Cerebellar Ataxia

Common Name(s)

Cerebellar Ataxia

Cerebellar Ataxia is a condition in which damage, degeneration, or loss of nerve cells in the cerebellum (part of the brain that controls movement), results in balance problems and difficulty coordinating complex movements (ataxia). Cerebellar ataxia can be caused by: spinal cord or nerve damage, head trauma, stroke, cerebral palsy, multiple sclerosis, tumors, or complications from chickenpox. Symptoms of this condition may include poor coordination, change in speech, involuntary eye movements, and difficulty with fine motor skills. There is no specific treatment for this condition, but symptoms can be alleviated by using adaptive devices (such as canes or modified eating utensils), and therapy (physical, speech, etc.).

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cerebellar Ataxia" for support, advocacy or research.

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cerebellar Ataxia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cerebellar Ataxia" returned 276 free, full-text research articles on human participants. First 3 results:

First de novo KCND3 mutation causes severe Kv4.3 channel dysfunction leading to early onset cerebellar ataxia, intellectual disability, oral apraxia and epilepsy.
 

Author(s): Katrien Smets, Anna Duarri, Tine Deconinck, Berten Ceulemans, Bart P van de Warrenburg, Stephan Züchner, Michael Anthony Gonzalez, Rebecca Schüle, Matthis Synofzik, Nathalie Van der Aa, Peter De Jonghe, Dineke S Verbeek, Jonathan Baets

Journal:

 

Identification of the first de novo mutation in potassium voltage-gated channel, shal-related subfamily, member 3 (KCND3) in a patient with complex early onset cerebellar ataxia in order to expand the genetic and phenotypic spectrum.

Last Updated: 20 Jul 2015

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Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity.
 

Author(s): Melanie D Mark, Martin Krause, Henk-Jan Boele, Wolfgang Kruse, Stefan Pollok, Thomas Kuner, Deniz Dalkara, Sebastiaan Koekkoek, Chris I De Zeeuw, Stefan Herlitze

Journal: J. Neurosci.. 2015 Jun;35(23):8882-95.

 

Spinocerebellar ataxia type 6 (SCA6) is linked to poly-glutamine (polyQ) within the C terminus (CT) of the pore-forming subunits of P/Q-type Ca(2+) channels (Cav2.1) and is characterized by CT protein aggregates found in cerebellar Purkinje cells (PCs). One hypothesis regarding SCA6 ...

Last Updated: 11 Jun 2015

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Paraneoplastic cerebellar ataxia associated with anti-Hu antibodies and benign ganglioneuroma.
 

Author(s): Roberto Fancellu, Elena Corsini, Giorgio Bernardi, Paolo Buzzo, Maria Luisa Ferrari, Eleonora Lamantea, Alberto Garaventa, Mauro Truini, Sandro Salvarani

Journal: Funct. Neurol.. ;29(4):277-80.

 

We describe a case of cerebellar ataxia associated with anti-Hu antibodies and benign ganglioneuroma. A 28-year-old woman developed progressive ataxia with hyporeflexia at the age of 19. Brain MRI showed progressive cerebellar atrophy. Neurophysiological studies, screening of immune-mediated ...

Last Updated: 13 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cerebellar Ataxia" returned 15 free, full-text review articles on human participants. First 3 results:

The Moonwalker mouse: new insights into TRPC3 function, cerebellar development, and ataxia.
 

Author(s): Esther B E Becker

Journal: Cerebellum. 2014 Oct;13(5):628-36.

 

The Moonwalker (Mwk) mouse is a recent model of dominantly inherited cerebellar ataxia. The motor phenotype of the Mwk mouse is due to a gain-of-function mutation in the gene encoding the cation-permeable transient receptor potential channel (TRPC3). This mutation converts a threonine ...

Last Updated: 5 Sep 2014

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The assessment and treatment of postural disorders in cerebellar ataxia: a systematic review.
 

Author(s): A Marquer, G Barbieri, D Pérennou

Journal: Ann Phys Rehabil Med. 2014 Mar;57(2):67-78.

 

Gait and balance disorders are often major causes of handicap in patients with cerebellar ataxia. Although it was thought that postural and balance disorders in cerebellar ataxia were not treatable, recent studies have demonstrated the beneficial effects of rehabilitation programs. ...

Last Updated: 24 Mar 2014

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[Acute cerebellar ataxia in childhood].
 

Author(s): Yaline Betancourt Fursow, Juan Carlos Jiménez León, Cristina S Jiménez Betancourt

Journal: Medicina (B Aires). 2013 ;73 Suppl 1():30-7.

 

Acute cerebellar ataxia of childhood is the most frequent neurological complication of chickenpox virus infection. Acute cerebellar ataxia is categorized within the group of acute postinfectious complications. The aims of this study were: (I) to evaluate the clinical presentation, ...

Last Updated: 27 Sep 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clinical Study to Evaluate the Safety and Efficacy BMMNC in Cerebellar Ataxia
 

Status: Recruiting

Condition Summary: Cerebellar Ataxia

 

Last Updated: 16 Sep 2014

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SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias
 

Status: Recruiting

Condition Summary: Cerebellar Ataxias; Spastic Paraplegias

 

Last Updated: 26 Mar 2012

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Last Updated: 1 Sep 2015

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