Cervical intraepithelial neoplasia

Common Name(s)

Cervical intraepithelial neoplasia, Cervical dysplasia

Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, refers to abnormal changes in the cells on the surface of the cervix. The cervix is the lower part of the uterus (womb) in a female that opens at the top of the vagina. These changes in the cervical cells can develop at any age, but they are most common in women ages to 25-35. The changes that occur as a result are not cancerous, but they can lead to cancer if the cervix is not treated.

The condition is most often caused by the human papillomavirus (HPV), which is spread through sexual contact (please also see: HPV). Other risk factors include sexual activity prior to age 18, multiple sexual partners, having a baby before age 16, smoking and other illnesses or medications that weaken the immune system. There are usually no symptoms, but CIN can be detected through a pap smear and often need to be confirmed through a biopsy (a sampling of cells from the affected area). Treatment is only needed if changes do not go away or get worse for mild CIN. For moderate-to-severe dysplasia a doctor may have to freeze abnormal cells, laser therapy, or surgery to remove the abnormal tissue. Early diagnosis and prompt treatment cures most cases of cervical dysplasia. However, the condition may return. If you or a loved one have been diagnosed with cervical intraepithelial neoplasia talk to your doctor about treatment options. Support groups are also a good source of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cervical intraepithelial neoplasia" for support, advocacy or research.

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Beautiful You MRKH Foundation, Inc.

The mission of the Beautiful You MRKH Foundation is to create a supportive community that partners with health care professionals to increase awareness and empower women of all ages with MRKH to feel beautiful, just as they are.

Last Updated: 12 Feb 2016

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cervical intraepithelial neoplasia" for support, advocacy or research.

Logo
Beautiful You MRKH Foundation, Inc.

The mission of the Beautiful You MRKH Foundation is to create a supportive community that partners with health care professionals to increase awareness and empower women of all ages with MRKH to feel beautiful, just as they are.

https://www.beautifulyoumrkh.org/

Last Updated: 12 Feb 2016

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cervical intraepithelial neoplasia" returned 522 free, full-text research articles on human participants. First 3 results:

Discovery of new methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3.
 

Author(s): A Boers, R Wang, R W van Leeuwen, H G Klip, G H de Bock, H Hollema, W van Criekinge, T de Meyer, S Denil, A G J van der Zee, E Schuuring, G B A Wisman

Journal:

 

Assessment of DNA promoter methylation markers in cervical scrapings for the detection of cervical intraepithelial neoplasia (CIN) and cervical cancer is feasible, but finding methylation markers with both high sensitivity as well as high specificity remains a challenge. In this study, ...

Last Updated: 10 Mar 2016

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Conventional cytology, visual tests and evaluation of P16(INK4A) as a biomarker in cervical intraepithelial neoplasia.
 

Author(s): S Kava, S Rajaram, V K Arora, N Goel, S Aggarwal, S Mehta

Journal: Indian J Cancer. ;52(3):270-5.

 

(1) To detect cervical intraepithelial neoplasia (CIN) using Papanicolaou test (PAP test), visual tests (visual inspection after the application of acetic acid [VIA], visual inspection after the application of Lugol's iodine [VILI]), colposcopy, and biopsy. (2) To study the biomarker ...

Last Updated: 24 Feb 2016

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TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC trial): study protocol for a randomized controlled trial.
 

Author(s): M M Koeneman, A J Kruse, L F S Kooreman, A Zur Hausen, A H N Hopman, S J S Sep, T Van Gorp, B F M Slangen, H J van Beekhuizen, M van de Sande, C G Gerestein, H W Nijman, R F P M Kruitwagen

Journal:

 

Cervical intraepithelial neoplasia (CIN) is the premalignant condition of cervical cancer. Whereas not all high grade CIN lesions progress to cervical cancer, the natural history and risk of progression of individual lesions remain unpredictable. Therefore, high-grade CIN is currently ...

Last Updated: 22 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cervical intraepithelial neoplasia" returned 27 free, full-text review articles on human participants. First 3 results:

Natural history of cervical intraepithelial neoplasia in pregnancy: postpartum histo-pathologic outcome and review of the literature.
 

Author(s): Mariella Mailath-Pokorny, Richard Schwameis, Christoph Grimm, Alexander Reinthaller, Stephan Polterauer

Journal:

 

To study the natural history of cervical intraepithelial neoplasia (CIN) during pregnancy and to compare the rates of persistence, progression and regression of CIN by colposcopically guided biopsy (CGB) during pregnancy with outcome in non-pregnant-women.

Last Updated: 8 Apr 2016

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Systematic reviews and meta-analyses of benefits and harms of cryotherapy, LEEP, and cold knife conization to treat cervical intraepithelial neoplasia.
 

Author(s): Nancy Santesso, Reem A Mustafa, Wojtek Wiercioch, Rohan Kehar, Shreyas Gandhi, Yaolong Chen, Adrienne Cheung, Jessica Hopkins, Rasha Khatib, Bin Ma, Ahmad A Mustafa, Nancy Lloyd, Darong Wu, Nathalie Broutet, Holger J Sch√ľnemann

Journal: Int J Gynaecol Obstet. 2016 Mar;132(3):266-71.

 

Cervical intraepithelial neoplasia (CIN) stage 2-3 is a premalignant lesion that can progress to cervical cancer in 10-20 years if untreated.

Last Updated: 29 Feb 2016

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Evidence supporting see-and-treat management of cervical intraepithelial neoplasia: a systematic review and meta-analysis.
 

Author(s): R M F Ebisch, M M Rovers, R P Bosgraaf, H W van der Pluijm-Schouten, W J G Melchers, P A J van den Akker, L F A G Massuger, R L M Bekkers

Journal: BJOG. 2016 Jan;123(1):59-66.

 

Studies of see-and-treat management of cervical intraepithelial neoplasia (CIN) vary in their inclusion criteria, resulting in a broad range of overtreatment rates.

Last Updated: 30 Dec 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effect of Curcumin in Treatment of Squamous Cervical Intraepithelial Neoplasias (CINs)
 

Status: Recruiting

Condition Summary: Cervical Intraepithelial Neoplasia

 

Last Updated: 16 Mar 2016

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Testing Use of Condoms on Regression of Cervical Intraepithelial Neoplasia
 

Status: Recruiting

Condition Summary: Cervical Intraepithelial Neoplasia

 

Last Updated: 19 Sep 2016

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Human Papillomavirus (HPV) Self-sampling as a Test of Cure After Treatment of Cervical Intra-epithelial Neoplasia
 

Status: Recruiting

Condition Summary: Cervical Intra-epithelial Neoplasia Grade 1 or Worse

 

Last Updated: 11 Aug 2016

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