Acquired Hemophilia

Common Name(s)

Acquired Hemophilia

Acquired hemophilia is a rare form of hemophilia in which the body makes specialized proteins called autoantibodies that attack and disable coagulation factors (proteins in the blood that assist with the clotting process).  The most common coagulation factor attacked is coagulation factor VIII, though other coagulation factors, including factor V and factor IX have been associated with the condition. The production of autoantibodies is sometimes associated with pregnancy, immune system disorders (e.g., systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome), viral infections cancer, or allergic reactions to certain drugs. In about half of cases, the cause of acquired hemophilia is unknown. Treatment may vary from person to person.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acquired Hemophilia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acquired Hemophilia" returned 76 free, full-text research articles on human participants. First 3 results:

Influence of factor VIII level and its inhibitor titer on the therapeutic response to corticosteroids alone in the management of acquired hemophilia: A retrospective single-center study.
 

Author(s): Mathieu Vautier, Hubert de Boysson, Christian Creveuil, Yohan Repesse, Annie Borel-Derlon, Xavier Troussard, Gandhi L Damaj, Boris Bienvenu, Philippe Gautier, Achille Aouba

Journal: Medicine (Baltimore). 2016 Nov;95(48):e5232.

 

The treatment of acquired hemophilia (AH) involves discussing whether corticosteroids should be administered alone or combined with immunosuppressant drugs, which increase the risk of infection especially in elderly patients and/or those with autoimmunity or neoplastic diseases, who ...

Last Updated: 30 Nov 2016

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Unusual Initial Manifestation of Acquired Hemophilia A: A Normal Activated Partial Thromboplastin Time, Intramuscular Hematoma and Cerebral Hemorrhage.
 

Author(s): Nobuaki Tsuyama, Toshihisa Ichiba, Hiroshi Naito

Journal: Intern. Med.. ;55(22):3347-3349.

 

We herein present a case of acquired hemophilia A with a normal activated partial thromboplastin (aPTT), intramuscular hematoma and cerebral hemorrhage occurring in a 73-year-old man. The patient visited our emergency department with gait disturbance, pain and swelling in his right ...

Last Updated: 17 Nov 2016

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Assessment of acquired hemophilia patient demographics in the United States: the Hemostasis and Thrombosis Research Society Registry.
 

Author(s): Craig M Kessler, Alice D Ma, Hamid A B Al-Mondhiry, Robert Z Gut, David L Cooper

Journal: Blood Coagul. Fibrinolysis. 2016 Oct;27(7):761-769.

 

The Hemostasis and Thrombosis Research Society (HTRS) Registry was used to monitor the postapproval use of recombinant factor VIIa. The objective of this manuscript is to provide key insights on the demographics of patients with acquired hemophilia in the HTRS Registry. Acquired hemophilia ...

Last Updated: 28 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acquired Hemophilia" returned 5 free, full-text review articles on human participants. First 3 results:

Acquired hemophilia A: an underdiagnosed, severe bleeding disorder.
 

Author(s): Joanna Zdziarska, Jacek Musiał

Journal: Pol. Arch. Med. Wewn.. 2014 ;124(4):200-6.

 

Acquired hemophilia is a rare bleeding disorder caused by autoantibodies that inhibit coagulation factor VIII. In most cases, it manifests with severe, often life‑threatening bleeds. Acquired hemophilia may be idiopathic or secondary to another condition, most commonly other autoimmune ...

Last Updated: 15 Apr 2014

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Acquired hemophilia associated with autoimmune bullous diseases: a report of two cases and a review of the literature.
 

Author(s): Shinichi Makita, Takumi Aoki, Akira Watarai, Azusa Aida, Takuji Katayama, Mikio Danbara, Masaaki Higashihara, Koji Miyazaki

Journal: Intern. Med.. 2013 ;52(7):807-10.

 

Acquired hemophilia (AHA) is a relatively rare and life-threatening disease caused by autoantibodies against factor VIII. Autoimmune bullous diseases (ABD) are also caused by autoantibodies against specific skin proteins. We herein report two cases of AHA associated with ABD. These ...

Last Updated: 2 Apr 2013

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Treatment of acquired hemophilia A.
 

Author(s): P W Collins

Journal: J. Thromb. Haemost.. 2007 May;5(5):893-900.

 

Acquired hemophilia A (AH) is an autoimmune disease that leads to potentially severe bleeding. Management relies on rapid and accurate diagnosis, control of bleeding episodes and eradication of the inhibitor by immunosuppression. There is extensive literature about the disease but ...

Last Updated: 27 Apr 2007

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 18 Nov 2016

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Use of a TGA and TEM in the Assessment of the Efficacy of Treatment With APCC or rFVIIa
 

Status: Recruiting

Condition Summary: Haemophilia

 

Last Updated: 17 Dec 2015

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