Cataplexy

Common Name(s)

Cataplexy

Cataplexy is a symptom shown only in people with narcolepsy. Cataplexy is a sudden loss of muscle tone while awake that makes you unable to move. Strong emotions, such as laughter or anger, can trigger this. Most attacks last for less than 30 seconds and can be missed. Your head will suddenly fall forward, your jaw will become slack, and your knees will buckle. In severe cases, a person may fall and stay paralyzed for as long as several minutes.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cataplexy" for support, advocacy or research.

Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

Last Updated: 29 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cataplexy" for support, advocacy or research.

Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

http://www.wakeupnarcolepsy.org/

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cataplexy" returned 92 free, full-text research articles on human participants. First 3 results:

DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe.
 

Author(s): Mehdi Tafti, Hyun Hor, Yves Dauvilliers, Gert J Lammers, Sebastiaan Overeem, Geert Mayer, Sirous Javidi, Alex Iranzo, Joan Santamaria, Rosa Peraita-Adrados, José L Vicario, Isabelle Arnulf, Giuseppe Plazzi, Sophie Bayard, Francesca Poli, Fabio Pizza, Peter Geisler, Aleksandra Wierzbicka, Claudio L Bassetti, Johannes Mathis, Michel Lecendreux, Claire E H M Donjacour, Astrid van der Heide, Raphaël Heinzer, José Haba-Rubio, Eva Feketeova, Birgit Högl, Birgit Frauscher, Antonio Benetó, Ramin Khatami, Francesca Cañellas, Corinne Pfister, Sabine Scholz, Michel Billiard, Christian R Baumann, Guadalupe Ercilla, Willem Verduijn, Frans H J Claas, Valérie Dubois, Jacek Nowak, Hans-Peter Eberhard, Sylvain Pradervand, Charlotte N Hor, Manuela Testi, Jean-Marie Tiercy, Zoltán Kutalik

Journal:

 

Prior research has identified five common genetic variants associated with narcolepsy with cataplexy in Caucasian patients. To replicate and/or extend these findings, we have tested HLA-DQB1, the previously identified 5 variants, and 10 other potential variants in a large European ...

Last Updated: 1 Jan 2014

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Treatment of cataplexy in a three-year-old using venlafaxine.
 

Author(s): Michelle Ratkiewicz, Mark Splaingard

Journal:

 

Narcolepsy with cataplexy is rare in children under 5 years of age. There is limited information on safe and effective treatment of cataplexy in young children. We describe successful treatment of cataplexy in a 3-year-old using venlafaxine and subsequently followed for over 2 years.

Last Updated: 16 Dec 2013

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Differences in brain morphological findings between narcolepsy with and without cataplexy.
 

Author(s): Masaki Nakamura, Shingo Nishida, Kenichi Hayashida, Yoichiro Ueki, Yves Dauvilliers, Yuichi Inoue

Journal:

 

Maps of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) obtained by diffusion tensor imaging (DTI) can detect microscopic axonal changes by estimating the diffusivity of water molecules using magnetic resonance imaging (MRI). We applied an MRI voxel-based statistical ...

Last Updated: 6 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cataplexy" returned 6 free, full-text review articles on human participants. First 3 results:

A patient with intractable attacks of cataplexy.
 

Author(s): Lourdes M DelRosso, Syeda Munir, Andrew L Chesson, Romy Hoque

Journal:

 

Last Updated: 15 Oct 2013

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Narcolepsy: neural mechanisms of sleepiness and cataplexy.
 

Author(s): Christian R Burgess, Thomas E Scammell

Journal: J. Neurosci.. 2012 Sep;32(36):12305-11.

 

Last Updated: 7 Sep 2012

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Sodium oxybate for narcolepsy with cataplexy: systematic review and meta-analysis.
 

Author(s): Mashael K Alshaikh, Andrea C Tricco, Mariam Tashkandi, Muhammad Mamdani, Sharon E Straus, Ahmed S BaHammam

Journal:

 

To assess the efficacy and safety of sodium oxybate (SXB) in narcolepsy-cataplexy patients.

Last Updated: 15 Aug 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pitolisant to Assess Weekly Frequency of Cataplexy Attacks and EDS in Narcoleptic Patients (HARMONY CTP)
 

Status: Recruiting

Condition Summary: Narcolepsy With Cataplexy; Excessive Daytime Sleepiness

 

Last Updated: 15 May 2013

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Risk of Narcolepsy Associated With Administration of H1N1 Vaccine
 

Status: Recruiting

Condition Summary: Narcolepsy

 

Last Updated: 13 Jul 2011

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