Calciphylaxis

Common Name(s)

Calciphylaxis

Calciphylaxis is a disease in which blood vessels (veins and arteries) become blocked by a build-up of calcium in the walls of the vessels, preventing blood from flowing to the skin or internal organs.  The lack of blood flow (ischemia) damages healthy tissue and causes it to die (necrosis).  The most obvious and frequent symptom of calciphylaxis is damage to the skin, as ulcers can develop and become infected easily.  Calciphylaxis can also affect fat tissue, internal organs, and skeletal muscle, causing infections, pain, and organ failure.  These symptoms are often irreversible, and many individuals with calciphylaxis may not survive more than a few months after they are diagnosed due to infection that spreads throughout the body (sepsis), or organ failure.   The exact cause of calciphylaxis is unknown.   Treatments may include medications to reduce pain, antibiotics to treat infections, and various approaches to preventing the development or worsening of this condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Calciphylaxis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Calciphylaxis" returned 81 free, full-text research articles on human participants. First 3 results:

Nonuremic calciphylaxis in a patient with rheumatoid arthritis and osteoporosis treated with teriparatide.
 

Author(s): Arturo R Dominguez, Shauna E Goldman

Journal: J. Am. Acad. Dermatol.. 2014 Feb;70(2):e41-2.

 

Last Updated: 20 Jan 2014

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Calciphylaxis: a rare but potentially fatal event of chronic kidney disease. Case report.
 

Author(s): Silvio Alencar Marques, Aline Cruz Kakuda, Thais Jung Menda├žolli, Luciana P Fernandes Abbade, Mari├óngela Esther Alencar Marques

Journal: An Bras Dermatol. ;88(6 Suppl 1):44-7.

 

Calciphylaxis or calcific uremic arteriolopathy is a rare cutaneous-systemic disease occurring in patients with advanced chronic kidney disease. The classical clinical picture is that of a necrotic and progressive skin ulcer of reticular pattern, mostly in the lower legs and susceptible ...

Last Updated: 18 Dec 2013

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Calciphylaxis treated with sodium thiosulfate: report of two cases.
 

Author(s): Celia Posada Garcia, Elena Roson, Gonzalo Peon, Maria Teresa Abalde, Carlos De La Torre

Journal:

 

Although traditionally observed in patients with end-stage renal disease and secondary hyperparathyroidism, calciphylaxis has been reported in patients with normal renal and parathyroid function. There is no evidence-based therapy available. The use of sodium thiosulfate (STS) has ...

Last Updated: 20 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Calciphylaxis" returned 13 free, full-text review articles on human participants. First 3 results:

Evolution of treatment strategies for calciphylaxis.
 

Author(s): Edward A Ross

Journal: Am. J. Nephrol.. 2011 ;34(5):460-7.

 

Treatment strategies for calciphylaxis are limited by inadequate understanding of its pathophysiology. Mortality reaches 80%, due to progressive skin ischemia, necrosis and infections. In addition to calcium and parathyroid disorders, hypercoagulability can have a role: primary thrombotic ...

Last Updated: 18 Nov 2011

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Calciphylaxis: a still unmet challenge.
 

Author(s): Vincent M Brandenburg, Mario Cozzolino, Markus Ketteler

Journal: J. Nephrol.. ;24(2):142-8.

 

Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a rare disease most frequently occurring in patients with advanced chronic kidney disease (CKD). The clinical picture is typically characterized by very painful skin lesions and ulcerations following calcification ...

Last Updated: 4 Mar 2011

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[A case of calciphylaxis in chronic renal failure].
 

Author(s): Masaki Watanabe, Satoshi Yamaguchi, Hiroaki Osanai, Masamoto Murakami

Journal: Hinyokika Kiyo. 2010 Oct;56(10):597-600.

 

Calciphylaxis is characterized by progressive vascular calcification, soft tissue necrosis, and ischemic necrosis of the skin. The condition is usually associated with end-stage renal disease and has a poor prognosis. We present a 76-year-old man on hemodialysis who developed small, ...

Last Updated: 10 Nov 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU)
 

Status: Recruiting

Condition Summary: Hypertensive Ischemic Leg Ulcer; Calciphylaxis

 

Last Updated: 13 Apr 2012

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Evaluation of Vitamin K Supplementation for Calcific Uremic Arteriolopathy
 

Status: Not yet recruiting

Condition Summary: Calciphylaxis; Calcific Uremic Arteriolopathy

 

Last Updated: 28 Oct 2014

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