Chagas Disease

Common Name(s)

Chagas Disease, American trypanosomiasis

Chagas disease is caused by the parasite, Trypanosoma cruzi. When a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. Chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. Symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. Early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. Chagas disease is common in Latin America but not in the United States.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chagas Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chagas Disease" returned 1148 free, full-text research articles on human participants. First 3 results:

Next-generation ELISA diagnostic assay for Chagas Disease based on the combination of short peptidic epitopes.
 

Author(s): Juan Mucci, Santiago J Carmona, Romina Volcovich, Jaime Altcheh, Estefanía Bracamonte, Jorge D Marco, Morten Nielsen, Carlos A Buscaglia, Fernán Agüero

Journal:

 

Chagas Disease, caused by the protozoan Trypanosoma cruzi, is a major health and economic problem in Latin America for which no vaccine or appropriate drugs for large-scale public health interventions are yet available. Accurate diagnosis is essential for the early identification ...

Last Updated: 9 Oct 2017

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Risk factors for treatment interruption and severe adverse effects to benznidazole in adult patients with Chagas disease.
 

Author(s): Mario J Olivera, Zulma M Cucunubá, Carlos A Valencia-Hernández, Rafael Herazo, Diana Agreda-Rudenko, Carolina Flórez, Sofía Duque, Rubén S Nicholls

Journal:

 

Etiological treatment of Chagas disease in chronic asymptomatic patients is still in debate and the adverse effects of traditional drugs are one of the main concerns in clinical practice. This study evaluated retrospectively the safety profile of benznidazole (BZN) and identified ...

Last Updated: 26 Sep 2017

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Access to benznidazole for Chagas disease in the United States-Cautious optimism?
 

Author(s): Jonathan D Alpern, Rogelio Lopez-Velez, William M Stauffer

Journal:

 

Drugs for neglected tropical diseases (NTD) are being excessively priced in the United States. Benznidazole, the first-line drug for Chagas disease, may become approved by the Food and Drug Administration (FDA) and manufactured by a private company in the US, thus placing it at risk ...

Last Updated: 14 Sep 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chagas Disease" returned 148 free, full-text review articles on human participants. First 3 results:

Chagas disease: review of needs, neglect, and obstacles to treatment access in Latin America.
 

Author(s): Eloan Pinheiro, Lucia Brum-Soares, Renata Reis, Juan-Carlos Cubides

Journal: Rev. Soc. Bras. Med. Trop.. ;50(3):296-300.

 

After more than one century since its discovery, Chagas disease is still extremely prevalent in 21 Latin American countries. Chagas disease is one of the most concerning public health problems in Latin America; the overall cost of CD treatment is approximately 7 billion United States ...

Last Updated: 12 Jul 2017

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Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps.
 

Author(s): V Balouz, F Agüero, C A Buscaglia

Journal: Adv. Parasitol.. 2017 ;97():1-45.

 

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating illness of major significance throughout Latin America and an emergent threat to global public health. Being a neglected disease, the vast majority of Chagasic patients have limited access to ...

Last Updated: 22 Mar 2017

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Putting Infection Dynamics at the Heart of Chagas Disease.
 

Author(s): Michael D Lewis, John M Kelly

Journal: Trends Parasitol.. 2016 11;32(11):899-911.

 

In chronic Trypanosoma cruzi infections, parasite burden is controlled by effective, but nonsterilising immune responses. Infected cells are difficult to detect because they are scarce and focally distributed in multiple sites. However, advances in detection technologies have established ...

Last Updated: 10 Sep 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lower Urinary Tract Dysfunction in Chronic Chagas' Disease : Clinical and Urodynamic Presentation
 

Status: Recruiting

Condition Summary: Chagas' Disease (Chronic) With Other Organ Involvement

 

Last Updated: 19 Jul 2017

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Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS)
 

Status: Recruiting

Condition Summary: Chagas Disease With Heart Failure

 

Last Updated: 1 Mar 2017

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Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease.
 

Status: Recruiting

Condition Summary: Chagas Disease; Trypanosoma Cruzi Infection

 

Last Updated: 16 Jun 2017

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