Calciphylaxis

Common Name(s)

Calciphylaxis

Calciphylaxis is a disease in which blood vessels (veins and arteries) become blocked by a build-up of calcium in the walls of the vessels, preventing blood from flowing to the skin or internal organs.  The lack of blood flow (ischemia) damages healthy tissue and causes it to die (necrosis).  The most obvious and frequent symptom of calciphylaxis is damage to the skin, as ulcers can develop and become infected easily.  Calciphylaxis can also affect fat tissue, internal organs, and skeletal muscle, causing infections, pain, and organ failure.  These symptoms are often irreversible, and many individuals with calciphylaxis may not survive more than a few months after they are diagnosed due to infection that spreads throughout the body (sepsis), or organ failure.   The exact cause of calciphylaxis is unknown.   Treatments may include medications to reduce pain, antibiotics to treat infections, and various approaches to preventing the development or worsening of this condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Calciphylaxis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Calciphylaxis" returned 111 free, full-text research articles on human participants. First 3 results:

Successful Treatment of Lung Calciphylaxis With Sodium Thiosulfate in a Patient With Sickle Cell Disease: A Case Report.
 

Author(s): Romain Arrestier, Caroline Dudreuilh, Philippe Remy, Ghada Boulahia, Bouteina Bentaarit, Claire Leibler, Amir Adedjouma, Tomek Kofman, Marie Matignon, Dil Sahali, Roger Dufresne, Jean-Francois Deux, Charlotte Colin, Philippe Grimbert, Philippe Lang, Pablo Bartolucci, Bernard Maitre, Jeanne Tran Van Nhieu, Vincent Audard

Journal: Medicine (Baltimore). 2016 Feb;95(6):e2768.

 

Calciphylaxis is a small vessel vasculopathy, characterized by medial wall calcification that develops in a few patients with chronic renal failure. The prognosis of skin calciphylaxis has improved considerably since the introduction of sodium thiosulfate (STS), but it remains unclear ...

Last Updated: 13 Feb 2016

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Calciphylaxis and the persistence of medical misinformation in the era of Google.
 

Author(s): Scott R Granter, Alvaro C Laga, Allison R Larson

Journal: Am. J. Clin. Pathol.. 2015 Sep;144(3):427-31.

 

We illustrate the important and troubling issue of persistent misinformation and false claims in the medical literature using a frequently cited case inaccurately believed by many to be the first case of calciphylaxis.

Last Updated: 15 Aug 2015

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Raman spectroscopy for label-free identification of calciphylaxis.
 

Author(s): William R Lloyd, Shailesh Agarwal, Sagar U Nigwekar, Karen Esmonde-White, Shawn Loder, Shawn Fagan, Jeremy Goverman, Bjorn R Olsen, Dolrudee Jumlongras, Michael D Morris, Benjamin Levi

Journal: J Biomed Opt. 2015 Aug;20(8):80501.

 

Calciphylaxis is a painful, debilitating, and premorbid condition, which presents as calcified vasculature and soft tissues. Traditional diagnosis of calciphylaxis lesions requires an invasive biopsy, which is destructive, time consuming, and often leads to exacerbation of the condition ...

Last Updated: 12 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Calciphylaxis" returned 15 free, full-text review articles on human participants. First 3 results:

Calciphylaxis: risk factors, diagnosis, and treatment.
 

Author(s): Sagar U Nigwekar, Daniela Kroshinsky, Rosalynn M Nazarian, Jeremy Goverman, Rajeev Malhotra, Vicki Ann Jackson, Mihir M Kamdar, David J R Steele, Ravi I Thadhani

Journal: Am. J. Kidney Dis.. 2015 Jul;66(1):133-46.

 

Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in patients with chronic kidney failure treated with dialysis (uremic calciphylaxis) ...

Last Updated: 26 Jun 2015

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Calciphylaxis is a cutaneous process without involvement of internal organs in a retrospective study of postmortem findings in three patients.
 

Author(s): Louise K Andersen, Julia S Lehman, Mark D P Davis

Journal: Acta Derm. Venereol.. 2014 May;94(3):298-302.

 

Calciphylaxis causes calcification, thrombosis, cutaneous ischemia, and necrosis in the skin and subcutaneous tissue. It is unclear to what extent it involves other organs. To identify whether other organs are affected we reviewed pathology reports of patients with calciphylaxis who ...

Last Updated: 7 May 2014

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Evolution of treatment strategies for calciphylaxis.
 

Author(s): Edward A Ross

Journal: Am. J. Nephrol.. 2011 ;34(5):460-7.

 

Treatment strategies for calciphylaxis are limited by inadequate understanding of its pathophysiology. Mortality reaches 80%, due to progressive skin ischemia, necrosis and infections. In addition to calcium and parathyroid disorders, hypercoagulability can have a role: primary thrombotic ...

Last Updated: 18 Nov 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

European Calciphylaxis Registry Network
 

Status: Recruiting

Condition Summary: Calcific Uremic Arteriolopathy (CUA); Calciphylaxis

 

Last Updated: 11 Jan 2016

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Phase 2 Study With SNF472 in Calciphylaxis Patients
 

Status: Recruiting

Condition Summary: Calciphylaxis; Calcific Uremic Arteriolopathy

 

Last Updated: 6 Jun 2016

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Calciphylaxis : Population, Risk Factors, Diagnostic Practice, Therapeutic and Outcome
 

Status: Not yet recruiting

Condition Summary: Calciphylaxis

 

Last Updated: 29 Jul 2016

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