Cholecystitis

Common Name(s)

Cholecystitis

In general, gallbladder disease (GBD) is one of the major digestive diseases. GBD prevalence is particularly high in some minority populations in the United States, including Native and Mexican Americans. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations of GBD in western countries, including the United States. Most people with gallstones remain asymptomatic through their lifetimes; however, it is estimated that approximately 10 to 50% of individuals eventually develop symptoms. Significant risk factors associated with GBD are age, female sex, obesity (especially central obesity), lipids, diet, parity, type 2 diabetes ({125853}), medications, and Mexican American ethnicity. GBD appears to be strongly related to the metabolic syndrome ({605552}) and/or its major components, such as hyperinsulinism, dyslipidemia, and abdominal adiposity ({2:Boland et al., 2002}; {17:Tsai et al., 2004}). Infection, specifically by Helicobacter, has been implicated in cholelithiasis and cholecystitis ({16:Silva et al., 2003}; {10:Maurer et al., 2005}). Low phospholipid-associated cholelithiasis is a specific form of gallbladder disease characterized by young-adult onset of chronic cholestasis with intrahepatic sludge and cholesterol cholelithiasis. Affected individuals have recurrence of the disorder after cholecystectomy and show a favorable response to treatment with ursodeoxycholic acid (UDCA) (summary by {11:Pasmant et al., 2012}). Mutation in the ABCB4 gene can cause a spectrum of related diseases, including the more severe progressive familial intrahepatic cholestasis-3 (PFIC3; {602347}), intrahepatic cholestasis of pregnancy-3 (ICP3; {614972}), andoral contraceptive-induced cholestasis (OCIC; see {614972}). Genetic Heterogeneity of Gallbladder Disease Two major susceptibility loci for symptomatic gallbladder disease have been identified on chromosome 1p in Mexican Americans (GBD2, {609918}; GBD3, {609919}). In addition, variations in the ABCG8 gene ({605460}) on chromosome 2p21 confer susceptibility to gallbladder disease (GBD4; {611465}).
 

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Condition Specific Organizations

Following organizations serve the condition "Cholecystitis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholecystitis" returned 563 free, full-text research articles on human participants. First 3 results:

Eosinophilic Granulomatosis with Polyangiitis Presenting with Skin Rashes, Eosinophilic Cholecystitis, and Retinal Vasculitis.
 

Author(s): Mingbing Zeng, Xialin Liu, Yizhi Liu

Journal:

 

BACKGROUND Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome (CSS), is a rare vasculitis of unknown etiology. Most of the patients have a long history of asthma and then develop autoimmune inflammation of small and medium-sized blood vessels, ...

Last Updated: 18 Nov 2016

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So-called Acute Acalculous Cholecystitis in Macrophage Activation Syndrome.
 

Author(s): Yukimi Otsuka, Yasushi Inoue

Journal: Intern. Med.. ;55(20):3043-3046.

 

Acute acalculous cholecystitis (AAC) is a severe disease seen in critically ill patients, including those with autoimmune diseases. We herein report the case of a 41-year-old female who developed macrophage activation syndrome (MAS) accompanied by a recurrence of Kikuchi disease. ...

Last Updated: 17 Oct 2016

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A case of acalculous cholecystitis in the course of dengue fever in a traveller returned from Brazil.
 

Author(s): Anna Kuna, Agnieszka Wroczyńska, Michał Gajewski, Iwona Felczak-Korzybska, Wacław L Nahorski

Journal: Int Marit Health. 2016 ;67(1):38-41.

 

Dengue is the second cause of fever after malaria in travellers returning from the tropics. The infection may be asymptomatic or it may manifest itself with fever only, some patients, however, may develop haemorrhagic symptoms and shock.

Last Updated: 31 Mar 2016

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Reviews from the PubMed Database

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The terms "Cholecystitis" returned 40 free, full-text review articles on human participants. First 3 results:

[Toxocarosis and acalculous acute cholecystitis: Consequence or coincidence?].
 

Author(s): Alexis Strickler, Natalia Vásquez, Leonardo Maggi, Juvenal Hernández, Ximena Hidalgo

Journal: Rev Chilena Infectol. 2016 Jun;33(3):346-51.

 

Human toxocarosis is a chronic larval parasitosis listed as one of the five most important neglected diseases by the CDC. The larvae can spread systemically and migrate to different tissues including liver and gallbladder. Acalculous acute cholecystitis (AAC) is a rare disease in ...

Last Updated: 7 Sep 2016

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Laparoscopic cholecystectomy for acute cholecystitis: early or delayed?: Evidence from a systematic review of discordant meta-analyses.
 

Author(s): Guo-Min Song, Wei Bian, Xian-Tao Zeng, Jian-Guo Zhou, Yong-Qiang Luo, Xu Tian

Journal: Medicine (Baltimore). 2016 Jun;95(23):e3835.

 

The laparoscopic cholecystectomy (LC) is an important approach of treating acute cholecystitis and the timing of performing this given treatment is associated with clinical outcomes. Although several meta-analyses have been done to investigate the optimal timing of implementing this ...

Last Updated: 10 Jun 2016

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Emphysematous cholecystitis presenting as gas-forming liver abscess and pneumoperitoneum in a dialysis patient: a case report and review of the literature.
 

Author(s): Chen-Yi Liao, Chi-Chang Tsai, Wu-Hsien Kuo, Ren-Jy Ben, Ho-Cheng Lin, Ching-Chang Lee, Kuan-Jen Su, Han-En Wang, Chih-Chiang Wang, I-Hung Chen, Shang-Tao Chien, Ming-Kai Tsai

Journal:

 

Emphysematous cholecystitis is a rare variant of acute cholecystitis with a high mortality rate. The combination of emphysematous cholecystitis, liver abscess and pneumoperitoneum are even rarer. Herein we present a case of emphysematous cholecystitis in a senile diabetic lady who ...

Last Updated: 2 Mar 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 16 Dec 2015

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Last Updated: 7 Apr 2015

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A Randomized Controlled Trial on EGBD vs PC for Acute Cholecystitis.
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 16 Nov 2016

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