Cerebellar Degeneration

Common Name(s)

Cerebellar Degeneration

Cerebellar degeneration is a disease process in which neurons in the cerebellum (the area of the brain that controls muscle coordination and balance) deteriorate and die.  Cerebellar degeneration does not constitute a specific diagnosis, but rather is used to describe the changes that occur in a person's nervous system. Diseases that cause cerebellar degeneration can also involve areas of the brain that connect the cerebellum to the spinal cord, such as the medulla oblongata, the cerebral cortex, and the brain stem. Cerebellar degeneration has many different causes, but is most often the result of inherited genetic mutations.
 

Advocacy and Support Organizations

 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cerebellar Degeneration" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cerebellar Degeneration" returned 85 free, full-text research articles on human participants. First 3 results:

Storage of a naturally acquired conditioned response is impaired in patients with cerebellar degeneration.
 

Author(s): Andreas Thieme, Markus Thürling, Julia Galuba, Roxana G Burciu, Sophia Göricke, Andreas Beck, Volker Aurich, Elke Wondzinski, Mario Siebler, Marcus Gerwig, Vlastislav Bracha, Dagmar Timmann

Journal: Brain. 2013 Jul;136(Pt 7):2063-76.

 

Previous findings suggested that the human cerebellum is involved in the acquisition but not the long-term storage of motor associations. The finding of preserved retention in cerebellar patients was fundamentally different from animal studies which show that both acquisition and ...

Last Updated: 26 Jun 2013

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Antibody repertoire in paraneoplastic cerebellar degeneration and small cell lung cancer.
 

Author(s): Lidia Sabater, Romana Höftberger, Anna Boronat, Albert Saiz, Josep Dalmau, Francesc Graus

Journal: PLoS ONE. 2013 ;8(3):e60438.

 

The goal of this study is to determine whether patients with paraneoplastic cerebellar degeneration (PCD) and small-cell lung cancer (SCLC) have a specific repertoire of antibodies, if SOX1 antibodies (SOX1-ab) can predict the presence of SCLC, and if antibodies to cell surface antigens ...

Last Updated: 28 Mar 2013

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Anti-Yo antibody-mediated paraneoplastic cerebellar degeneration in a female patient with pleural malignant mesothelioma.
 

Author(s): Ozgur Tanriverdi, Nezih Meydan, Sabri Barutca, Nazan Ozsan, Duygu Gurel, Ali Veral

Journal: Jpn. J. Clin. Oncol.. 2013 May;43(5):563-8.

 

Paraneoplastic cerebellar degeneration is a rare non-metastatic complication of malignancies. It presents with acute or subacute onset of ataxia, dysarthria and intention tremor. Paraneoplastic cerebellar degeneration is most commonly associated with malignancies of the ovary, breast ...

Last Updated: 30 Apr 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cerebellar Degeneration" returned 6 free, full-text review articles on human participants. First 3 results:

Gastric diffuse large B cell lymphoma presenting as paraneoplastic cerebellar degeneration: case report and review of literature.
 

Author(s): K C Lakshmaiah, B K Viveka, N Anil Kumar, Monika L Saini, Sanjib Sinha, Kamal S Saini

Journal: J Egypt Natl Canc Inst. 2013 Dec;25(4):231-5.

 

Paraneoplastic cerebellar degeneration (PCD) is a type of paraneoplastic neurological disorder (PND) that is associated with many solid tumors, Hodgkin's lymphoma (HL) and very rarely with non-Hodgkin's lymphoma (NHL). We report a case of PCD associated with gastric diffuse large ...

Last Updated: 11 Nov 2013

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A case of follicular lymphoma associated with paraneoplastic cerebellar degeneration.
 

Author(s): Yayoi Shimazu, Eiko N Minakawa, Momoko Nishikori, Masafumi Ihara, Yuichiro Hashi, Hirofumi Matsuyama, Masakatsu Hishizawa, Sonoyo Yoshida, Toshiyuki Kitano, Tadakazu Kondo, Takayuki Ishikawa, Ryosuke Takahashi, Akifumi Takaori-Kondo

Journal: Intern. Med.. 2012 ;51(11):1387-92.

 

Paraneoplastic neurological disorders (PND) are neurological effects of malignancy that are recognized as immune-mediated disorders caused by aberrant expression of a tumor antigen that is normally expressed in the nervous system. We report a case of cerebellar ataxia which turned ...

Last Updated: 12 Jun 2012

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Anti-Ri-associated paraneoplastic cerebellar degeneration. Report of a case and revision of the literature.
 

Author(s): Michelangelo Mancuso, Daniele Orsucci, Andrea Bacci, Elena Caldarazzo Ienco, Gabriele Siciliano

Journal: Arch Ital Biol. 2011 Sep;149(3):318-22.

 

Paraneoplastic cerebellar degeneration associated with anti-Ri antibodies mainly presents with opsoclonus-myoclonus-ataxia. We report here the case of a patient with anti-Ri-antibody paraneoplastic syndrome, who presented four years after treatment for small-cell lung cancer (SCLC) ...

Last Updated: 26 Oct 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

An Extension Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
 

Status: Recruiting

Condition Summary: Spinocerebellar Degeneration

 

Last Updated: 22 Oct 2013

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A Confirmatory Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
 

Status: Recruiting

Condition Summary: Spinocerebellar Degeneration

 

Last Updated: 22 Oct 2013

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A Long-Term Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
 

Status: Recruiting

Condition Summary: Spinocerebellar Degeneration

 

Last Updated: 22 Oct 2013

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