CD4 Deficiency

Common Name(s)

CD4 Deficiency

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "CD4 Deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "CD4 Deficiency" returned 17 free, full-text research articles on human participants. First 3 results:

Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth.
 

Author(s): Wiebke Hansen, Marina Hutzler, Simone Abel, Christina Alter, Christian Stockmann, Stefanie Kliche, Juliane Albert, Tim Sparwasser, Shimon Sakaguchi, Astrid M Westendorf, Dirk Schadendorf, Jan Buer, Iris Helfrich

Journal: J. Exp. Med.. 2012 Oct;209(11):2001-16.

 

Infiltration of Foxp3(+) regulatory T (T reg) cells is considered to be a critical step during tumor development and progression. T reg cells supposedly suppress locally an effective anti-tumor immune response within tumor tissues, although the precise mechanism by which T reg cells ...

Last Updated: 23 Oct 2012

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Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.
 

Author(s): Won Fen Wong, Kazuyoshi Kohu, Akira Nakamura, Masahito Ebina, Toshiaki Kikuchi, Ryushi Tazawa, Keisuke Tanaka, Shunsuke Kon, Tomo Funaki, Akiko Sugahara-Tobinai, Chung Yeng Looi, Shota Endo, Ryo Funayama, Mineo Kurokawa, Sonoko Habu, Naoto Ishii, Manabu Fukumoto, Koh Nakata, Toshiyuki Takai, Masanobu Satake

Journal: J. Immunol.. 2012 Jun;188(11):5408-20.

 

The Runx1 transcription factor is abundantly expressed in naive T cells but rapidly downregulated in activated T cells, suggesting that it plays an important role in a naive stage. In the current study, Runx1(-/-)Bcl2(tg) mice harboring Runx1-deleted CD4(+) T cells developed a fatal ...

Last Updated: 21 May 2012

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CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells.
 

Author(s): Sonia Fernandez, Sara Tanaskovic, Karla Helbig, Reena Rajasuriar, Marit Kramski, John M Murray, Michael Beard, Damian Purcell, Sharon R Lewin, Patricia Price, Martyn A French

Journal: J. Infect. Dis.. 2011 Dec;204(12):1927-35.

 

Most patients with human immunodeficiency virus (HIV) who remain CD4(+) T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As CD4(+) T-cell activation may be mediated by microbial translocation or interferon-alpha (IFN-α), we examined these factors ...

Last Updated: 8 Nov 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "CD4 Deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ Lymphocytopenia
 

Status: Recruiting

Condition Summary: Idiopathic CD4+ Lymphocytopenia; Cryptococcal Meningitis; Warts

 

Last Updated: 5 Jun 2014

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Idiopathic CD4 Lymphocytopenia
 

Status: Recruiting

Condition Summary: Idiopathic CD4 Lymphocytopenia

 

Last Updated: 11 Apr 2014

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