Calciphylaxis

Common Name(s)

Calciphylaxis

Calciphylaxis is a disease in which blood vessels (veins and arteries) become blocked by a build-up of calcium in the walls of the vessels, preventing blood from flowing to the skin or internal organs.  The lack of blood flow (ischemia) damages healthy tissue and causes it to die (necrosis).  The most obvious and frequent symptom of calciphylaxis is damage to the skin, as ulcers can develop and become infected easily.  Calciphylaxis can also affect fat tissue, internal organs, and skeletal muscle, causing infections, pain, and organ failure.  These symptoms are often irreversible, and many individuals with calciphylaxis may not survive more than a few months after they are diagnosed due to infection that spreads throughout the body (sepsis), or organ failure.   The exact cause of calciphylaxis is unknown.   Treatments may include medications to reduce pain, antibiotics to treat infections, and various approaches to preventing the development or worsening of this condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Calciphylaxis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Calciphylaxis" returned 92 free, full-text research articles on human participants. First 3 results:

Minimal Change Nephrotic Syndrome Sequentially Complicated by Acute Kidney Injury and Painful Skin Ulcers due to Calciphylaxis.
 

Author(s): Ryuta Sato, Tetsu Akimoto, Toshimi Imai, Saki Nakagawa, Mari Okada, Atsushi Miki, Shinichi Takeda, Hisashi Yamamoto, Osamu Saito, Shigeaki Muto, Eiji Kusano, Daisuke Nagata

Journal: Intern. Med.. ;55(22):3315-3320.

 

Calciphylaxis is rare cutaneous manifestation associated with painful skin ulceration and necrosis. It primarily occurs in patients with end-stage chronic kidney disease. In this report, we would like to show our experience with a male patient presenting with minimal change nephrotic ...

Last Updated: 17 Nov 2016

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The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease.
 

Author(s): Seishi Aihara, Shunsuke Yamada, Yushi Uchida, Hokuto Arase, Akihiro Tsuchimoto, Toshiaki Nakano, Masatomo Taniguchi, Harumichi Higashi, Takanari Kitazono, Kazuhiko Tsuruya

Journal: Intern. Med.. 2016 ;55(14):1899-905.

 

We present the case of a non-dialyzed patient with chronic kidney disease and biopsy-proven calciphylaxis who presented with painful cutaneous ulcers on both legs. The skin ulcers drastically improved within 6 months after the initiation of hemodialysis, aggressive wound care, the ...

Last Updated: 19 Jul 2016

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Successful Treatment of Lung Calciphylaxis With Sodium Thiosulfate in a Patient With Sickle Cell Disease: A Case Report.
 

Author(s): Romain Arrestier, Caroline Dudreuilh, Philippe Remy, Ghada Boulahia, Bouteina Bentaarit, Claire Leibler, Amir Adedjouma, Tomek Kofman, Marie Matignon, Dil Sahali, Roger Dufresne, Jean-Francois Deux, Charlotte Colin, Philippe Grimbert, Philippe Lang, Pablo Bartolucci, Bernard Maitre, Jeanne Tran Van Nhieu, Vincent Audard

Journal: Medicine (Baltimore). 2016 Feb;95(6):e2768.

 

Calciphylaxis is a small vessel vasculopathy, characterized by medial wall calcification that develops in a few patients with chronic renal failure. The prognosis of skin calciphylaxis has improved considerably since the introduction of sodium thiosulfate (STS), but it remains unclear ...

Last Updated: 13 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Calciphylaxis" returned 16 free, full-text review articles on human participants. First 3 results:

POEMS syndrome and calciphylaxis: an unrecognized cause of abnormal small vessel calcification.
 

Author(s): Nobuyuki Araki, Sonoko Misawa, Kazumoto Shibuya, Satoshi Ota, Takashi Oide, Asuka Kawano, Minako Beppu, Yukio Nakatani, Satoshi Kuwabara

Journal:

 

Calciphylaxis is a syndrome consisting of vascular calcification, thrombosis, and skin necrosis. The syndrome develops often in chronic hemodialysis patients. However, there have been several case reports on calciphylaxis in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, ...

Last Updated: 12 Apr 2016

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The Relationship Between Obesity and Calciphylaxis: A Review of the Literature.
 

Author(s): Janet M Davis

Journal: Ostomy Wound Manage. 2016 Jan;62(1):12-8.

 

Calciphylaxis is characterized by calcification in the medium and small vessel arterioles and can be a life-threatening complication often associated with chronic kidney disease (CKD). A review of the literature was conducted to explore existing evidence about the relationship between ...

Last Updated: 19 Jan 2016

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Calciphylaxis: risk factors, diagnosis, and treatment.
 

Author(s): Sagar U Nigwekar, Daniela Kroshinsky, Rosalynn M Nazarian, Jeremy Goverman, Rajeev Malhotra, Vicki Ann Jackson, Mihir M Kamdar, David J R Steele, Ravi I Thadhani

Journal: Am. J. Kidney Dis.. 2015 Jul;66(1):133-46.

 

Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in patients with chronic kidney failure treated with dialysis (uremic calciphylaxis) ...

Last Updated: 26 Jun 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Calciphylaxis : Population, Risk Factors, Diagnostic Practice, Therapeutic and Outcome
 

Status: Not yet recruiting

Condition Summary: Calciphylaxis

 

Last Updated: 29 Jul 2016

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European Calciphylaxis Registry Network
 

Status: Recruiting

Condition Summary: Calcific Uremic Arteriolopathy (CUA); Calciphylaxis

 

Last Updated: 13 Oct 2016

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Phase 2 Study With SNF472 in Calciphylaxis Patients
 

Status: Recruiting

Condition Summary: Calciphylaxis; Calcific Uremic Arteriolopathy

 

Last Updated: 22 Mar 2017

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