Cholecystitis

Common Name(s)

Cholecystitis

In general, gallbladder disease (GBD) is one of the major digestive diseases. GBD prevalence is particularly high in some minority populations in the United States, including Native and Mexican Americans. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations of GBD in western countries, including the United States. Most people with gallstones remain asymptomatic through their lifetimes; however, it is estimated that approximately 10 to 50% of individuals eventually develop symptoms. Significant risk factors associated with GBD are age, female sex, obesity (especially central obesity), lipids, diet, parity, type 2 diabetes ({125853}), medications, and Mexican American ethnicity. GBD appears to be strongly related to the metabolic syndrome ({605552}) and/or its major components, such as hyperinsulinism, dyslipidemia, and abdominal adiposity ({2:Boland et al., 2002}; {17:Tsai et al., 2004}). Infection, specifically by Helicobacter, has been implicated in cholelithiasis and cholecystitis ({16:Silva et al., 2003}; {10:Maurer et al., 2005}). Low phospholipid-associated cholelithiasis is a specific form of gallbladder disease characterized by young-adult onset of chronic cholestasis with intrahepatic sludge and cholesterol cholelithiasis. Affected individuals have recurrence of the disorder after cholecystectomy and show a favorable response to treatment with ursodeoxycholic acid (UDCA) (summary by {11:Pasmant et al., 2012}). Mutation in the ABCB4 gene can cause a spectrum of related diseases, including the more severe progressive familial intrahepatic cholestasis-3 (PFIC3; {602347}), intrahepatic cholestasis of pregnancy-3 (ICP3; {614972}), andoral contraceptive-induced cholestasis (OCIC; see {614972}). Genetic Heterogeneity of Gallbladder Disease Two major susceptibility loci for symptomatic gallbladder disease have been identified on chromosome 1p in Mexican Americans (GBD2, {609918}; GBD3, {609919}). In addition, variations in the ABCG8 gene ({605460}) on chromosome 2p21 confer susceptibility to gallbladder disease (GBD4; {611465}).
 

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Condition Specific Organizations

Following organizations serve the condition "Cholecystitis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholecystitis" returned 537 free, full-text research articles on human participants. First 3 results:

Juxtarenal Mycotic Aneurysm as a Complication of Acute Exacerbation of Chronic Cholecystitis Treated by Resection and Replacement by a Fresh Allograft.
 

Author(s): Tomáš Grus, Lukáš Lambert, Vilém Rohn, Tomáš Klika, Gabriela Grusová, Pavel Michálek

Journal: Prague Med Rep. 2016 ;117(1):54-60.

 

We present a case of a female patient with infectious (mycotic) juxtarenal abdominal aneurysm with atypical symptoms beginning as acute exacerbation of chronic cholecystitis. Apart from common antibiotic treatment, the patient successfully underwent resection of the diseased segment ...

Last Updated: 21 Mar 2016

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Comment on "The correlation of Helicobacter pylori with the development of cholelithiasis and cholecystitis: the results of a prospective clinical study in Saudi Arabia".
 

Author(s): J Kountouras, E Tsiaousi, S Trigonis, S A Polyzos, P Katsinelos, C Zavos, E Vardaka, C Kountouras, E Gavalas, K Anastasiadou, E Vlachaki, M Boziki, C Zeglinas, I Venizelos, G Deretzi

Journal: Eur Rev Med Pharmacol Sci. 2016 ;20(1):3-4.

 

Last Updated: 27 Jan 2016

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Q Fever Manifested as Acalculous Cholecystitis.
 

Author(s): Moshe Simons, Samuel N Heyman, Michael Bursztyn, Oded Shalev, Nurith Hiller, Sarah Israel

Journal: Isr. Med. Assoc. J.. 2015 Nov;17(11):714-6.

 

Last Updated: 13 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholecystitis" returned 36 free, full-text review articles on human participants. First 3 results:

Acute Cholecystitis Complicated with Portal Vein Thrombosis: A Case Report and Literature Review.
 

Author(s): Mohammed Muneer, Husham Abdelrahman, Ayman El-Menyar, Ahmad Zarour, Ahmed Awad, Hassan Al-Thani

Journal:

 

Portal vein thrombosis (PVT) is an infrequent clinical condition usually associated with multiple etiological factors and diseases. In some cases, PVT remains undiagnosed and is incidentally detected during routine examination for a known etiology.

Last Updated: 18 Sep 2015

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Cholecystectomy vs. percutaneous cholecystostomy for the management of critically ill patients with acute cholecystitis: a protocol for a systematic review.
 

Author(s): Peter C Ambe, Sarantos Kaptanis, Marios Papadakis, Sebastian A Weber, Hubert Zirngibl

Journal:

 

Acute cholecystitis is a common diagnosis. However, the heterogeneity of presentation makes it difficult to standardize management. Although surgery is the mainstay of treatment, critically ill patients have been managed via percutaneous cholecystostomy. However, the role of percutaneous ...

Last Updated: 6 Jun 2015

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Acute acalculous cholecystitis in a patient with primary Epstein-Barr virus infection: a case report and literature review.
 

Author(s): J Agergaard, C S Larsen

Journal: Int. J. Infect. Dis.. 2015 Jun;35():67-72.

 

Epstein-Barr Virus (EBV) infection can lead to infectious mononucleosis syndrome with the typical symptoms of fever, pharyngitis, and lymphadenopathy. Self-limited mild to moderate elevation of liver enzymes and hepatosplenomegaly are common. However, cholecystitis is not usually ...

Last Updated: 8 Jul 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 7 Apr 2015

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Functional MRC With Eovist for Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 1 Dec 2015

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Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis
 

Status: Recruiting

Condition Summary: Acute Cholecystitis

 

Last Updated: 16 Dec 2015

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