Chagas Disease

Common Name(s)

Chagas Disease, American trypanosomiasis

Chagas disease is caused by the parasite, Trypanosoma cruzi. When a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. Chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. Symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. Early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. Chagas disease is common in Latin America but not in the United States.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chagas Disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chagas Disease" returned 1117 free, full-text research articles on human participants. First 3 results:

Expression of co-stimulatory molecules CD80 and CD86 is altered in CD14 + HLA-DR + monocytes from patients with Chagas disease following induction by Trypanosoma cruzi recombinant antigens.
 

Author(s): Ana Karine de Araújo Soares, Patrícia Areias Feitosa Neves, Maria da Glória Aureliano de Melo Cavalcanti, Sílvia Martins Marinho, Wilson de Oliveira, Joelma Rodrigues de Souza, Virginia Maria Barros de Lorena, Yara de Miranda Gomes

Journal: Rev. Soc. Bras. Med. Trop.. ;49(5):632-636.

 

The relationships between monocytes and lymphocytes through MHC class II molecules and costimulatory, are of utmost importance for the production of an efficient immune response. In this work, we assessed the expression of surface molecules CD80 and CD86 on CD14+HLA-DR+ monocytes ...

Last Updated: 4 Nov 2016

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Assessment of the Housing Improvement Program for Chagas Disease Control in the Northwestern municipalities of Rio Grande do Sul, Brazil.
 

Author(s): Cibele Velleda Dos Santos, Clenonara Bedin, Tania Stasiak Wilhelms, Marcos Marreiro Villela

Journal: Rev. Soc. Bras. Med. Trop.. ;49(5):572-578.

 

The Housing Improvement Program for Chagas Disease Control (HIPCDC) was established in 2001 in Northwestern Rio Grande do Sul State, aiming to improve the conditions of the domiciliary and peridomiciliary environments to make them resistant to triatomine colonization. This study aimed ...

Last Updated: 4 Nov 2016

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Chagas disease prevalence in pregnant women: migration and risk of congenital transmission.
 

Author(s): Rodolfo A Kolliker-Frers, Ivan Insua, Gabriela Razzitte, Francisco Capani

Journal:

 

Argentina has been a preferential target for Bolivian immigrants for decades. The relatively recent migratory flux includes Germany, France, the United States, Australia, Japan, and some Latin American countries. The aim of this cross-sectional study was to describe the prevalence ...

Last Updated: 3 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chagas Disease" returned 142 free, full-text review articles on human participants. First 3 results:

Control and management of congenital Chagas disease in Europe and other non-endemic countries: current policies and practices.
 

Author(s): Antoni Soriano-Arandes, Andrea Angheben, Nuria Serre-Delcor, Begoña Treviño-Maruri, Jordi Gómez I Prat, Yves Jackson

Journal: Trop. Med. Int. Health. 2016 May;21(5):590-6.

 

Identifying pregnant women infected with Trypanosoma cruzi is one of the major challenges for preventing and controlling Chagas disease (CD) in non-endemic countries. The aim of this paper was to perform a policy evaluation of the current practices of congenital Chagas disease (CCD) ...

Last Updated: 20 Apr 2016

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Commercial enzyme-linked immunosorbent assay versuspolymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis.
 

Author(s): Pedro Emmanuel Alvarenga Americano do Brasil, Rodolfo Castro, Liane de Castro

Journal: Mem. Inst. Oswaldo Cruz. 2016 Jan;111(1):1-19.

 

Chronic Chagas disease diagnosis relies on laboratory tests due to its clinical characteristics. The aim of this research was to review commercial enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) diagnostic test performance. Performance of commercial ELISA ...

Last Updated: 28 Jan 2016

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Revisiting the Posttherapeutic Cure Criterion in Chagas Disease: Time for New Methods, More Questions, Doubts, and Polemics or Time to Change Old Concepts?
 

Author(s): Marta de Lana, Olindo Assis Martins-Filho

Journal: Biomed Res Int. 2015 ;2015():652985.

 

One of the most relevant issues beyond the effectiveness of etiological treatment of Chagas disease is the lack of consensual/feasible tools to identify and certify the definitive parasitological cure. Several methods of distinct natures (parasitological, serological, and molecular) ...

Last Updated: 20 Nov 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prospective Study of a Pediatric Nifurtimox Formulation for Chagas' Disease
 

Status: Recruiting

Condition Summary: Chagas Disease

 

Last Updated: 3 Feb 2017

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Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS)
 

Status: Recruiting

Condition Summary: Chagas Disease With Heart Failure

 

Last Updated: 2 Sep 2015

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Selenium Treatment and Chagasic Cardiopathy (STCC)
 

Status: Recruiting

Condition Summary: Chagas Disease

 

Last Updated: 9 Nov 2015

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