Chagas Disease

Common Name(s)

Chagas Disease, American trypanosomiasis

Chagas disease is caused by the parasite, Trypanosoma cruzi. When a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. Chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. Symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. Early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. Chagas disease is common in Latin America but not in the United States.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chagas Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chagas Disease" returned 1129 free, full-text research articles on human participants. First 3 results:

Changes in Proteome Profile of Peripheral Blood Mononuclear Cells in Chronic Chagas Disease.
 

Author(s): Nisha Jain Garg, Kizhake V Soman, Maria P Zago, Sue-Jie Koo, Heidi Spratt, Susan Stafford, Zinzi N Blell, Shivali Gupta, Julio Nuñez Burgos, Natalia Barrientos, Allan R Brasier, John E Wiktorowicz

Journal:

 

Trypanosoma cruzi (Tc) infection causes chagasic cardiomyopathy; however, why 30-40% of the patients develop clinical disease is not known. To discover the pathomechanisms in disease progression, we obtained the proteome signature of peripheral blood mononuclear cells (PBMCs) of normal ...

Last Updated: 27 Feb 2016

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Amazonian Triatomine Biodiversity and the Transmission of Chagas Disease in French Guiana: In Medio Stat Sanitas.
 

Author(s): Julie Péneau, Anne Nguyen, Alheli Flores-Ferrer, Denis Blanchet, Sébastien Gourbière

Journal:

 

The effects of biodiversity on the transmission of infectious diseases now stand as a cornerstone of many public health policies. The upper Amazonia and Guyana shield are hot-spots of biodiversity that offer genuine opportunities to explore the relationship between the risk of transmission ...

Last Updated: 12 Feb 2016

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High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation.
 

Author(s): Adrián Sánchez-Montalvá, María Moris, Marianela Mego, Fernando Salvador, Anna Accarino, Kathleen Ramírez, Fernando Azpiroz, Antonio Ruiz-de-Leon, Israel Molina

Journal:

 

Gastrointestinal involvement affects 30-40% of the patients with chronic Chagas disease. Esophageal symptoms appear once the structural damage is established. Little is known about the usefulness of high resolution manometry to early identification of esophageal involvement.

Last Updated: 6 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chagas Disease" returned 142 free, full-text review articles on human participants. First 3 results:

Historical Perspectives on the Epidemiology of Human Chagas Disease in Texas and Recommendations for Enhanced Understanding of Clinical Chagas Disease in the Southern United States.
 

Author(s): Melissa N Garcia, Laila Woc-Colburn, David Aguilar, Peter J Hotez, Kristy O Murray

Journal:

 

Chagas disease (Trypanosoma cruzi infection) has recently been identified as an important neglected tropical disease in the United States. Anecdotally referred to as a "silent killer," it leads to the development of potentially fatal cardiac disease in approximately 30% of those infected. ...

Last Updated: 6 Nov 2015

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Modulation of Intrathymic Sphingosine-1-Phosphate Levels Promotes Escape of Immature Thymocytes to the Periphery with a Potential Proinflammatory Role in Chagas Disease.
 

Author(s): Ana Flávia Nardy, Leonardo Santos, Célio Geraldo Freire-de-Lima, Alexandre Morrot

Journal: Biomed Res Int. 2015 ;2015():709846.

 

The sphingosine-1-phosphate (S1P) system regulates both thymic and lymph nodes T cell egress which is essential for producing and maintaining the recycling T cell repertoire. Infection with the protozoan parasite Trypanosoma cruzi induces a hormonal systemic deregulation that has ...

Last Updated: 8 Sep 2015

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Translational challenges of animal models in Chagas disease drug development: a review.
 

Author(s): Eric Chatelain, Nandini Konar

Journal:

 

Chagas disease, or American trypanosomiasis, caused by Trypanosoma cruzi parasite infection is endemic in Latin America and presents an increasing clinical challenge due to migrating populations. Despite being first identified over a century ago, only two drugs are available for its ...

Last Updated: 28 Aug 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study to Evaluate Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chagas Disease
 

Status: Recruiting

Condition Summary: Chagas Disease; Trypanosomiasis, South American; South American Trypanosomiasis; Disease, Chagas

 

Last Updated: 14 Jul 2015

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Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease
 

Status: Recruiting

Condition Summary: Chagas Disease; Heart Diseases

 

Last Updated: 3 Dec 2013

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Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease
 

Status: Recruiting

Condition Summary: Heart Failure; Heart Failure, Systolic; Chagas Disease; Chagas Cardiomyopathy

 

Last Updated: 26 Mar 2014

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