Wilms' tumor

Common Name(s)

Wilms' tumor, Nephroblastoma

A Wilms’ tumor, also known as a nephroblastoma, is a rare, cancerous, kidney tumor that affects children. The tumor can be found in one or both kidneys and tends to be found in children between the ages of 3 and 4. The risk for a Wilms’ tumor decreases after the age of 5. Although some children who have a Wilms’ tumor appear healthy, some symptoms may include a lump in the abdomen (abdominal mass), pain or swelling, blood in the urine, nausea, constipation, loss of appetite, and fever.

All tumors are the result of an overgrowth of tissue that is caused by errors in the DNA of a cell. A Wilms’ tumor is the result of this happening in the kidney. There are multiple risk factors for a child having a Wilms’ tumor, including being African American, having a family history of Wilms’ tumors, being born with an abnormality in the colored portion of the eye (aniridia), having one part of the body that is larger than the other (hemihypertrophy), having undescended testicles (cryptorchidism), or having the urinary opening on the underside of the penis (hypospadias). Wilms’ tumors are also seen as part of a few different genetic conditions, including WAGR syndrome, Denys-Drash Syndrome, and Beckwith-Wiedemann syndrome.

A diagnosis is usually made using a physical exam, blood and urine tests, and imaging tests (CT or MRI). Once a diagnosis is made, the options for treatment include surgery to remove the tumor, chemotherapy, or radiation. Recent improvements for detection and treatment of a Wilms’ tumor has improved the outlook for many children. If your child has been diagnosed with a Wilms’ tumor, talk with their doctor about all treatment options. Support groups can provide additional information and connect you with other affected families.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wilms' tumor" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

Last Updated: 24 Jul 2015

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International WAGR Syndrome Association

Our mission is to promote international knowledge and awareness of WAGR syndrome and its complications and treatments, to stimulate research and to reach out to those affected by WAGR syndrome in an effort to improve their lives.

Last Updated: 12 Dec 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wilms' tumor" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

http://www.trisomy18.org

Last Updated: 24 Jul 2015

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International WAGR Syndrome Association

Our mission is to promote international knowledge and awareness of WAGR syndrome and its complications and treatments, to stimulate research and to reach out to those affected by WAGR syndrome in an effort to improve their lives.

http://www.wagr.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Wilms' tumor" returned 268 free, full-text research articles on human participants. First 3 results:

[Efficacy and safety of the WT-2009 chemotherapy protocol in treatment of Wilms' tumor in children].
 

Author(s): Xia Guo, Chao Lin, Ju Gao, Chen-Yan Zhou, Qiang Li, Yi-Ping Zhu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Mar;17(3):262-5.

 

To evaluate the efficacy and safety of the WT-2009 chemotherapy protocol for Wilms' tumor (WT) in children.

Last Updated: 30 Mar 2015

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Clinical factors in relapses of Wilms' tumor--results for the Polish Pediatric Solid Tumors Study Group.
 

Author(s): Ewa Niedzielska, Krzysztof Bronowicki, Wojciech Pietras, Krystyna Sawicz-Birkowska, Katarzyna Trybucka, Małgorzata Rąpała, Irena Karpińska-Derda, Andrzej Kurylak, Patrycja Marciniak-Stępak, Anna Panasiuk, Joanna Nurzyńska-Flak, Jarosław Peregud-Pogorzelski, Danuta Pietrys, Iwona Rurańska, Grażyna Sobol, Joanna Stefanowicz, Sabina Szymik-Kantorowicz, Małgorzata Zubowska, Jan Godziński

Journal: Adv Clin Exp Med. ;23(6):925-31.

 

The risk factors responsible for recurrences of Wilms' tumor (nephroblastoma) are still under discussion. The aim of the study was to analyze the relationship between relapses of Wilms' tumor and the patients' clinical history.

Last Updated: 27 Jan 2015

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Wilms' tumor gene (WT1) expression correlates with vascular epithelial growth factor (VEGF) in newly acute leukemia patients undergoing chemotherapy.
 

Author(s): Sara Iranparast, Mohammad-Ali Assarehzadegan, Yuji Heike, Mehran Hossienzadeh, Ali Khodadadi

Journal: Asian Pac. J. Cancer Prev.. 2014 ;15(21):9217-23.

 

Today, leukemia is one of the biggest problems worldwide. The Wilms' tumor gene (WT1) and the vascular endothelial growth factor (VEGF) gene are highly expressed in patients with various cancers. This study concerned the relationship between expression of WT1 and VEGF in patients ...

Last Updated: 25 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Wilms' tumor" returned 15 free, full-text review articles on human participants. First 3 results:

Botryoid Wilms' tumor: a case report and review of the literature.
 

Author(s): Guofeng Xu, Jimeng Hu, Yeming Wu, Yongtao Xiao, Maosheng Xu

Journal:

 

Here, we report a new case of botryoid Wilms' tumor, a 4-year-old boy, who was referred to us with a chief complaint of dysuria and gross hematuria. The computed tomography and radical nephroureterectomy showed that a botryoid sarcoma-like appearance occupied the right renal pelvis ...

Last Updated: 23 May 2013

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Active specific immunotherapy targeting the Wilms' tumor protein 1 (WT1) for patients with hematological malignancies and solid tumors: lessons from early clinical trials.
 

Author(s): Ann Van Driessche, Zwi N Berneman, Viggo F I Van Tendeloo

Journal: Oncologist. 2012 ;17(2):250-9.

 

There is a growing body of evidence that Wilms' tumor protein 1 (WT1) is a promising tumor antigen for the development of a novel class of universal cancer vaccines. Recently, in a National Cancer Institute prioritization project, WT1 was ranked first in a list of 75 cancer antigens. ...

Last Updated: 27 Feb 2012

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WT1 (Wilms' tumor gene 1): biology and cancer immunotherapy.
 

Author(s): Haruo Sugiyama

Journal: Jpn. J. Clin. Oncol.. 2010 May;40(5):377-87.

 

Wilms' tumor gene WT1 encodes a transcription factor and plays an important role in cell growth and differentiation. The WT1 gene is highly expressed in leukemia and various types of solid tumors, whereas WT1 is a tumor marker convenient for the detection of minimal residual disease ...

Last Updated: 4 May 2010

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gene Expression Profiles to Categorize Wilms Tumors
 

Status: Recruiting

Condition Summary: Recurrent Wilms Tumor and Other Childhood Kidney Tumors; Stage I Wilms Tumor; Stage II Wilms Tumor; Stage III Wilms Tumor; Stage IV Wilms Tumor; Stage V Wilms Tumor

 

Last Updated: 5 May 2015

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Biomarkers in Tissue Samples From Patients With High-Risk Wilms Tumor
 

Status: Recruiting

Condition Summary: Clear Cell Sarcoma of the Kidney; Recurrent Wilms Tumor and Other Childhood Kidney Tumors; Rhabdoid Tumor of the Kidney; Stage I Wilms Tumor; Stage II Wilms Tumor; Stage III Wilms Tumor; Stage IV Wilms Tumor; Stage V Wilms Tumor

 

Last Updated: 5 May 2015

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Collaborative Wilms Tumour Africa Project
 

Status: Recruiting

Condition Summary: Wilms Tumour

 

Last Updated: 9 Dec 2014

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