Cataplexy

Common Name(s)

Cataplexy

Cataplexy is a symptom shown only in people with narcolepsy. Cataplexy is a sudden loss of muscle tone while awake that makes you unable to move. Strong emotions, such as laughter or anger, can trigger this. Most attacks last for less than 30 seconds and can be missed. Your head will suddenly fall forward, your jaw will become slack, and your knees will buckle. In severe cases, a person may fall and stay paralyzed for as long as several minutes.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cataplexy" for support, advocacy or research.

Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cataplexy" for support, advocacy or research.

Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

http://www.wakeupnarcolepsy.org/

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cataplexy" returned 110 free, full-text research articles on human participants. First 3 results:

Comments on 'Sleep Disordered Breathing and Periodic Limb Movements in Patients with Narcolepsy with Cataplexy'.
 

Author(s): Nitin K Sethi

Journal: Eur. Neurol.. 2015 ;74(3-4):169.

 

Last Updated: 1 Dec 2015

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Reply to Comments on 'Sleep Disordered Breathing and Periodic Limb Movements in Patients with Narcolepsy with Cataplexy'.
 

Author(s): Fabio Pizza, Claudio L Bassetti

Journal: Eur. Neurol.. 2015 ;74(3-4):170.

 

Last Updated: 1 Dec 2015

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The Brain Correlates of Laugh and Cataplexy in Childhood Narcolepsy.
 

Author(s): Stefano Meletti, Anna Elisabetta Vaudano, Fabio Pizza, Andrea Ruggieri, Stefano Vandi, Alberto Teggi, Christian Franceschini, Francesca Benuzzi, Paolo Frigio Nichelli, Giuseppe Plazzi

Journal: J. Neurosci.. 2015 Aug;35(33):11583-94.

 

The brain suprapontine mechanisms associated with human cataplexy have not been clarified. Animal data suggest that the amygdala and the ventromedial prefrontal cortex are key regions in promoting emotion-induced cataplectic attacks. Twenty-one drug-naive children/adolescent (13 males, ...

Last Updated: 20 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cataplexy" returned 6 free, full-text review articles on human participants. First 3 results:

[Narcolepsy with cataplexy: an autoimmune disease?].
 

Author(s): Louis Jacob, Yves Dauvilliers

Journal: Med Sci (Paris). 2014 Dec;30(12):1136-43.

 

Narcolepsy type 1 (also named narcolepsy-cataplexy or hypocretin deficiency syndrome) is a rare sleep disorder characterized by excessive daytime sleepiness and cataplexy, plus frequently hypnagogic hallucinations, sleep paralysis and nocturnal sleep disturbances. Narcolepsy type ...

Last Updated: 24 Dec 2014

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A patient with intractable attacks of cataplexy.
 

Author(s): Lourdes M DelRosso, Syeda Munir, Andrew L Chesson, Romy Hoque

Journal:

 

Last Updated: 15 Oct 2013

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Narcolepsy: neural mechanisms of sleepiness and cataplexy.
 

Author(s): Christian R Burgess, Thomas E Scammell

Journal: J. Neurosci.. 2012 Sep;32(36):12305-11.

 

Last Updated: 7 Sep 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 21 Apr 2016

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Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy
 

Status: Not yet recruiting

Condition Summary: Excessive Daytime Sleepiness; Cataplexy; Narcolepsy

 

Last Updated: 25 Mar 2016

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