Cerebellar Ataxia

Common Name(s)

Cerebellar Ataxia

Cerebellar Ataxia is a condition in which damage, degeneration, or loss of nerve cells in the cerebellum (part of the brain that controls movement), results in balance problems and difficulty coordinating complex movements (ataxia). Cerebellar ataxia can be caused by: spinal cord or nerve damage, head trauma, stroke, cerebral palsy, multiple sclerosis, tumors, or complications from chickenpox. Symptoms of this condition may include poor coordination, change in speech, involuntary eye movements, and difficulty with fine motor skills. There is no specific treatment for this condition, but symptoms can be alleviated by using adaptive devices (such as canes or modified eating utensils), and therapy (physical, speech, etc.).

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cerebellar Ataxia" for support, advocacy or research.

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cerebellar Ataxia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cerebellar Ataxia" returned 250 free, full-text research articles on human participants. First 3 results:

Mutations in SNX14 cause a distinctive autosomal-recessive cerebellar ataxia and intellectual disability syndrome.
 

Author(s): Anna C Thomas, Hywel Williams, Núria Setó-Salvia, Chiara Bacchelli, Dagan Jenkins, Mary O'Sullivan, Konstantinos Mengrelis, Miho Ishida, Louise Ocaka, Estelle Chanudet, Chela James, Francesco Lescai, Glenn Anderson, Deborah Morrogh, Mina Ryten, Andrew J Duncan, Yun Jin Pai, Jorge M Saraiva, Fabiana Ramos, Bernadette Farren, Dawn Saunders, Bertrand Vernay, Paul Gissen, Anna Straatmaan-Iwanowska, Frank Baas, Nicholas W Wood, Joshua Hersheson, Henry Houlden, Jane Hurst, Richard Scott, Maria Bitner-Glindzicz, Gudrun E Moore, Sérgio B Sousa, Philip Stanier

Journal: Am. J. Hum. Genet.. 2014 Nov;95(5):611-21.

 

Intellectual disability and cerebellar atrophy occur together in a large number of genetic conditions and are frequently associated with microcephaly and/or epilepsy. Here we report the identification of causal mutations in Sorting Nexin 14 (SNX14) found in seven affected individuals ...

Last Updated: 2 Dec 2014

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Cerebellar pathology in Friedreich's ataxia: atrophied dentate nuclei with normal iron content.
 

Author(s): K Solbach, O Kraff, M Minnerop, A Beck, L Schöls, E R Gizewski, M E Ladd, D Timmann

Journal:

 

In Friedreich's ataxia (FA) the genetically decreased expression of the mitochondrial protein frataxin leads to disturbance of the mitochondrial iron metabolism. Within the cerebellum the dentate nuclei (DN) are primarily affected. Histopathological studies show atrophy and accumulation ...

Last Updated: 7 Nov 2014

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Midbrain infarction causing oculomotor nerve palsy and ipsilateral cerebellar ataxia.
 

Author(s): Makoto Tokunaga, Kimiko Fukunaga, Ryoji Nakanishi, Susumu Watanabe, Hiroaki Yamanaga

Journal: Intern. Med.. 2014 ;53(18):2143-7.

 

We herein report the case of an 81-year-old woman with midbrain infarction causing pupil-sparing oculomotor nerve palsy with ipsilateral cerebellar ataxia. The lesion was located at the rostral end of the decussation of the superior cerebellar peduncle touching the dorsal side, further ...

Last Updated: 16 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cerebellar Ataxia" returned 14 free, full-text review articles on human participants. First 3 results:

The Moonwalker mouse: new insights into TRPC3 function, cerebellar development, and ataxia.
 

Author(s): Esther B E Becker

Journal: Cerebellum. 2014 Oct;13(5):628-36.

 

The Moonwalker (Mwk) mouse is a recent model of dominantly inherited cerebellar ataxia. The motor phenotype of the Mwk mouse is due to a gain-of-function mutation in the gene encoding the cation-permeable transient receptor potential channel (TRPC3). This mutation converts a threonine ...

Last Updated: 5 Sep 2014

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The assessment and treatment of postural disorders in cerebellar ataxia: a systematic review.
 

Author(s): A Marquer, G Barbieri, D Pérennou

Journal: Ann Phys Rehabil Med. 2014 Mar;57(2):67-78.

 

Gait and balance disorders are often major causes of handicap in patients with cerebellar ataxia. Although it was thought that postural and balance disorders in cerebellar ataxia were not treatable, recent studies have demonstrated the beneficial effects of rehabilitation programs. ...

Last Updated: 24 Mar 2014

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[Acute cerebellar ataxia in childhood].
 

Author(s): Yaline Betancourt Fursow, Juan Carlos Jiménez León, Cristina S Jiménez Betancourt

Journal: Medicina (B Aires). 2013 ;73 Suppl 1():30-7.

 

Acute cerebellar ataxia of childhood is the most frequent neurological complication of chickenpox virus infection. Acute cerebellar ataxia is categorized within the group of acute postinfectious complications. The aims of this study were: (I) to evaluate the clinical presentation, ...

Last Updated: 27 Sep 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clinical Study to Evaluate the Safety and Efficacy BMMNC in Cerebellar Ataxia
 

Status: Recruiting

Condition Summary: Cerebellar Ataxia

 

Last Updated: 16 Sep 2014

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SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias
 

Status: Recruiting

Condition Summary: Cerebellar Ataxias; Spastic Paraplegias

 

Last Updated: 26 Mar 2012

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Transcranial Magnetic Stimulation in Spino-Cerebellar Ataxia
 

Status: Recruiting

Condition Summary: Spinocerebellar Ataxia

 

Last Updated: 26 Jan 2015

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