Cerebellar Degeneration

Common Name(s)

Cerebellar Degeneration

Cerebellar degeneration refers to the deterioration of neurons in the cerebellum (the area of the brain that controls muscle coordination and balance). Conditions that cause cerebellar degeneration may also affect other areas of the central nervous system, such as the spinal cord, the cerebral cortex, and the brain stem. Signs and symptoms of cerebellar degeneration may include a wide-based, uncoordinated walk; a back and forth tremor in the trunk of the body; uncoordinated movements of the arms and legs; slow and slurred speech; and nystagmus. Cerebellar degeneration can be caused by a variety of factors including inherited gene changes (mutations), chronic alcohol abuse, and paraneoplastic disorders. Treatment for cerebellar degeneration varies depending on the underlying cause.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cerebellar Degeneration" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cerebellar Degeneration" returned 113 free, full-text research articles on human participants. First 3 results:

Early-stage Alcoholic Cerebellar Degeneration: Diagnostic Imaging Clues.
 

Author(s): Ji Hoon Lee, Sung Hyuk Heo, Dae-il Chang

Journal: J. Korean Med. Sci.. 2015 Nov;30(11):1539.

 

Last Updated: 4 Feb 2016

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Anti-Hu Antibody Associated Paraneoplastic Cerebellar Degeneration in Head and Neck Cancer.
 

Author(s): Florian Huemer, Thomas Melchardt, Wolfgang Tränkenschuh, Daniel Neureiter, Gerhard Moser, Teresa Magnes, Lukas Weiss, Alexander Schlattau, Clemens Hufnagl, Gerda Ricken, Romana Höftberger, Richard Greil, Alexander Egle

Journal:

 

Paraneoplastic syndromes are most frequently associated with small cell lung carcinoma, hematologic and gynecologic malignancies while reports in head and neck cancer are rare.

Last Updated: 23 Dec 2015

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Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.
 

Author(s): Kai Wang, Ruijuan Xu, Jennifer Schrandt, Prithvi Shah, Yong Z Gong, Chet Preston, Louis Wang, Jae Kyo Yi, Chih-Li Lin, Wei Sun, Demetri D Spyropoulos, Soyoung Rhee, Mingsong Li, Jie Zhou, Shaoyu Ge, Guofeng Zhang, Ashley J Snider, Yusuf A Hannun, Lina M Obeid, Cungui Mao

Journal:

 

Dyshomeostasis of both ceramides and sphingosine-1-phosphate (S1P) in the brain has been implicated in aging-associated neurodegenerative disorders in humans. However, mechanisms that maintain the homeostasis of these bioactive sphingolipids in the brain remain unclear. Mouse alkaline ...

Last Updated: 17 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cerebellar Degeneration" returned 6 free, full-text review articles on human participants. First 3 results:

Gastric diffuse large B cell lymphoma presenting as paraneoplastic cerebellar degeneration: case report and review of literature.
 

Author(s): K C Lakshmaiah, B K Viveka, N Anil Kumar, Monika L Saini, Sanjib Sinha, Kamal S Saini

Journal: J Egypt Natl Canc Inst. 2013 Dec;25(4):231-5.

 

Paraneoplastic cerebellar degeneration (PCD) is a type of paraneoplastic neurological disorder (PND) that is associated with many solid tumors, Hodgkin's lymphoma (HL) and very rarely with non-Hodgkin's lymphoma (NHL). We report a case of PCD associated with gastric diffuse large ...

Last Updated: 11 Nov 2013

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A case of follicular lymphoma associated with paraneoplastic cerebellar degeneration.
 

Author(s): Yayoi Shimazu, Eiko N Minakawa, Momoko Nishikori, Masafumi Ihara, Yuichiro Hashi, Hirofumi Matsuyama, Masakatsu Hishizawa, Sonoyo Yoshida, Toshiyuki Kitano, Tadakazu Kondo, Takayuki Ishikawa, Ryosuke Takahashi, Akifumi Takaori-Kondo

Journal: Intern. Med.. 2012 ;51(11):1387-92.

 

Paraneoplastic neurological disorders (PND) are neurological effects of malignancy that are recognized as immune-mediated disorders caused by aberrant expression of a tumor antigen that is normally expressed in the nervous system. We report a case of cerebellar ataxia which turned ...

Last Updated: 12 Jun 2012

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A new family of Boucher-Neuhäuser syndrome: coexistence of Holmes type cerebellar atrophy, hypogonadotropic hypogonadism and retinochoroidal degeneration: case reports and review of literature.
 

Author(s): K Tojo, M Ichinose, M Nakayama, H Yamamoto, T Hasegawa, Y Kawaguchi, S C Sealfon, O Sakai

Journal: Endocr. J.. 1995 Jun;42(3):367-76.

 

The association of familial hypogonadism with progressive cerebellar ataxia is only rarely encountered, and the exact link between the symptoms remains unknown. We report here two sisters presenting with Holmes type cerebellar ataxia, hypogonadotropic hypogonadism and retinochoroidal ...

Last Updated: 19 Oct 1995

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sporadic Degenerative Ataxia With Adult Onset: Natural History Study
 

Status: Recruiting

Condition Summary: Late Onset Sporadic Cerebellar Ataxia

 

Last Updated: 9 Mar 2016

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Last Updated: 18 Apr 2016

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The Influence of Deep TMS on Cerebellar Signs in Patients With Machado Joseph Disease
 

Status: Recruiting

Condition Summary: Machado Joseph Disease (SCA3)

 

Last Updated: 15 Sep 2014

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