Squamous cell carcinoma

Common Name(s)

Squamous cell carcinoma

Squamous cell carcinoma is a type of cancer that develops in a type of flat-shaped cell that lines the skin and other organs. The most common location where squamous cell carcinoma develops is the skin, usually in areas that are frequently exposed to sunlight. Although less common, squamous cell carcinoma can also grow on the lips, in the mouth, or in the lungs. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis).

Squamous cell carcinoma most commonly occurs in adults between the ages of 40 and 60, although it can be found in all age groups. Factors that increase the risk of developing squamous cell carcinoma include prolonged exposure to ultraviolet (UV) light and fair skin. Having an organ transplant can also increase the risk of developing squamous cell carcinoma, as medications taken after surgery can decrease the body’s ability to protect itself from damage.

The most common symptoms of squamous cell carcinoma of the skin include scaly, red skin patches and unexplained bleeding in areas affected by tumor growth. Other signs include the formation of white ulcers in the mouth and sun-exposed areas. Diagnosis is usually made with a combination of a physical exam, imaging studies, blood tests, and other laboratory studies. Diagnosis may require a doctor to take a biopsy, or sample, of the tissue to look at under a microscope in order to determine if the cells are growing in an abnormal way.

Treatment for squamous cell carcinoma depends on many factors such as how large the cancer is and if it has spread to other areas of the body. If you or a family member has been diagnosed with squamous cell carcinoma, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Squamous cell carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Squamous cell carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Squamous cell carcinoma" returned 6627 free, full-text research articles on human participants. First 3 results:

Cardiac metastasis of tongue squamous cell carcinoma complicated by pulmonary embolism: A case report.
 

Author(s): Sonaz Malekzadeh, Alexandra Platon, Pierre-Alexandre Poletti

Journal: Medicine (Baltimore). 2017 Jul;96(28):e7462.

 

Cardiac metastasis is known as a rare complication of head and neck malignancy.

Last Updated: 12 Jul 2017

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Nivolumab-induced myasthenia gravis in a patient with squamous cell lung carcinoma: Case report.
 

Author(s): Yu-Hsiu Chen, Feng-Cheng Liu, Chang-Hung Hsu, Chih-Feng Chian

Journal: Medicine (Baltimore). 2017 Jul;96(27):e7350.

 

Nivolumab (Nivo) is an immune checkpoint inhibitor that has been used to treat advanced melanoma, nonsmall cell lung carcinoma, and renal cell carcinoma since 2015. Nivo is associated with several side effects, including hepatitis, pneumonitis, acute renal failure, endocrine disorder, ...

Last Updated: 6 Jul 2017

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A genome-wide association scan of biological processes involved in oral lichen planus and oral squamous cell carcinoma.
 

Author(s): Qiaozhen Yang, Beiyun Xu, Hongying Sun, Xiaxia Wang, Jie Zhang, Xuedi Yu, Xiaojuan Ma

Journal: Medicine (Baltimore). 2017 Jun;96(25):e7012.

 

In this study, the molecular mechanisms underlying malignant transformation from oral lichen planus (OLP) to oral squamous cell carcinoma (OSCC) were examined.

Last Updated: 22 Jun 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Squamous cell carcinoma" returned 362 free, full-text review articles on human participants. First 3 results:

Immunotherapy for Esophageal Squamous Cell Carcinoma.
 

Author(s): Takashi Kojima, Toshihiko Doi

Journal: Curr Oncol Rep. 2017 May;19(5):33.

 

Esophageal squamous cell carcinoma have been frustrating to treat, with slow progress made on extending survival. Immunotherapy targeting immune checkpoints, T cells, and infiltrating lymphocytes has shown promise in early studies. The efficacy of pembrolizumab and nivolumab is encouraging. ...

Last Updated: 31 Mar 2017

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Clinical value of monoclonal antibodies and tyrosine kinase inhibitors in the treatment of head and neck squamous cell carcinoma.
 

Author(s): Wiktoria Blaszczak, Wojciech Barczak, Anna Wegner, Wojciech Golusinski, Wiktoria Maria Suchorska

Journal: Med. Oncol.. 2017 Apr;34(4):60.

 

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of malignant tumours that affects over 500,000 patients per year. Treatment failure is generally due to the heterogeneity of these tumours and to the serious adverse effects associated with treatment. Immunological ...

Last Updated: 18 Mar 2017

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Endoscopic imaging modalities for diagnosing invasion depth of superficial esophageal squamous cell carcinoma: a systematic review and meta-analysis.
 

Author(s): Ryu Ishihara, Noriko Matsuura, Noboru Hanaoka, Sachiko Yamamoto, Tomofumi Akasaka, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Hiroyasu Iishi

Journal:

 

Diagnosis of cancer invasion depth is crucial for selecting the optimal treatment strategy in patients with gastrointestinal cancers. We conducted a meta-analysis to determine the utilities of different endoscopic modalities for diagnosing invasion depth of esophageal squamous cell carcinoma (SCC).

Last Updated: 3 Feb 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alpha Radiation Emitters Device for the Treatment of Squamous Cell Carcinoma
 

Status: Not yet recruiting

Condition Summary: Squamous Cell Carcinoma

 

Last Updated: 8 Jan 2017

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PEmbrolizumab Combined With Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck
 

Status: Not yet recruiting

Condition Summary: Squamous Cell Carcinoma of the Head and Neck; Squamous Cell Carcinoma

 

Last Updated: 27 Jun 2016

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Trial of Pembrolizumab for Advanced Penile Squamous Cell Carcinoma
 

Status: Recruiting

Condition Summary: Penile Squamous Cell Carcinoma

 

Last Updated: 22 Jun 2017

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