Acinic cell carcinoma

Common Name(s)

Acinic cell carcinoma

Acinic cell carcinoma (ACC) is a rare type of cancer that most commonly develops in areas of the body where saliva is produced (salivary glands). The largest of these saliva-producing sites, and also the most common location where ACCs develop, is the parotid gland, which can be found on either side of the face just a little in front of and below the ears. Less commonly, ACCs grow inside the mouth. Very rarely, some types of ACCs can also develop in areas such as the pancreas and lungs. Cancers form when a mutation in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread (metastasize) to other parts of the body.

ACCs most commonly occur in adults between the ages of 40 and 60, though they can appear in all age groups. Factors that may increase the risk of developing ACCs include smoking, exposure to radiation, exposure to viral infections, and workplace exposure to rubber or asbestos. The most common symptoms of ACCs include weakness of the muscles of the face or numbness of the face. There may also be swelling or the presence of a lump near the neck, mouth, or cheek areas, which may or may not be painful. Depending on the size of the cancer, one may experience difficulty swallowing as well. Diagnoses are made usually with a combination of a physical exam, imaging studies, and other laboratory studies.

Treatment for ACCs depend on many factors such as how large the tumor is, and if it has spread to other areas of the body. If you or a family member has been diagnosed with ACC, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acinic cell carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acinic cell carcinoma" returned 34 free, full-text research articles on human participants. First 3 results:

Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype.
 

Author(s): Niamh Conlon, Navid Sadri, Adriana D Corben, Lee K Tan

Journal: Hum. Pathol.. 2016 May;51():16-24.

 

Acinic cell carcinoma of breast is a rare subtype of triple-negative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. In this study, we perform a detailed morphologic and immunohistochemical description of 2 cases of ...

Last Updated: 12 Apr 2016

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Acinic cell carcinoma of buccal mucosa: An unusual presentation.
 

Author(s): R M Aravind, N Sangara Narayanan, K S Ravishankar, N Ganesh Babu

Journal: J Cancer Res Ther. ;11(4):931-3.

 

Acinic cell carcinoma (ACC) is a rare epithelial malignant neoplasm of salivary glands affecting predominantly the female population. Unusual occurrences of this neoplasm are reported in hard palate, maxillary sinuses, lip, etc. [1] We report one such case where a submandibular swelling ...

Last Updated: 17 Feb 2016

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Solid blue dot tumour: minor salivary gland acinic cell carcinoma.
 

Author(s): Radhika M Bavle, Soumya Makarla, Afreen Nadaf, Srinath Narasimhamurthy

Journal:

 

Acinic cell adenocarcinoma (ACC) is a low-grade malignant salivary neoplasm that constitutes approximately 17% of all primary salivary gland malignancies. In the head and neck region, the parotid gland is the predominant site of origin and ACC is usually more frequent in women than ...

Last Updated: 14 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acinic cell carcinoma" returned 2 free, full-text review articles on human participants. First 3 results:

Acinic cell carcinoma of the breast: review of the literature.
 

Author(s): G Limite, R Di Micco, E Esposito, V Sollazzo, M Cervotti, G Pettinato, V Varone, G Benassai, B Amato, V Pilone, G Luglio, A Vitiello, A Hasani, F Liccardo, P Forestieri

Journal: Int J Surg. 2014 ;12 Suppl 1():S35-9.

 

The breast and salivary gland tissue share embryologic and thus pathological similarities. Acinic cell carcinoma (ACC) is a typical tumor in salivary glands, but rarely arises in breast too. We reviewed 38 cases of mammary ACC reported in literature and our case, the first ACC born ...

Last Updated: 9 Aug 2014

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Acinic cell carcinoma. Clinicopathologic review.
 

Author(s): J E Lewis, K D Olsen, L H Weiland

Journal: Cancer. 1991 Jan;67(1):172-9.

 

The authors reviewed 90 cases of acinic cell carcinoma treated at the Mayo Clinic to assess long-term follow-up and to study features predictive of disease progression. Sixty-three patients (55 females and 35 males) were seen for primary treatment; 27 had recurrent disease when first ...

Last Updated: 12 Feb 1991

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Selinexor, Gemcitabine Hydrochloride, and Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Metastatic Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Stage IV Pancreatic Cancer

 

Last Updated: 11 Feb 2016

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Ultrasound-Guided Photodynamic Therapy With Photofrin & Gemcitabine for Patients With Locally Advanced Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Stage III Pancreatic Cancer

 

Last Updated: 29 Aug 2016

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Stereotactic Radiosurgery and Metformin Hydrochloride in Treating Patients With Borderline-Resectable or Locally-Advanced Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage I-III Pancreatic Cancer

 

Last Updated: 28 Sep 2016

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