Cataplexy

Common Name(s)

Cataplexy

Cataplexy is a symptom shown only in people with narcolepsy. Cataplexy is a sudden loss of muscle tone while awake that makes you unable to move. Strong emotions, such as laughter or anger, can trigger this. Most attacks last for less than 30 seconds and can be missed. Your head will suddenly fall forward, your jaw will become slack, and your knees will buckle. In severe cases, a person may fall and stay paralyzed for as long as several minutes.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cataplexy" for support, advocacy or research.

Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

Last Updated: 29 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cataplexy" for support, advocacy or research.

Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

http://www.wakeupnarcolepsy.org/

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cataplexy" returned 87 free, full-text research articles on human participants. First 3 results:

Clinical and polysomnographic course of childhood narcolepsy with cataplexy.
 

Author(s): Fabio Pizza, Christian Franceschini, Hanna Peltola, Stefano Vandi, Elena Finotti, Francesca Ingravallo, Lino Nobili, Oliviero Bruni, Ling Lin, Mark J Edwards, Markku Partinen, Yves Dauvilliers, Emmanuel Mignot, Kailash P Bhatia, Giuseppe Plazzi

Journal: Brain. 2013 Dec;136(Pt 12):3787-95.

 

Our aim was to investigate the natural evolution of cataplexy and polysomnographic features in untreated children with narcolepsy with cataplexy. To this end, clinical, polysomnographic, and cataplexy-video assessments were performed at diagnosis (mean age of 10 ± 3 and disease duration ...

Last Updated: 16 Dec 2013

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Effect of psychostimulants on impulsivity and risk taking in narcolepsy with cataplexy.
 

Author(s): Sophie Bayard, Muriel Croisier Langenier, Yves Dauvilliers

Journal:

 

To investigate the effect of psychostimulants on impulsivity, depressive symptoms, addiction, pathological gambling, and risk-taking using objective sensitivity tests in narcolepsy with cataplexy (NC). Drug-free patients with NC present alterations in reward processing, but changes ...

Last Updated: 2 Sep 2013

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Test-retest reliability of the multiple sleep latency test in narcolepsy without cataplexy and idiopathic hypersomnia.
 

Author(s): Lynn Marie Trotti, Beth A Staab, David B Rye

Journal:

 

Differentiation of narcolepsy without cataplexy from idiopathic hypersomnia relies entirely upon the multiple sleep latency test (MSLT). However, the test-retest reliability for these central nervous system hypersomnias has never been determined.

Last Updated: 15 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cataplexy" returned 6 free, full-text review articles on human participants. First 3 results:

A patient with intractable attacks of cataplexy.
 

Author(s): Lourdes M DelRosso, Syeda Munir, Andrew L Chesson, Romy Hoque

Journal:

 

Last Updated: 15 Oct 2013

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Narcolepsy: neural mechanisms of sleepiness and cataplexy.
 

Author(s): Christian R Burgess, Thomas E Scammell

Journal: J. Neurosci.. 2012 Sep;32(36):12305-11.

 

Last Updated: 7 Sep 2012

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Sodium oxybate for narcolepsy with cataplexy: systematic review and meta-analysis.
 

Author(s): Mashael K Alshaikh, Andrea C Tricco, Mariam Tashkandi, Muhammad Mamdani, Sharon E Straus, Ahmed S BaHammam

Journal:

 

To assess the efficacy and safety of sodium oxybate (SXB) in narcolepsy-cataplexy patients.

Last Updated: 15 Aug 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pitolisant to Assess Weekly Frequency of Cataplexy Attacks and EDS in Narcoleptic Patients (HARMONY CTP)
 

Status: Recruiting

Condition Summary: Narcolepsy With Cataplexy; Excessive Daytime Sleepiness

 

Last Updated: 15 May 2013

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Risk of Narcolepsy Associated With Administration of H1N1 Vaccine
 

Status: Recruiting

Condition Summary: Narcolepsy

 

Last Updated: 13 Jul 2011

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