Chagas Disease

Common Name(s)

Chagas Disease, American trypanosomiasis

Chagas disease is caused by the parasite, Trypanosoma cruzi. When a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. Chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. Symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. Early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. Chagas disease is common in Latin America but not in the United States.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chagas Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chagas Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chagas Disease" returned 1187 free, full-text research articles on human participants. First 3 results:

Serological and molecular inquiry of Chagas disease in an Afro-descendant settlement in Mato Grosso do Sul State, Brazil.
 

Author(s): Mariana Furquim da Silva Martins, Mariane Barroso Pereira, Juliana de Jesus Guimarães Ferreira, Adriana de Oliveira França, Marlon Cézar Cominetti, Eduardo de Castro Ferreira, Maria Elizabeth Moraes Cavalheiros Dorval, Cláudio Lúcio Rossi, Sílvia de Barros Mazon, Eros Antonio de Almeida, Sandra Cecília Botelho Costa, Gláucia Elisete Barbosa Marcon

Journal:

 

Furnas do Dionísio is a Brazilian Afro-descendant settlement in the city of Jaraguari, 21.4 miles from Campo Grande, Mato Grosso do Sul, Brazil. Approximately 96 families live in this quilombola (Maroon) settlement, also known in Brazil as a remnant community of descendants of African ...

Last Updated: 31 Dec 1969

Go To URL
Comprehensive analysis of three TYK2 gene variants in the susceptibility to Chagas disease infection and cardiomyopathy.
 

Author(s): Daniel A Leon Rodriguez, Marialbert Acosta-Herrera, F David Carmona, Nuria Dolade, Sofia Vargas, Luis Eduardo Echeverría, Clara Isabel González, Javier Martin

Journal:

 

Tyrosine kinase 2 (TYK2) is a member of the Janus kinases family implicated in the signal transduction of type I interferons and several interleukins. It has been described that genetic mutations within TYK2 lead to multiple deleterious effects in the immune response. In this work, ...

Last Updated: 31 Dec 1969

Go To URL
Role of T. cruzi exposure in the pattern of T cell cytokines among chronically infected HIV and Chagas disease patients.
 

Author(s): Tania Regina Tozetto-Mendoza, Dewton de Moraes Vasconcelos, Karim Yaqub Ibrahim, Ana Marli Christovam Sartori, Rita C Bezerra, Vera Lúcia Teixeira de Freitas, Maria Aparecida Shikanai-Yasuda

Journal: Clinics (Sao Paulo). 2017 Nov;72(11):652-660.

 

The impact of Chagas disease (CD) in HIV-infected patients is relevant throughout the world. In fact, the characterization of the adaptive immune response in the context of co-infection is important for predicting the need for interventions in areas in which HIV and Chagas disease co-exist.

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chagas Disease" returned 148 free, full-text review articles on human participants. First 3 results:

Chagas disease: review of needs, neglect, and obstacles to treatment access in Latin America.
 

Author(s): Eloan Pinheiro, Lucia Brum-Soares, Renata Reis, Juan-Carlos Cubides

Journal: Rev. Soc. Bras. Med. Trop.. ;50(3):296-300.

 

After more than one century since its discovery, Chagas disease is still extremely prevalent in 21 Latin American countries. Chagas disease is one of the most concerning public health problems in Latin America; the overall cost of CD treatment is approximately 7 billion United States ...

Last Updated: 31 Dec 1969

Go To URL
Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps.
 

Author(s): V Balouz, F Agüero, C A Buscaglia

Journal: Adv. Parasitol.. 2017 ;97():1-45.

 

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating illness of major significance throughout Latin America and an emergent threat to global public health. Being a neglected disease, the vast majority of Chagasic patients have limited access to ...

Last Updated: 31 Dec 1969

Go To URL
Putting Infection Dynamics at the Heart of Chagas Disease.
 

Author(s): Michael D Lewis, John M Kelly

Journal: Trends Parasitol.. 2016 11;32(11):899-911.

 

In chronic Trypanosoma cruzi infections, parasite burden is controlled by effective, but nonsterilising immune responses. Infected cells are difficult to detect because they are scarce and focally distributed in multiple sites. However, advances in detection technologies have established ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Lower Urinary Tract Dysfunction in Chronic Chagas' Disease : Clinical and Urodynamic Presentation
 

Status: Recruiting

Condition Summary: Chagas' Disease (Chronic) With Other Organ Involvement

 

Last Updated: 19 Jul 2017

Go to URL
Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease.
 

Status: Recruiting

Condition Summary: Chagas Disease; Trypanosoma Cruzi Infection

 

Last Updated: 16 Jun 2017

Go to URL
Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS)
 

Status: Recruiting

Condition Summary: Chagas Disease With Heart Failure

 

Last Updated: 1 Mar 2017

Go to URL