Cervical intraepithelial neoplasia

Common Name(s)

Cervical intraepithelial neoplasia, Cervical dysplasia

Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, refers to abnormal changes in the cells on the surface of the cervix. The cervix is the lower part of the uterus (womb) in a female that opens at the top of the vagina. These changes in the cervical cells can develop at any age, but they are most common in women ages to 25-35. The changes that occur as a result are not cancerous, but they can lead to cancer if the cervix is not treated.

The condition is most often caused by the human papillomavirus (HPV), which is spread through sexual contact (please also see: HPV). Other risk factors include sexual activity prior to age 18, multiple sexual partners, having a baby before age 16, smoking and other illnesses or medications that weaken the immune system. There are usually no symptoms, but CIN can be detected through a pap smear and often need to be confirmed through a biopsy (a sampling of cells from the affected area). Treatment is only needed if changes do not go away or get worse for mild CIN. For moderate-to-severe dysplasia a doctor may have to freeze abnormal cells, laser therapy, or surgery to remove the abnormal tissue. Early diagnosis and prompt treatment cures most cases of cervical dysplasia. However, the condition may return. If you or a loved one have been diagnosed with cervical intraepithelial neoplasia talk to your doctor about treatment options. Support groups are also a good source of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cervical intraepithelial neoplasia" for support, advocacy or research.

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Beautiful You MRKH Foundation, Inc.

The mission of the Beautiful You MRKH Foundation is to create a supportive community that partners with health care professionals to increase awareness and empower women of all ages with MRKH to feel beautiful, just as they are.

Last Updated: 12 Feb 2016

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cervical intraepithelial neoplasia" for support, advocacy or research.

Logo
Beautiful You MRKH Foundation, Inc.

The mission of the Beautiful You MRKH Foundation is to create a supportive community that partners with health care professionals to increase awareness and empower women of all ages with MRKH to feel beautiful, just as they are.

https://www.beautifulyoumrkh.org/

Last Updated: 12 Feb 2016

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cervical intraepithelial neoplasia" returned 523 free, full-text research articles on human participants. First 3 results:

Low recurrence rate of high-grade cervical intraepithelial neoplasia after successful excision and routine colposcopy during follow-up.
 

Author(s): Eleftheria Lili, Kimon Chatzistamatiou, Andromachi Kalpaktsidou-Vakiani, Theodoros Moysiadis, Theodoros Agorastos

Journal: Medicine (Baltimore). 2018 Jan;97(4):e9719.

 

The aim of the present cohort study was to assess the long-term (follow-up period up to 22 years) recurrence rate of preinvasive disease and the newly detected invasive disease rate in a cohort of women treated with excisional methods for high-grade cervical intraepithelial neoplasia ...

Last Updated: 31 Dec 1969

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Medical Devices; Hematology and Pathology Devices; Classification of a Cervical Intraepithelial Neoplasia Test System. Final order.
 

Author(s):

Journal: Fed Regist. 2018 Jan;83(2):232-4.

 

The Food and Drug Administration (FDA or we) is classifying the cervical intraepithelial neoplasia (CIN) test system into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the ...

Last Updated: 31 Dec 1969

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Perceived cervical cancer risk among women treated for high-grade cervical intraepithelial neoplasia: The importance of specific knowledge.
 

Author(s): Sonia Andersson, Karen Belkić, Selin Safer Demirbüker, Miriam Mints, Ellinor Östensson

Journal:

 

Women with high-grade cervical intraepithelial neoplasia (CIN) are at increased risk for developing cervical cancer. We examine how women with high-grade CIN perceive their own risk, and about pertinent knowledge concerning human high-risk papillomavirus (HPV), CIN and cervical cancer.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cervical intraepithelial neoplasia" returned 31 free, full-text review articles on human participants. First 3 results:

Efficacy and safety of photodynamic therapy for cervical intraepithelial neoplasia and human papilloma virus infection: A systematic review and meta-analysis of randomized clinical trials.
 

Author(s): Wenjia Zhang, Aijia Zhang, Wende Sun, Ying Yue, Hong Li

Journal: Medicine (Baltimore). 2018 May;97(21):e10864.

 

We sought to conduct a systemic review and meta-analysis of randomized clinical trials to assess the efficacy and safety of photodynamic therapy (PDT) in cervical intraepithelial neoplasia (CIN) and cervical human papilloma virus (HPV) infection.

Last Updated: 31 Dec 1969

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Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis.
 

Author(s): Karoliina Tainio, Antonios Athanasiou, Kari A O Tikkinen, Riikka Aaltonen, Jovita Cárdenas, Hernándes, Sivan Glazer-Livson, Maija Jakobsson, Kirsi Joronen, Mari Kiviharju, Karolina Louvanto, Sanna Oksjoki, Riikka Tähtinen, Seppo Virtanen, Pekka Nieminen, Maria Kyrgiou, Ilkka Kalliala

Journal:

 

To estimate the regression, persistence, and progression of untreated cervical intraepithelial neoplasia grade 2 (CIN2) lesions managed conservatively as well as compliance with follow-up protocols.

Last Updated: 31 Dec 1969

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Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis.
 

Author(s): Mingzhu Liu, Xiaolong Yan, Mei Zhang, Xiaoju Li, Shugang Li, Mingxia Jing

Journal: Biomed Res Int. 2017 ;2017():8971059.

 

To provide a scientific basis for the prevention and treatment of cervical intraepithelial neoplasia grade 1 (CIN1). This study evaluated the impact of human papillomavirus (HPV) infection on the natural history of CIN1.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Physical Cold Atmospheric Plasma for the Treatment of Cervical Intraepithelial Neoplasia
 

Status: Recruiting

Condition Summary: Cervical Intraepithelial Neoplasia

 

Last Updated: 28 May 2018

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Testing Use of Condoms on Regression of Cervical Intraepithelial Neoplasia
 

Status: Recruiting

Condition Summary: Cervical Intraepithelial Neoplasia

 

Last Updated: 30 Oct 2017

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A Trial to Evaluate the Efficacy and Safety of BLS-ILB-E710c in Patients With Cervical Intraepithelial Neoplasia 2/3 (CIN2/3)
 

Status: Recruiting

Condition Summary: Cervical Intraepithelial Neoplasia Grade 2/3

 

Last Updated: 5 Apr 2018

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