Growth Hormone Deficiency

Common Name(s)

Growth Hormone Deficiency

Growth hormone deficiency is characterized by abnormally short height due to lack (or shortage) of growth hormone. It can be congenital (present at birth) or acquired. Most of the time, no single clear cause can be identified. Most cases are identified in children. Although it is uncommon, growth hormone deficiency may also be diagnosed in adults. Too little growth hormone can cause short stature in children, and changes in muscle mass, cholesterol levels, and bone strength in adults.  In adolescents, puberty may be delayed or absent. Treatment involves growth hormone injections.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Growth Hormone Deficiency" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

Last Updated: 7 Nov 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Growth Hormone Deficiency" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 7 Nov 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Growth Hormone Deficiency" returned 242 free, full-text research articles on human participants. First 3 results:

[Coexistence of growth hormone deficiency and lipodystrophia centrifugalis abdominalis infantilis in a child].
 

Author(s): Xiao-Yun Chen, Gui-Mei Li

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Jan;16(1):92-3.

 

Last Updated: 27 Jan 2014

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Reappraisal of serum insulin-like growth factor-I (IGF-1) measurement in the detection of isolated and combined growth hormone deficiency (GHD) during the transition period.
 

Author(s): Cesar L Boguszewski, Claudio Silva de Lacerda, Luiz de Lacerda Filho, Julienne A R de Carvalho, Margaret C S Boguszewski

Journal: Arq Bras Endocrinol Metabol. 2013 Dec;57(9):709-16.

 

To evaluate the accuracy of serum IGF-1 in the detection of isolated (IGHD) or combined growth hormone deficiency (CGHD) at the transition phase.

Last Updated: 9 Jan 2014

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Influence of body mass index on the growth hormone response to provocative testing in short children without growth hormone deficiency.
 

Author(s): Jieun Lee, Juyoung Yoon, Min Jae Kang, Young Ah Lee, Seong Yong Lee, Choong Ho Shin, Sei Won Yang

Journal: J. Korean Med. Sci.. 2013 Sep;28(9):1351-5.

 

Obesity and its related factors are known to suppress the secretion of growth hormone (GH). We aimed to evaluate the influence of body mass index (BMI) on the peak GH response to provocative testing in short children without GH deficiency. We conducted a retrospective review of medical ...

Last Updated: 9 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Growth Hormone Deficiency" returned 18 free, full-text review articles on human participants. First 3 results:

[STAT5B deficiency: a new growth hormone insensitivity syndrome associated to immunological dysfunction].
 

Author(s): Renata C Scalco, Patrícia N Pugliese-Pires, Alexander A L Jorge

Journal: Arq Bras Endocrinol Metabol. 2013 Jul;57(5):333-8.

 

A new presentation of growth hormone insensitivity (GHI) caused by homozygous mutations in STAT5B (signal transducer and activator of transcription 5B) gene has been characterized in the last years. Its particularity is the association with severe immune dysfunction, especially with ...

Last Updated: 30 Jul 2013

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Idiopathic adult growth hormone deficiency.
 

Author(s): Shlomo Melmed

Journal: J. Clin. Endocrinol. Metab.. 2013 Jun;98(6):2187-97.

 

GH secretion is controlled by hypothalamic as well as intrapituitary and peripheral signals, all of which converge upon the somatotroph, resulting in integrated GH synthesis and secretion. Enabling an accurate diagnosis of idiopathic adult GH deficiency (IAGHD) is challenged by the ...

Last Updated: 3 Jun 2013

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Diagnosis of growth hormone deficiency in childhood.
 

Author(s): Takara Stanley

Journal: Curr Opin Endocrinol Diabetes Obes. 2012 Feb;19(1):47-52.

 

The diagnosis of growth hormone deficiency (GHD) in childhood is challenging, in large part because of the lack of a true gold standard and the relatively poor performance of available diagnostic testing. This review discusses the recent literature on this topic.

Last Updated: 19 Dec 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of Growth Hormone on Glucose and Protein Metabolism in Children With Growth Hormone Deficiency
 

Status: Recruiting

Condition Summary: Growth Hormone Deficiency

 

Last Updated: 21 Dec 2010

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Last Updated: 6 May 2009

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