CD3 Deficiency

Common Name(s)

CD3 Deficiency

Description for this condition is not yet available.
 

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "CD3 Deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "CD3 Deficiency" returned 4 free, full-text research articles on human participants. First 3 results:

Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child.
 

Author(s): Manola Comar, Pierlanfranco D'Agaro, Douglas Horejsh, Monica Galvan, Simona Fiorentini, Marino Andolina, Arnaldo Caruso, Dario Di Luca, Cesare Campello

Journal: J. Clin. Microbiol.. 2005 Apr;43(4):2002-3.

 

We report a long-lasting (8-month) reactivation of human herpesvirus 6 (HHV-6) infection in child who had undergone cord blood stem cell transplantation. The reactivation was characterized by high viral loads and by immediate-early mRNA positivity. HHV-6 infection was associated with ...

Last Updated: 7 Apr 2005

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Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.
 

Author(s): Geneviève de Saint Basile, Frédéric Geissmann, Elisabeth Flori, Béatrice Uring-Lambert, Claire Soudais, Marina Cavazzana-Calvo, Anne Durandy, Nada Jabado, Alain Fischer, Françoise Le Deist

Journal: J. Clin. Invest.. 2004 Nov;114(10):1512-7.

 

We investigated the molecular mechanism underlying a severe combined immunodeficiency characterized by the selective and complete absence of T cells. The condition was found in 5 patients and 2 fetuses from 3 consanguineous families. Linkage analysis performed on the 3 families revealed ...

Last Updated: 16 Nov 2004

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Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.
 

Author(s): X Shan, M J Czar, S C Bunnell, P Liu, Y Liu, P L Schwartzberg, R L Wange

Journal: Mol. Cell. Biol.. 2000 Sep;20(18):6945-57.

 

Pleckstrin homology (PH) domain binding to D3-phosphorylated phosphatidylinositides (PI) provides a reversible means of recruiting proteins to the plasma membrane, with the resultant change in subcellular localization playing a key role in the activation of multiple intracellular ...

Last Updated: 22 Sep 2000

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "CD3 Deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases
 

Status: Recruiting

Condition Summary: Severe Combined Immunodeficiency (SCID); Immunodeficiency With Predominant T-cell Defect, Unspecified; Severe Chronic Neutropenia; Chronic Granulomatous Disease (CGD); Hyper IgE Syndromes; Hyper IgM Deficiencies; Wiskott-Aldrich Syndrome; Mendelian Susceptibility to Mycobacterial Disease; Common Variable Immune Deficiency (CVID)

 

Last Updated: 10 Dec 2014

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Reduced Intensity Conditioning Using CD3+/CD19+ Depletion for Non Malignant Transplantable Diseases
 

Status: Recruiting

Condition Summary: Bone Marrow Failure Syndromes; Immunodeficiencies; Immune Dysregulation Syndromes

 

Last Updated: 27 Oct 2014

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