Juvenile idiopathic arthritis

Common Name(s)

Juvenile idiopathic arthritis, JIA, Juvenile rheumatoid arthritis, JRA, Pediatric arthritis

Juvenile idiopathic arthritis (JIA), also known as juvenile rheumatoid arthritis (JRA), is the most common form of arthritis in children ages 6 months to 17 years. JIA causes inflammation (redness, swelling, heat, pain) in one, or many, joints (areas of the body where two bones fit together). JIA is not the same as the adult type of arthritis. There are seven different types of JIA (see related conditions below).

JIA causes pain, stiffness, swelling, and redness most commonly in the knees and joints of hands and feet. The joint may not move fully (decreased range of motion). Symptoms are usually worse in the morning or after a nap. The symptoms may go away after a few months or be lifelong. Some types of JIA can affect other parts of the body, causing swollen lymph nodes, rashes and fever, eye inflammation and growth problems.

The cause of JIA is unknown (idiopathic). However, it is believed that both environmental and genetic factors play a role. JIA may be an autoimmune or autoinflammatory disease. Usually, our immune system protects us from illness and infection by attacking viruses, bacteria and other foreign bodies. Sometimes our immune system attacks its own healthy cells. Different parts of our immune system can go wrong causing either an autoimmune or an autoinflammatory response.

Girls are more likely to have JIA. Certain viruses may also increase a child’s risk. To diagnose this condition, your child’s doctor or specialist may perform a physical exam, blood tests and special imaging tests of your child’s joints (using X-ray, MRI and video imaging). Although there is no cure for JIA, there are treatments that help reduce pain and swelling. These treatments include medications, therapy, and possibly surgery. If your child has been diagnosed with JIA, talk with their doctor about the most current treatment options. Support groups are also a good source of information and will help connect you with other families.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Juvenile idiopathic arthritis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

View Details
International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

Last Updated: 18 Apr 2010

View Details
Isabella's Aviary Alliance, LLC

Isabella’s Aviary Alliance, LLC actively demonstrates, through Isabella’s passionate and loving care in breeding and raising baby parrots for other special needs children, the possibility for two hearts—bird and child—coming together and connecting in a way which infinitely brightens the lives of both.

Last Updated: 2 Aug 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Juvenile idiopathic arthritis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

View Details
International Scleroderma Network

Our mission is to provide stellar worldwide research, support, education and awareness for scleroderma and related illnesses.

http://www.sclero.org/

Last Updated: 18 Apr 2010

View Details
Isabella's Aviary Alliance, LLC

Isabella’s Aviary Alliance, LLC actively demonstrates, through Isabella’s passionate and loving care in breeding and raising baby parrots for other special needs children, the possibility for two hearts—bird and child—coming together and connecting in a way which infinitely brightens the lives of both.

http://www.isabellasaviary.com

Last Updated: 2 Aug 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Juvenile idiopathic arthritis" returned 572 free, full-text research articles on human participants. First 3 results:

Medical clowns facilitate nitrous oxide sedation during intra-articular corticosteroid injection for juvenile idiopathic arthritis.
 

Author(s): Yael Weintraub, Noa Rabinowicz, Penny Hanuka, Michal Rothschild, Shulamit Kotzki, Yosef Uziel

Journal: Isr. Med. Assoc. J.. 2014 Dec;16(12):771-3.

 

Intra-articular corticosteroid injection (IACI), a common procedure in juvenile idiopathic arthritis, is usually associated with anxiety and pain. In a previous study, we concluded that nitrous oxide (NO2) provides effective and safe sedation for such procedures. Following the introduction ...

Last Updated: 29 Jan 2015

Go To URL
Independent confirmation of juvenile idiopathic arthritis genetic risk loci previously identified by immunochip array analysis.
 

Author(s): Rachel C Chiaroni-Clarke, Jane E Munro, Raul A Chavez, Angela Pezic, Roger C Allen, Jonathan D Akikusa, Susan E Piper, Richard Saffery, Anne-Louise Ponsonby, Justine A Ellis

Journal:

 

Our understanding of the genetic factors underlying juvenile idiopathic arthritis (JIA) is growing, but remains incomplete. Recently, a number of novel genetic loci were reported to be associated with JIA at (or near) genome-wide significance in a large case-control discovery sample ...

Last Updated: 25 Dec 2014

Go To URL
[Serum cytokine levels in children with newly diagnosed active systemic juvenile idiopathic arthritis].
 

Author(s): Li Guo, Mei-Ping Lu, Yong-Min Tang, Li-Ping Teng, Yi-Ping Xu, Li-Xia Zou, Rong-Jun Zheng, Qi Zheng

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Dec;16(12):1241-4.

 

To study the changes in serum cytokines levels in children with newly diagnosed active systemic juvenile idiopathic arthritis (SJIA) and to explore the role of cytokines in the development and progression of SJIA.

Last Updated: 19 Dec 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Juvenile idiopathic arthritis" returned 71 free, full-text review articles on human participants. First 3 results:

Prediction of methotrexate efficacy and adverse events in patients with juvenile idiopathic arthritis: a systematic literature review.
 

Author(s): E H Pieter van Dijkhuizen, Nico M Wulffraat

Journal:

 

Methotrexate (MTX) is the cornerstone disease-modifying anti-rheumatic drug in juvenile idiopathic arthritis (JIA). In JIA, it is important to start effective treatment early to avoid long-term sequelae, such as joint damage. To accomplish this goal, it is crucial to know beforehand ...

Last Updated: 19 Dec 2014

Go To URL
Leisure in children and adolescents with juvenile idiopathic arthritis: a systematic review.
 

Author(s): Sabrina Cavallo, Karine Toupin April, Viviane Grandpierre, Annette Majnemer, Debbie Ehrmann Feldman

Journal:

 

The aim of this systematic review is to describe participation in social and physical leisure activities among children and adolescents with JIA, as well as identify potential determinants of leisure participation.

Last Updated: 21 Oct 2014

Go To URL
Anti-TNF therapy for juvenile idiopathic arthritis-related uveitis.
 

Author(s): Francesco Semeraro, Barbara Arcidiacono, Giuseppe Nascimbeni, Martina Angi, Barbara Parolini, Ciro Costagliola

Journal:

 

Juvenile idiopathic arthritis-related uveitis is the most common type of uveitis in childhood and one of the main causes of visual impairment in children. The introduction of biological treatment has widened the range of therapeutic options for children with uveitis refractory to ...

Last Updated: 8 Apr 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Cost of Care for Juvenile Idiopathic Arthritis
 

Status: Not yet recruiting

Condition Summary: Juvenile Idiopathic Arthritis

 

Last Updated: 17 Nov 2011

Go to URL
Pharmacovigilance in Juvenile Idiopathic Arthritis Patients Treated With Biologic Agents and/or Methotrexate
 

Status: Recruiting

Condition Summary: Juvenile Idiopathic Arthritis

 

Last Updated: 16 Dec 2014

Go to URL
Effective Dose of Etanercept in Patients Treated for Juvenile Idiopathic Arthritis
 

Status: Recruiting

Condition Summary: Juvenile Idiopathic Arthritis

 

Last Updated: 7 Apr 2015

Go to URL