Childhood-Onset Schizophrenia

Common Name(s)

Childhood-Onset Schizophrenia

Childhood schizophrenia is a rare form of schizophrenia that develops before a child is 13 years old. Schizophrenia is a severe brain disorder that involves problems with thinking, behavior or emotions. Early-onset schizophrenia has a significant impact on a child’s behavior and development. With childhood schizophrenia, symptoms may build up gradually and may be hard to identify. The earliest signs are language delays, late crawling, late walking or abnormal movements. As the child gets older they may withdraw from friends and family, have trouble sleeping, be depressed, lack motivation and have strange behavior. At later stages they begin to show more typical symptoms of schizophrenia, which are hallucinations, delusions, disorganized thinking, and abnormal motor behavior. To diagnose schizophrenia, a physician will ask about medical, psychiatric and school performance history and will potentially use imaging tests, such as MRIs, to look for abnormalities of the brain. Schizophrenia in children requires lifelong treatment by a psychiatrist. Typical treatment for early-onset schizophrenia are medications, individual and family therapy, social and academic skills training.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Childhood-Onset Schizophrenia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Childhood-Onset Schizophrenia" returned 31 free, full-text research articles on human participants. First 3 results:

Childhood onset schizophrenia and early onset schizophrenia spectrum disorders.
 

Author(s): David I Driver, Nitin Gogtay, Judith L Rapoport

Journal: Child Adolesc Psychiatr Clin N Am. 2013 Oct;22(4):539-55.

 

The clinical severity, impact on development, and poor prognosis of childhood onset schizophrenia may represent a more homogeneous group. Positive symptoms in children are necessary for the diagnosis and hallucinations are more often multimodal. In healthy children and children with ...

Last Updated: 9 Sep 2013

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Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings.
 

Author(s): Sarah L M Johnson, Lei Wang, Kathryn I Alpert, Deanna Greenstein, Liv Clasen, Francois Lalonde, Rachel Miller, Judith Rapoport, Nitin Gogtay

Journal: J Am Acad Child Adolesc Psychiatry. 2013 May;52(5):527-536.e2.

 

The hippocampus has been implicated in the pathogenesis of schizophrenia, and hippocampal volume deficits have been a consistently reported abnormality, but the subregional specificity of the deficits remains unknown. The authors explored the nature and developmental trajectory of ...

Last Updated: 29 Apr 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Childhood-Onset Schizophrenia" returned 3 free, full-text review articles on human participants. First 3 results:

The genetics of childhood-onset schizophrenia: when madness strikes the prepubescent.
 

Author(s): Anjené M Addington, Judith L Rapoport

Journal: Curr Psychiatry Rep. 2009 Apr;11(2):156-61.

 

Stratification by age at onset has been useful for genetic studies across all of medicine. For the past 20 years, the National Institute of Mental Health has been systematically recruiting patients with onset of schizophrenia before age 13 years. Examination of familial transmission ...

Last Updated: 23 Mar 2009

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Cortical brain development in schizophrenia: insights from neuroimaging studies in childhood-onset schizophrenia.
 

Author(s): Nitin Gogtay

Journal: Schizophr Bull. 2008 Jan;34(1):30-6.

 

Childhood-onset schizophrenia (COS; defined as onset by age 12 years) is rare, difficult to diagnose, and represents a severe and chronic phenotype of the adult-onset illness. A study of childhood-onset psychoses has been ongoing at the National Institute of Mental Health (NIMH) since ...

Last Updated: 14 Dec 2007

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The clinical presentation of childhood-onset schizophrenia.
 

Author(s): A T Russell

Journal: Schizophr Bull. 1994 ;20(4):631-46.

 

This review describes the symptomatic presentation of schizophrenia with onset in childhood. Phenomenologic data from an original sample of 35 children with onset before the age of 12, from the University of California, Los Angeles (UCLA) Childhood-Onset Schizophrenia Research Program, ...

Last Updated: 3 May 1995

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Symptoms, Diagnosis, and Treatment

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There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Daily Intranasal Oxytocin for Childhood-Onset Schizophrenia
 

Status: Recruiting

Condition Summary: Childhood Onset Psychotic Disorders; Schizophrenia

 

Last Updated: 1 Jul 2014

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Transcranial Direct Current Brain Stimulation to Treat Patients With Childhood-Onset Schizophrenia
 

Status: Recruiting

Condition Summary: Childhood Onset Psychotic Disorders; Schizophrenia; Psychosis; Mental Disorders Mental Disorder Diagnosed in Childhood

 

Last Updated: 14 Mar 2014

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Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia
 

Status: Recruiting

Condition Summary: Psychosis; Schizophrenia; Genetic Structure; Childhood Onset Psychotic Disorders; Schizoaffective Disorder

 

Last Updated: 11 Nov 2014

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