Prothrombin thrombophilia

Common Name(s)

Prothrombin thrombophilia

Prothrombin thrombophilia is an inherited disorder of blood clotting. Thrombophilia is an increased tendency to form abnormal blood clots in blood vessels. People who have prothrombin thrombophilia are at somewhat higher than average risk for a type of clot called a deep venous thrombosis, which typically occur in the deep veins of the legs. Affected people also have an increased risk of developing a pulmonary embolism. However, most people with prothrombin thrombophilia never develop abnormal blood clots. Prothrombin thrombophilia is the second most common inherited form of thrombophilia after factor V Leiden thrombophilia. It is more common in Caucasian populations. This condition is caused by a particular mutation (written G20210A or 20210G>A) in the F2 gene. People can inherit one or two copies of the gene mutation from their parents.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prothrombin thrombophilia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Prothrombin thrombophilia" returned 8 free, full-text research articles on human participants. First 3 results:

Evaluation of GenoFlow Thrombophilia Array Test Kit in its detection of mutations in Factor V Leiden (G1691A), prothrombin G20210A, MTHFR C677T and A1298C in blood samples from 113 Turkish female patients.
 

Author(s): Ebru Aytekin, Sezen Guntekin Ergun, Mehmet Ali Ergun, Ferda E Percin

Journal: Genet Test Mol Biomarkers. 2014 Nov;18(11):717-21.

 

Thrombophilia is a heritable blood disease characterized by an increased tendency to form abnormal blood clots that can block blood vessels. In obstetrics and gynecology, it has been shown by a number of reports that a proportion of recurrent miscarriages involve thrombophilia-related ...

Last Updated: 5 Nov 2014

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A novel prothrombin mutation in two families with prominent thrombophilia--the first cases of antithrombin resistance in a Caucasian population.
 

Author(s): V Djordjevic, M Kovac, P Miljic, M Murata, A Takagi, I Pruner, D Francuski, T Kojima, D Radojkovic

Journal: J. Thromb. Haemost.. 2013 Oct;11(10):1936-9.

 

Last Updated: 14 Oct 2013

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Type and location of venous thromboembolism in patients with factor V Leiden or prothrombin G20210A and in those with no thrombophilia.
 

Author(s): I Martinelli, T Battaglioli, C Razzari, P M Mannucci

Journal: J. Thromb. Haemost.. 2007 Jan;5(1):98-101.

 

Patients with factor (F) V Leiden or the prothrombin G20210A polymorphism are at increased risk of developing deep vein thrombosis (DVT). On the other hand, the risk of developing pulmonary embolism (PE) appears to be low in carriers of FV Leiden, perhaps because of a lower tendency ...

Last Updated: 22 Jan 2007

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Reviews from the PubMed Database

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The terms "Prothrombin thrombophilia" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Thrombin Generation and Gestational Outcome
 

Status: Recruiting

Condition Summary: Thrombophilia

 

Last Updated: 16 Aug 2016

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Safety, Pharmacokinetics and Efficacy of an AT-III Concentrate.
 

Status: Recruiting

Condition Summary: Antithrombin III Deficiency

 

Last Updated: 17 Feb 2014

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