Cerebellar Degeneration

Common Name(s)

Cerebellar Degeneration

Cerebellar degeneration refers to the deterioration of neurons in the cerebellum (the area of the brain that controls muscle coordination and balance). Conditions that cause cerebellar degeneration may also affect other areas of the central nervous system, such as the spinal cord, the cerebral cortex, and the brain stem. Signs and symptoms of cerebellar degeneration may include a wide-based, uncoordinated walk; a back and forth tremor in the trunk of the body; uncoordinated movements of the arms and legs; slow and slurred speech; and nystagmus. Cerebellar degeneration can be caused by a variety of factors including inherited gene changes (mutations), chronic alcohol abuse, and paraneoplastic disorders. Treatment for cerebellar degeneration varies depending on the underlying cause.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cerebellar Degeneration" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cerebellar Degeneration" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cerebellar Degeneration" returned 90 free, full-text research articles on human participants. First 3 results:

Pathological findings of anti-Yo cerebellar degeneration with Holmes tremor.
 

Author(s): David Rydz, Chi-Ying Lin, Tao Xie, Etty Cortes, Jean-Paul Vonsattel, Sheng-Han Kuo

Journal: J. Neurol. Neurosurg. Psychiatr.. 2015 Jan;86(1):121-2.

 

Last Updated: 18 Dec 2014

Go To URL
Impaired temporal processing of tactile and proprioceptive stimuli in cerebellar degeneration.
 

Author(s): Michele Tinazzi, Francesca Morgante, Alessia Peretti, Caterina Mariotti, Marta Panzeri, Mirta Fiorio, Alfonso Fasano

Journal:

 

Performance of timed motor sequences relies on the cerebellum and basal ganglia, which integrate proprioceptive information during the motor task and set internal timing mechanisms. Accordingly, these structures are also involved in other temporal processes, such as the discrimination ...

Last Updated: 18 Nov 2013

Go To URL
Paraneoplastic cerebellar degeneration associated with lymphoepithelial carcinoma of the tonsil.
 

Author(s): Christian Henke, Johannes Rieger, Sylvia Hartmann, Marcus Middendorp, Helmuth Steinmetz, Ulf Ziemann

Journal:

 

Paraneoplastic cerebellar degeneration (PCD) is a classical tumor-associated, immune-mediated disease typically associated with gynecological malignancies, small-cell lung-cancer or lymphoma.

Last Updated: 17 Jan 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cerebellar Degeneration" returned 5 free, full-text review articles on human participants. First 3 results:

Gastric diffuse large B cell lymphoma presenting as paraneoplastic cerebellar degeneration: case report and review of literature.
 

Author(s): K C Lakshmaiah, B K Viveka, N Anil Kumar, Monika L Saini, Sanjib Sinha, Kamal S Saini

Journal: J Egypt Natl Canc Inst. 2013 Dec;25(4):231-5.

 

Paraneoplastic cerebellar degeneration (PCD) is a type of paraneoplastic neurological disorder (PND) that is associated with many solid tumors, Hodgkin's lymphoma (HL) and very rarely with non-Hodgkin's lymphoma (NHL). We report a case of PCD associated with gastric diffuse large ...

Last Updated: 11 Nov 2013

Go To URL
A case of follicular lymphoma associated with paraneoplastic cerebellar degeneration.
 

Author(s): Yayoi Shimazu, Eiko N Minakawa, Momoko Nishikori, Masafumi Ihara, Yuichiro Hashi, Hirofumi Matsuyama, Masakatsu Hishizawa, Sonoyo Yoshida, Toshiyuki Kitano, Tadakazu Kondo, Takayuki Ishikawa, Ryosuke Takahashi, Akifumi Takaori-Kondo

Journal: Intern. Med.. 2012 ;51(11):1387-92.

 

Paraneoplastic neurological disorders (PND) are neurological effects of malignancy that are recognized as immune-mediated disorders caused by aberrant expression of a tumor antigen that is normally expressed in the nervous system. We report a case of cerebellar ataxia which turned ...

Last Updated: 12 Jun 2012

Go To URL
A new family of Boucher-Neuhäuser syndrome: coexistence of Holmes type cerebellar atrophy, hypogonadotropic hypogonadism and retinochoroidal degeneration: case reports and review of literature.
 

Author(s): K Tojo, M Ichinose, M Nakayama, H Yamamoto, T Hasegawa, Y Kawaguchi, S C Sealfon, O Sakai

Journal: Endocr. J.. 1995 Jun;42(3):367-76.

 

The association of familial hypogonadism with progressive cerebellar ataxia is only rarely encountered, and the exact link between the symptoms remains unknown. We report here two sisters presenting with Holmes type cerebellar ataxia, hypogonadotropic hypogonadism and retinochoroidal ...

Last Updated: 19 Oct 1995

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

An Extension Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
 

Status: Recruiting

Condition Summary: Spinocerebellar Degeneration

 

Last Updated: 22 Oct 2013

Go to URL
A Confirmatory Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
 

Status: Recruiting

Condition Summary: Spinocerebellar Degeneration

 

Last Updated: 22 Oct 2013

Go to URL
A Long-Term Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
 

Status: Recruiting

Condition Summary: Spinocerebellar Degeneration

 

Last Updated: 22 Oct 2013

Go to URL