Childhood onset schizophrenia

Common Name(s)

Childhood onset schizophrenia, Early onset schizophrenia, Adolescent schizophrenia

Childhood onset schizophrenia is a rare form of schizophrenia that develops before a child is 17 years old. Schizophrenia is a severe brain disorder that involves problems with thinking, behavior and emotions. Schizophrenia symptoms generally start in the late teens to the mid-30s. Early-onset schizophrenia begins in children younger than age 17. Very early-onset schizophrenia in children younger than age 13 is very rare. Childhood schizophrenia has a significant impact on a child’s behavior and development. Symptoms may build up gradually and may be hard to identify. The earliest signs of schizophrenia in children under 13 may include language delays, late crawling, late walking or abnormal movements. These symptoms may also suggest other conditions including pervasive developmental disorders such as autism spectrum disorders. Symptoms of schizophrenia developing between ages 13-17 may include withdrawal from friends and family, trouble sleeping, depression, lack of motivation and strange behavior. Unfortunately many of these symptoms may also be present during typical teenage development. As children and teens age, later symptoms become more typical of adult schizophrenia and may include hallucinations, delusions, disorganized thinking, and abnormal motor behavior. Teenagers are more likely to experience visual hallucinations and less likely to have delusions than adults.

Schizophrenia is believed to be caused by both genetics and environment. To diagnose schizophrenia, a physician will ask about medical, psychiatric and school performance history and may use imaging tests, such as MRIs, to look for abnormalities of the brain. Schizophrenia no matter what the age it develops requires lifelong treatment by a psychiatrist. Typical treatment for childhood schizophrenia includes medications, individual and family therapy, social and academic skills training. Support groups may be very helpful if your child has been diagnosed with schi

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Childhood onset schizophrenia" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Childhood onset schizophrenia" returned 35 free, full-text research articles on human participants. First 3 results:

Childhood onset schizophrenia and early onset schizophrenia spectrum disorders.
 

Author(s): David I Driver, Nitin Gogtay, Judith L Rapoport

Journal: Child Adolesc Psychiatr Clin N Am. 2013 Oct;22(4):539-55.

 

The clinical severity, impact on development, and poor prognosis of childhood onset schizophrenia may represent a more homogeneous group. Positive symptoms in children are necessary for the diagnosis and hallucinations are more often multimodal. In healthy children and children with ...

Last Updated: 9 Sep 2013

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The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth.
 

Author(s): Lachlan A Jolly, Claire C Homan, Reuben Jacob, Simon Barry, Jozef Gecz

Journal: Hum. Mol. Genet.. 2013 Dec;22(23):4673-87.

 

Loss-of-function mutations in UPF3B result in variable clinical presentations including intellectual disability (ID, syndromic and non-syndromic), autism, childhood onset schizophrenia and attention deficit hyperactivity disorder. UPF3B is a core member of the nonsense-mediated mRNA ...

Last Updated: 8 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Childhood onset schizophrenia" returned 3 free, full-text review articles on human participants. First 3 results:

The genetics of childhood-onset schizophrenia: when madness strikes the prepubescent.
 

Author(s): Anjené M Addington, Judith L Rapoport

Journal: Curr Psychiatry Rep. 2009 Apr;11(2):156-61.

 

Stratification by age at onset has been useful for genetic studies across all of medicine. For the past 20 years, the National Institute of Mental Health has been systematically recruiting patients with onset of schizophrenia before age 13 years. Examination of familial transmission ...

Last Updated: 23 Mar 2009

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Cortical brain development in schizophrenia: insights from neuroimaging studies in childhood-onset schizophrenia.
 

Author(s): Nitin Gogtay

Journal: Schizophr Bull. 2008 Jan;34(1):30-6.

 

Childhood-onset schizophrenia (COS; defined as onset by age 12 years) is rare, difficult to diagnose, and represents a severe and chronic phenotype of the adult-onset illness. A study of childhood-onset psychoses has been ongoing at the National Institute of Mental Health (NIMH) since ...

Last Updated: 14 Dec 2007

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The clinical presentation of childhood-onset schizophrenia.
 

Author(s): A T Russell

Journal: Schizophr Bull. 1994 ;20(4):631-46.

 

This review describes the symptomatic presentation of schizophrenia with onset in childhood. Phenomenologic data from an original sample of 35 children with onset before the age of 12, from the University of California, Los Angeles (UCLA) Childhood-Onset Schizophrenia Research Program, ...

Last Updated: 3 May 1995

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Daily Intranasal Oxytocin for Childhood-Onset Schizophrenia
 

Status: Recruiting

Condition Summary: Childhood Onset Psychotic Disorders; Schizophrenia

 

Last Updated: 1 Jul 2014

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Transcranial Direct Current Brain Stimulation to Treat Patients With Childhood-Onset Schizophrenia
 

Status: Recruiting

Condition Summary: Childhood Onset Psychotic Disorders; Schizophrenia; Psychosis; Mental Disorders Mental Disorder Diagnosed in Childhood

 

Last Updated: 11 Dec 2014

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Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia
 

Status: Recruiting

Condition Summary: Psychosis; Schizophrenia; Genetic Structure; Childhood Onset Psychotic Disorders; Schizoaffective Disorder

 

Last Updated: 11 Nov 2014

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