Squamous cell carcinoma

Common Name(s)

Squamous cell carcinoma

Squamous cell carcinoma is a type of cancer that develops in a type of flat-shaped cell that lines the skin and other organs. The most common location where squamous cell carcinoma develops is the skin, usually in areas that are frequently exposed to sunlight. Although less common, squamous cell carcinoma can also grow on the lips, in the mouth, or in the lungs. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis).

Squamous cell carcinoma most commonly occurs in adults between the ages of 40 and 60, although it can be found in all age groups. Factors that increase the risk of developing squamous cell carcinoma include prolonged exposure to ultraviolet (UV) light and fair skin. Having an organ transplant can also increase the risk of developing squamous cell carcinoma, as medications taken after surgery can decrease the body’s ability to protect itself from damage.

The most common symptoms of squamous cell carcinoma of the skin include scaly, red skin patches and unexplained bleeding in areas affected by tumor growth. Other signs include the formation of white ulcers in the mouth and sun-exposed areas. Diagnosis is usually made with a combination of a physical exam, imaging studies, blood tests, and other laboratory studies. Diagnosis may require a doctor to take a biopsy, or sample, of the tissue to look at under a microscope in order to determine if the cells are growing in an abnormal way.

Treatment for squamous cell carcinoma depends on many factors such as how large the cancer is and if it has spread to other areas of the body. If you or a family member has been diagnosed with squamous cell carcinoma, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Squamous cell carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Squamous cell carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Squamous cell carcinoma" returned 6855 free, full-text research articles on human participants. First 3 results:

Biomarker MicroRNAs for Diagnosis of Oral Squamous Cell Carcinoma Identified Based on Gene Expression Data and MicroRNA-mRNA Network Analysis.
 

Author(s): Hui Zhang, Tangxin Li, Linqing Zheng, Xiangya Huang

Journal: Comput Math Methods Med. 2017 ;2017():9803018.

 

Oral squamous cell carcinoma is one of the most malignant tumors with high mortality rate worldwide. Biomarker discovery is critical for early diagnosis and precision treatment of this disease. MicroRNAs are small noncoding RNA molecules which often regulate essential biological processes ...

Last Updated: 3 Nov 2017

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Epstein-Barr virus infection and oral squamous cell carcinoma risk: A meta-analysis.
 

Author(s): Yangyang She, Xiaolin Nong, Min Zhang, Menglin Wang

Journal:

 

The evidence for association between Epstein-Barr virus (EBV) infection and risk of oral squamous cell carcinoma (OSCC) is inconsistent in the literature. Therefore, this meta-analysis was conducted to clarify this association.

Last Updated: 24 Oct 2017

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Association between a miRNA-146a polymorphism and susceptibility to head and neck squamous cell carcinoma in Chinese patients: A meta-analysis of 8 case-control studies.
 

Author(s): Silin Zhang, Fangling Hu, Hongxing Liang, Yuanzhou Liu, Jianqiang Yang, Wensheng Zhou

Journal:

 

A closer association has been found between the microRNA-146a rs2910164 polymorphism and the risk of head and neck carcinoma in some molecular epidemiological studies. Recently two meta-analyses were performed to explore the relationship between miRNA-146a polymorphisms and the susceptibility ...

Last Updated: 19 Oct 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Squamous cell carcinoma" returned 377 free, full-text review articles on human participants. First 3 results:

A case report of tongue metastasis from lung squamous cell carcinoma and literature review.
 

Author(s): Xiaolong Cheng, Zhenli Hu, Yipin Han, Chong Bai

Journal: Medicine (Baltimore). 2017 Oct;96(40):e8208.

 

Tongue metastasis from lung cancer is extremely rare, and the prognosis of these patients is rather poor.

Last Updated: 6 Oct 2017

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Clinical and Incidental Perineural Invasion of Cutaneous Squamous Cell Carcinoma: A Systematic Review and Pooled Analysis of Outcomes Data.
 

Author(s): Pritesh S Karia, Frederick C Morgan, Emily Stamell Ruiz, Chrysalyne D Schmults

Journal: JAMA Dermatol. 2017 Aug;153(8):781-788.

 

Perineural invasion (PNI) in cutaneous squamous cell carcinoma (CSCC) has been associated with an increased risk of poor outcomes. Patients with PNI may present with clinical symptoms and/or radiologic evidence of PNI (clinical PNI [CPNI]), yet most patients are asymptomatic and PNI ...

Last Updated: 5 Jul 2017

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Survivin, a molecular target for therapeutic interventions in squamous cell carcinoma.
 

Author(s): Zakir Khan, Abdul Arif Khan, Hariom Yadav, Godavarthi B K S Prasad, Prakash Singh Bisen

Journal:

 

Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of locally advanced disease generally requires various combinations of radiotherapy, surgery, and systemic therapy. Despite aggressive multimodal treatment, most of the patients relapse. Identification ...

Last Updated: 24 May 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alpha Radiation Emitters Device for the Treatment of Squamous Cell Carcinoma
 

Status: Recruiting

Condition Summary: Squamous Cell Carcinoma

 

Last Updated: 20 Aug 2017

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PEmbrolizumab Combined With Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck
 

Status: Not yet recruiting

Condition Summary: Squamous Cell Carcinoma of the Head and Neck; Squamous Cell Carcinoma

 

Last Updated: 27 Jun 2016

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Immune Checkpoint Therapy With Nivolumab Esophageal Squamous Cell Carcinoma
 

Status: Recruiting

Condition Summary: Esophageal Squamous Cell Carcinoma

 

Last Updated: 1 Nov 2017

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