Castleman's Disease

Common Name(s)

Castleman's Disease, Angiofollicular ganglionic hyperplasia

Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. While the cause of Castleman's disease is unknown, many doctors suspect a virus is involved. Problems with the way an individual's immune system functions may also contribute to the development of the condition. There are 2 main forms of Castleman's disease: localized (discussed here) and multicentric. They affect people very differently. Localized or unicentric Castleman's disease only affects a single set of lymph nodes and is not widespread. The lymph nodes that are more commonly affected are in the chest and abdomen. Castleman’s disease causes the lymph nodes to get larger. The enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. Sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. People with localized Castleman's disease are often cured when the lymph node is removed with surgery. Chemotherapy and radiation may also be used. Please talk with your doctor about the most current treatment options if you or a family member has been diagnosed with Castleman's disease. See also Multicentric Castleman’s disease.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Castleman's Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Castleman's Disease" returned 245 free, full-text research articles on human participants. First 3 results:

Last Updated: 14 Sep 2015

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A Patient with Pancreatic Castleman's Disease Arising around the Main Pancreatic Duct.
 

Author(s): Takaaki Matsumoto, Kosuke Okuwaki, Mitsuhiro Kida, Shi-Xu Jiang, Hiroshi Imaizumi, Hiroshi Yamauchi, Shiro Miyazawa, Tomohisa Iwai, Miyoko Takezawa, Hiroshi Tajima, Wasaburo Koizumi

Journal: Intern. Med.. 2015 ;54(16):2007-12.

 

Castleman's disease of the pancreas is extremely rare. To the best of our knowledge, Castleman's disease arising around the main pancreatic duct has not been previously reported. The patient was a 74-year-old man. Abdominal ultrasonography performed at a health check-up revealed a ...

Last Updated: 17 Aug 2015

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Successful Treatment of TAFRO Syndrome, a Variant of Multicentric Castleman's Disease, with Cyclosporine A: Possible Pathogenetic Contribution of Interleukin-2.
 

Author(s): Yoshinobu Konishi, Satoshi Takahashi, Katsuyuki Nishi, Taro Sakamaki, Sachiko Mitani, Hitomi Kaneko, Chisato Mizutani, Naoya Ukyo, Hirokazu Hirata, Mitsuru Tsudo

Journal: Tohoku J. Exp. Med.. 2015 ;236(4):289-95.

 

Multicentric Castleman's disease is a systemic inflammatory disorder characterized by lymphadenopathy and excessive interleukin-6 production. A unique clinicopathologic variant of multicentric Castleman's disease, TAFRO (i.e., thrombocytopenia, anasarca, fever, renal failure or reticulin ...

Last Updated: 7 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Castleman's Disease" returned 30 free, full-text review articles on human participants. First 3 results:

Pathogenesis of Castleman's Disease.
 

Author(s): Lu Zhang, Jian Li

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016 Feb;38(1):118-21.

 

Castleman's disease (CD) is a rare lymphoproliferative disorder that comprises at least two distinct clinical subtypes (unicentric and multicentric). Three pathologic variants (hyaline vascular variant, plasma cell variant, and mixed variant) have been recognized. In addition to interleukin-6 ...

Last Updated: 9 Mar 2016

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[Hyaline-vascular Multicentric Castleman's Disease in an immunocompetent patient].
 

Author(s): Sergio Armando Zapata-Bonilla, Roberto López Vargas, Aldo Alfonso Scherling-Ocampo, Ana Lilia Morales Leyte, Liliana García Ilizaliturri

Journal: Gac Med Mex. ;151(5):648-54.

 

A previously healthy, immunocompetent 67-year-old female presented with a one-month history of general symptoms, weight loss, night fevers, and bilateral lower extremity edema. On admission she had severe anemia, acute kidney injury, and multiple lymphadenopathies. An excisional biopsy ...

Last Updated: 3 Nov 2015

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Castleman's disease mimicking a parotid gland tumor: report of a case and review of the literature.
 

Author(s): G Iaconetta, M Friscia, G Dell'Aversana Orabona, S de Biasi, A Romano, P Piombino, P Graziano, V Abbate, G Salzano, F Maglitto, L Califano

Journal: Eur Rev Med Pharmacol Sci. 2014 ;18(8):1241-6.

 

Castleman's disease (giant lymph node hyperplasia, angiofollicular hyperplasia, lymphoid hamartoma, benign giant lymphoma), is a quite rare and complex disease of lymphoid tissue that causes progressive lymph node enlargement, typically presenting as a solitary mediastinal mass. It ...

Last Updated: 12 May 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Castleman Disease Collaborative Network Biobank
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia; Angiofollicular Lymph Hyperplasia; Angiofollicular Lymph Node Hyperplasia; Angiofollicular Lymphoid Hyperplasia; GLNH; Hyperplasia; Giant Lymph Node

 

Last Updated: 17 Aug 2016

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Unlock the Cell: Castleman's Disease Flow Cytometry Study
 

Status: Recruiting

Condition Summary: Castleman Disease; Angiofollicular Lymphoid Hyperplasia; GLNH; Hyperplasia; Castleman's Disease; Angiofollicular Lymph Hyperplasia; Giant Lymph Node Hyperplasia

 

Last Updated: 8 Aug 2016

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International Registry for Patients With Castleman Disease
 

Status: Not yet recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia; Angiofollicular Lymph Hyperplasia; Angiofollicular Lymph Node Hyperplasia; Angiofollicular Lymphoid Hyperplasia; GLNH; Hyperplasia, Giant Lymph Node; Lymph Node Hyperplasia, Giant

 

Last Updated: 24 Jun 2016

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