Castleman's Disease

Common Name(s)

Castleman's Disease

CastlemanÕs disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. While the cause of Castleman's disease is unknown, many doctors suspect a virus is involved. Problems with the way an individual's immune system functions may also contribute to the development of the condition. There are 2 main forms of Castleman's disease: localized (discussed here) and multicentric. They affect people very differently. Localized or unicentric Castleman's disease only affects a single set of lymph nodes and is not widespread. The lymph nodes that are more commonly affected are in the chest and abdomen. CastlemanÕs disease causes the lymph nodes to get larger. The enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. Sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. People with localized Castleman's disease are often cured when the lymph node is removed with surgery. Chemotherapy and radiation may also be used.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Castleman's Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Castleman's Disease" returned 174 free, full-text research articles on human participants. First 3 results:

Retroperitoneal Castleman's disease: advocating a multidisciplinary approach for a rare clinical entity.
 

Author(s): Austin D Williams, Adriana Sanchez, Jun Steve Hou, Rene Rothstein Rubin, Mark E Hysell, Blake D Babcock, Mohammad F Shaikh, Michael S Weingarten, Wilbur B Bowne

Journal:

 

Castleman's disease is a rare and poorly understood disease entity that may resemble more common conditions and represents a clinical challenge to the treating surgeon.

Last Updated: 13 Mar 2014

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A case of paraneoplastic pemphigus associated with Castleman's disease.
 

Author(s): Meihua Zeng, Min Zhang, Wenxing Hu, Qingtao Kong, Hong Sang, Xiulian Xu

Journal: An Bras Dermatol. ;88(6 Suppl 1):11-4.

 

We present a case of PNP associated with Castleman's Disease. We have also reviewed the literature and described the characteristics of the two associated diseases. Gene clonal rearrangement was done to help diagnosis. We used, in addition, stereotactic radiosurgery which, as far ...

Last Updated: 18 Dec 2013

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Classic case of unicentric mixed-type Castleman's disease.
 

Author(s): Ravi Nagubandi, Yanhua Wang, Janice P Dutcher, Prakashchandra M Rao

Journal: J. Clin. Oncol.. 2013 Dec;31(36):e452-5.

 

Last Updated: 18 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Castleman's Disease" returned 19 free, full-text review articles on human participants. First 3 results:

Mixed-type multicentric Castleman's disease developing during a 17-year follow-up of sarcoidosis.
 

Author(s): Nobuyasu Awano, Minoru Inomata, Keisuke Kondoh, Kohta Satake, Hiroyuki Kamiya, Atsuko Moriya, Tsunehiro Ando, Toshio Kumasaka, Tamiko Takemura, Kengo Takeuchi, Soichiro Ikushima

Journal: Intern. Med.. 2012 ;51(21):3061-6.

 

Multicentric Castleman's Disease (MCD) is a systemic disease characterized by generalized lymphadenopathy and the proliferation of plasma cells. The development of MCD in a patient with preexisting sarcoidosis has not been previously reported. We herein describe a case of MCD developing ...

Last Updated: 5 Nov 2012

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Plasma cell type of Castleman's disease involving renal parenchyma and sinus with cardiac tamponade: case report and literature review.
 

Author(s): Tae Un Kim, Suk Kim, Jun Woo Lee, Nam Kyung Lee, Ung Bae Jeon, Hong Gu Ha, Dong Hoon Shin

Journal: Korean J Radiol. ;13(5):658-63.

 

Castleman's disease is an uncommon disorder characterized by benign proliferation of the lymphoid tissue that occurs most commonly in the mediastinum. Although unusual locations and manifestations have been reported, involvement of the renal parenchyma and sinus, and moreover, manifestations ...

Last Updated: 14 Sep 2012

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Membranoproliferative glomerulonephritis in Castleman's disease: a systematic review of the literature and 2 case reports.
 

Author(s): Haoyuan Zhang, Rending Wang, Huiping Wang, Ying Xu, Jianghua Chen

Journal: Intern. Med.. 2012 ;51(12):1537-42.

 

We report two cases of membranoproliferative glomerulonephritis, involved in Castleman's disease of hyaline vascular variant and mixed variant, respectively. The diagnoses were confirmed by cervical lymph node and renal biopsy. Both cases were sensitive to chemotherapy with cyclophosphamide, ...

Last Updated: 25 Jun 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 26 Aug 2014

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Dose-escalation Study of Oral CX-4945
 

Status: Recruiting

Condition Summary: Advanced Solid Tumors; Breast Cancer; Inflammatory Breast Cancer; Castleman's Disease; Multiple Myeloma

 

Last Updated: 13 Jun 2011

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Last Updated: 16 Apr 2014

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