Squamous cell carcinoma

Common Name(s)

Squamous cell carcinoma

Squamous cell carcinoma is a type of cancer that develops in a type of flat-shaped cell that lines the skin and other organs. The most common location where squamous cell carcinoma develops is the skin, usually in areas that are frequently exposed to sunlight. Although less common, squamous cell carcinoma can also grow on the lips, in the mouth, or in the lungs. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis).

Squamous cell carcinoma most commonly occurs in adults between the ages of 40 and 60, although it can be found in all age groups. Factors that increase the risk of developing squamous cell carcinoma include prolonged exposure to ultraviolet (UV) light and fair skin. Having an organ transplant can also increase the risk of developing squamous cell carcinoma, as medications taken after surgery can decrease the body’s ability to protect itself from damage.

The most common symptoms of squamous cell carcinoma of the skin include scaly, red skin patches and unexplained bleeding in areas affected by tumor growth. Other signs include the formation of white ulcers in the mouth and sun-exposed areas. Diagnosis is usually made with a combination of a physical exam, imaging studies, blood tests, and other laboratory studies. Diagnosis may require a doctor to take a biopsy, or sample, of the tissue to look at under a microscope in order to determine if the cells are growing in an abnormal way.

Treatment for squamous cell carcinoma depends on many factors such as how large the cancer is and if it has spread to other areas of the body. If you or a family member has been diagnosed with squamous cell carcinoma, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Squamous cell carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Squamous cell carcinoma" for support, advocacy or research.

Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Squamous cell carcinoma" returned 7367 free, full-text research articles on human participants. First 3 results:

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma.
 

Author(s): Si-Yu Zhao, Jun Wang, Shao-Bo Ouyang, Zi-Kun Huang, Lan Liao

Journal: Cell. Physiol. Biochem.. 2018 ;47(6):2511-2521.

 

Recent studies have demonstrated that circular RNAs (circRNAs) can serve as potential molecular markers for disease diagnosis. However, little is known about their diagnostic potential for oral squamous cell carcinoma (OSCC). This study aimed to determine the expression of circRNAs ...

Last Updated: 31 Dec 1969

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Gremlin1 Delivered by Mesenchymal Stromal Cells Promoted Epithelial-Mesenchymal Transition in Human Esophageal Squamous Cell Carcinoma.
 

Author(s): Dongxi Hong, Te Liu, Weijun Huang, Yan Liao, Lin Wang, Zhen Zhang, Haixuan Chen, Xinchun Zhang, Qiuling Xiang

Journal: Cell. Physiol. Biochem.. 2018 ;47(5):1785-1799.

 

Backgroud/Aims: Mesenchymal stromal cells (MSCs) are a major component of the tumor microenvironment (TME). Several studies focusing on tumor-derived MSCs have demonstrated that they exhibit a strong ability to promote the tumor epithelial-mesenchymal transition (EMT). However, the ...

Last Updated: 31 Dec 1969

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Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells.
 

Author(s): Yongyan Wu, Yuliang Zhang, Min Niu, Yong Shi, Hongliang Liu, Dongli Yang, Fei Li, Yan Lu, Yunfeng Bo, Ruiping Zhang, Zhenyu Li, Hongjie Luo, Jiajia Cui, Jiangwei Sang, Caixia Xiang, Wei Gao, Shuxin Wen

Journal: Cell. Physiol. Biochem.. 2018 ;47(4):1696-1710.

 

CD133+CD44+ cancer stem cells previously isolated from laryngeal squamous cell carcinoma (LSCC) cell lines showed strong malignancy and tumorigenicity. However, the molecular mechanism underlying the enhanced malignancy remained unclear.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Squamous cell carcinoma" returned 416 free, full-text review articles on human participants. First 3 results:

Successful outcome after radiotherapy in esophageal squamous cell carcinoma with choroidal metastasis: A case report and review of literature.
 

Author(s): Yu-Ting Hsiao, Shau-Hsuan Li, Yu-Ming Wang, Hsi-Kung Kuo

Journal: Indian J Ophthalmol. 2018 08;66(8):1215-1217.

 

Choroid metastasis from esophageal carcinoma is rare; reports addressing the effectiveness of treatment strategies are limited. We report a case of a 51-year-old man with metastatic esophageal carcinoma who had a 1-month history of blurred vision in his left eye. An ophthalmologic ...

Last Updated: 31 Dec 1969

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Rare case of squamous cell carcinoma arising in a recurrent ovarian mature cystic teratoma of a young woman: A case report and review of the literature.
 

Author(s): Xinge Feng, Lian Xu

Journal: Medicine (Baltimore). 2018 May;97(20):e10802.

 

Malignant transformations of ovarian mature cystic teratomas (MCTs) occur rarely, especially in young women. Although it is extremely difficult to diagnose them, serum tumor marker level testing in combination with the use of imaging techniques may be useful in preoperative diagnosis.

Last Updated: 31 Dec 1969

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The association between serum squamous cell carcinoma antigen and recurrence and survival of patients with cervical squamous cell carcinoma: A systematic review and meta-analysis.
 

Author(s): Chuenkamon Charakorn, Kunlawat Thadanipon, Sawarat Chaijindaratana, Sasivimol Rattanasiri, Pawin Numthavaj, Ammarin Thakkinstian

Journal: Gynecol. Oncol.. 2018 07;150(1):190-200.

 

The aim of this systematic review and meta-analysis was to pool association effects of serum squamous cell carcinoma antigen (SCC-Ag) on recurrence and mortality in mainly squamous cell cervical cancer patients.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alpha Radiation Emitters Device for the Treatment of Squamous Cell Carcinoma
 

Status: Recruiting

Condition Summary: Squamous Cell Carcinoma

 

Last Updated: 26 Jun 2018

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Assessment of Anti-cancerous Effect of Green, Roasted and Decaffeinated Coffee on Oral Squamous Cell Carcinoma Cell Line
 

Status: Not yet recruiting

Condition Summary: Oral Squamous Cell Carcinoma

 

Last Updated: 2 Aug 2018

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PEmbrolizumab Combined With Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck
 

Status: Not yet recruiting

Condition Summary: Squamous Cell Carcinoma of the Head and Neck; Squamous Cell Carcinoma

 

Last Updated: 27 Jun 2016

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