Castleman's Disease

Common Name(s)

Castleman's Disease, Angiofollicular ganglionic hyperplasia

Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. While the cause of Castleman's disease is unknown, many doctors suspect a virus is involved. Problems with the way an individual's immune system functions may also contribute to the development of the condition. There are 2 main forms of Castleman's disease: localized (discussed here) and multicentric. They affect people very differently. Localized or unicentric Castleman's disease only affects a single set of lymph nodes and is not widespread. The lymph nodes that are more commonly affected are in the chest and abdomen. Castleman’s disease causes the lymph nodes to get larger. The enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. Sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. People with localized Castleman's disease are often cured when the lymph node is removed with surgery. Chemotherapy and radiation may also be used. Please talk with your doctor about the most current treatment options if you or a family member has been diagnosed with Castleman's disease. See also Multicentric Castleman’s disease.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Castleman's Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Castleman's Disease" returned 247 free, full-text research articles on human participants. First 3 results:

[A case of retroperitoneal Castleman's disease with paraneoplastic pemphigus].
 

Author(s): Zhipeng Zhang, Maosong Zhou, Jin Guo, Tiecheng Feng, Xinying Li, Huan Chen, Jindong Li

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 May;41(5):548-52.

 

Paraneoplastic pemphigus is a rare autoimmune bullous dermatosis, which is caused by potential neoplasm, especially the Castleman's disease. Castleman's disease associated with paraneoplastic pemphigus is misdiagnosed frequently and easily in clinical practices. Furthermore, it is ...

Last Updated: 9 Jun 2016

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Clinicopathological characteristics of unicentric retroperitoneal Castleman's disease: a study of 14 cases.
 

Author(s): Shuai Wang, Shanwen Chen, Jiangfeng Xu, Songliang Cai

Journal:

 

The objectives of this study are to investigate the clinicopathological characteristics and prognosis analysis of unicentric retroperitoneal Castleman's disease (CD), and to improve the level of diagnosis and treatment of unicentric retroperitoneal CD.

Last Updated: 7 Jan 2016

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Last Updated: 14 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Castleman's Disease" returned 29 free, full-text review articles on human participants. First 3 results:

Pathogenesis of Castleman's Disease.
 

Author(s): Lu Zhang, Jian Li

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016 Feb;38(1):118-21.

 

Castleman's disease (CD) is a rare lymphoproliferative disorder that comprises at least two distinct clinical subtypes (unicentric and multicentric). Three pathologic variants (hyaline vascular variant, plasma cell variant, and mixed variant) have been recognized. In addition to interleukin-6 ...

Last Updated: 9 Mar 2016

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[Hyaline-vascular Multicentric Castleman's Disease in an immunocompetent patient].
 

Author(s): Sergio Armando Zapata-Bonilla, Roberto López Vargas, Aldo Alfonso Scherling-Ocampo, Ana Lilia Morales Leyte, Liliana García Ilizaliturri

Journal: Gac Med Mex. ;151(5):648-54.

 

A previously healthy, immunocompetent 67-year-old female presented with a one-month history of general symptoms, weight loss, night fevers, and bilateral lower extremity edema. On admission she had severe anemia, acute kidney injury, and multiple lymphadenopathies. An excisional biopsy ...

Last Updated: 3 Nov 2015

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Castleman's disease mimicking a parotid gland tumor: report of a case and review of the literature.
 

Author(s): G Iaconetta, M Friscia, G Dell'Aversana Orabona, S de Biasi, A Romano, P Piombino, P Graziano, V Abbate, G Salzano, F Maglitto, L Califano

Journal: Eur Rev Med Pharmacol Sci. 2014 ;18(8):1241-6.

 

Castleman's disease (giant lymph node hyperplasia, angiofollicular hyperplasia, lymphoid hamartoma, benign giant lymphoma), is a quite rare and complex disease of lymphoid tissue that causes progressive lymph node enlargement, typically presenting as a solitary mediastinal mass. It ...

Last Updated: 12 May 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 17 Nov 2016

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Castleman Disease Collaborative Network Biobank
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia; Angiofollicular Lymph Hyperplasia; Angiofollicular Lymph Node Hyperplasia; Angiofollicular Lymphoid Hyperplasia; GLNH; Hyperplasia; Giant Lymph Node

 

Last Updated: 17 Aug 2016

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Unlock the Cell: Castleman's Disease Flow Cytometry Study
 

Status: Recruiting

Condition Summary: Castleman Disease; Angiofollicular Lymphoid Hyperplasia; GLNH; Hyperplasia; Castleman's Disease; Angiofollicular Lymph Hyperplasia; Giant Lymph Node Hyperplasia

 

Last Updated: 8 Aug 2016

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