Castleman's Disease

Common Name(s)

Castleman's Disease, Angiofollicular ganglionic hyperplasia

Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. While the cause of Castleman's disease is unknown, many doctors suspect a virus is involved. Problems with the way an individual's immune system functions may also contribute to the development of the condition. There are 2 main forms of Castleman's disease: localized (discussed here) and multicentric. They affect people very differently. Localized or unicentric Castleman's disease only affects a single set of lymph nodes and is not widespread. The lymph nodes that are more commonly affected are in the chest and abdomen. Castleman’s disease causes the lymph nodes to get larger. The enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. Sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. People with localized Castleman's disease are often cured when the lymph node is removed with surgery. Chemotherapy and radiation may also be used. Please talk with your doctor about the most current treatment options if you or a family member has been diagnosed with Castleman's disease. See also Multicentric Castleman’s disease.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Castleman's Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Castleman's Disease" returned 177 free, full-text research articles on human participants. First 3 results:

Elevated plasma fibrinogen in clinically asymptomatic unicentric Castleman's disease: a case report.
 

Author(s): Anne Bauters, Moshe Rogosnitzky, Eric Hachulla, Marie Christine Copin, Alain Saudemont, Philippe Zerbib

Journal: J Clin Exp Hematop. 2014 ;54(1):85-8.

 

This is the first report of an early association between elevated fibrinogen and asymptomatic unicentric Castleman's disease (CD). A 49-year-old asymptomatic female who was serving as a normal control in an unrelated study was incidentally found to have significantly elevated levels ...

Last Updated: 19 Jun 2014

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The first report of adolescent TAFRO syndrome, a unique clinicopathologic variant of multicentric Castleman's disease.
 

Author(s): Ikuko Kubokawa, Akihiro Yachie, Akira Hayakawa, Satoshi Hirase, Nobuyuki Yamamoto, Takeshi Mori, Tomoko Yanai, Yasuhiro Takeshima, Eiryu Kyo, Goichi Kageyama, Hiroshi Nagai, Keiichiro Uehara, Masaru Kojima, Kazumoto Iijima

Journal:

 

TAFRO syndrome is a unique clinicopathologic variant of multicentric Castleman's disease that has recently been identified in Japan. It is characterized by a constellation of symptoms: Thrombocytopenia, Anasarca, reticulin Fibrosis of the bone marrow, Renal dysfunction and Organomegaly ...

Last Updated: 11 Jul 2014

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[Castleman's disease of the kidney: a case report].
 

Author(s): Yoko Koh, Takanori Kinjo, Daichi Nonomura, Yoshiyuki Yamamoto, Suguru Yoneda, Hironori Nomura, Norihide Tei, Shingo Takada, Kiyomi Matsumiya, Ryo Jokoji, Masahiko Tsujimoto

Journal: Hinyokika Kiyo. 2014 Mar;60(3):129-32.

 

Castleman's disease is a rare disorder characterized by benign proliferation of lymphoid tissue. A 61-year-old man was referred to our department for a renal mass incidentally detected by magnetic resonance imaging. Computed tomography showed a 18 × 20 × 14 mm mass in the upper ...

Last Updated: 24 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Castleman's Disease" returned 20 free, full-text review articles on human participants. First 3 results:

Castleman's disease mimicking a parotid gland tumor: report of a case and review of the literature.
 

Author(s): G Iaconetta, M Friscia, G Dell'Aversana Orabona, S de Biasi, A Romano, P Piombino, P Graziano, V Abbate, G Salzano, F Maglitto, L Califano

Journal: Eur Rev Med Pharmacol Sci. 2014 ;18(8):1241-6.

 

Castleman's disease (giant lymph node hyperplasia, angiofollicular hyperplasia, lymphoid hamartoma, benign giant lymphoma), is a quite rare and complex disease of lymphoid tissue that causes progressive lymph node enlargement, typically presenting as a solitary mediastinal mass. It ...

Last Updated: 12 May 2014

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Mixed-type multicentric Castleman's disease developing during a 17-year follow-up of sarcoidosis.
 

Author(s): Nobuyasu Awano, Minoru Inomata, Keisuke Kondoh, Kohta Satake, Hiroyuki Kamiya, Atsuko Moriya, Tsunehiro Ando, Toshio Kumasaka, Tamiko Takemura, Kengo Takeuchi, Soichiro Ikushima

Journal: Intern. Med.. 2012 ;51(21):3061-6.

 

Multicentric Castleman's Disease (MCD) is a systemic disease characterized by generalized lymphadenopathy and the proliferation of plasma cells. The development of MCD in a patient with preexisting sarcoidosis has not been previously reported. We herein describe a case of MCD developing ...

Last Updated: 5 Nov 2012

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Plasma cell type of Castleman's disease involving renal parenchyma and sinus with cardiac tamponade: case report and literature review.
 

Author(s): Tae Un Kim, Suk Kim, Jun Woo Lee, Nam Kyung Lee, Ung Bae Jeon, Hong Gu Ha, Dong Hoon Shin

Journal: Korean J Radiol. ;13(5):658-63.

 

Castleman's disease is an uncommon disorder characterized by benign proliferation of the lymphoid tissue that occurs most commonly in the mediastinum. Although unusual locations and manifestations have been reported, involvement of the renal parenchyma and sinus, and moreover, manifestations ...

Last Updated: 14 Sep 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 3 Mar 2015

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Dose-escalation Study of Oral CX-4945
 

Status: Recruiting

Condition Summary: Advanced Solid Tumors; Breast Cancer; Inflammatory Breast Cancer; Castleman's Disease; Multiple Myeloma

 

Last Updated: 13 Jun 2011

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Study of Pomalidomide Combined With Modified DA-EPOCH and Rituximab in KSHV-Associated Lymphomas
 

Status: Recruiting

Condition Summary: Large Cell Lymphoma Arising in KSHV-associated Multicentric Castleman Disease; Primary Effusion Lymphoma

 

Last Updated: 27 Aug 2014

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