Cervical intraepithelial neoplasia

Common Name(s)

Cervical intraepithelial neoplasia, Cervical dysplasia

Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, refers to abnormal changes in the cells on the surface of the cervix. The cervix is the lower part of the uterus (womb) in a female that opens at the top of the vagina. These changes in the cervical cells can develop at any age, but they are most common in women ages to 25-35. The changes that occur as a result are not cancerous, but they can lead to cancer if the cervix is not treated.

The condition is most often caused by the human papillomavirus (HPV), which is spread through sexual contact (please also see: HPV). Other risk factors include sexual activity prior to age 18, multiple sexual partners, having a baby before age 16, smoking and other illnesses or medications that weaken the immune system. There are usually no symptoms, but CIN can be detected through a pap smear and often need to be confirmed through a biopsy (a sampling of cells from the affected area). Treatment is only needed if changes do not go away or get worse for mild CIN. For moderate-to-severe dysplasia a doctor may have to freeze abnormal cells, laser therapy, or surgery to remove the abnormal tissue. Early diagnosis and prompt treatment cures most cases of cervical dysplasia. However, the condition may return. If you or a loved one have been diagnosed with cervical intraepithelial neoplasia talk to your doctor about treatment options. Support groups are also a good source of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cervical intraepithelial neoplasia" for support, advocacy or research.

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Beautiful You MRKH Foundation, Inc.

The mission of the Beautiful You MRKH Foundation is to create a supportive community that partners with health care professionals to increase awareness and empower women of all ages with MRKH to feel beautiful, just as they are.

Last Updated: 12 Feb 2016

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cervical intraepithelial neoplasia" for support, advocacy or research.

Logo
Beautiful You MRKH Foundation, Inc.

The mission of the Beautiful You MRKH Foundation is to create a supportive community that partners with health care professionals to increase awareness and empower women of all ages with MRKH to feel beautiful, just as they are.

https://www.beautifulyoumrkh.org/

Last Updated: 12 Feb 2016

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cervical intraepithelial neoplasia" returned 504 free, full-text research articles on human participants. First 3 results:

Expression of p63, p53 and Ki-67 in Patients with Cervical Intraepithelial Neoplasia.
 

Author(s): Androniks Mitildzans, Anastasija Arechvo, Dace Rezeberga, Sergejs Isajevs

Journal: Turk Patoloji Derg. 2017 ;33(1):9-16.

 

Cervical intraepithelial neoplasia (CIN) is a dysplastic process in cervical squamous epithelium and carries a risk of progression to cervical cancer. The aim of this study was to compare expression of three biomarkers named p53, p63 and Ki-67 in patients with various grades of cervical ...

Last Updated: 3 Jan 2017

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Silent High Grade Cervical Intraepithelial Neoplasia in Atypical Smears from Liquid Based Cervical Cytology - Three Years Experience in Thammasat University Hospital.
 

Author(s): Supapen Lertvutivivat, Athita Chanthasenanont, Athita Chanthasenanont, Teerapat Muangto, Tongta Nanthakomon, Densak Pongrojpaw, Kornkarn Bhamarapravatana, Komsun Suwannarurk

Journal: Asian Pac. J. Cancer Prev.. 2016 ;17(9):4353-4356.

 

To study the prevalence of CIN2+ diagnosis in women with atypical Papaniculoau (Pap) smears to suggest appropriate management option for Thai health care.

Last Updated: 31 Oct 2016

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Prior human papillomavirus-16/18 AS04-adjuvanted vaccination prevents recurrent high grade cervical intraepithelial neoplasia after definitive surgical therapy: Post-hoc analysis from a randomized controlled trial.
 

Author(s): Suzanne M Garland, Jorma Paavonen, Unnop Jaisamrarn, Paulo Naud, Jorge Salmerón, Song-Nan Chow, Dan Apter, Xavier Castellsagué, Júlio C Teixeira, S Rachel Skinner, James Hedrick, Genara Limson, Tino F Schwarz, Willy A J Poppe, F Xavier Bosch, Newton S de Carvalho, Maria Julieta V Germar, Klaus Peters, M Rowena Del Rosario-Raymundo, Grégory Catteau, Dominique Descamps, Frank Struyf, Matti Lehtinen, Gary Dubin,

Journal: Int. J. Cancer. 2016 Dec;139(12):2812-2826.

 

We evaluated the efficacy of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in preventing HPV-related disease after surgery for cervical lesions in a post-hoc analysis of the PApilloma TRIal against Cancer In young Adults (PATRICIA; NCT00122681). Healthy women aged 15-25 ...

Last Updated: 9 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cervical intraepithelial neoplasia" returned 27 free, full-text review articles on human participants. First 3 results:

Natural history of cervical intraepithelial neoplasia in pregnancy: postpartum histo-pathologic outcome and review of the literature.
 

Author(s): Mariella Mailath-Pokorny, Richard Schwameis, Christoph Grimm, Alexander Reinthaller, Stephan Polterauer

Journal:

 

To study the natural history of cervical intraepithelial neoplasia (CIN) during pregnancy and to compare the rates of persistence, progression and regression of CIN by colposcopically guided biopsy (CGB) during pregnancy with outcome in non-pregnant-women.

Last Updated: 8 Apr 2016

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Systematic reviews and meta-analyses of benefits and harms of cryotherapy, LEEP, and cold knife conization to treat cervical intraepithelial neoplasia.
 

Author(s): Nancy Santesso, Reem A Mustafa, Wojtek Wiercioch, Rohan Kehar, Shreyas Gandhi, Yaolong Chen, Adrienne Cheung, Jessica Hopkins, Rasha Khatib, Bin Ma, Ahmad A Mustafa, Nancy Lloyd, Darong Wu, Nathalie Broutet, Holger J Schünemann

Journal: Int J Gynaecol Obstet. 2016 Mar;132(3):266-71.

 

Cervical intraepithelial neoplasia (CIN) stage 2-3 is a premalignant lesion that can progress to cervical cancer in 10-20 years if untreated.

Last Updated: 29 Feb 2016

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Evidence supporting see-and-treat management of cervical intraepithelial neoplasia: a systematic review and meta-analysis.
 

Author(s): R M F Ebisch, M M Rovers, R P Bosgraaf, H W van der Pluijm-Schouten, W J G Melchers, P A J van den Akker, L F A G Massuger, R L M Bekkers

Journal: BJOG. 2016 Jan;123(1):59-66.

 

Studies of see-and-treat management of cervical intraepithelial neoplasia (CIN) vary in their inclusion criteria, resulting in a broad range of overtreatment rates.

Last Updated: 30 Dec 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effect of Curcumin in Treatment of Squamous Cervical Intraepithelial Neoplasias (CINs)
 

Status: Recruiting

Condition Summary: Cervical Intraepithelial Neoplasia

 

Last Updated: 16 Mar 2016

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Testing Use of Condoms on Regression of Cervical Intraepithelial Neoplasia
 

Status: Recruiting

Condition Summary: Cervical Intraepithelial Neoplasia

 

Last Updated: 19 Sep 2016

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Study of SOR007 Ointment for Cervical Intraepithelial Neoplasia (CIN)
 

Status: Not yet recruiting

Condition Summary: Cervical Intraepithelial Neoplasia

 

Last Updated: 4 May 2017

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