Cardiomyopathy

Common Name(s)

Cardiomyopathy

Cardiomyopathy refers to group of conditions affecting the heart muscle, which cause the heart to become enlarged, thick and/or rigid. There are many different causes for cardiomyopathy including certain infections, exposure to toxic chemicals, and autoimmune conditions, where the body’s defense system actually attacks itself. As cardiomyopathy worsens, the heart muscle becomes weaker and is less able to pump blood through the body and maintain its rhythm. This can lead to heart failure, a condition where the heart tires out. Some may experience no symptoms and need no treatment, while, for others, cardiomyopathy may develop quickly with severe symptoms and serious complications. Typical symptoms of cardiomyopathy include breathlessness, swelling of the legs, bloating, cough, fatigue, dizziness and irregular heartbeats. A physician can diagnose cardiomyopathy using imaging tests, stress tests, blood tests or biopsy, where a needle is used to take out heart tissue to look at under a microscope. Treatment varies by type of cardiomyopathy, but commonly medications are used to manage symptoms. If the heart is badly damaged, certain more invasive procedures and surgeries may be needed to repair or replace the heart.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

Last Updated: 29 May 2015

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Cardiomyopathy Association

The Cardiomyopathy Association is a charity that provides information and support to families affected by the heart muscle disease cardiomyopathy. The charity helps families through cardiomyopathy support nurses, information days, support groups and a network of affected volunteers who provide support to others by telephone and email. It also has an extensive website (www.cardiomyopathy.org) with details about the condition, treatments, living with the disease, and latest research.

Last Updated: 15 Mar 2013

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Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

Last Updated: 20 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

https://www.barthsyndrome.org

Last Updated: 29 May 2015

View Details
Cardiomyopathy Association

The Cardiomyopathy Association is a charity that provides information and support to families affected by the heart muscle disease cardiomyopathy. The charity helps families through cardiomyopathy support nurses, information days, support groups and a network of affected volunteers who provide support to others by telephone and email. It also has an extensive website (www.cardiomyopathy.org) with details about the condition, treatments, living with the disease, and latest research.

http://www.cardiomyopathy.org

Last Updated: 15 Mar 2013

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Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

http://www.childrenscardiomyopathy.org

Last Updated: 20 Jul 2015

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General Resources

CCF General Brochure

This brochure is an introduction to the Children's Cardiomyopathy Foundation, including a brief history of the organization and descriptions of the foundation's work.

Updated 18 Oct 2012

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CCF Educational Materials

A link to the various educational materials CCF offers for families and professionals.

Updated 18 Oct 2012

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CCF Patient Resource Overview

An overview of the patient resources CCF has to offer.

Updated 22 Oct 2012

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CCF Awarded Research Grants

A description of the types of projects CCF funds to promote scientific knowledge related to the treatment and cure of pediatric cardiomyopathy.

Updated 22 Oct 2012

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CCF Research Grant Program Overview.

CCF Research Grant Program Overview.

Updated 22 Oct 2012

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Barth Syndrome Professional Healthcare Brochure

Important information regarding diagnosis and treatment of Barth syndrome.

Updated 12 Apr 2014

Open Doc
2014 Conference Program

2014 Conference Program

Updated 14 Jan 2015

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How to Diagnose

How to diagnose Barth syndrome

Updated 14 Jan 2015

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Overview of Barth syndrome

Overview of Barth syndrome

Updated 14 Jan 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cardiomyopathy" returned 5009 free, full-text research articles on human participants. First 3 results:

A study in Polish patients with cardiomyopathy emphasizes pathogenicity of phospholamban (PLN) mutations at amino acid position 9 and low penetrance of heterozygous null PLN mutations.
 

Author(s): Grażyna T Truszkowska, Zofia T Bilińska, Joanna Kosińska, Justyna Śleszycka, Małgorzata Rydzanicz, Małgorzata Sobieszczańska-Małek, Maria Franaszczyk, Maria Bilińska, Piotr Stawiński, Ewa Michalak, Łukasz A Małek, Przemysław Chmielewski, Bogna Foss-Nieradko, Marcin M Machnicki, Tomasz Stokłosa, Joanna Ponińska, Łukasz Szumowski, Jacek Grzybowski, Jerzy Piwoński, Wojciech Drygas, Tomasz Zieliński, Rafał Płoski

Journal:

 

In humans mutations in the PLN gene, encoding phospholamban - a regulator of sarcoplasmic reticulum calcium ATPase (SERCA), cause cardiomyopathy with prevalence depending on the population. Our purpose was to identify PLN mutations in Polish cardiomyopathy patients.

