Castleman's Disease

Common Name(s)

Castleman's Disease, Angiofollicular ganglionic hyperplasia

Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. While the cause of Castleman's disease is unknown, many doctors suspect a virus is involved. Problems with the way an individual's immune system functions may also contribute to the development of the condition. There are 2 main forms of Castleman's disease: localized (discussed here) and multicentric. They affect people very differently. Localized or unicentric Castleman's disease only affects a single set of lymph nodes and is not widespread. The lymph nodes that are more commonly affected are in the chest and abdomen. Castleman’s disease causes the lymph nodes to get larger. The enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. Sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. People with localized Castleman's disease are often cured when the lymph node is removed with surgery. Chemotherapy and radiation may also be used. Please talk with your doctor about the most current treatment options if you or a family member has been diagnosed with Castleman's disease. See also Multicentric Castleman’s disease.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Castleman's Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Castleman's Disease" returned 231 free, full-text research articles on human participants. First 3 results:

Fulminant HHV-8 associated Castleman's disease in a non-HIV, Kaposi sarcoma patient with borderline hemophagocytic syndrome.
 

Author(s): Irena Barbarov, Maya Koren-Michowitz, Ginette Schiby, Orith Portnoy, David Livingstone, Gad Segal

Journal: Isr. Med. Assoc. J.. 2015 Apr;17(4):253-5.

 

Last Updated: 4 Jun 2015

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Unicentric Castleman's disease presenting as a pulmonary mass: a diagnostic dilemma.
 

Author(s): Badi Rawashdeh, Mark Meyer, Dong Yimin, Colon Anthony, Duy Nguyn, Mohammad Moslemi, Simin Golestani, Sobonya Richard, Samuel Kim

Journal:

 

Castleman's disease, or angiofollicular lymphoid hyperplasia, is a rare disorder and can be easily misdiagnosed as lymphoma, neoplasm, or infection. The diagnosis is challenging due to the nonspecific signs and symptoms as well as the rarity of the disease. We present an unusual case ...

Last Updated: 1 May 2015

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Castleman's disease and sarcoidosis, a rare association resulting in a "mixed" response: a case report.
 

Author(s): Anwarullah Mohammed, Filip Janku, Ming Qi, Razelle Kurzrock

Journal:

 

Multicentric Castleman's disease is a rare lymphoproliferative disorder whose hallmark is atypical lymph node hyperplasia. Symptoms can include fever, splenomegaly, and abnormal blood cell counts. High levels of interleukin 6 (IL-6) are observed frequently in this disorder and are ...

Last Updated: 18 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Castleman's Disease" returned 27 free, full-text review articles on human participants. First 3 results:

Castleman's disease mimicking a parotid gland tumor: report of a case and review of the literature.
 

Author(s): G Iaconetta, M Friscia, G Dell'Aversana Orabona, S de Biasi, A Romano, P Piombino, P Graziano, V Abbate, G Salzano, F Maglitto, L Califano

Journal: Eur Rev Med Pharmacol Sci. 2014 ;18(8):1241-6.

 

Castleman's disease (giant lymph node hyperplasia, angiofollicular hyperplasia, lymphoid hamartoma, benign giant lymphoma), is a quite rare and complex disease of lymphoid tissue that causes progressive lymph node enlargement, typically presenting as a solitary mediastinal mass. It ...

Last Updated: 12 May 2014

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Isolated intrapulmonary Castleman's disease: a case report, review of the literature.
 

Author(s): Aydin Nadir, Necmettin Colak, Asli Koktener, Umran Yildirim

Journal: Ann Thorac Cardiovasc Surg. 2014 ;20 Suppl():689-91.

 

Castleman's disease (CD), also known as angiofollicular lymph node hyperplasia, is an uncommon, lymphoproliferative disorder of unknown etiology, mostly involving the mediastinum. Parenchymal lung involvement of the disease is extremely rare. Intrapulmonary CD has been reported in ...

Last Updated: 6 Mar 2015

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A case of Castleman's disease with myasthenia gravis.
 

Author(s): Keidai Ishikawa, Tatsuya Kato, Masato Aragaki, Toshiro Ohbuchi, Sachiko Kimura, Yoshiro Matsui, Mitsuhito Kaji

Journal: Ann Thorac Cardiovasc Surg. 2014 ;20 Suppl():585-8.

 

A rare case of Castleman's disease with myasthenia gravis is reported. A 55-year-old woman with bilateral ptosis, speech impairment, and severe dyspnea had been previously diagnosed with myasthenia gravis. Computed tomography showed a 5 cm × 3 cm paratracheal mass in the mediastinum, ...

Last Updated: 6 Mar 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 2 Feb 2016

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Dose-escalation Study of Oral CX-4945
 

Status: Recruiting

Condition Summary: Advanced Solid Tumors; Breast Cancer; Inflammatory Breast Cancer; Castleman's Disease; Multiple Myeloma

 

Last Updated: 13 Jun 2011

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Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors
 

Status: Recruiting

Condition Summary: Non-Hodgkin Lymphoma; Hodgkin Lymphoma; Kaposi Sarcoma; Gastric Cancer; Nasopharyngeal Cancer; EBV; Castleman Disease

 

Last Updated: 7 May 2015

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