Cholecystitis

Common Name(s)

Cholecystitis

In general, gallbladder disease (GBD) is one of the major digestive diseases. GBD prevalence is particularly high in some minority populations in the United States, including Native and Mexican Americans. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations of GBD in western countries, including the United States. Most people with gallstones remain asymptomatic through their lifetimes; however, it is estimated that approximately 10 to 50% of individuals eventually develop symptoms. Significant risk factors associated with GBD are age, female sex, obesity (especially central obesity), lipids, diet, parity, type 2 diabetes ({125853}), medications, and Mexican American ethnicity. GBD appears to be strongly related to the metabolic syndrome ({605552}) and/or its major components, such as hyperinsulinism, dyslipidemia, and abdominal adiposity ({2:Boland et al., 2002}; {17:Tsai et al., 2004}). Infection, specifically by Helicobacter, has been implicated in cholelithiasis and cholecystitis ({16:Silva et al., 2003}; {10:Maurer et al., 2005}). Low phospholipid-associated cholelithiasis is a specific form of gallbladder disease characterized by young-adult onset of chronic cholestasis with intrahepatic sludge and cholesterol cholelithiasis. Affected individuals have recurrence of the disorder after cholecystectomy and show a favorable response to treatment with ursodeoxycholic acid (UDCA) (summary by {11:Pasmant et al., 2012}). Mutation in the ABCB4 gene can cause a spectrum of related diseases, including the more severe progressive familial intrahepatic cholestasis-3 (PFIC3; {602347}), intrahepatic cholestasis of pregnancy-3 (ICP3; {614972}), andoral contraceptive-induced cholestasis (OCIC; see {614972}). Genetic Heterogeneity of Gallbladder Disease Two major susceptibility loci for symptomatic gallbladder disease have been identified on chromosome 1p in Mexican Americans (GBD2, {609918}; GBD3, {609919}). In addition, variations in the ABCG8 gene ({605460}) on chromosome 2p21 confer susceptibility to gallbladder disease (GBD4; {611465}).
 

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Condition Specific Organizations

Following organizations serve the condition "Cholecystitis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholecystitis" returned 564 free, full-text research articles on human participants. First 3 results:

Percutaneous transhepatic gallbladder drainage followed by elective laparoscopic cholecystectomy for patients with moderate to severe acute cholecystitis.
 

Author(s): Ryukyung Lee, Heontak Ha, Young Seok Han, Hyung Jun Kwon, Hunkyu Ryeom, Jae Min Chun

Journal: Medicine (Baltimore). 2017 Nov;96(44):e8533.

 

Percutaneous transhepatic gallbladder drainage followed by laparoscopic cholecystectomy (PTGBD+LC) is one treatment option for patients with moderate to severe acute cholecystitis (AC). However, the impact of PTGBD on operative difficulties in performing LC is controversial. We designed ...

Last Updated: 31 Dec 1969

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Patient with metastatic breast cancer presenting as acute cholecystitis with one-year survival on hormonotherapy.
 

Author(s): Mateusz Zamkowski, Michał Kąkol, Wojciech Makarewicz, Jerzy Ropel, Maciej Bobowicz

Journal: Pol Przegl Chir. 2017 Aug;89(4):46-49.

 

Breast cancer has high metastatic potential with distant metastases involving mainly lungs, liver and bones. Less frequently it gives distant spread to other organs. Herein we would like to present a very rare case of an acute cholecystitis which turned out to be a metastatic breast ...

Last Updated: 31 Dec 1969

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Percutaneous transhepatic papilla balloon dilatation combined with a percutaneous transcystic approach for removing concurrent gallbladder stone and common bile duct stone in a patient with billroth II gastrectomy and acute cholecystitis: A case report.
 

Author(s): Dong Li, Yu-Liang Li, Wu-Jie Wang, Bin Liu, Hai-Yang Chang, Wei Wang, Yong-Zheng Wang, Zheng Li

Journal: Medicine (Baltimore). 2017 Sep;96(35):e7964.

 

A 61-year-old man presented with upper abdominal pain and jaundice. Abdominal computed tomography imaging revealed stones in the gallbladder and the common bile duct, with a thickening of the gallbladder wall and an obvious increase in the volume of the gallbladder. Initial treatment ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholecystitis" returned 41 free, full-text review articles on human participants. First 3 results:

Emphysematous cholecystitis in a young male without predisposing factors: A case report.
 

Author(s): Ming-Yu Chen, Chen Lu, Yi-Fan Wang, Xiu-Jun Cai

Journal: Medicine (Baltimore). 2016 Nov;95(44):e5367.

 

This report describes the diagnosis and treatment for Emphysematous cholecystitis (EC) without predisposing factors, and reviews the current literature.A 49-year-old male without predisposition presented to emergency department with a two-day history of sudden onset abdominal pain, ...

Last Updated: 31 Dec 1969

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[Toxocarosis and acalculous acute cholecystitis: Consequence or coincidence?].
 

Author(s): Alexis Strickler, Natalia Vásquez, Leonardo Maggi, Juvenal Hernández, Ximena Hidalgo

Journal: Rev Chilena Infectol. 2016 Jun;33(3):346-51.

 

Human toxocarosis is a chronic larval parasitosis listed as one of the five most important neglected diseases by the CDC. The larvae can spread systemically and migrate to different tissues including liver and gallbladder. Acalculous acute cholecystitis (AAC) is a rare disease in ...

Last Updated: 31 Dec 1969

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Laparoscopic cholecystectomy for acute cholecystitis: early or delayed?: Evidence from a systematic review of discordant meta-analyses.
 

Author(s): Guo-Min Song, Wei Bian, Xian-Tao Zeng, Jian-Guo Zhou, Yong-Qiang Luo, Xu Tian

Journal: Medicine (Baltimore). 2016 Jun;95(23):e3835.

 

The laparoscopic cholecystectomy (LC) is an important approach of treating acute cholecystitis and the timing of performing this given treatment is associated with clinical outcomes. Although several meta-analyses have been done to investigate the optimal timing of implementing this ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Randomized Controlled Trial on EGBD vs PC for Acute Cholecystitis.
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 18 Jul 2017

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Bile Aspiration vs Drain in Acute Cholecystitis
 

Status: Not yet recruiting

Condition Summary: Cholecystitis, Acute

 

Last Updated: 12 Nov 2017

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Piperacllin Versus Placebo in Patients Undergoing Surgery for Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Cholecystitis, Acute

 

Last Updated: 3 Jan 2017

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