Williams syndrome

Common Name(s)

Williams syndrome

Williams syndrome is a developmental disorder that affects many parts of the body. This condition is characterized by mild to moderate intellectual disability, unique personality characteristics, distinctive facial features, and heart and blood vessel (cardiovascular) problems.  Williams syndrome is caused by missing genes from a specific region of chromosome 7. The deleted region includes more than 25 genes and researchers believe that a loss of several of these genes probably contributes to the characteristic features of this disorder. Although Williams syndrome is considered an autosomal dominant condition, most cases are not inherited, but occur as random events during the formation of reproductive cells (eggs or sperm) in a parent of an affected individual.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Williams syndrome" for support, advocacy or research.

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CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

Last Updated: 12 Oct 2013

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Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 30 Oct 2012

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Williams Syndrome Association

The Williams Syndrome Association is a non-profit organization that strives to enrich the lives of individuals and families affected by Williams syndrome and similar conditions through support, research and education. The Williams Syndrome Association (WSA) is the most comprehensive resource for people and families living with WS as well as doctors, researchers and educators. The WSA provides the resources and referrals that families need, and a strong and supportive community with which to connect throughout that child’s life.

Last Updated: 21 Mar 2013

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Williams Syndrome Changing Lives Foundation

The Williams Syndrome Changing Lives Foundation is a non-profit foundation centered on increasing Williams syndrome awareness, increasing education for families, the public, physicians and therapists. The Williams Syndrome Changing Lives Foundation was formed to enhance the lives of children and adults with Williams syndrome by providing needed financial assistance with medical, therapeutic, recreational needs and other developmental resources. In addition, the Williams Syndrome Changing Lives Foundation provides support for individuals, parents and families through support and outreach.

Last Updated: 12 Dec 2012

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Williams Syndrome Family of Hope

Williams Syndrome Family of Hope, Inc. has been created to enhance the lives of individuals living with Williams syndrome. We are dedicated to raising public awareness about Williams syndrome and its effects on the individual and their family. Please join our efforts to provide hope, financial aid and relief for the constant, complex and ongoing medical and financial needs of families and individuals with Williams syndrome.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Williams syndrome" for support, advocacy or research.

Logo
CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

http://www.cnsfoundation.org

Last Updated: 12 Oct 2013

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Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 30 Oct 2012

View Details
Williams Syndrome Association

The Williams Syndrome Association is a non-profit organization that strives to enrich the lives of individuals and families affected by Williams syndrome and similar conditions through support, research and education. The Williams Syndrome Association (WSA) is the most comprehensive resource for people and families living with WS as well as doctors, researchers and educators. The WSA provides the resources and referrals that families need, and a strong and supportive community with which to connect throughout that child’s life.

http://www.williams-syndrome.org

Last Updated: 21 Mar 2013

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Williams Syndrome Changing Lives Foundation

The Williams Syndrome Changing Lives Foundation is a non-profit foundation centered on increasing Williams syndrome awareness, increasing education for families, the public, physicians and therapists. The Williams Syndrome Changing Lives Foundation was formed to enhance the lives of children and adults with Williams syndrome by providing needed financial assistance with medical, therapeutic, recreational needs and other developmental resources. In addition, the Williams Syndrome Changing Lives Foundation provides support for individuals, parents and families through support and outreach.

http://www.wschanginglives.org

Last Updated: 12 Dec 2012

View Details
Williams Syndrome Family of Hope

Williams Syndrome Family of Hope, Inc. has been created to enhance the lives of individuals living with Williams syndrome. We are dedicated to raising public awareness about Williams syndrome and its effects on the individual and their family. Please join our efforts to provide hope, financial aid and relief for the constant, complex and ongoing medical and financial needs of families and individuals with Williams syndrome.

http://www.wsfamilyofhope.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Williams syndrome" returned 224 free, full-text research articles on human participants. First 3 results:

Genetic mapping of brain plasticity across development in Williams syndrome: ERP markers of face and language processing.
 

Author(s): D L Mills, L Dai, I Fishman, A Yam, L G Appelbaum, M St George, A Galaburda, U Bellugi, J R Korenberg

Journal: Dev Neuropsychol. 2013 ;38(8):613-42.

 

In Williams Syndrome (WS), a known genetic deletion results in atypical brain function with strengths in face and language processing. We examined how genetic influences on brain activity change with development. In three studies, event-related potentials (ERPs) from large samples ...

Last Updated: 13 Nov 2013

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Accelerometer-determined physical activity and walking capacity in persons with Down syndrome, Williams syndrome and Prader-Willi syndrome.
 

Author(s): Marianne Nordstrøm, Bjørge Herman Hansen, Benedicte Paus, Svein Olav Kolset

Journal: Res Dev Disabil. 2013 Dec;34(12):4395-403.

 

In this study we describe by use of accelerometers the total physical activity (PA), intensity pattern and walking capacity in 87 persons age 16-45 years with Down syndrome (DS), Williams syndrome (WS) and Prader-Willi syndrome (PWS). Participants were recruited from all over Norway, ...

Last Updated: 15 Nov 2013

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Assessment of clinical scoring systems for the diagnosis of Williams-Beuren syndrome.
 

Author(s): D E S Leme, D H Souza, G Mercado, E Pastene, A Dias, D Moretti-Ferreira

Journal:

 

Williams-Beuren syndrome (WBS) is a genetic disorder characterized by physical and intellectual developmental delay, associated with congenital heart disease and facial dysmorphism. WBS is caused by a microdeletion on chromosome 7 (7q11.23), which encompasses the elastin (ELN) gene ...

Last Updated: 25 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Williams syndrome" returned 21 free, full-text review articles on human participants. First 3 results:

Cardiovascular disease in Williams syndrome.
 

Author(s): R Thomas Collins

Journal: Circulation. 2013 May;127(21):2125-34.

 

Last Updated: 29 May 2013

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Genes, language, and the nature of scientific explanations: the case of Williams syndrome.
 

Author(s): Julien Musolino, Barbara Landau

Journal: Cogn Neuropsychol. 2012 ;29(1-2):123-48.

 

In this article, we discuss two experiments of nature and their implications for the sciences of the mind. The first, Williams syndrome, bears on one of cognitive science's holy grails: the possibility of unravelling the causal chain between genes and cognition. We sketch the outline ...

Last Updated: 28 Sep 2012

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Conceptualizing neurodevelopmental disorders through a mechanistic understanding of fragile X syndrome and Williams syndrome.
 

Author(s): Lawrence K Fung, Eve-Marie Quintin, Brian W Haas, Allan L Reiss

Journal: Curr. Opin. Neurol.. 2012 Apr;25(2):112-24.

 

The overarching goal of this review is to compare and contrast the cognitive-behavioral features of fragile X syndrome (FraX) and Williams syndrome and to review the putative neural and molecular underpinnings of these features. Information is presented in a framework that provides ...

Last Updated: 7 Mar 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Defining the Brain Phenotype of Children With Williams Syndrome
 

Status: Recruiting

Condition Summary: Williams Syndrome

 

Last Updated: 14 Mar 2014

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Fat Distribution and Glucose Metabolism in Williams Syndrome
 

Status: Recruiting

Condition Summary: Williams Syndrome

 

Last Updated: 5 Mar 2014

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The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome
 

Status: Recruiting

Condition Summary: Velocardiofacial Syndrome; Williams Syndrome; Fragile X Syndrome

 

Last Updated: 31 May 2012

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