Cervical intraepithelial neoplasia

Common Name(s)

Cervical intraepithelial neoplasia, Cervical dysplasia

Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, refers to abnormal changes in the cells on the surface of the cervix. The cervix is the lower part of the uterus (womb) in a female that opens at the top of the vagina. These changes in the cervical cells can develop at any age, but they are most common in women ages to 25-35. The changes that occur as a result are not cancerous, but they can lead to cancer if the cervix is not treated.

The condition is most often caused by the human papillomavirus (HPV), which is spread through sexual contact (please also see: HPV). Other risk factors include sexual activity prior to age 18, multiple sexual partners, having a baby before age 16, smoking and other illnesses or medications that weaken the immune system. There are usually no symptoms, but CIN can be detected through a pap smear and often need to be confirmed through a biopsy (a sampling of cells from the affected area). Treatment is only needed if changes do not go away or get worse for mild CIN. For moderate-to-severe dysplasia a doctor may have to freeze abnormal cells, laser therapy, or surgery to remove the abnormal tissue. Early diagnosis and prompt treatment cures most cases of cervical dysplasia. However, the condition may return. If you or a loved one have been diagnosed with cervical intraepithelial neoplasia talk to your doctor about treatment options. Support groups are also a good source of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cervical intraepithelial neoplasia" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cervical intraepithelial neoplasia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cervical intraepithelial neoplasia" returned 487 free, full-text research articles on human participants. First 3 results:

microRNAs' differential regulations mediate the progress of Human Papillomavirus (HPV)-induced Cervical Intraepithelial Neoplasia (CIN).
 

Author(s): Wenjuan Mo, Chao Tong, Yan Zhang, Hong Lu

Journal:

 

microRNA (miRNA)'s direct regulation on target mRNA is affected by complex factors beyond miRNA. Therefore, at different stages during the course of carcinogenesis, miRNA may regulate different targets, which we termed 'miRNA's differential regulation'. HPV-induced cervical intraepithelial ...

Last Updated: 19 Apr 2015

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Circulating soluble neuropilin-1 in patients with early cervical cancer and cervical intraepithelial neoplasia can be used as a valuable diagnostic biomarker.
 

Author(s): Shouhua Yang, Henghui Cheng, Zaiju Huang, Xiaoling Wang, Yinglu Wan, Jing Cai, Zehua Wang

Journal: Dis. Markers. 2015 ;2015():506428.

 

To investigate soluble neuropilin-1 (sNRP-1) in circulating and NRP-1 protein in cervical tissues from patients with cervical cancer or cervical intraepithelial neoplasia (CIN).

Last Updated: 15 Apr 2015

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RAP1 GTPase overexpression is associated with cervical intraepithelial neoplasia.
 

Author(s): Marcelo Antonio Pascoal-Xavier, Anna Carolina Cançado Figueiredo, Luciana Inácia Gomes, Vanessa Peruhype-Magalhães, Carlos Eduardo Calzavara-Silva, Marcelo Azevedo Costa, Ilka Afonso Reis, Claudio Antônio Bonjardim, Erna Geessien Kroon, Jaquelline G de Oliveira, Paulo César Peregrino Ferreira

Journal:

 

RAP1 (RAS proximate 1), a small GTP-binding protein of the RAS superfamily, is a putative oncogene that is highly expressed in several malignant cell lines and types of cancers, including some types of squamous cell carcinoma. However, the participation of RAP1 in cervical carcinogenesis ...

Last Updated: 10 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cervical intraepithelial neoplasia" returned 25 free, full-text review articles on human participants. First 3 results:

Fertility and early pregnancy outcomes after treatment for cervical intraepithelial neoplasia: systematic review and meta-analysis.
 

Author(s): Maria Kyrgiou, Anita Mitra, Marc Arbyn, Sofia Melina Stasinou, Pierre Martin-Hirsch, Phillip Bennett, Evangelos Paraskevaidis

Journal:

 

To determine the impact of cervical excision for cervical intraepithelial neoplasia on fertility and early pregnancy outcomes.

Last Updated: 29 Oct 2014

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Cervical Intraepithelial Neoplasia (CIN) in pregnancy: the state of the art.
 

Author(s): M Origoni, S Salvatore, A Perino, G Cucinella, M Candiani

Journal: Eur Rev Med Pharmacol Sci. 2014 ;18(6):851-60.

 

Cervical cancer is the most commonly diagnosed malignancy in pregnancy and cervical screening should be accordingly performed in this particular situation. Occurrence of a preneoplastic cervical disease in pregnancy has for a long time represented a challenge for the clinician, both ...

Last Updated: 7 Apr 2014

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Meta-analysis of the efficacy of cold coagulation as a treatment method for cervical intraepithelial neoplasia: a systematic review.
 

Author(s): L Dolman, C Sauvaget, R Muwonge, R Sankaranarayanan

Journal: BJOG. 2014 Jul;121(8):929-42.

 

Cold coagulation is an ablative method for treatment of cervical intraepithelial neoplasia (CIN). Despite reports of efficacy against all grades of CIN (CIN1-3), cold coagulation has been infrequently used since the 1980s, and was absent from the recent Cochrane review on CIN treatment.

Last Updated: 24 Jun 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Multispectral Digital Colposcope With Probe for Detection of Cervical Intraepithelial Neoplasia
 

Status: Recruiting

Condition Summary: Carcinoma in Situ of Uterine Cervix; Cervical Intraepithelial Neoplasias; High Grade Cervical Intraepithelial Neoplasia

 

Last Updated: 9 Apr 2015

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Intravaginal Artesunate for the Treatment of HPV+ High Grade Cervical Intraepithelial Neoplasia (CIN2/3)
 

Status: Recruiting

Condition Summary: Cervical Intraepithelial Neoplasia Grade 2/3; High-risk HPV (Any Strain)

 

Last Updated: 6 Feb 2015

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Topical Imiquimod Versus Conization to Treat Cervical Intraepithelial Neoplasia
 

Status: Recruiting

Condition Summary: Cervical Intraepithelial Neoplasia

 

Last Updated: 15 Jul 2013

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