Cardiomyopathy

Common Name(s)

Cardiomyopathy

Cardiomyopathy refers to group of conditions affecting the heart muscle, which cause the heart to become enlarged, thick and/or rigid. There are many different causes for cardiomyopathy including certain infections, exposure to toxic chemicals, and autoimmune conditions, where the body’s defense system actually attacks itself. As cardiomyopathy worsens, the heart muscle becomes weaker and is less able to pump blood through the body and maintain its rhythm. This can lead to heart failure, a condition where the heart tires out. Some may experience no symptoms and need no treatment, while, for others, cardiomyopathy may develop quickly with severe symptoms and serious complications. Typical symptoms of cardiomyopathy include breathlessness, swelling of the legs, bloating, cough, fatigue, dizziness and irregular heartbeats. A physician can diagnose cardiomyopathy using imaging tests, stress tests, blood tests or biopsy, where a needle is used to take out heart tissue to look at under a microscope. Treatment varies by type of cardiomyopathy, but commonly medications are used to manage symptoms. If the heart is badly damaged, certain more invasive procedures and surgeries may be needed to repair or replace the heart.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

Last Updated: 12 Apr 2014

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Cardiomyopathy Association

The Cardiomyopathy Association is a charity that provides information and support to families affected by the heart muscle disease cardiomyopathy. The charity helps families through cardiomyopathy support nurses, information days, support groups and a network of affected volunteers who provide support to others by telephone and email. It also has an extensive website (www.cardiomyopathy.org) with details about the condition, treatments, living with the disease, and latest research.

Last Updated: 15 Mar 2013

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Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

Last Updated: 20 May 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

http://www.barthsyndrome.org

Last Updated: 12 Apr 2014

View Details
Cardiomyopathy Association

The Cardiomyopathy Association is a charity that provides information and support to families affected by the heart muscle disease cardiomyopathy. The charity helps families through cardiomyopathy support nurses, information days, support groups and a network of affected volunteers who provide support to others by telephone and email. It also has an extensive website (www.cardiomyopathy.org) with details about the condition, treatments, living with the disease, and latest research.

http://www.cardiomyopathy.org

Last Updated: 15 Mar 2013

View Details
Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

http://www.childrenscardiomyopathy.org

Last Updated: 20 May 2014

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General Support Organizations

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General Resources

CCF General Brochure

This brochure is an introduction to the Children's Cardiomyopathy Foundation, including a brief history of the organization and descriptions of the foundation's work.

Updated 18 Oct 2012

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CCF Educational Materials

A link to the various educational materials CCF offers for families and professionals.

Updated 18 Oct 2012

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CCF Patient Resource Overview

An overview of the patient resources CCF has to offer.

Updated 22 Oct 2012

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CCF Awarded Research Grants

A description of the types of projects CCF funds to promote scientific knowledge related to the treatment and cure of pediatric cardiomyopathy.

Updated 22 Oct 2012

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CCF Research Grant Program Overview.

CCF Research Grant Program Overview.

Updated 22 Oct 2012

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2012 Conference Program

Barth Syndrome Foundation 2012 Conference Program

Updated 2 Nov 2012

Open Doc
Barth Syndrome Professional Healthcare Brochure

Important information regarding diagnosis and treatment of Barth syndrome.

Updated 12 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cardiomyopathy" returned 4686 free, full-text research articles on human participants. First 3 results:

Seroprevalence of T. cruzi infection in blood donors and Chagas cardiomyopathy in patients from the coal mining region of Coahuila, Mexico.
 

Author(s): José Gerardo Martínez-Tovar, Eduardo A Rebollar-Téllez, Ildefonso Fernández Salas

Journal: Rev. Inst. Med. Trop. Sao Paulo. ;56(2):169-74.

 

Chagas disease is considered a worldwide emerging disease; it is endemic in Mexico and the state of Coahuila and is considered of little relevance. The objective of this study was to determine the seroprevalence of T. cruzi infection in blood donors and Chagas cardiomyopathy in patients ...

Last Updated: 14 Mar 2014

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D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.
 

