Carotid body tumor

Common Name(s)

Carotid body tumor

A carotid body tumor, also known as a chemodectoma or paraganglioma, is a tumor found in the upper neck where the two cartoid arteries branch off. There are three types of CBT's, sporadic, familial and hyperplastic. Sporadic CBTs are most common representing roughly 85% of all CBT cases. Familial CBTs are more common in younger children, and hyperplastic CBTs are typically found in people living in high altitude environments, such as New Mexico or Colorado. Carotid body tumors can be found in children, but the average age of onset is 45 years old. CBTs do not usually initially present with any symptoms other than being a physical mass on the neck. As the tumor grows and pushes against the carotid artery and surrounding nerves, other symptoms may occur, such as pain, a weak tongue or less ability to move the tongue, hoarseness, difficulty swallowing, and Horner syndrome (for more information see Horner syndrome.). Although most carotid body tumors are not fatal, some can be locally aggressive, so it is recommended that they are removed. Surgical removal of the tumor is sometimes followed by radiation therapy. Treatment for carotid body tumors is generally very safe, and outcomes are typically very successful.

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Condition Specific Organizations

Following organizations serve the condition "Carotid body tumor" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Carotid body tumor" returned 45 free, full-text research articles on human participants. First 3 results:

Carotid Body Tumor as a Cause of Stroke.
 

Author(s): Hrvoje Budincevic, Ana Piršic, Tihana Bohm, Tomislav Trajbar, Ante Ivkošic, Tomislav Pavlovic, Ivan Bielen, Silva Soldo-Butkovic

Journal: Intern. Med.. 2016 ;55(3):295-8.

 

We herein report a case of a 78-year-old woman who was admitted to our hospital due to a stroke with left-sided hemiparesis. Ultrasound of the carotid arteries showed a carotid body tumor on the bifurcation of the right common carotid artery, which was subsequently confirmed by a ...

Last Updated: 2 Feb 2016

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Effects of carotid body tumor resection on the blood pressure of essential hypertensive patients.
 

Author(s): Marat Fudim, Kelly L Groom, Cheryl L Laffer, James L Netterville, David Robertson, Fernando Elijovich

Journal: J Am Soc Hypertens. 2015 Jun;9(6):435-42.

 

Removal of carotid body (CB) improves animal models of hypertension (HTN) and heart failure, via withdrawal of chemoreflex-induced sympathetic activation. Effect of CB tumor (CBT) resection on blood pressure (BP) in subjects with HTN is unknown. A retrospective analysis of 20 subjects ...

Last Updated: 8 Jun 2015

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Sleep-mediated heart rate variability after bilateral carotid body tumor resection.
 

Author(s): Nicolasine D Niemeijer, Eleonora P M Corssmit, Robert H A M Reijntjes, Gert Jan Lammers, J Gert van Dijk, Roland D Thijs

Journal:

 

The carotid bodies are thought to play an important role in sleep-dependent autonomic changes. Patients who underwent resection of bilateral carotid body tumors have chronically attenuated baroreflex sensitivity. These subjects provide a unique opportunity to investigate the role ...

Last Updated: 7 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Carotid body tumor" returned 5 free, full-text review articles on human participants. First 3 results:

Case of spontaneous regression of carotid body tumor in a SDHD mutant: a discussion on potential mechanisms based on a review of the literature.
 

Author(s): Sebastiaan Hammer, Jeroen C Jansen, Eleonora P M van der Kleij-Corssmit, Frederik J Hes, Mark C Kruit

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Head and neck paragangliomas are tumors associated with the parasympathetic nerve system and typically show an indolent growth pattern. Therefore a conservative management strategy is considered in selected cases.

Last Updated: 19 Nov 2012

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A rare case of familial carotid body tumor in a patient with bilateral fibromuscular dysplasia.
 

Author(s): Daniel K Han, Eric W Fishman, Maggie H Walkup, Jeffrey W Olin, Michael L Marin, Peter L Faries

Journal: J. Vasc. Surg.. 2010 Sep;52(3):746-50.

 

Carotid body tumors (CBTs) are neuroendocrine tumors that arise due to mutations of respiratory cycle enzymes. Fibromuscular dysplasia (FMD) is a disease that causes narrowing of medium-sized arteries. There is no documented link between CBT and FMD. In this article, we report a case ...

Last Updated: 6 Sep 2010

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Paraganglioma: carotid body tumor.
 

Author(s): Jacqueline A Wieneke, Alice Smith

Journal: Head Neck Pathol. 2009 Dec;3(4):303-6.

 

Last Updated: 2 Jul 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytoma
 

Status: Recruiting

Condition Summary: Paraganglioma; Pheochromocytoma

 

Last Updated: 21 Jun 2016

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131-I-MIBG Therapy for Refractory Neuroblastoma and Metastatic Paraganglioma/Pheochromocytoma
 

Status: Available

Condition Summary: Neuroblastoma; Childhood Metastatic Pheochromocytoma; Paraganglioma

 

Last Updated: 16 May 2016

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Expanded Access Protocol Using 131I-MIBG Therapy for Refractory Neuroblastoma, Pheochromocytoma, or Paraganglioma
 

Status: Available

Condition Summary: Neuroblastoma; Pheochromocytoma; Paraganglioma

 

Last Updated: 26 Aug 2016

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