Castleman's Disease

Common Name(s)

Castleman's Disease, Angiofollicular ganglionic hyperplasia

Castleman’s disease is a lymphoproliferative disorder affecting the lymph nodes and related tissues. While the cause of Castleman's disease is unknown, many doctors suspect a virus is involved. Problems with the way an individual's immune system functions may also contribute to the development of the condition. There are 2 main forms of Castleman's disease: localized (discussed here) and multicentric. They affect people very differently. Localized or unicentric Castleman's disease only affects a single set of lymph nodes and is not widespread. The lymph nodes that are more commonly affected are in the chest and abdomen. Castleman’s disease causes the lymph nodes to get larger. The enlarged lymph nodes press on other organs and tissues inside the chest or abdomen, causing discomfort or difficulty breathing. Sometimes the enlarged lymph nodes are in places such as the neck, groin, or armpit and can be easily felt. People with localized Castleman's disease are often cured when the lymph node is removed with surgery. Chemotherapy and radiation may also be used. Please talk with your doctor about the most current treatment options if you or a family member has been diagnosed with Castleman's disease. See also Multicentric Castleman’s disease.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Castleman's Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Castleman's Disease" returned 227 free, full-text research articles on human participants. First 3 results:

A case of abdominal mesenteric Castleman's disease with left renal cell carcinoma and stomach leiomyoma.
 

Author(s): Shunjun Chen, Lele Song, Xinli Xie, Xingmin Han, Bing Cheng

Journal: Hell J Nucl Med. ;19(3):285-288.

 

A rare case of abdominal mesenteric Castleman's disease with left renal cell carcinoma and stomach leiomyoma is reported. A 57 years old male patient was transferred to our hospital for investigation of a left kidney tumor. Physical examination and routine laboratory tests were normal. ...

Last Updated: 21 Dec 2016

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Laparoscopic treatment of Castleman's disease in a patient with a history of malignant Brenner tumor.
 

Author(s): Won Moo Lee, Joong Sub Choi, Jaeman Bae, Un Suk Jung, Bo-Kyeong Kang

Journal: Taiwan J Obstet Gynecol. 2016 Oct;55(5):754-756.

 

Last Updated: 18 Oct 2016

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Recurrent corneal melting in the paraneoplastic pemphigus associated with Castleman's disease.
 

Author(s): Haijun Gong, Shiyou Zhou, Yuxin Hu, Yuqin Lan, Hong Zeng, Liangchun Wang, Qingyu Liu, Mei Wang

Journal:

 

The ocular presentation of Castleman's disease (CD)-associated paraneoplastic pemphigus (PNP) has rarely been reported. In this report, we describe a young patient with CD-associated PNP who had recurrent corneal ulceration in addition to cicatrizing conjunctivitis.

Last Updated: 13 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Castleman's Disease" returned 29 free, full-text review articles on human participants. First 3 results:

Laparoscopic treatment of abdominal unicentric castleman's disease: a case report and literature review.
 

Author(s): Umberto Bracale, Francesco Pacelli, Marco Milone, Umberto Marcello Bracale, Maurizio Sodo, Giovanni Merola, Teresa Troiani, Enrico Di Salvo

Journal:

 

Castleman's disease is a rare lymphoproliferative disorder of unknown etiology that most commonly presents as a mediastinal nodal mass. It is exceptionally uncommon for Castleman's disease to present in the mesentery and, only 53 cases have ever been described in the literature. Standard ...

Last Updated: 13 Apr 2017

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Pathogenesis of Castleman's Disease.
 

Author(s): Lu Zhang, Jian Li

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016 Feb;38(1):118-21.

 

Castleman's disease (CD) is a rare lymphoproliferative disorder that comprises at least two distinct clinical subtypes (unicentric and multicentric). Three pathologic variants (hyaline vascular variant, plasma cell variant, and mixed variant) have been recognized. In addition to interleukin-6 ...

Last Updated: 9 Mar 2016

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[Hyaline-vascular Multicentric Castleman's Disease in an immunocompetent patient].
 

Author(s): Sergio Armando Zapata-Bonilla, Roberto López Vargas, Aldo Alfonso Scherling-Ocampo, Ana Lilia Morales Leyte, Liliana García Ilizaliturri

Journal: Gac Med Mex. ;151(5):648-54.

 

A previously healthy, immunocompetent 67-year-old female presented with a one-month history of general symptoms, weight loss, night fevers, and bilateral lower extremity edema. On admission she had severe anemia, acute kidney injury, and multiple lymphadenopathies. An excisional biopsy ...

Last Updated: 3 Nov 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tocilizumab for KSHV-Associated Multicentric Castleman Disease
 

Status: Recruiting

Condition Summary: Castleman Disease; Castleman's Disease; Giant Lymph Node Hyperplasia

 

Last Updated: 30 Jun 2017

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TCP Regimen in Newly Diagnosed MCD:a Prospective, Single-center, Single-arm, Phase-II Pilot Trial
 

Status: Recruiting

Condition Summary: Multicentric Castleman Disease

 

Last Updated: 3 Feb 2017

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Unlock the Cell: Castleman's Disease Flow Cytometry Study
 

Status: Recruiting

Condition Summary: Castleman Disease; Angiofollicular Lymphoid Hyperplasia; GLNH; Hyperplasia; Castleman's Disease; Angiofollicular Lymph Hyperplasia; Giant Lymph Node Hyperplasia

 

Last Updated: 26 Jun 2017

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