Growth Hormone Deficiency

Common Name(s)

Growth Hormone Deficiency

Growth hormone deficiency is characterized by abnormally short height due to lack (or shortage) of growth hormone. It can be congenital (present at birth) or acquired. Most of the time, no single clear cause can be identified. Most cases are identified in children. Although it is uncommon, growth hormone deficiency may also be diagnosed in adults. Too little growth hormone can cause short stature in children, and changes in muscle mass, cholesterol levels, and bone strength in adults.  In adolescents, puberty may be delayed or absent. Treatment involves growth hormone injections.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Growth Hormone Deficiency" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

Last Updated: 18 Jun 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Growth Hormone Deficiency" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 18 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Growth Hormone Deficiency" returned 324 free, full-text research articles on human participants. First 3 results:

Dental caries and vitamin D3 in children with growth hormone deficiency: A STROBE compliant study.
 

Author(s): Dorota Wójcik, Aleksandra Krzewska, Leszek Szalewski, Elżbieta Pietryka-Michałowska, Magdalena Szalewska, Szymon Krzewski, Elżbieta Pels, Iwona Beń-Skowronek

Journal: Medicine (Baltimore). 2018 Feb;97(8):e9811.

 

Vitamin D may prevent dental caries. To date, no attempts have been made to examine the correlation between the incidence of caries and the concentrations of vitamin D in children with pituitary growth hormone deficiency.The study observed patients of the Department of Endocrinology ...

Last Updated: 31 Dec 1969

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Argininemia as a cause of severe chronic stunting and partial growth hormone deficiency (PGHD): A case report.
 

Author(s): Xiaotang Cai, Dan Yu, Yongmei Xie, Hui Zhou

Journal: Medicine (Baltimore). 2018 Feb;97(7):e9880.

 

Argininemia is an autosomal recessive inherited disorder of the urea cycle. Because of its atypical symptoms in early age, diagnosis can be delayed until the typical chronic manifestations - including spastic diplegia, deterioration in cognitive function, and epilepsy - appear in later childhood.

Last Updated: 31 Dec 1969

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Growth Hormone Deficiency in Children: From Suspecting to Diagnosing.
 

Author(s): Varuna Vyas, Anil Kumar, Vandana Jain

Journal: Indian Pediatr. 2017 Nov;54(11):955-960.

 

Isolated Growth hormone deficiency is an important and treatable cause of short stature. However, it is often difficult to diagnose the condition with certainty due to the lack of a single robust diagnostic test. Short children, other than those with the classical phenotype of immature ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Growth Hormone Deficiency" returned 30 free, full-text review articles on human participants. First 3 results:

Growth hormone replacement therapy reduces risk of cancer in adult with growth hormone deficiency: A meta-analysis.
 

Author(s): Zhanzhan Li, Qin Zhou, Yanyan Li, Jun Fu, Xinqiong Huang, Liangfang Shen

Journal: Oncotarget. 2016 Dec;7(49):81862-81869.

 

The risk of growth hormone on cancer in adult with growth hormone deficiency remains unclear. We carried out a meta-analysis to evaluate the risk of cancer in adult with and without growth hormone replacement therapy. We searched PubMed, Web of Science, China National Knowledge Infrastructure, ...

Last Updated: 31 Dec 1969

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A Critical Appraisal of Growth Hormone Therapy in Growth Hormone Deficiency and Turner Syndrome Patients in Turkey.
 

Author(s): Zehra Yavaş Abalı, Feyza Darendeliler, Olcay Neyzi

Journal: J Clin Res Pediatr Endocrinol. 2016 12;8(4):490-495.

 

Early detection of abnormal growth, identification of the underlying cause, and appropriate treatment of the medical condition is an important issue for children with short stature. Growth hormone (GH) therapy is widely used in GH-deficient children and also in non-GH-deficient short ...

Last Updated: 31 Dec 1969

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Growth Hormone Deficiency in Prepubertal Children: Predictive Markers of Cardiovascular Disease.
 

Author(s): Chiara De Leonibus, Stefania De Marco, Adam Stevens, Peter Clayton, Francesco Chiarelli, Angelika Mohn

Journal: Horm Res Paediatr. 2016 ;85(6):363-71.

 

Cardiovascular (CV) risk factors have been identified in adults with untreated growth hormone deficiency (GHD). Existing evidence suggests that the development of the atheromatous plaque begins early in childhood. Previous reports have shown that GHD children are prone to increased ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pegylated Somatropin (PEG Somatropin) in the Treatment of Children With Growth Hormone Deficiency
 

Status: Recruiting

Condition Summary: Growth Hormone Deficiency

 

Last Updated: 10 Aug 2017

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Clinical Study of Pegylated Somatropin to Treat Children Growth Hormone Deficiency
 

Status: Recruiting

Condition Summary: Growth Hormone Deficiency

 

Last Updated: 13 Jun 2017

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Pegylated Somatropin (PEG Somatropin) in the Treatment of Children With Growth Hormone Deficiency
 

Status: Recruiting

Condition Summary: Growth Hormone Deficiency

 

Last Updated: 14 Jun 2017

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