Author(s): Esra A Akbay, Javid Moslehi, Camilla L Christensen, Supriya Saha, Jeremy H Tchaicha, Shakti H Ramkissoon, Kelly M Stewart, Julian Carretero, Eiki Kikuchi, Haikuo Zhang, Travis J Cohoon, Stuart Murray, Wei Liu, Kazumasa Uno, Sudeshna Fisch, Kristen Jones, Sushma Gurumurthy, Camelia Gliser, Sung Choe, Marie Keenan, Jaekyoung Son, Illana Stanley, Julie A Losman, Robert Padera, Roderick T Bronson, John M Asara, Omar Abdel-Wahab, Philip C Amrein, Amir T Fathi, Nika N Danial, Alec C Kimmelman, Andrew L Kung, Keith L Ligon, Katharine E Yen, William G Kaelin, Nabeel Bardeesy, Kwok-Kin Wong

Journal: Genes Dev.. 2014 Mar;28(5):479-90.

 

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) have been discovered in several cancer types and cause the neurometabolic syndrome D2-hydroxyglutaric aciduria (D2HGA). The mutant enzymes exhibit neomorphic activity resulting in production of D2-hydroxyglutaric acid (D-2HG). ...

Last Updated: 4 Mar 2014

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Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome.
 

Author(s): Jason R Cook, Luca Carta, Ludovic Bénard, Elie R Chemaly, Emily Chiu, Satish K Rao, Thomas G Hampton, Peter Yurchenco, , Kevin D Costa, Roger J Hajjar, Francesco Ramirez

Journal: J. Clin. Invest.. 2014 Mar;124(3):1329-39.

 

Patients with Marfan syndrome (MFS), a multisystem disorder caused by mutations in the gene encoding the extracellular matrix (ECM) protein fibrillin 1, are unusually vulnerable to stress-induced cardiac dysfunction. The prevailing view is that MFS-associated cardiac dysfunction is ...

Last Updated: 4 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cardiomyopathy" returned 420 free, full-text review articles on human participants. First 3 results:

Capecitabine induces both cardiomyopathy and multifocal cerebral leukoencephalopathy.
 

Author(s): Akihiro Endo, Yasuyuki Yoshida, Ryuma Nakashima, Nobuyuki Takahashi, Kazuaki Tanabe

Journal: Int Heart J. 2013 ;54(6):417-20.

 

Chemotherapy for malignant tumors has diversified, and recognizing its side effects has become more important than ever. Both cardiotoxicity and neurotoxicity are rare, but they are among the most serious side effects caused by 5-fluorouracil (5-FU). Capecitabine is an orally administered ...

Last Updated: 6 Dec 2013

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Alteration of energy substrates and ROS production in diabetic cardiomyopathy.
 

Author(s): O Lorenzo, E Ramírez, B Picatoste, J Egido, J Tuñón

Journal: Mediators Inflamm.. 2013 ;2013():461967.

 

Diabetic cardiomyopathy is initiated by alterations in energy substrates. Despite excess of plasma glucose and lipids, the diabetic heart almost exclusively depends on fatty acid degradation. Glycolytic enzymes and transporters are impaired by fatty acid metabolism, leading to accumulation ...

Last Updated: 29 Nov 2013

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Taking diabetes to heart--deregulation of myocardial lipid metabolism in diabetic cardiomyopathy.
 

Author(s): Marina Bayeva, Konrad Teodor Sawicki, Hossein Ardehali

Journal:

 

Last Updated: 26 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genotype-Phenotype Associations in Pediatric Cardiomyopathy (PCM GENES)
 

Status: Recruiting

Condition Summary: Dilated Cardiomyopathy; Hypertrophic Cardiomyopathy; Restrictive Cardiomyopathy

 

Last Updated: 5 May 2014

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Effects of Continous Positive Airway Pressure (CPAP) in Hypertrophic Cardiomyopathy
 

Status: Recruiting

Condition Summary: Non-obstructive Hypertrophic Cardiomyopathy; Obstructive Hypertrophic Cardiomyopathy

 

Last Updated: 27 Jun 2012

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Virtual LV Lead Navigation in Patients With Ischemic Cardiomyopathy
 

Status: Recruiting

Condition Summary: Cardiomyopathy; Ischemic Cardiomyopathy

 

Last Updated: 10 Dec 2013

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