Squamous cell carcinoma

Common Name(s)

Squamous cell carcinoma

Squamous cell carcinoma is a type of cancer that develops in a type of flat-shaped cell that lines the skin and other organs. The most common location where squamous cell carcinoma develops is the skin, usually in areas that are frequently exposed to sunlight. Although less common, squamous cell carcinoma can also grow on the lips, in the mouth, or in the lungs. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis).

Squamous cell carcinoma most commonly occurs in adults between the ages of 40 and 60, although it can be found in all age groups. Factors that increase the risk of developing squamous cell carcinoma include prolonged exposure to ultraviolet (UV) light and fair skin. Having an organ transplant can also increase the risk of developing squamous cell carcinoma, as medications taken after surgery can decrease the body’s ability to protect itself from damage.

The most common symptoms of squamous cell carcinoma of the skin include scaly, red skin patches and unexplained bleeding in areas affected by tumor growth. Other signs include the formation of white ulcers in the mouth and sun-exposed areas. Diagnosis is usually made with a combination of a physical exam, imaging studies, blood tests, and other laboratory studies. Diagnosis may require a doctor to take a biopsy, or sample, of the tissue to look at under a microscope in order to determine if the cells are growing in an abnormal way.

Treatment for squamous cell carcinoma depends on many factors such as how large the cancer is and if it has spread to other areas of the body. If you or a family member has been diagnosed with squamous cell carcinoma, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Squamous cell carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Squamous cell carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Squamous cell carcinoma" returned 6740 free, full-text research articles on human participants. First 3 results:

Prognosis impact of clinical characteristics in patients with inoperable esophageal squamous cell carcinoma.
 

Author(s): Ying Yang, Jun Jia, Zhiwei Sun, Feng Du, Jing Yu, Chuanling Liu, Yanjie Xiao, Xiaodong Zhang

Journal:

 

Patients with inoperable esophageal squamous cell carcinoma (ESCC) were not homogeneous and their outcomes were widely divergent. There was a lack of identified clinical factors related to prognosis; and there were no previous studies constructing prognosis score to predict survival ...

Last Updated: 7 Aug 2017

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Risk factors of lymph node metastasis in lung squamous cell carcinoma of 3 cm or less in diameter.
 

Author(s): Lijian Huang, Wenshan Li, Lufeng Zhao, Baizhou Li, Ying Chai

Journal: Medicine (Baltimore). 2017 Jul;96(29):e7563.

 

Through literature review we cannot find an efficient risk factor of lymph node metastasis in lung squamous cell carcinoma (SCC). This study aimed to investigate the risk factors of pathological lymph node status in patients with lung SCC of 3 cm or less in diameter, to provide ...

Last Updated: 20 Jul 2017

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Cardiac metastasis of tongue squamous cell carcinoma complicated by pulmonary embolism: A case report.
 

Author(s): Sonaz Malekzadeh, Alexandra Platon, Pierre-Alexandre Poletti

Journal: Medicine (Baltimore). 2017 Jul;96(28):e7462.

 

Cardiac metastasis is known as a rare complication of head and neck malignancy.

Last Updated: 12 Jul 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Squamous cell carcinoma" returned 372 free, full-text review articles on human participants. First 3 results:

Survivin, a molecular target for therapeutic interventions in squamous cell carcinoma.
 

Author(s): Zakir Khan, Abdul Arif Khan, Hariom Yadav, Godavarthi B K S Prasad, Prakash Singh Bisen

Journal:

 

Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of locally advanced disease generally requires various combinations of radiotherapy, surgery, and systemic therapy. Despite aggressive multimodal treatment, most of the patients relapse. Identification ...

Last Updated: 24 May 2017

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Immunotherapy for Esophageal Squamous Cell Carcinoma.
 

Author(s): Takashi Kojima, Toshihiko Doi

Journal: Curr Oncol Rep. 2017 May;19(5):33.

 

Esophageal squamous cell carcinoma have been frustrating to treat, with slow progress made on extending survival. Immunotherapy targeting immune checkpoints, T cells, and infiltrating lymphocytes has shown promise in early studies. The efficacy of pembrolizumab and nivolumab is encouraging. ...

Last Updated: 31 Mar 2017

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Clinical value of monoclonal antibodies and tyrosine kinase inhibitors in the treatment of head and neck squamous cell carcinoma.
 

Author(s): Wiktoria Blaszczak, Wojciech Barczak, Anna Wegner, Wojciech Golusinski, Wiktoria Maria Suchorska

Journal: Med. Oncol.. 2017 Apr;34(4):60.

 

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of malignant tumours that affects over 500,000 patients per year. Treatment failure is generally due to the heterogeneity of these tumours and to the serious adverse effects associated with treatment. Immunological ...

Last Updated: 18 Mar 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alpha Radiation Emitters Device for the Treatment of Squamous Cell Carcinoma
 

Status: Recruiting

Condition Summary: Squamous Cell Carcinoma

 

Last Updated: 20 Aug 2017

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PEmbrolizumab Combined With Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck
 

Status: Not yet recruiting

Condition Summary: Squamous Cell Carcinoma of the Head and Neck; Squamous Cell Carcinoma

 

Last Updated: 27 Jun 2016

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Immune Checkpoint Therapy With Nivolumab Esophageal Squamous Cell Carcinoma
 

Status: Recruiting

Condition Summary: Esophageal Squamous Cell Carcinoma

 

Last Updated: 8 Sep 2017

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