Cataplexy

Common Name(s)

Cataplexy

Cataplexy is a symptom shown only in people with narcolepsy. Cataplexy is a sudden loss of muscle tone while awake that makes you unable to move. Strong emotions, such as laughter or anger, can trigger this. Most attacks last for less than 30 seconds and can be missed. Your head will suddenly fall forward, your jaw will become slack, and your knees will buckle. In severe cases, a person may fall and stay paralyzed for as long as several minutes.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cataplexy" for support, advocacy or research.

Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

Last Updated: 29 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cataplexy" for support, advocacy or research.

Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

http://www.wakeupnarcolepsy.org/

Last Updated: 29 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cataplexy" returned 121 free, full-text research articles on human participants. First 3 results:

Impact of sodium oxybate, modafinil, and combination treatment on excessive daytime sleepiness in patients who have narcolepsy with or without cataplexy.
 

Author(s): Jed Black, Todd Swick, Richard Bogan, Chinglin Lai, Lawrence P Carter

Journal: Sleep Med.. 2016 Aug;24():57-62.

 

Effects of sodium oxybate (SXB) on patients with narcolepsy with cataplexy (NC) or without cataplexy (NWOC) have not been separately evaluated in clinical trials.

Last Updated: 31 Dec 1969

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Smoking Prevalence and Its Clinical Correlations in Patients with Narcolepsy-cataplexy.
 

Author(s): Pavla Peřinová, Eva Feketeová, David Kemlink, Petra Kovalská, Karolína Chlebušová, Jiří Nepožitek, Veronika Ibarburu, Eva Králíková, Soňa Nevšímalová, Karel Šonka

Journal: Prague Med Rep. ;117(2-3):81-89.

 

Narcolepsy-cataplexy (NC) is a chronic neurological disease with suggested autoimmune etiopathogenesis. Nicotine stimulates central nervous system and smoking increases the risk of autoimmune diseases. Assessment of smoking habits and its correlation to clinical parameters among 87 ...

Last Updated: 31 Dec 1969

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Emotion stimulus processing in narcolepsy with cataplexy.
 

Author(s): Marek Susta, Veronika Nemcova, Gustav Bizik, Karel Sonka

Journal: J Sleep Res. 2017 02;26(1):30-37.

 

Reported brain abnormalities in anatomy and function in patients with narcolepsy with cataplexy led to a project based on qualitative electroencephalography examination and analysis in an attempt to find a narcolepsy with cataplexy-specific brain-derived pattern, or a sequence of ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cataplexy" returned 8 free, full-text review articles on human participants. First 3 results:

[Narcolepsy with cataplexy: an autoimmune disease?].
 

Author(s): Louis Jacob, Yves Dauvilliers

Journal: Med Sci (Paris). 2014 Dec;30(12):1136-43.

 

Narcolepsy type 1 (also named narcolepsy-cataplexy or hypocretin deficiency syndrome) is a rare sleep disorder characterized by excessive daytime sleepiness and cataplexy, plus frequently hypnagogic hallucinations, sleep paralysis and nocturnal sleep disturbances. Narcolepsy type ...

Last Updated: 31 Dec 1969

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A patient with intractable attacks of cataplexy.
 

Author(s): Lourdes M DelRosso, Syeda Munir, Andrew L Chesson, Romy Hoque

Journal:

 

Last Updated: 31 Dec 1969

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Narcolepsy: neural mechanisms of sleepiness and cataplexy.
 

Author(s): Christian R Burgess, Thomas E Scammell

Journal: J. Neurosci.. 2012 Sep;32(36):12305-11.

 

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of the Efficacy and Safety of JZP-258 in Subjects With Narcolepsy With Cataplexy
 

Status: Recruiting

Condition Summary: Narcolepsy With Cataplexy

 

Last Updated: 7 Feb 2018

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Last Updated: 13 Apr 2017

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Last Updated: 8 Feb 2018

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