Castleman's Disease

Common Name(s)

Castleman's Disease, Angiofollicular ganglionic hyperplasia

Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. While the cause of Castleman's disease is unknown, many doctors suspect a virus is involved. Problems with the way an individual's immune system functions may also contribute to the development of the condition. There are 2 main forms of Castleman's disease: localized (discussed here) and multicentric. They affect people very differently. Localized or unicentric Castleman's disease only affects a single set of lymph nodes and is not widespread. The lymph nodes that are more commonly affected are in the chest and abdomen. Castleman’s disease causes the lymph nodes to get larger. The enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. Sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. People with localized Castleman's disease are often cured when the lymph node is removed with surgery. Chemotherapy and radiation may also be used. Please talk with your doctor about the most current treatment options if you or a family member has been diagnosed with Castleman's disease. See also Multicentric Castleman’s disease.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Castleman's Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Castleman's Disease" returned 233 free, full-text research articles on human participants. First 3 results:

[Large B-cell lymphoma coexisting with Castleman's disease. Report of one case].
 

Author(s): Alejandro Avilés-Salas, Myrna Candelaria, Diana Brisa Sevilla-Lizcano, Sebastián Burgos

Journal: Rev Med Chil. 2017 Jul;145(7):945-949.

 

We report a 73-year-old female patient with Castleman's disease coexistent with large B cell type non-Hodgkin's lymphoma in a right axillary lymphadenopathy. An excisional biopsy was performed: microscopically, the lymph node revealed the presence of numerous plasma cells and small ...

Last Updated: 31 Dec 1969

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Gross Hepatosplenomegaly In A Patient With Human Herpes Virus-8 Associated Multicentric Castleman's Disease.
 

Author(s): Mohammad Fawwad Khattak

Journal: J Ayub Med Coll Abbottabad. ;28(4):837.

 

Last Updated: 31 Dec 1969

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A Case of Advanced Unicentric Retroperitoneal Castleman's Disease, Associated With Psoriasis.
 

Author(s): Mohammad Ali Mohagheghi, Ramesh Omranipur, Fereshteh Ensani, Alireza Ghannadan, Shahriar Shahriaran, Farhad Samiee, Zahra Sedighi

Journal: Acta Med Iran. 2017 Apr;55(4):277-279.

 

We present here a 32-year-old male with advanced lately diagnosed, right sided retroperitoneal mass, which had been already treated due to progressive muco-cutaneous lesions clinically consistent with psoriasis, during recent four years. The advanced retroperitoneal mass resected ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Castleman's Disease" returned 29 free, full-text review articles on human participants. First 3 results:

Laparoscopic treatment of abdominal unicentric castleman's disease: a case report and literature review.
 

Author(s): Umberto Bracale, Francesco Pacelli, Marco Milone, Umberto Marcello Bracale, Maurizio Sodo, Giovanni Merola, Teresa Troiani, Enrico Di Salvo

Journal:

 

Castleman's disease is a rare lymphoproliferative disorder of unknown etiology that most commonly presents as a mediastinal nodal mass. It is exceptionally uncommon for Castleman's disease to present in the mesentery and, only 53 cases have ever been described in the literature. Standard ...

Last Updated: 31 Dec 1969

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Clinical Features of Patients with Castleman's Disease Complicated Systemic Lupus Erythematosus.
 

Author(s): Lu Zhang, Xin-Xin Cao, Shu-Jie Wang, Dao-Bin Zhou, Jian Li

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016 10;38(5):543-547.

 

Objective To investigate the clinical features of patients with Castleman's disease (CD) and systemic lupus erythematosus (SLE). Methods According to the diagnostic information between 1994 to 2014 extracted from the database of the Medical Record Department of Peking Union Medical ...

Last Updated: 31 Dec 1969

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Pathogenesis of Castleman's Disease.
 

Author(s): Lu Zhang, Jian Li

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016 Feb;38(1):118-21.

 

Castleman's disease (CD) is a rare lymphoproliferative disorder that comprises at least two distinct clinical subtypes (unicentric and multicentric). Three pathologic variants (hyaline vascular variant, plasma cell variant, and mixed variant) have been recognized. In addition to interleukin-6 ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 27 Dec 2017

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TCP Regimen in Newly Diagnosed MCD:a Prospective, Single-center, Single-arm, Phase-II Pilot Trial
 

Status: Recruiting

Condition Summary: Multicentric Castleman Disease

 

Last Updated: 3 Feb 2017

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Unlock the Cell: Castleman's Disease Flow Cytometry Study
 

Status: Recruiting

Condition Summary: Castleman Disease; Angiofollicular Lymphoid Hyperplasia; GLNH; Hyperplasia; Castleman's Disease; Angiofollicular Lymph Hyperplasia; Giant Lymph Node Hyperplasia

 

Last Updated: 26 Jun 2017

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