Growth Hormone Deficiency

Common Name(s)

Growth Hormone Deficiency

Growth hormone deficiency is characterized by abnormally short height due to lack (or shortage) of growth hormone. It can be congenital (present at birth) or acquired. Most of the time, no single clear cause can be identified. Most cases are identified in children. Although it is uncommon, growth hormone deficiency may also be diagnosed in adults. Too little growth hormone can cause short stature in children, and changes in muscle mass, cholesterol levels, and bone strength in adults.  In adolescents, puberty may be delayed or absent. Treatment involves growth hormone injections.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Growth Hormone Deficiency" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

Last Updated: 18 Jun 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Growth Hormone Deficiency" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 18 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Growth Hormone Deficiency" returned 288 free, full-text research articles on human participants. First 3 results:

Reversible Albumin-Binding GH Possesses a Potential Once-Weekly Treatment Profile in Adult Growth Hormone Deficiency.
 

Author(s): Michael Højby Rasmussen, Jurgita Janukonyté, Marianne Klose, Djordje Marina, Mette Tanvig, Lene F Nielsen, Charlotte Höybye, Marianne Andersen, Ulla Feldt-Rasmussen, Jens Sandahl Christiansen

Journal: J. Clin. Endocrinol. Metab.. 2016 Mar;101(3):988-98.

 

NNC0195-0092 is a reversible, albumin-binding GH derivative, developed for once-weekly administration.

Last Updated: 4 Mar 2016

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A Randomized Safety and Efficacy Study of Somavaratan (VRS-317), a Long-Acting rhGH, in Pediatric Growth Hormone Deficiency.
 

Author(s): Wayne V Moore, Huong Jil Nguyen, Gad B Kletter, Bradley S Miller, Douglas Rogers, David Ng, Jerome A Moore, Eric Humphriss, Jeffrey L Cleland, George M Bright

Journal: J. Clin. Endocrinol. Metab.. 2016 Mar;101(3):1091-7.

 

Somavaratan (VRS-317) is a long-acting form of recombinant human GH under development for children and adults with GH deficiency (GHD).

Last Updated: 4 Mar 2016

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Five-year response to growth hormone in children with Noonan syndrome and growth hormone deficiency.
 

Author(s): Niki Zavras, Cristina Meazza, Alba Pilotta, Chiara Gertosio, Sara Pagani, Carmine Tinelli, Mauro Bozzola

Journal:

 

Noonan syndrome (NS) is an autosomal dominant disorder characterized by specific features including short stature, distinctive facial dysmorphic features, congenital heart defects, hypertrophic cardiomyopathy, skeletal anomalies and webbing of the neck. Molecular screening has shown ...

Last Updated: 8 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Growth Hormone Deficiency" returned 20 free, full-text review articles on human participants. First 3 results:

Agenesis of internal carotid artery associated with isolated growth hormone deficiency: a case report and literature review.
 

Author(s): Stefano Stagi, Giovanna Traficante, Elisabetta Lapi, Marilena Pantaleo, Sabrina Becciani, Marzia Mortilla, Salvatore Seminara, Maurizio de Martino

Journal:

 

Agenesis of the internal carotid artery (ICA) is a rare congenital abnormality, sporadically reported to be associated with a combined congenital hypopituitarism. Nevertheless, only a few cases have been extensively described, and none of these have been characterized by an isolated ...

Last Updated: 20 Oct 2015

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A new case of de novo 6q24.2-q25.2 deletion on paternal chromosome 6 with growth hormone deficiency: a twelve-year follow-up and literature review.
 

Author(s): Stefano Stagi, Elisabetta Lapi, Marilena Pantaleo, Massimo Carella, Antonio Petracca, Agostina De Crescenzo, Leopoldo Zelante, Andrea Riccio, Maurizio de Martino

Journal:

 

Deletions on the distal portion of the long arm of chromosome 6 are relatively uncommon, and only a small number occurs in the paternal copy, causing growth abnormalities. As a result, extensive clinical descriptions are lacking.

Last Updated: 22 Aug 2015

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A SOX3 (Xq26.3-27.3) duplication in a boy with growth hormone deficiency, ocular dyspraxia, and intellectual disability: a long-term follow-up and literature review.
 

Author(s): Stefano Stagi, Elisabetta Lapi, Marilena Pantaleo, Giovanna Traficante, Sabrina Giglio, Salvatore Seminara, Maurizio de Martino

Journal: Hormones (Athens). ;13(4):552-60.

 

SOX3 is located on the long arm of the X chromosome (Xq27.1) and both the under- and over-expression of this gene have been reported in cases of hypopituitarism with or without intellectual disabilities. Nevertheless, only a few cases have as yet been extensively described.

Last Updated: 5 Jan 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Phase 3 Trial of the Safety, Tolerability and Efficacy of TransCon hGH Weekly Versus Daily hGH in Children With Growth Hormone Deficiency (GHD)
 

Status: Not yet recruiting

Condition Summary: Growth Hormone Deficiency, Pediatric; hGH (Human Growth Hormone); Endocrine System Diseases; Hormones; Pituitary Diseases

 

Last Updated: 9 Aug 2016

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Validation of Macimorelin as a Test for Adult Growth Hormone Deficiency
 

Status: Recruiting

Condition Summary: Growth Hormone Deficiency With Pituitary Anomalies

 

Last Updated: 15 Aug 2016

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Effects of Growth Hormone on Glucose and Protein Metabolism in Children With Growth Hormone Deficiency
 

Status: Recruiting

Condition Summary: Growth Hormone Deficiency

 

Last Updated: 21 Dec 2010

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