Cataplexy

Common Name(s)

Cataplexy

Cataplexy is a symptom shown only in people with narcolepsy. Cataplexy is a sudden loss of muscle tone while awake that makes you unable to move. Strong emotions, such as laughter or anger, can trigger this. Most attacks last for less than 30 seconds and can be missed. Your head will suddenly fall forward, your jaw will become slack, and your knees will buckle. In severe cases, a person may fall and stay paralyzed for as long as several minutes.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cataplexy" for support, advocacy or research.

Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

Last Updated: 29 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cataplexy" for support, advocacy or research.

Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

http://www.wakeupnarcolepsy.org/

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cataplexy" returned 96 free, full-text research articles on human participants. First 3 results:

Challenges in diagnosing narcolepsy without cataplexy: a consensus statement.
 

Author(s): Christian R Baumann, Emmanuel Mignot, Gert Jan Lammers, Sebastiaan Overeem, Isabelle Arnulf, David Rye, Yves Dauvilliers, Makoto Honda, Judith A Owens, Giuseppe Plazzi, Thomas E Scammell

Journal:

 

Diagnosing narcolepsy without cataplexy is often a challenge as the symptoms are nonspecific, current diagnostic tests are limited, and there are no useful biomarkers. In this report, we review the clinical and physiological aspects of narcolepsy without cataplexy, the limitations ...

Last Updated: 2 Jun 2014

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A case of REM sleep behavior disorder, narcolepsy-cataplexy, parkinsonism, and rheumatoid arthritis.
 

Author(s): Filomena I I Cosentino, Angela Distefano, Giuseppe Plazzi, Carlos H Schenck, Raffaele Ferri

Journal: Behav Neurol. 2014 ;2014():572931.

 

A patient is reported in whom signs and symptoms of REM sleep behavior disorder (RBD) and narcolepsy have been associated for almost two decades with a late development of parkinsonism and rheumatoid arthritis. A 78-year-old male patient in whom RBD was first diagnosed was followed-up ...

Last Updated: 14 May 2014

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GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy.
 

Author(s): Sarah Wurts Black, Stephen R Morairty, Tsui-Ming Chen, Andrew K Leung, Jonathan P Wisor, Akihiro Yamanaka, Thomas S Kilduff

Journal: J. Neurosci.. 2014 May;34(19):6485-94.

 

γ-Hydroxybutyrate (GHB) is an approved therapeutic for the excessive sleepiness and sudden loss of muscle tone (cataplexy) characteristic of narcolepsy. The mechanism of action for these therapeutic effects is hypothesized to be GABAB receptor dependent. We evaluated the effects ...

Last Updated: 8 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cataplexy" returned 5 free, full-text review articles on human participants. First 3 results:

A patient with intractable attacks of cataplexy.
 

Author(s): Lourdes M DelRosso, Syeda Munir, Andrew L Chesson, Romy Hoque

Journal:

 

Last Updated: 15 Oct 2013

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Narcolepsy: neural mechanisms of sleepiness and cataplexy.
 

Author(s): Christian R Burgess, Thomas E Scammell

Journal: J. Neurosci.. 2012 Sep;32(36):12305-11.

 

Last Updated: 7 Sep 2012

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Sodium oxybate for narcolepsy with cataplexy: systematic review and meta-analysis.
 

Author(s): Mashael K Alshaikh, Andrea C Tricco, Mariam Tashkandi, Muhammad Mamdani, Sharon E Straus, Ahmed S BaHammam

Journal:

 

To assess the efficacy and safety of sodium oxybate (SXB) in narcolepsy-cataplexy patients.

Last Updated: 15 Aug 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Risk of Narcolepsy Associated With Administration of H1N1 Vaccine
 

Status: Recruiting

Condition Summary: Narcolepsy

 

Last Updated: 13 Jul 2011

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