Carney Complex

Common Name(s)

Carney Complex

Carney complex is a hereditary cancer syndrome characterized by spotty skin pigmentation, cardiac (heart) myxomas (tumors composed of mucous connective tissue), skin myxomas, and endocrine gland tumors. Some families with this condition have been found to have mutations in the PRKAR1A gene. Carney syndrome is believed to be inherited in an autosomal dominant manner, which means that an affected parent has a 50% chance of passing on the affected gene to each of his/her children.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Carney Complex" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Carney Complex" returned 63 free, full-text research articles on human participants. First 3 results:

Functional Characterization of PRKAR1A Mutations Reveals a Unique Molecular Mechanism Causing Acrodysostosis but Multiple Mechanisms Causing Carney Complex.
 

Author(s): Yara Rhayem, Catherine Le Stunff, Waed Abdel Khalek, Colette Auzan, Jerome Bertherat, Agn├Ęs Linglart, Alain Couvineau, Caroline Silve, Eric Clauser

Journal: J. Biol. Chem.. 2015 Nov;290(46):27816-28.

 

The main target of cAMP is PKA, the main regulatory subunit of which (PRKAR1A) presents mutations in two genetic disorders: acrodysostosis and Carney complex. In addition to the initial recurrent mutation (R368X) of the PRKAR1A gene, several missense and nonsense mutations have been ...

Last Updated: 14 Nov 2015

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A novel PRKAR1A mutation resulting in a splicing variant in a case of Carney complex.
 

Author(s): Yi Sun Jang, Sung Dae Moon, Ju Hee Kim, Ihn Suk Lee, Jong Min Lee, Hye Soo Kim

Journal: Korean J. Intern. Med.. 2015 Sep;30(5):730-4.

 

Last Updated: 10 Sep 2015

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Psammomatous melanotic schwannoma as a component of Carney complex.
 

Author(s): Salapathi Shanmugam, Mitra Ghosh, Sadiya Niamathullah, Siddhartha Ghosh

Journal: Indian J Pathol Microbiol. ;58(3):368-70.

 

Melanotic schwannoma is a rare form of pigmented neural tumor commonly arising from the posterior spinal nerves and ganglia. Two variants have been described, psammomatous and nonpsammomatous. 50% of psammomatous tumors are associated with Carney complex. The biologic behavior of ...

Last Updated: 15 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Carney Complex" returned 15 free, full-text review articles on human participants. First 3 results:

Carney complex: an update.
 

Author(s): Ricardo Correa, Paraskevi Salpea, Constantine A Stratakis

Journal: Eur. J. Endocrinol.. 2015 Oct;173(4):M85-97.

 

Carney complex (CNC) is a rare autosomal dominant syndrome, characterized by pigmented lesions of the skin and mucosa, cardiac, cutaneous and other myxomas and multiple endocrine tumors. The disease is caused by inactivating mutations or large deletions of the PRKAR1A gene located ...

Last Updated: 28 Aug 2015

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MEN1, MEN4, and Carney Complex: Pathology and Molecular Genetics.
 

Author(s): Marie Helene Schernthaner-Reiter, Giampaolo Trivellin, Constantine A Stratakis

Journal: Neuroendocrinology. 2016 ;103(1):18-31.

 

Pituitary adenomas are a common feature of a subset of endocrine neoplasia syndromes, which have otherwise highly variable disease manifestations. We provide here a review of the clinical features and human molecular genetics of multiple endocrine neoplasia (MEN) type 1 and 4 (MEN1 ...

Last Updated: 9 Feb 2016

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Carney complex and McCune Albright syndrome: an overview of clinical manifestations and human molecular genetics.
 

Author(s): Paraskevi Salpea, Constantine A Stratakis

Journal: Mol. Cell. Endocrinol.. 2014 Apr;386(1-2):85-91.

 

Endocrine neoplasia syndromes feature a wide spectrum of benign and malignant tumors of endocrine and non-endocrine organs associated with other clinical manifestations. This study outlines the main clinical features, genetic basis, and molecular mechanisms behind two multiple endocrine ...

Last Updated: 3 Mar 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
 

Status: Recruiting

Condition Summary: Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm

 

Last Updated: 30 Sep 2016

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