Acinic cell carcinoma

Common Name(s)

Acinic cell carcinoma

Acinic cell carcinoma (ACC) is a rare type of cancer that most commonly develops in areas of the body where saliva is produced (salivary glands). The largest of these saliva-producing sites, and also the most common location where ACCs develop, is the parotid gland, which can be found on either side of the face just a little in front of and below the ears. Less commonly, ACCs grow inside the mouth. Very rarely, some types of ACCs can also develop in areas such as the pancreas and lungs. Cancers form when a mutation in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread (metastasize) to other parts of the body.

ACCs most commonly occur in adults between the ages of 40 and 60, though they can appear in all age groups. Factors that may increase the risk of developing ACCs include smoking, exposure to radiation, exposure to viral infections, and workplace exposure to rubber or asbestos. The most common symptoms of ACCs include weakness of the muscles of the face or numbness of the face. There may also be swelling or the presence of a lump near the neck, mouth, or cheek areas, which may or may not be painful. Depending on the size of the cancer, one may experience difficulty swallowing as well. Diagnoses are made usually with a combination of a physical exam, imaging studies, and other laboratory studies.

Treatment for ACCs depend on many factors such as how large the tumor is, and if it has spread to other areas of the body. If you or a family member has been diagnosed with ACC, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

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Condition Specific Organizations

Following organizations serve the condition "Acinic cell carcinoma" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acinic cell carcinoma" returned 39 free, full-text research articles on human participants. First 3 results:

Recurrent rearrangements of the Myb/SANT-like DNA-binding domain containing 3 gene (MSANTD3) in salivary gland acinic cell carcinoma.
 

Author(s): Nicholas Barasch, Xue Gong, Kevin A Kwei, Sushama Varma, Jewison Biscocho, Kunbin Qu, Nan Xiao, Joseph S Lipsick, Robert J Pelham, Robert B West, Jonathan R Pollack

Journal:

 

Pathogenic gene fusions have been identified in several histologic types of salivary gland neoplasia, but not previously in acinic cell carcinoma (AcCC). To discover novel gene fusions, we performed whole-transcriptome sequencing surveys of three AcCC archival cases. In one specimen ...

Last Updated: 17 Feb 2017

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Lysozyme Expression Can be Useful to Distinguish Mammary Analog Secretory Carcinoma from Acinic Cell Carcinoma of Salivary Glands.
 

Author(s): Fernanda Viviane Mariano, Camila Andrea Concha Gómez, Juliana de Souza do Nascimento, Harim Tavares Dos Santos, Erika Said Egal, Victor Angelo Martins Montalli, Pablo Agustin Vargas, Oslei Paes de Almeida, Albina Altemani

Journal: Head Neck Pathol. 2016 Dec;10(4):429-436.

 

Lysozyme is an enzymatic marker of acinar and intercalated duct cells of normal salivary glands. The aim of this study was to verify whether lysozyme expression could be useful to distinguish acinic cell carcinoma (ACC) from its main mimic, mammary analog secretory carcinoma (MASC). ...

Last Updated: 14 May 2016

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Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype.
 

Author(s): Niamh Conlon, Navid Sadri, Adriana D Corben, Lee K Tan

Journal: Hum. Pathol.. 2016 May;51():16-24.

 

Acinic cell carcinoma of breast is a rare subtype of triple-negative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. In this study, we perform a detailed morphologic and immunohistochemical description of 2 cases of ...

Last Updated: 12 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acinic cell carcinoma" returned 3 free, full-text review articles on human participants. First 3 results:

Acinic cell carcinoma of the breast: review of the literature.
 

Author(s): G Limite, R Di Micco, E Esposito, V Sollazzo, M Cervotti, G Pettinato, V Varone, G Benassai, B Amato, V Pilone, G Luglio, A Vitiello, A Hasani, F Liccardo, P Forestieri

Journal: Int J Surg. 2014 ;12 Suppl 1():S35-9.

 

The breast and salivary gland tissue share embryologic and thus pathological similarities. Acinic cell carcinoma (ACC) is a typical tumor in salivary glands, but rarely arises in breast too. We reviewed 38 cases of mammary ACC reported in literature and our case, the first ACC born ...

Last Updated: 9 Aug 2014

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Acinic cell carcinoma of the salivary glands: a literature review.
 

Author(s): Nabil Al-Zaher, Amani Obeid, Suhail Al-Salam, Bassam Sulaiman Al-Kayyali

Journal: Hematol Oncol Stem Cell Ther. 2009 ;2(1):259-64.

 

Acinic cell carcinoma (ACC) is a low-grade malignant salivary neoplasm that constitutes approximately 17% of primary salivary gland malignancies. In the head and neck region, the parotid gland is the predominant site of origin and women are usually more frequently diagnosed than men. ...

Last Updated: 12 Jan 2010

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Acinic cell carcinoma. Clinicopathologic review.
 

Author(s): J E Lewis, K D Olsen, L H Weiland

Journal: Cancer. 1991 Jan;67(1):172-9.

 

The authors reviewed 90 cases of acinic cell carcinoma treated at the Mayo Clinic to assess long-term follow-up and to study features predictive of disease progression. Sixty-three patients (55 females and 35 males) were seen for primary treatment; 27 had recurrent disease when first ...

Last Updated: 12 Feb 1991

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Stereotactic Radiosurgery and Metformin Hydrochloride in Treating Patients With Borderline-Resectable or Locally-Advanced Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage I-III Pancreatic Cancer

 

Last Updated: 24 Apr 2017

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Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage IV Pancreatic Cancer

 

Last Updated: 17 Jul 2017

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Combination Chemotherapy Before and After Surgery in Treating Patients With Localized Pancreatic Cancer
 

Status: Recruiting

Condition Summary: Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Stage I Pancreatic Cancer; Stage IIA Pancreatic Cancer; Stage IIB Pancreatic Cancer

 

Last Updated: 18 Jan 2017

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