Early onset schizophrenia

Common Name(s)

Early onset schizophrenia, Childhood schizophrenia, Adolescent schizophrenia

Early onset schizophrenia is a rare form of schizophrenia that develops before a child is 17 years old. Schizophrenia is a severe brain disorder that involves problems with thinking, behavior and emotions. Schizophrenia symptoms generally start in the late teens to the mid-30s. Early-onset schizophrenia begins in children younger than age 17. Very early-onset schizophrenia in children younger than age 13 is very rare. Early onset schizophrenia has a significant impact on a child’s behavior and development. Symptoms may build up gradually and may be hard to identify. The earliest signs of schizophrenia in children under 13 may include language delays, late crawling, late walking or abnormal movements. These symptoms may also suggest other conditions including pervasive developmental disorders such as autism spectrum disorders. Symptoms of schizophrenia developing between ages 13-17 may include withdrawal from friends and family, trouble sleeping, depression, lack of motivation and strange behavior. Unfortunately many of these symptoms may also be present during typical teenage development. As children and teens age, later symptoms become more typical of adult schizophrenia and may include hallucinations, delusions, disorganized thinking, and abnormal motor behavior. Teenagers are more likely to experience visual hallucinations and less likely to have delusions than adults.

Schizophrenia is believed to be caused by both genetics and environment. To diagnose schizophrenia, a physician will ask about medical, psychiatric and school performance history and may use imaging tests, such as MRIs, to look for abnormalities of the brain. Schizophrenia requires lifelong treatment by a psychiatrist and therapist. Treatment for childhood schizophrenia may include medications, individual and family therapy, social and academic skills training. Support groups are also a good resource for information and connecting to other families.

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Condition Specific Organizations

Following organizations serve the condition "Early onset schizophrenia" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Early onset schizophrenia" returned 46 free, full-text research articles on human participants. First 3 results:

Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia.
 

Author(s): A Uezato, N Yamamoto, Y Iwayama, S Hiraoka, E Hiraaki, A Umino, E Haramo, M Umino, T Yoshikawa, T Nishikawa

Journal:

 

The human discs, large homolog 1 gene (DLG1) is mapped to the schizophrenia-susceptibility locus 3q29, and it encodes a scaffold protein that interacts with the N-methyl-D-aspartate receptor presumably dysregulated in schizophrenia. In the current study, we have newly identified a ...

Last Updated: 7 Oct 2015

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Impaired Verbal Learning Is Associated with Larger Caudate Volumes in Early Onset Schizophrenia Spectrum Disorders.
 

Author(s): Monica Juuhl-Langseth, Cecilie B Hartberg, Aina Holmén, Rune Thormodsen, Inge R Groote, Lars M Rimol, Kyrre E Emblem, Ingrid Agartz, Bjørn R Rund

Journal:

 

Both brain structural abnormalities and neurocognitive impairments are core features of schizophrenia. We have previously reported enlargements in subcortical brain structure volumes and impairment of neurocognitive functioning as measured by the MATRICS Cognitive Consensus Battery ...

Last Updated: 3 Aug 2015

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[Internal capsule integrity and its sex-related structural differences in early-onset schizophrenia - diffusion tensor imaging study].
 

Author(s): Marta Gawłowska, Jolanta Rabe-Jabłońska, Piotr Gębski, Piotr Chomczyński

Journal: Psychiatr. Pol.. ;49(2):349-61.

 

In schizophrenia, the most repeatable DTI findings concern reduced FA in temporal and frontal lobes with associated abnormalities in connecting neural fibers. The goal of study was to evaluate the differences in FA of the internal capsule in EOS-patients and healthy controls and to ...

Last Updated: 23 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Early onset schizophrenia" returned 3 free, full-text review articles on human participants. First 3 results:

Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings.
 

Author(s): Benjamin K Brent, Heidi W Thermenos, Matcheri S Keshavan, Larry J Seidman

Journal: Child Adolesc Psychiatr Clin N Am. 2013 Oct;22(4):689-714.

 

This article reviews the literature on structural magnetic resonance imaging findings in pediatric and young adult populations at clinical or genetic high-risk for schizophrenia and early-onset schizophrenia. The implications of this research are discussed for understanding the pathophysiology ...

Last Updated: 9 Sep 2013

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A systematic review of the long-term outcome of early onset schizophrenia.
 

Author(s): Lars Clemmensen, Ditte Lammers Vernal, Hans-Christoph Steinhausen

Journal:

 

The current review analyzes the long-term outcome and prognosis of early onset schizophrenia based on previously published studies in 1980.

Last Updated: 14 Dec 2012

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Efficacy of atypical antipsychotics in early-onset schizophrenia and other psychotic disorders.
 

Author(s): Linmarie Sikich

Journal: J Clin Psychiatry. 2008 ;69 Suppl 4():21-5.

 

Early-onset psychotic illnesses in children and adolescents are not as rare as is commonly believed. These disorders, which include schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, and major depression with psychotic features, often have a chronic ...

Last Updated: 6 Jun 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 26 Feb 2016

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Last Updated: 4 May 2016

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Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset Psychosis
 

Status: Recruiting

Condition Summary: Psychotic Disorders; Schizophrenia; Schizoaffective Disorder; Delusional Disorder; Schizophreniform Disorder

 

Last Updated: 19 Feb 2009

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