Calciphylaxis

Common Name(s)

Calciphylaxis

Calciphylaxis is a disease in which blood vessels (veins and arteries) become blocked by a build-up of calcium in the walls of the vessels, preventing blood from flowing to the skin or internal organs.  The lack of blood flow (ischemia) damages healthy tissue and causes it to die (necrosis).  The most obvious and frequent symptom of calciphylaxis is damage to the skin, as ulcers can develop and become infected easily.  Calciphylaxis can also affect fat tissue, internal organs, and skeletal muscle, causing infections, pain, and organ failure.  These symptoms are often irreversible, and many individuals with calciphylaxis may not survive more than a few months after they are diagnosed due to infection that spreads throughout the body (sepsis), or organ failure.   The exact cause of calciphylaxis is unknown.   Treatments may include medications to reduce pain, antibiotics to treat infections, and various approaches to preventing the development or worsening of this condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Calciphylaxis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Calciphylaxis" returned 98 free, full-text research articles on human participants. First 3 results:

Multiple sites of calciphylaxis in a patient with chronic renal failure.
 

Author(s): Ramy Magdy Hanna, Joseph Riad Nabil, Eduardo A Lopez, Dalila B Corry, James Wilson

Journal: Saudi J Kidney Dis Transpl. 2015 Mar;26(2):344-8.

 

Calciphylaxis has seldom been reported in patients with acute renal failure or in pre-dialysis patients. It also has been reported at lower calcium phosphorous products and in patients with adynamic bone disease. We report a pre-hemodialysis (HD) patient with acute renal failure and ...

Last Updated: 12 Mar 2015

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Successful treatment of calciphylaxis with pamidronate.
 

Author(s): Nakysa Hooman, Rama Naghshi-Zadiyan, Mitra Mehrazma, Fariba Jahangiri

Journal: Iran J Kidney Dis. 2015 Jan;9(1):67-70.

 

Calciphylaxis is a complication of chronic kidney disease characterized by necrotic lesion in the skin. Histological examination reveals microcalcification of medium-sized blood vessels. We report on a 21-month-old girl with end-stage renal disease with severe calcium-phosphate imbalance. ...

Last Updated: 20 Jan 2015

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Aggressive calciphylaxis in end-stage renal disease after a failed kidney allograft.
 

Author(s): Charat Thongprayoon, Wisit Cheungpasitporn, Jackrapong Bruminhent

Journal: Indian J Dermatol Venereol Leprol. ;81(1):50.

 

Last Updated: 8 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Calciphylaxis" returned 15 free, full-text review articles on human participants. First 3 results:

Calciphylaxis: risk factors, diagnosis, and treatment.
 

Author(s): Sagar U Nigwekar, Daniela Kroshinsky, Rosalynn M Nazarian, Jeremy Goverman, Rajeev Malhotra, Vicki Ann Jackson, Mihir M Kamdar, David J R Steele, Ravi I Thadhani

Journal: Am. J. Kidney Dis.. 2015 Jul;66(1):133-46.

 

Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in patients with chronic kidney failure treated with dialysis (uremic calciphylaxis) ...

Last Updated: 26 Jun 2015

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Calciphylaxis is a cutaneous process without involvement of internal organs in a retrospective study of postmortem findings in three patients.
 

Author(s): Louise K Andersen, Julia S Lehman, Mark D P Davis

Journal: Acta Derm. Venereol.. 2014 May;94(3):298-302.

 

Calciphylaxis causes calcification, thrombosis, cutaneous ischemia, and necrosis in the skin and subcutaneous tissue. It is unclear to what extent it involves other organs. To identify whether other organs are affected we reviewed pathology reports of patients with calciphylaxis who ...

Last Updated: 7 May 2014

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Evolution of treatment strategies for calciphylaxis.
 

Author(s): Edward A Ross

Journal: Am. J. Nephrol.. 2011 ;34(5):460-7.

 

Treatment strategies for calciphylaxis are limited by inadequate understanding of its pathophysiology. Mortality reaches 80%, due to progressive skin ischemia, necrosis and infections. In addition to calcium and parathyroid disorders, hypercoagulability can have a role: primary thrombotic ...

Last Updated: 18 Nov 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

European Calciphylaxis Registry Network
 

Status: Recruiting

Condition Summary: Calcific Uremic Arteriolopathy (CUA); Calciphylaxis

 

Last Updated: 11 Jan 2016

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Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU)
 

Status: Recruiting

Condition Summary: Hypertensive Ischemic Leg Ulcer; Calciphylaxis

 

Last Updated: 1 Dec 2015

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Evaluation of Vitamin K Supplementation for Calcific Uremic Arteriolopathy
 

Status: Recruiting

Condition Summary: Calciphylaxis; Calcific Uremic Arteriolopathy

 

Last Updated: 27 Aug 2015

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