Growth Hormone Deficiency

Common Name(s)

Growth Hormone Deficiency

Growth hormone deficiency is characterized by abnormally short height due to lack (or shortage) of growth hormone. It can be congenital (present at birth) or acquired. Most of the time, no single clear cause can be identified. Most cases are identified in children. Although it is uncommon, growth hormone deficiency may also be diagnosed in adults. Too little growth hormone can cause short stature in children, and changes in muscle mass, cholesterol levels, and bone strength in adults.  In adolescents, puberty may be delayed or absent. Treatment involves growth hormone injections.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Growth Hormone Deficiency" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 7 Nov 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Growth Hormone Deficiency" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

View Details
The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 7 Nov 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Growth Hormone Deficiency" returned 239 free, full-text research articles on human participants. First 3 results:

Influence of body mass index on the growth hormone response to provocative testing in short children without growth hormone deficiency.
 

Author(s): Jieun Lee, Juyoung Yoon, Min Jae Kang, Young Ah Lee, Seong Yong Lee, Choong Ho Shin, Sei Won Yang

Journal: J. Korean Med. Sci.. 2013 Sep;28(9):1351-5.

 

Obesity and its related factors are known to suppress the secretion of growth hormone (GH). We aimed to evaluate the influence of body mass index (BMI) on the peak GH response to provocative testing in short children without GH deficiency. We conducted a retrospective review of medical ...

Last Updated: 9 Sep 2013

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Submicroscopic deletion involving the fibroblast growth factor receptor 1 gene in a patient with combined pituitary hormone deficiency.
 

Author(s): Maki Fukami, Manami Iso, Naoko Sato, Maki Igarashi, Misuzu Seo, Itsuro Kazukawa, Eiichi Kinoshita, Sumito Dateki, Tsutomu Ogata

Journal: Endocr. J.. 2013 ;60(8):1013-20.

 

Combined pituitary hormone deficiency (CPHD), isolated hypogonadotropic hypogonadism (IHH), Kallmann syndrome (KS), and septo-optic dysplasia (SOD) are genetically related conditions caused by abnormal development of the anterior midline in the forebrain. Although mutations in the ...

Last Updated: 2 Sep 2013

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Implications of a data-driven approach to treatment with growth hormone in children with growth hormone deficiency and Turner syndrome.
 

Author(s): Stefan Kaspers, Michael B Ranke, Donald Han, Jane Loftus, Hartmut Wollmann, Anders Lindberg, Mathieu Roelants, Joris Kleintjens

Journal: Appl Health Econ Health Policy. 2013 Jun;11(3):237-49.

 

Response to growth hormone (GH) therapy may vary between individual patients. Therefore the use of GH in children should be closely monitored to avoid over, under, or ineffective treatment regimens. The treatment response can be evaluated using growth prediction models. In an effort ...

Last Updated: 27 May 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Growth Hormone Deficiency" returned 16 free, full-text review articles on human participants. First 3 results:

Diagnosis of growth hormone deficiency in childhood.
 

Author(s): Takara Stanley

Journal: Curr Opin Endocrinol Diabetes Obes. 2012 Feb;19(1):47-52.

 

The diagnosis of growth hormone deficiency (GHD) in childhood is challenging, in large part because of the lack of a true gold standard and the relatively poor performance of available diagnostic testing. This review discusses the recent literature on this topic.

Last Updated: 19 Dec 2011

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Genetics of isolated growth hormone deficiency.
 

Author(s): Primus E Mullis

Journal: J Clin Res Pediatr Endocrinol. 2010 ;2(2):52-62.

 

When a child is not following the normal, predicted growth curve, an evaluation for underlying illnesses and central nervous system abnormalities is required, and appropriate consideration should be given to genetic defects causing growth hormone (GH) deficiency (GHD). Because Insulin-like ...

Last Updated: 28 Jan 2011

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Health-related quality of life of children and adolescents with growth hormone deficiency or idiopathic short stature - part 2: available results and future directions.
 

Author(s): Monika Bullinger, Maria Kołtowska-Häggström, David Sandberg, John Chaplin, Hartmut Wollmann, Meinolf Noeker, Anna Levke Brütt

Journal: Horm. Res.. 2009 ;72(2):74-81.

 

Research on the health-related quality of life (HrQoL) impact of short stature and its treatment in children and adolescents has developed recently. Based on a PubMed literature search, studies addressing this issue were identified and considerable methodological problems mainly related ...

Last Updated: 19 Aug 2009

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Diagnostic Accuracy of the Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and the Hypothalamic-Pituitary-Adrenal Axis
 

Status: Recruiting

Condition Summary: Adult Growth Hormone Deficiency; Hypothalamic-pituitary Disorders

 

Last Updated: 13 Aug 2013

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Effects of Growth Hormone on Glucose and Protein Metabolism in Children With Growth Hormone Deficiency
 

Status: Recruiting

Condition Summary: Growth Hormone Deficiency

 

Last Updated: 21 Dec 2010

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