Chagas Disease

Common Name(s)

Chagas Disease, American trypanosomiasis

Chagas disease is caused by the parasite, Trypanosoma cruzi. When a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. Chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. Symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. Early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. Chagas disease is common in Latin America but not in the United States.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chagas Disease" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chagas Disease" returned 1106 free, full-text research articles on human participants. First 3 results:

Genetically Determined MBL Deficiency Is Associated with Protection against Chronic Cardiomyopathy in Chagas Disease.
 

Author(s): Paola Rosa Luz, Márcia I Miyazaki, Nelson Chiminacio Neto, Marcela C Padeski, Ana Cláudia M Barros, Angelica B W Boldt, Iara J Messias-Reason

Journal:

 

Chagas disease (CD) is caused by Trypanosoma cruzi, whose sugar moieties are recognized by mannan binding lectin (MBL), a soluble pattern-recognition molecule that activates the lectin pathway of complement. MBL levels and protein activity are affected by polymorphisms in the MBL2 ...

Last Updated: 9 Jan 2016

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Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response.
 

Author(s): Maria-Jesus Pinazo, Elizabeth de Jesus Posada, Luis Izquierdo, Dolors Tassies, Alexandre-Ferreira Marques, Elisa de Lazzari, Edelweiss Aldasoro, Jose Muñoz, Alba Abras, Silvia Tebar, Montserrat Gallego, Igor Correia de Almeida, Joan-Carles Reverter, Joaquim Gascon

Journal:

 

Thromboembolic events were described in patients with Chagas disease without cardiomyopathy. We aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. Ninety-nine ...

Last Updated: 5 Jan 2016

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Chagas disease: morbidity profile in an endemic area of Northeastern Brazil.
 

Author(s): Cléber de Mesquita Andrade, Antônia Cláudia Jácome da Câmara, Daniela Ferreira Nunes, Paulo Marcos da Matta Guedes, Wogelsanger Oliveira Pereira, Egler Chiari, Rosiane Viana Zuza Diniz, Lúcia Maria da Cunha Galvão

Journal: Rev. Soc. Bras. Med. Trop.. ;48(6):706-15.

 

This study evaluated the clinical forms and manifestation severities of Chagas disease among serologically reactive individuals from Western Rio Grande do Norte (Northeastern Brazil).

Last Updated: 17 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chagas Disease" returned 139 free, full-text review articles on human participants. First 3 results:

Historical Perspectives on the Epidemiology of Human Chagas Disease in Texas and Recommendations for Enhanced Understanding of Clinical Chagas Disease in the Southern United States.
 

Author(s): Melissa N Garcia, Laila Woc-Colburn, David Aguilar, Peter J Hotez, Kristy O Murray

Journal:

 

Chagas disease (Trypanosoma cruzi infection) has recently been identified as an important neglected tropical disease in the United States. Anecdotally referred to as a "silent killer," it leads to the development of potentially fatal cardiac disease in approximately 30% of those infected. ...

Last Updated: 6 Nov 2015

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Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease.
 

Author(s): Louisa A Messenger, Michael A Miles, Caryn Bern

Journal: Expert Rev Anti Infect Ther. 2015 Aug;13(8):995-1029.

 

Over the last 30 years, concomitant with successful transnational disease control programs across Latin America, Chagas disease has expanded from a neglected, endemic parasitic infection of the rural poor to an urbanized chronic disease, and now a potentially emergent global health ...

Last Updated: 11 Jul 2015

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Experimental Vaccines against Chagas Disease: A Journey through History.
 

Author(s): Olivia Rodríguez-Morales, Víctor Monteón-Padilla, Silvia C Carrillo-Sánchez, Martha Rios-Castro, Mariana Martínez-Cruz, Alejandro Carabarin-Lima, Minerva Arce-Fonseca

Journal: J Immunol Res. 2015 ;2015():489758.

 

Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite Trypanosoma cruzi, is primarily a vector disease endemic in 21 Latin American countries, including Mexico. Although many vector control programs have been implemented, T. cruzi has not been eradicated. ...

Last Updated: 19 Jun 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study to Evaluate Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chagas Disease
 

Status: Recruiting

Condition Summary: Chagas Disease; Trypanosomiasis, South American; South American Trypanosomiasis; Disease, Chagas

 

Last Updated: 14 Jul 2015

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Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease
 

Status: Recruiting

Condition Summary: Heart Failure; Heart Failure, Systolic; Chagas Disease; Chagas Cardiomyopathy

 

Last Updated: 26 Mar 2014

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Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease
 

Status: Recruiting

Condition Summary: Chagas Disease; Heart Diseases

 

Last Updated: 3 Dec 2013

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