Castleman's Disease

Common Name(s)

Castleman's Disease, Angiofollicular ganglionic hyperplasia

Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. While the cause of Castleman's disease is unknown, many doctors suspect a virus is involved. Problems with the way an individual's immune system functions may also contribute to the development of the condition. There are 2 main forms of Castleman's disease: localized (discussed here) and multicentric. They affect people very differently. Localized or unicentric Castleman's disease only affects a single set of lymph nodes and is not widespread. The lymph nodes that are more commonly affected are in the chest and abdomen. Castleman’s disease causes the lymph nodes to get larger. The enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. Sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. People with localized Castleman's disease are often cured when the lymph node is removed with surgery. Chemotherapy and radiation may also be used. Please talk with your doctor about the most current treatment options if you or a family member has been diagnosed with Castleman's disease. See also Multicentric Castleman’s disease.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Castleman's Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Castleman's Disease" returned 187 free, full-text research articles on human participants. First 3 results:

Fulminant HHV-8 associated Castleman's disease in a non-HIV, Kaposi sarcoma patient with borderline hemophagocytic syndrome.
 

Author(s): Irena Barbarov, Maya Koren-Michowitz, Ginette Schiby, Orith Portnoy, David Livingstone, Gad Segal

Journal: Isr. Med. Assoc. J.. 2015 Apr;17(4):253-5.

 

Last Updated: 4 Jun 2015

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Rapid multiorgan failure due to large B-cell lymphoma arising in human herpesvirus-8-associated multicentric Castleman's disease in a patient with human immunodeficiency virus infection.
 

Author(s): Yoshihiko Ogawa, Dai Watanabe, Kazuyuki Hirota, Motoko Ikuma, Keishiro Yajima, Daisuke Kasai, Kiyoshi Mori, Yasunori Ota, Yasuharu Nishida, Tomoko Uehira, Masayuki Mano, Takahisa Yamane, Takuma Shirasaka

Journal: Intern. Med.. 2014 ;53(24):2805-9.

 

A 46-year-old man presented with a high-grade fever, multiple lymphadenopathies, hepatosplenomegaly and human immunodeficiency virus (HIV) seropositivity, without severe immunosuppression. We suspected human herpesvirus-8 (HHV-8)-associated multicentric Castleman's disease (MCD) based ...

Last Updated: 16 Dec 2014

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A case report of retroperitoneal pararenal Castleman's disease associated with myasthenia gravis.
 

Author(s): Shuai Wang, Shan-Wen Chen, Song-Liang Cai, Bai-Yan Jin

Journal:

 

Castleman's disease (CD) is a relatively rare disorder characterized by the benign proliferation of lymphoid tissue. The combination of an occurrence of retroperitoneal pararenal CD with myasthenia gravis (MG) is extremely rare.

Last Updated: 17 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Castleman's Disease" returned 20 free, full-text review articles on human participants. First 3 results:

[Diffuse large B cell lymphoma arising from unicentric Castleman's disease: a case report and literature review].
 

Author(s): Jun Cui, Li Wang, Lei Fan, Ji Xu, Jianyong Li, Wei Xu

Journal: Zhonghua Xue Ye Xue Za Zhi. 2014 May;35(5):461-2.

 

Last Updated: 26 May 2014

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Castleman's disease mimicking a parotid gland tumor: report of a case and review of the literature.
 

Author(s): G Iaconetta, M Friscia, G Dell'Aversana Orabona, S de Biasi, A Romano, P Piombino, P Graziano, V Abbate, G Salzano, F Maglitto, L Califano

Journal: Eur Rev Med Pharmacol Sci. 2014 ;18(8):1241-6.

 

Castleman's disease (giant lymph node hyperplasia, angiofollicular hyperplasia, lymphoid hamartoma, benign giant lymphoma), is a quite rare and complex disease of lymphoid tissue that causes progressive lymph node enlargement, typically presenting as a solitary mediastinal mass. It ...

Last Updated: 12 May 2014

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Mixed-type multicentric Castleman's disease developing during a 17-year follow-up of sarcoidosis.
 

Author(s): Nobuyasu Awano, Minoru Inomata, Keisuke Kondoh, Kohta Satake, Hiroyuki Kamiya, Atsuko Moriya, Tsunehiro Ando, Toshio Kumasaka, Tamiko Takemura, Kengo Takeuchi, Soichiro Ikushima

Journal: Intern. Med.. 2012 ;51(21):3061-6.

 

Multicentric Castleman's Disease (MCD) is a systemic disease characterized by generalized lymphadenopathy and the proliferation of plasma cells. The development of MCD in a patient with preexisting sarcoidosis has not been previously reported. We herein describe a case of MCD developing ...

Last Updated: 5 Nov 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 3 Mar 2015

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Dose-escalation Study of Oral CX-4945
 

Status: Recruiting

Condition Summary: Advanced Solid Tumors; Breast Cancer; Inflammatory Breast Cancer; Castleman's Disease; Multiple Myeloma

 

Last Updated: 13 Jun 2011

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Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors
 

Status: Recruiting

Condition Summary: Non-Hodgkin Lymphoma; Hodgkin Lymphoma; Kaposi Sarcoma; Gastric Cancer; Nasopharyngeal Cancer; EBV; Castleman Disease

 

Last Updated: 7 May 2015

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