;10(5):250-8.

 

A best evidence topic was written according to a structured protocol. The question addressed was whether early laparoscopic cholecystectomy (ELC) in patients presenting with a short history of acute cholecystitis provides better post-operative outcomes than a delayed laparoscopic ...

Last Updated: 1 Jun 2012

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 1 May 2014

Go to URL
Functional MRC With Eovist for Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 26 Mar 2014

Go to URL
A Randomized Controlled Trial on EGBD vs PC for Acute Cholecystitis.
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 19 Aug 2014

Go to URL