Last Updated: 1 May 2015

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Concurrent early-onset peripartum cardiomyopathy in a preeclampsia patient with acute pulmonary edema.
 

Author(s): Erdal Belen, Fahri Fatih Tipi, Aysen Helvaci, Akif Bayyigit

Journal: Intern. Med.. 2015 ;54(8):925-7.

 

We herein report the case of a preeclampsia patient with comorbid peripartum cardiomyopathy (PPCMP). A 22-year-old woman in the 26th week of gestation was admitted with acute pulmonary edema. Hypertension and proteinuria were detected, and echocardiography showed an ejection fraction ...

Last Updated: 16 Apr 2015

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Prognostic impact of blood pressure response plus gadolinium enhancement in dilated cardiomyopathy.
 

Author(s): Emi Tateishi, Teruo Noguchi, Yoichi Goto, Yoshiaki Morita, Hatsue Ishibashi-Ueda, Naoaki Yamada, Hideaki Kanzaki, Kunihiro Nishimura, Yoshihiro Miyamoto, Toshihisa Anzai, Hisao Ogawa, Satoshi Yasuda

Journal: Heart. 2015 May;101(10):774-80.

 

Late gadolinium enhancement (LGE) is not necessarily ideal for detecting diffuse myocardial fibrosis in idiopathic dilated cardiomyopathy (DCM). Since systolic blood pressure response (SBPR) during exercise has been proposed to reflect cardiac pump reserve in patients with heart failure, ...

Last Updated: 27 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cardiomyopathy" returned 454 free, full-text review articles on human participants. First 3 results:

Cardiomyopathy induced by artificial cardiac pacing: myth or reality sustained by evidence?
 

Author(s): Andrés Di Leoni Ferrari, Anibal Pires Borges, Luciano Cabral Albuquerque, Carolina Pelzer Sussenbach, Priscila Raupp da Rosa, Ricardo Medeiros Piantá, Mario Wiehe, Marco Antônio Goldani

Journal: Rev Bras Cir Cardiovasc. ;29(3):402-13.

 

Implantable cardiac pacing systems are a safe and effective treatment for symptomatic irreversible bradycardia. Under the proper indications, cardiac pacing might bring significant clinical benefit. Evidences from literature state that the action of the artificial pacing system, mainly ...

Last Updated: 6 Nov 2014

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The role of cardiotonic steroids in the pathogenesis of cardiomyopathy in chronic kidney disease.
 

Author(s): Davor Pavlovic

Journal: Nephron Clin Pract. 2014 ;128(1-2):11-21.

 

Cardiotonic steroids (CTS) are a new class of hormones that circulate in the blood and are divided into two distinct groups, cardenolides, such as ouabain and digoxin, and bufadienolides, such as marinobufagenin, telocinobufagin and bufalin. They have the ability to bind and inhibit ...

Last Updated: 23 Dec 2014

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Pathophysiological and clinical approach to cirrhotic cardiomyopathy.
 

Author(s): Alida Páll, Arpád Czifra, Zsuzsanna Vitális, Mária Papp, György Paragh, Zoltán Szabó

Journal: J Gastrointestin Liver Dis. 2014 Sep;23(3):301-10.

 

Hyperdynamic circulation, systolic and diastolic left ventricular dysfunction and certain electrophysiological abnormalities have been associated with cirrhosis and known for a long time. These clinical features have been introduced as cirrhotic cardiomyopathy (CCM), which is characterized ...

Last Updated: 30 Sep 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pediatric Cardiomyopathy Mutation Analysis
 

Status: Recruiting

Condition Summary: Cardiomyopathies; Dilated Cardiomyopathy; Hypertrophic Cardiomyopathy; Restrictive Cardiomyopathy; Arrhythmogenic Right Ventricular Cardiomyopathy; Left Ventricular Non-compaction Cardiomyopathy

 

Last Updated: 28 Apr 2015

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Registry and Survey of Women With Pregnancy Related Cardiomyopathy
 

Status: Recruiting

Condition Summary: Cardiomyopathy; Pregnancy-Associated Cardiomyopathy; Heart Failure

 

Last Updated: 25 May 2006

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Genotype-Phenotype Associations in Pediatric Cardiomyopathy (PCM GENES)
 

Status: Recruiting

Condition Summary: Dilated Cardiomyopathy; Hypertrophic Cardiomyopathy; Restrictive Cardiomyopathy

 

Last Updated: 5 May 2014

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