Chagas Disease

Common Name(s)

Chagas Disease, American trypanosomiasis

Chagas disease is caused by the parasite, Trypanosoma cruzi. When a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. Chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. Symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. Early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. Chagas disease is common in Latin America but not in the United States.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chagas Disease" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chagas Disease" returned 1196 free, full-text research articles on human participants. First 3 results:

Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease.
 

Author(s): Eduardo Ov Curvo, Roberto R Ferreira, Fabiana S Madeira, Gabriel F Alves, Mayara C Chambela, Veronica G Mendes, Luiz Henrique C Sangenis, Mariana C Waghabi, Roberto M Saraiva

Journal:

 

Transforming growth factor β1 (TGF-β1) and tumour necrosis factor (TNF) have been implicated in Chagas disease pathophysiology and may correlate with left ventricular (LV) function.

Last Updated: 31 Dec 1969

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Chagas disease and systemic autoimmune diseases among Bolivian patients in Switzerland.
 

Author(s): Yves Jackson, Drenusha Vieira de Mello Pula, Axel Finckh, Carlo Chizzolini, François Chappuis

Journal:

 

Chronic cardiomyopathy occurs in 20-40% of the patients with Chagas disease. Autoimmune mechanisms may contribute to its pathogenesis. We diagnosed several cases of systemic autoimmune diseases among Bolivian migrants in Geneva with a high prevalence of Chagas disease.

Last Updated: 31 Dec 1969

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Diet Quality of patients with chronic Chagas disease in a tertiary hospital: a case-control study.
 

Author(s): Mariana Pereira de Castilhos, Grazielle Vilas Bôas Huguenin, Paulo Rogério Melo Rodrigues, Emília Matos do Nascimento, Basílio de Bragança Pereira, Roberto Coury Pedrosa

Journal: Rev. Soc. Bras. Med. Trop.. ;50(6):795-804.

 

Nutritional status has been implicated in the modulation of the immune response, possibly augmenting the pathogenesis of Chagas disease (Cd). We evaluated diet quality and nutritional status in adults and elderly patients with chronic Cd in a tertiary hospital.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chagas Disease" returned 149 free, full-text review articles on human participants. First 3 results:

Chagas disease: review of needs, neglect, and obstacles to treatment access in Latin America.
 

Author(s): Eloan Pinheiro, Lucia Brum-Soares, Renata Reis, Juan-Carlos Cubides

Journal: Rev. Soc. Bras. Med. Trop.. ;50(3):296-300.

 

After more than one century since its discovery, Chagas disease is still extremely prevalent in 21 Latin American countries. Chagas disease is one of the most concerning public health problems in Latin America; the overall cost of CD treatment is approximately 7 billion United States ...

Last Updated: 31 Dec 1969

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Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps.
 

Author(s): V Balouz, F Agüero, C A Buscaglia

Journal: Adv. Parasitol.. 2017 ;97():1-45.

 

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating illness of major significance throughout Latin America and an emergent threat to global public health. Being a neglected disease, the vast majority of Chagasic patients have limited access to ...

Last Updated: 31 Dec 1969

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Chagas disease transmission by consumption of game meat: systematic review.
 

Author(s): Luiz Henrique Conde Sangenis, Marco Antonio Prates Nielebock, Ceumara da Silva Santos, Mateus Curty Carriello da Silva, Glauber Motta Ribeiro Bento

Journal: Rev Bras Epidemiol. ;19(4):803-811.

 

To evaluate the influence of game meat consumption in Chagas disease (CD) transmission, the conditions under which it occurs and the frequency of reports in the literature.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease.
 

Status: Recruiting

Condition Summary: Chagas Disease; Trypanosoma Cruzi Infection

 

Last Updated: 16 Jun 2017

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Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS)
 

Status: Recruiting

Condition Summary: Chagas Disease With Heart Failure

 

Last Updated: 1 Mar 2017

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Last Updated: 10 Apr 2018

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