Cervical intraepithelial neoplasia

Common Name(s)

Cervical intraepithelial neoplasia, Cervical dysplasia

Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, refers to abnormal changes in the cells on the surface of the cervix. The cervix is the lower part of the uterus (womb) in a female that opens at the top of the vagina. These changes in the cervical cells can develop at any age, but they are most common in women ages to 25-35. The changes that occur as a result are not cancerous, but they can lead to cancer if the cervix is not treated.

The condition is most often caused by the human papillomavirus (HPV), which is spread through sexual contact (please also see: HPV). Other risk factors include sexual activity prior to age 18, multiple sexual partners, having a baby before age 16, smoking and other illnesses or medications that weaken the immune system. There are usually no symptoms, but CIN can be detected through a pap smear and often need to be confirmed through a biopsy (a sampling of cells from the affected area). Treatment is only needed if changes do not go away or get worse for mild CIN. For moderate-to-severe dysplasia a doctor may have to freeze abnormal cells, laser therapy, or surgery to remove the abnormal tissue. Early diagnosis and prompt treatment cures most cases of cervical dysplasia. However, the condition may return. If you or a loved one have been diagnosed with cervical intraepithelial neoplasia talk to your doctor about treatment options. Support groups are also a good source of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cervical intraepithelial neoplasia" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cervical intraepithelial neoplasia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cervical intraepithelial neoplasia" returned 371 free, full-text research articles on human participants. First 3 results:

Efficacy of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical intraepithelial neoplasia and cervical infection in young Japanese women.
 

Author(s): Ryo Konno, Hiroyuki Yoshikawa, Marie Okutani, Wim Quint, Pemmaraju V Suryakiran, Lan Lin, Frank Struyf

Journal: Hum Vaccin Immunother. 2014 ;10(7):1781-94.

 

In this open, extended follow-up study (NCT00929526, Clinicaltrials.gov), we evaluated the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine efficacy, immunogenicity and safety up to 4 years after first vaccination in Japanese women aged 20-25 years. In the initial randomized, ...

Last Updated: 26 Nov 2014

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Risk of preterm delivery with increasing depth of excision for cervical intraepithelial neoplasia in England: nested case-control study.
 

Author(s): Alejandra Castanon, Rebecca Landy, Peter Brocklehurst, Heather Evans, Donald Peebles, Naveena Singh, Patrick Walker, Julietta Patnick, Peter Sasieni,

Journal:

 

To determine the association between depth of excision of cervical intraepithelial neoplasia and risk of preterm birth.

Last Updated: 7 Nov 2014

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Molecular detection of human papillomavirus in Brazilian women with cervical intraepithelial neoplasia in a northeast Brazilian city.
 

Author(s): J D C Nunes, F C B Vidal, C T L Ferraro, M B C Chein, L M O Brito, S C M Monteiro

Journal:

 

We examined the prevalence of human papillomavirus (HPV) infection in Brazilian women with cervical intraepithelial neoplasia. Our goal was to identify the types of HPV and their association with risk factors. This prospective cross-sectional study included 97 samples collected from ...

Last Updated: 4 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cervical intraepithelial neoplasia" returned 19 free, full-text review articles on human participants. First 3 results:

Fertility and early pregnancy outcomes after treatment for cervical intraepithelial neoplasia: systematic review and meta-analysis.
 

Author(s): Maria Kyrgiou, Anita Mitra, Marc Arbyn, Sofia Melina Stasinou, Pierre Martin-Hirsch, Phillip Bennett, Evangelos Paraskevaidis

Journal:

 

To determine the impact of cervical excision for cervical intraepithelial neoplasia on fertility and early pregnancy outcomes.

Last Updated: 29 Oct 2014

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Cervical Intraepithelial Neoplasia (CIN) in pregnancy: the state of the art.
 

Author(s): M Origoni, S Salvatore, A Perino, G Cucinella, M Candiani

Journal: Eur Rev Med Pharmacol Sci. 2014 ;18(6):851-60.

 

Cervical cancer is the most commonly diagnosed malignancy in pregnancy and cervical screening should be accordingly performed in this particular situation. Occurrence of a preneoplastic cervical disease in pregnancy has for a long time represented a challenge for the clinician, both ...

Last Updated: 7 Apr 2014

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Viral and cellular biomarkers in the diagnosis of cervical intraepithelial neoplasia and cancer.
 

Author(s): Maria Lina Tornesello, Luigi Buonaguro, Paolo Giorgi-Rossi, Franco M Buonaguro

Journal: Biomed Res Int. 2013 ;2013():519619.

 

Cervical cancer arises from cells localized in the ectoendocervical squamocolumnar junction of the cervix persistently infected with one of about 13 human papillomavirus (HPV) genotypes. The majority of HPV infections induces low grade squamous epithelial lesions that in more than ...

Last Updated: 2 Jan 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Multispectral Digital Colposcope With Probe for Detection of Cervical Intraepithelial Neoplasia
 

Status: Recruiting

Condition Summary: Carcinoma in Situ of Uterine Cervix; Cervical Intraepithelial Neoplasias; High Grade Cervical Intraepithelial Neoplasia

 

Last Updated: 9 Apr 2015

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Intravaginal Artesunate for the Treatment of HPV+ High Grade Cervical Intraepithelial Neoplasia (CIN2/3)
 

Status: Recruiting

Condition Summary: Cervical Intraepithelial Neoplasia Grade 2/3; High-risk HPV (Any Strain)

 

Last Updated: 6 Feb 2015

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Topical Imiquimod Versus Conization to Treat Cervical Intraepithelial Neoplasia
 

Status: Recruiting

Condition Summary: Cervical Intraepithelial Neoplasia

 

Last Updated: 15 Jul 2013

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