Prothrombin thrombophilia

Common Name(s)

Prothrombin thrombophilia

Prothrombin thrombophilia is an inherited disorder of blood clotting. Thrombophilia is an increased tendency to form abnormal blood clots in blood vessels. People who have prothrombin thrombophilia are at somewhat higher than average risk for a type of clot called a deep venous thrombosis, which typically occur in the deep veins of the legs. Affected people also have an increased risk of developing a pulmonary embolism. However, most people with prothrombin thrombophilia never develop abnormal blood clots. Prothrombin thrombophilia is the second most common inherited form of thrombophilia after factor V Leiden thrombophilia. It is more common in Caucasian populations. This condition is caused by a particular mutation (written G20210A or 20210G>A) in the F2 gene. People can inherit one or two copies of the gene mutation from their parents.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prothrombin thrombophilia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prothrombin thrombophilia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Prothrombin thrombophilia" returned 4 free, full-text research articles on human participants. First 3 results:

Risk of thrombosis associated with oral contraceptives of women from 97 families with inherited thrombophilia: high risk of thrombosis in carriers of the G20210A mutation of the prothrombin gene.
 

Author(s): A Santamaría, J Mateo, A Oliver, B Menéndez, J C Souto, M Borrell, J M Soria, I Tirado, J Fontcuberta

Journal: Haematologica. 2001 Sep;86(9):965-71.

 

Oral contraceptives (OC) and inherited thrombophilia are well-known risk factors associated with venous thromboembolism (VTE). However, there are only few studies on the risk of VTE in women with inherited thrombophilia who use oral contraceptives.

Last Updated: 4 Sep 2001

Go To URL
Prothrombin G20210A gene mutation and further prothrombotic risk factors in childhood thrombophilia.
 

Author(s): R Junker, H G Koch, K Auberger, N Münchow, S Ehrenforth, U Nowak-Göttl

Journal: Arterioscler. Thromb. Vasc. Biol.. 1999 Oct;19(10):2568-72.

 

Risk factors for venous thrombosis in adults are the prothrombin G20210A and the factor V (FV) G1691A mutations and hereditary deficiencies of protein C, protein S and antithrombin. However, data are limited on the relevance of these risk factors for thrombosis in children and adolescents. ...

Last Updated: 29 Oct 1999

Go To URL
Severe thrombophilia in a paediatric patient with end-stage renal disease: detection of the prothrombin gene G20210A mutation.
 

Author(s): C Stier, B Pötzsch, G Müller-Berghaus, M Soergel, G Klaus

Journal: Nephrol. Dial. Transplant.. 1998 Aug;13(8):2130-2.

 

Last Updated: 6 Nov 1998

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Prothrombin thrombophilia" returned 0 free, full-text review articles on human participants.

 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Thrombin Generation and Gestational Outcome
 

Status: Recruiting

Condition Summary: Thrombophilia

 

Last Updated: 13 May 2014

Go to URL

Last Updated: 21 Jul 2014

Go to URL
Safety, Pharmacokinetics and Efficacy of an AT-III Concentrate.
 

Status: Recruiting

Condition Summary: Antithrombin III Deficiency

 

Last Updated: 17 Feb 2014

Go to URL