Chagas Disease

Common Name(s)

Chagas Disease, American trypanosomiasis

Chagas disease is caused by the parasite, Trypanosoma cruzi. When a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. Chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. Symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. Early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. Chagas disease is common in Latin America but not in the United States.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chagas Disease" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chagas Disease" returned 1137 free, full-text research articles on human participants. First 3 results:

Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients.
 

Author(s): Paulo Marcos Matta Guedes, Cléber Mesquita de Andrade, Daniela Ferreira Nunes, Nathalie de Sena Pereira, Tamyres Bernadete Dantas Queiroga, George Luiz Lins Machado-Coelho, Manuela Sales Lima Nascimento, Maria Adelaide Do-Valle-Matta, Antônia Cláudia Jácome da Câmara, Egler Chiari, Lúcia Maria da Cunha Galvão

Journal:

 

Ischemic strokes have been implicated as a cause of death in Chagas disease patients. Inflammation has been recognized as a key component in all ischemic processes, including the intravascular events triggered by vessel interruption, brain damage and repair. In this study, we evaluated ...

Last Updated: 27 Apr 2016

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Development of a Novel Multiplex Immunoassay Multi-cruzi for the Serological Confirmation of Chagas Disease.
 

Author(s): Elodie Granjon, Marie-Laure Dichtel-Danjoy, Esber Saba, Ester Sabino, Lea Campos de Oliveira, Maan Zrein

Journal:

 

Chagas disease is due to the parasite Trypanosoma cruzi, a protist disseminated by a Triatome vector. This disease is endemic to Latin America and considered by WHO as one of the 17 world's neglected diseases. In Europe and in North America, imported cases are also detected, due to ...

Last Updated: 2 Apr 2016

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IL18 Gene Variants Influence the Susceptibility to Chagas Disease.
 

Author(s): Daniel A Leon Rodriguez, F David Carmona, Luis Eduardo Echeverría, Clara Isabel González, Javier Martin

Journal:

 

Chagas disease is a parasitic disorder caused by the infection with the flagellated protozoan Trypanosoma cruzi. According to the World Health Organization, more than six million people are currently infected in endemic regions. Genetic factors have been proposed to influence predisposition ...

Last Updated: 31 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chagas Disease" returned 145 free, full-text review articles on human participants. First 3 results:

Commercial enzyme-linked immunosorbent assay versuspolymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis.
 

Author(s): Pedro Emmanuel Alvarenga Americano do Brasil, Rodolfo Castro, Liane de Castro

Journal: Mem. Inst. Oswaldo Cruz. 2016 Jan;111(1):1-19.

 

Chronic Chagas disease diagnosis relies on laboratory tests due to its clinical characteristics. The aim of this research was to review commercial enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) diagnostic test performance. Performance of commercial ELISA ...

Last Updated: 28 Jan 2016

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Historical Perspectives on the Epidemiology of Human Chagas Disease in Texas and Recommendations for Enhanced Understanding of Clinical Chagas Disease in the Southern United States.
 

Author(s): Melissa N Garcia, Laila Woc-Colburn, David Aguilar, Peter J Hotez, Kristy O Murray

Journal:

 

Chagas disease (Trypanosoma cruzi infection) has recently been identified as an important neglected tropical disease in the United States. Anecdotally referred to as a "silent killer," it leads to the development of potentially fatal cardiac disease in approximately 30% of those infected. ...

Last Updated: 6 Nov 2015

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Chagas disease and transfusion medicine: a perspective from non-endemic countries.
 

Author(s): Andrea Angheben, Lucia Boix, Dora Buonfrate, Federico Gobbi, Zeno Bisoffi, Simonetta Pupella, Giorgio Gandini, Giuseppe Aprili

Journal: Blood Transfus. 2015 Oct;13(4):540-50.

 

In the last decades, increasing international migration and travel from Latin America to Europe have favoured the emergence of tropical diseases outside their "historical" boundaries. Chagas disease, a zoonosis endemic in rural areas of Central and South America represents a clear ...

Last Updated: 30 Oct 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study to Evaluate Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chagas Disease
 

Status: Recruiting

Condition Summary: Chagas Disease; Trypanosomiasis, South American; South American Trypanosomiasis; Disease, Chagas

 

Last Updated: 14 Jul 2015

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Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease
 

Status: Recruiting

Condition Summary: Chagas Disease; Heart Diseases

 

Last Updated: 3 Dec 2013

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Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease
 

Status: Recruiting

Condition Summary: Heart Failure; Heart Failure, Systolic; Chagas Disease; Chagas Cardiomyopathy

 

Last Updated: 26 Mar 2014

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