Prothrombin thrombophilia

Common Name(s)

Prothrombin thrombophilia

Prothrombin thrombophilia is an inherited disorder of blood clotting. Thrombophilia is an increased tendency to form abnormal blood clots in blood vessels. People who have prothrombin thrombophilia are at somewhat higher than average risk for a type of clot called a deep venous thrombosis, which typically occur in the deep veins of the legs. Affected people also have an increased risk of developing a pulmonary embolism. However, most people with prothrombin thrombophilia never develop abnormal blood clots. Prothrombin thrombophilia is the second most common inherited form of thrombophilia after factor V Leiden thrombophilia. It is more common in Caucasian populations. This condition is caused by a particular mutation (written G20210A or 20210G>A) in the F2 gene. People can inherit one or two copies of the gene mutation from their parents.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prothrombin thrombophilia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prothrombin thrombophilia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Prothrombin thrombophilia" returned 6 free, full-text research articles on human participants. First 3 results:

Evaluation of GenoFlow Thrombophilia Array Test Kit in its detection of mutations in Factor V Leiden (G1691A), prothrombin G20210A, MTHFR C677T and A1298C in blood samples from 113 Turkish female patients.
 

Author(s): Ebru Aytekin, Sezen Guntekin Ergun, Mehmet Ali Ergun, Ferda E Percin

Journal: Genet Test Mol Biomarkers. 2014 Nov;18(11):717-21.

 

Thrombophilia is a heritable blood disease characterized by an increased tendency to form abnormal blood clots that can block blood vessels. In obstetrics and gynecology, it has been shown by a number of reports that a proportion of recurrent miscarriages involve thrombophilia-related ...

Last Updated: 5 Nov 2014

Go To URL
Risk of thrombosis associated with oral contraceptives of women from 97 families with inherited thrombophilia: high risk of thrombosis in carriers of the G20210A mutation of the prothrombin gene.
 

Author(s): A Santamaría, J Mateo, A Oliver, B Menéndez, J C Souto, M Borrell, J M Soria, I Tirado, J Fontcuberta

Journal: Haematologica. 2001 Sep;86(9):965-71.

 

Oral contraceptives (OC) and inherited thrombophilia are well-known risk factors associated with venous thromboembolism (VTE). However, there are only few studies on the risk of VTE in women with inherited thrombophilia who use oral contraceptives.

Last Updated: 4 Sep 2001

Go To URL
Primary thrombophilia in Mexico. II. Factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase C677T polymorphism in thrombophilic Mexican mestizos.
 

Author(s): G J Ruiz-Argüelles, J Garcés-Eisele, V Reyes-Núñez, F J Ramírez-Cisneros

Journal: Am. J. Hematol.. 2001 Jan;66(1):28-31.

 

We have shown that in Mexican mestizo patients with clinical features of primary thrombophilia, 39% have activated protein C resistance phenotype, 5% protein C deficiency, and 2% protein S deficiency. In the present study, in a group of 37 thrombophilic Mexicans and 50 normal controls, ...

Last Updated: 27 Jun 2001

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Prothrombin thrombophilia" returned 0 free, full-text review articles on human participants.

 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Thrombin Generation and Gestational Outcome
 

Status: Recruiting

Condition Summary: Thrombophilia

 

Last Updated: 15 Dec 2015

Go to URL

Last Updated: 15 Oct 2015

Go to URL
Safety, Pharmacokinetics and Efficacy of an AT-III Concentrate.
 

Status: Recruiting

Condition Summary: Antithrombin III Deficiency

 

Last Updated: 17 Feb 2014

Go to URL