Carney Complex

Common Name(s)

Carney Complex

Carney complex is a hereditary cancer syndrome characterized by spotty skin pigmentation, cardiac (heart) myxomas (tumors composed of mucous connective tissue), skin myxomas, and endocrine gland tumors. Some families with this condition have been found to have mutations in the PRKAR1A gene. Carney syndrome is believed to be inherited in an autosomal dominant manner, which means that an affected parent has a 50% chance of passing on the affected gene to each of his/her children.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Carney Complex" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Carney Complex" returned 51 free, full-text research articles on human participants. First 3 results:

Cutaneous myxoma: an important clue to Carney complex.
 

Author(s): Dhaneshwar N Lanjewar, Varsha O Bhatia, Sonali D Lanjewar, J Aidan Carney

Journal: Indian J Pathol Microbiol. ;57(3):460-2.

 

A 22-year-old male became unconscious and was found to have left-sided weakness and facial asymmetry. Previously, he had up to 35 excisions for subcutaneous swellings all over the body, commencing at age 6 years. Examination revealed small nodular skin lesions on the neck, the eyelid ...

Last Updated: 14 Aug 2014

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Recurrent right ventricular cardiac myxoma in a patient with Carney complex: a case report.
 

Author(s): Muhammad Rizwan Sardar, Ankush Lahoti, Amanulla Khaji, Wajeeha Saeed, Khawar Maqsood, Harry G Zegel, Jeanine E Romanelli, Frank C McGeehin

Journal:

 

Carney complex is a multiple neoplasia syndrome involving cardiac, endocrine, neural and cutaneous tumors with a variety of pigmented skin lesions. It has an autosomal dominant mode of inheritance. Approximately 7% of cardiac myxomas are related to the Carney complex. Myxomas that ...

Last Updated: 4 Jun 2014

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PRKACB and Carney complex.
 

Author(s): Antonella Forlino, Annalisa Vetro, Livia Garavelli, Roberto Ciccone, Edra London, Constantine A Stratakis, Orsetta Zuffardi

Journal: N. Engl. J. Med.. 2014 Mar;370(11):1065-7.

 

Last Updated: 13 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Carney Complex" returned 12 free, full-text review articles on human participants. First 3 results:

Carney complex and McCune Albright syndrome: an overview of clinical manifestations and human molecular genetics.
 

Author(s): Paraskevi Salpea, Constantine A Stratakis

Journal: Mol. Cell. Endocrinol.. 2014 Apr;386(1-2):85-91.

 

Endocrine neoplasia syndromes feature a wide spectrum of benign and malignant tumors of endocrine and non-endocrine organs associated with other clinical manifestations. This study outlines the main clinical features, genetic basis, and molecular mechanisms behind two multiple endocrine ...

Last Updated: 3 Mar 2014

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Genetic predisposition to peripheral nerve neoplasia: diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes.
 

Author(s): Fausto J Rodriguez, Constantine A Stratakis, D Gareth Evans

Journal: Acta Neuropathol.. 2012 Mar;123(3):349-67.

 

Neoplasms of the peripheral nerve sheath represent essential clinical manifestations of the syndromes known as the neurofibromatoses. Although involvement of multiple organ systems, including skin, central nervous system, and skeleton, may also be conspicuous, peripheral nerve neoplasia ...

Last Updated: 21 Feb 2012

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Carney complex and lentiginosis.
 

Author(s): Anelia Horvath, Constantine A Stratakis

Journal: Pigment Cell Melanoma Res. 2009 Oct;22(5):580-7.

 

Initially described as the 'complex of myxomas, spotty skin pigmentation and endocrine overactivity,' Carney complex (CNC) is known as an autosomal dominant multiple neoplasia syndrome involving skin and cardiac myxomas, pigmented skin lesions and endocrine tumors. Pigmented cutaneous ...

Last Updated: 28 Aug 2009

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
 

Status: Recruiting

Condition Summary: Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm

 

Last Updated: 28 Jan 2015

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