Buruli Ulcer

Common Name(s)

Buruli Ulcer

Buruli ulcer is a tropical disease caused by an infection from the Mycobacterium ulcerans, a bacterium which belongs to the same family of bacteria that causes tuberculosis and leprosy. Most cases of buruli ulcer occur in tropical and subtropical regions, and has been reported in 33 countries in Africa, the Americas, Asia and the Western Pacific. The exact way that the disease is transmitted is unknown, though it is thought that living agents, such as aquatic insects or mosquitoes may play some role. Buruli ulcer usually begins with a painless swelling or a large painless area in the skin. Without treatment, however, the area will form a large ulcer within four weeks, and can sometimes result in permanent disfigurement and disability. When Buruli ulcer is detected early, it can be cured with a combination of antibiotics.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Buruli Ulcer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Buruli Ulcer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Buruli Ulcer" returned 142 free, full-text research articles on human participants. First 3 results:

The incubation period of Buruli ulcer (Mycobacterium ulcerans infection).
 

Author(s): Jason A Trubiano, Caroline J Lavender, Janet A M Fyfe, Simone Bittmann, Paul D R Johnson

Journal:

 

Buruli Ulcer (BU) is caused by the environmental microbe Mycobacterium ulcerans. Despite unclear transmission, contact with a BU endemic region is the key known risk factor. In Victoria, Australia, where endemic areas have been carefully mapped, we aimed to estimate the Incubation ...

Last Updated: 7 Oct 2013

Go To URL
Geographic distribution, age pattern and sites of lesions in a cohort of Buruli ulcer patients from the Mapé Basin of Cameroon.
 

Author(s): Martin W Bratschi, Miriam Bolz, Jacques C Minyem, Leticia Grize, Fidèle G Wantong, Sarah Kerber, Earnest Njih Tabah, Marie-Thérèse Ruf, Ferdinand Mou, Djeunga Noumen, Alphonse Um Boock, Gerd Pluschke

Journal:

 

Buruli ulcer (BU), a neglected tropical disease of the skin, caused by Mycobacterium ulcerans, occurs most frequently in children in West Africa. Risk factors for BU include proximity to slow flowing water, poor wound care and not wearing protective clothing. Man-made alterations ...

Last Updated: 20 Jun 2013

Go To URL
Secondary bacterial infections of buruli ulcer lesions before and after chemotherapy with streptomycin and rifampicin.
 

Author(s): Dorothy Yeboah-Manu, Grace S Kpeli, Marie-Thérèse Ruf, Kobina Asan-Ampah, Kwabena Quenin-Fosu, Evelyn Owusu-Mireku, Albert Paintsil, Isaac Lamptey, Benjamin Anku, Cynthia Kwakye-Maclean, Mercy Newman, Gerd Pluschke

Journal:

 

Buruli ulcer (BU), caused by Mycobacterium ulcerans is a chronic necrotizing skin disease. It usually starts with a subcutaneous nodule or plaque containing large clusters of extracellular acid-fast bacilli. Surrounding tissue is destroyed by the cytotoxic macrolide toxin mycolactone ...

Last Updated: 9 May 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Buruli Ulcer" returned 6 free, full-text review articles on human participants. First 3 results:

The impact of community health workers (CHWs) on Buruli ulcer in sub-Saharan Africa: a systematic review.
 

Author(s): Marius Zambou Vouking, Violette Claire Tamo, Lawrence Mbuagbaw

Journal:

 

Buruli ulcer (BU) is a cutaneous neglected tropical disease caused by Mycobacterium ulcerans. Participation of Community Health Workers (CHWs) is an integral part of the management of BU, yet their impact has not been systematically evaluated in sub-Saharan Africa.

Last Updated: 6 Sep 2013

Go To URL
Buruli ulcer and mycolactone-producing mycobacteria.
 

Author(s): Kazue Nakanaga, Rie Roselyne Yotsu, Yoshihiko Hoshino, Koichi Suzuki, Masahiko Makino, Norihisa Ishii

Journal: Jpn. J. Infect. Dis.. 2013 ;66(2):83-8.

 

Buruli ulcer (BU) is an emerging human disease caused by Mycobacterium ulcerans, which mainly affects the extremities. It is most endemic in sub-Saharan Africa; however, it has been reported worldwide, including in some non-tropical areas. "M. ulcerans subsp. shinshuense" is proposed ...

Last Updated: 21 Mar 2013

Go To URL
Buruli ulcer.
 

Author(s): Thorbjorg Einarsdottir, Kris Huygen

Journal: Hum Vaccin. 2011 Nov;7(11):1198-203.

 

Buruli Ulcer (BU) is a neglected, necrotizing skin disease, caused by M. ulcerans, that can leave patients with prominent scars and lifelong disability. M. ulcerans produces a diffusible lipid toxin, mycolactone, essential for bacterial virulence. Prevention is difficult as little ...

Last Updated: 29 Dec 2011

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Pathogenesis and Management of M. Ulcerans Disease, Buruli Ulcer
 

Status: Recruiting

Condition Summary: Buruli Ulcer; Mycobacterium Ulcerans Disease

 

Last Updated: 31 May 2014

Go to URL
Timing of Surgical Intervention in Buruli Ulcer Patients Treated With Antibiotics
 

Status: Recruiting

Condition Summary: Mycobacterium Ulcerans Disease; Buruli Ulcer

 

Last Updated: 13 Jul 2012

Go to URL
WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8
 

Status: Recruiting

Condition Summary: Mycobacterium Ulcerans Infection

 

Last Updated: 4 Aug 2013

Go to URL