Chagas Disease

Common Name(s)

Chagas Disease, American trypanosomiasis

Chagas disease is caused by the parasite, Trypanosoma cruzi. When a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. Chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. Symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. Early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. Chagas disease is common in Latin America but not in the United States.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chagas Disease" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chagas Disease" returned 1098 free, full-text research articles on human participants. First 3 results:

Rapid diagnostic tests duo as alternative to conventional serological assays for conclusive Chagas disease diagnosis.
 

Author(s): Karina E Egüez, Julio Alonso-Padilla, Carolina Terán, Zenobia Chipana, Wilson García, Faustino Torrico, Joaquim Gascon, Daniel-Franz Lozano-Beltran, María-Jesús Pinazo

Journal:

 

Chagas disease is caused by the parasite Trypanosoma cruzi. It affects several million people, mainly in Latin America, and severe cardiac and/or digestive complications occur in ~30% of the chronically infected patients. Disease acute stage is mostly asymptomatic and infection goes ...

Last Updated: 3 Apr 2017

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Analysis of the seroprevalence of and factors associated with Chagas disease in an endemic area in Northeastern Brazil.
 

Author(s): Erlane Chaves Freitas, Maria de Fátima Oliveira, Arduina Sofia Ortet de Barros Vasconcelos, José Damião da Silva, Carlos Eduardo Menezes Viana, Kátia Cristina Morais Soares Gomes, Luciano Pamplona de Góes Cavalcanti

Journal: Rev. Soc. Bras. Med. Trop.. ;50(1):44-51.

 

Chagas disease (CD) is currently considered a neglected disease; hence, identifying the factors associated with its high prevalence is essential. This study aimed to identify the seroprevalence of and the possible factors associated with CD in inhabitants of the City of Limoeiro do ...

Last Updated: 22 Mar 2017

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Trypanosoma cruzi I genotype among isolates from patients with chronic Chagas disease followed at the Evandro Chagas National Institute of Infectious Diseases (FIOCRUZ, Brazil).
 

Author(s): Tatiana da Silva Fonseca de Oliveira, Barbara Neves Dos Santos, Tainah Silva Galdino, Alejandro Marcel Hasslocher-Moreno, Otilio Machado Pereira Bastos, Maria Auxiliadora de Sousa

Journal: Rev. Soc. Bras. Med. Trop.. ;50(1):35-43.

 

Trypanosoma cruzi is the etiologic agent of Chagas disease in humans, mainly in Latin America. Trypanosome stocks were isolated by hemoculture from patients followed at Evandro Chagas National Institute of Infectious Diseases (FIOCRUZ) and studied using different approaches.

Last Updated: 22 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chagas Disease" returned 146 free, full-text review articles on human participants. First 3 results:

Carlos Chagas Discoveries as a Drop Back to Scientific Construction of Chronic Chagas Heart Disease.
 

Author(s): Reinaldo B Bestetti, Carolina Baraldi A Restini, Lucélio B Couto

Journal: Arq. Bras. Cardiol.. 2016 Jul;107(1):63-70.

 

The scientific construction of chronic Chagas heart disease (CCHD) started in 1910 when Carlos Chagas highlighted the presence of cardiac arrhythmia during physical examination of patients with chronic Chagas disease, and described a case of heart failure associated with myocardial ...

Last Updated: 18 Aug 2016

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Control and management of congenital Chagas disease in Europe and other non-endemic countries: current policies and practices.
 

Author(s): Antoni Soriano-Arandes, Andrea Angheben, Nuria Serre-Delcor, Begoña Treviño-Maruri, Jordi Gómez I Prat, Yves Jackson

Journal: Trop. Med. Int. Health. 2016 May;21(5):590-6.

 

Identifying pregnant women infected with Trypanosoma cruzi is one of the major challenges for preventing and controlling Chagas disease (CD) in non-endemic countries. The aim of this paper was to perform a policy evaluation of the current practices of congenital Chagas disease (CCD) ...

Last Updated: 20 Apr 2016

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Commercial enzyme-linked immunosorbent assay versuspolymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis.
 

Author(s): Pedro Emmanuel Alvarenga Americano do Brasil, Rodolfo Castro, Liane de Castro

Journal: Mem. Inst. Oswaldo Cruz. 2016 Jan;111(1):1-19.

 

Chronic Chagas disease diagnosis relies on laboratory tests due to its clinical characteristics. The aim of this research was to review commercial enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) diagnostic test performance. Performance of commercial ELISA ...

Last Updated: 28 Jan 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prospective Study of a Pediatric Nifurtimox Formulation for Chagas' Disease
 

Status: Recruiting

Condition Summary: Chagas Disease

 

Last Updated: 9 May 2017

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Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS)
 

Status: Recruiting

Condition Summary: Chagas Disease With Heart Failure

 

Last Updated: 1 Mar 2017

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Selenium Treatment and Chagasic Cardiopathy (STCC)
 

Status: Recruiting

Condition Summary: Chagas Disease

 

Last Updated: 9 Nov 2015

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