Cerebellar Degeneration

Common Name(s)

Cerebellar Degeneration

Cerebellar degeneration refers to the deterioration of neurons in the cerebellum (the area of the brain that controls muscle coordination and balance). Conditions that cause cerebellar degeneration may also affect other areas of the central nervous system, such as the spinal cord, the cerebral cortex, and the brain stem. Signs and symptoms of cerebellar degeneration may include a wide-based, uncoordinated walk; a back and forth tremor in the trunk of the body; uncoordinated movements of the arms and legs; slow and slurred speech; and nystagmus. Cerebellar degeneration can be caused by a variety of factors including inherited gene changes (mutations), chronic alcohol abuse, and paraneoplastic disorders. Treatment for cerebellar degeneration varies depending on the underlying cause.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cerebellar Degeneration" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cerebellar Degeneration" returned 122 free, full-text research articles on human participants. First 3 results:

Anti-Yo positive and late-onset paraneoplastic cerebellar degeneration associated with ovarian carcinoma: A case report.
 

Author(s): Dan Cui, Li Xu, Wen-Yi Li, Wei-Dong Qian

Journal: Medicine (Baltimore). 2017 Aug;96(32):e7362.

 

Paraneoplastic cerebellar degeneration (PCD) is a rare nonmetastatic neurological complication often associated with ovarian, breast, and other gynecologic cancers. Anti-Yo is one of the antionconeural antibodies found in patients with PCD. It primarily emerges before a malignancy is detected.

Last Updated: 10 Aug 2017

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Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration.
 

Author(s): Chan Chung, Prasanth Puthanveetil, Daniel S Ory, Andrew P Lieberman

Journal: Hum. Mol. Genet.. 2016 Apr;25(7):1434-46.

 

Niemann-Pick C1 (NPC) disease, an autosomal recessive lipid trafficking disorder caused by loss-of-function mutations in the NPC1 gene, is characterized by progressive neurodegeneration resulting in cognitive impairment, ataxia and early death. Little is known about the cellular pathways ...

Last Updated: 12 Mar 2016

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Early-stage Alcoholic Cerebellar Degeneration: Diagnostic Imaging Clues.
 

Author(s): Ji Hoon Lee, Sung Hyuk Heo, Dae-il Chang

Journal: J. Korean Med. Sci.. 2015 Nov;30(11):1539.

 

Last Updated: 4 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cerebellar Degeneration" returned 8 free, full-text review articles on human participants. First 3 results:

An uncommon manifestation of paraneoplastic cerebellar degeneration in a patient with high grade urothelial, carcinoma with squamous differentiation: A case report and literature review.
 

Author(s): Yaofeng Zhu, Shouzhen Chen, Songyu Chen, Jing Song, Fan Chen, Hu Guo, Zhenhua Shang, Yong Wang, Changkuo Zhou, Benkang Shi

Journal:

 

Paraneoplastic neurological syndromes (PNS) are rare disorders associated with malignant tumours, which are triggered by autoimmune reactions. Paraneoplastic cerebellar degeneration (PCD) is the PNS type most commonly associated with ovarian and breast cancer. Two bladder cancers ...

Last Updated: 23 May 2016

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Boucher-Neuhäuser syndrome: cerebellar degeneration, chorioretinal dystrophy and hypogonadotropic hypogonadism: two novel cases and a review of 40 cases from the literature.
 

Author(s): A A Tarnutzer, C Gerth-Kahlert, D Timmann, D I Chang, F Harmuth, P Bauer, D Straumann, M Synofzik

Journal: J. Neurol.. 2015 Jan;262(1):194-202.

 

The combination of progressive cerebellar degeneration, hypogonadotropic hypogonadism and chorioretinal dystrophy defines the rare Boucher-Neuhäuser syndrome (BNS), which has recently been linked to autosomal-recessive mutations in the PNPLA6 gene in four index patients. Here we ...

Last Updated: 12 Jan 2015

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Gastric diffuse large B cell lymphoma presenting as paraneoplastic cerebellar degeneration: case report and review of literature.
 

Author(s): K C Lakshmaiah, B K Viveka, N Anil Kumar, Monika L Saini, Sanjib Sinha, Kamal S Saini

Journal: J Egypt Natl Canc Inst. 2013 Dec;25(4):231-5.

 

Paraneoplastic cerebellar degeneration (PCD) is a type of paraneoplastic neurological disorder (PND) that is associated with many solid tumors, Hodgkin's lymphoma (HL) and very rarely with non-Hodgkin's lymphoma (NHL). We report a case of PCD associated with gastric diffuse large ...

Last Updated: 11 Nov 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sporadic Degenerative Ataxia With Adult Onset: Natural History Study
 

Status: Recruiting

Condition Summary: Late Onset Sporadic Cerebellar Ataxia

 

Last Updated: 28 Jun 2017

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Efficacy and Safety Study of Stemchymal® in Polyglutamine Spinocerebellar Ataxia
 

Status: Recruiting

Condition Summary: Cerebellar Ataxia

 

Last Updated: 30 Oct 2016

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FA Clinical Outcome Measures
 

Status: Recruiting

Condition Summary: Friedreich Ataxia; Neuro-Degenerative Disease

 

Last Updated: 21 Mar 2017

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