Werner's syndrome

Common Name(s)

Werner's syndrome, Werner Syndrome

Werner's syndrome is a disease chiefly characterized by premature aging and cancer predisposition. Development is typically normal until the end of the first decade; the first sign is the lack of a growth spurt during puberty. Early signs (usually in the 20s) include loss and graying of hair, hoarseness, and scleroderma-like skin changes, followed by cataracts, type 2 diabetes mellitus, hypogonadism, skin ulcers, and osteoporosis in the 30s. Myocardial infarction (heart attack) and cancer are the most common causes of death, which typically occurs in the late 40s. It is caused by mutations in the WRN gene and is inherited in an autosomal recessive manner. Management focuses on treatment of signs and symptoms and prevention of secondary complications.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Werner's syndrome" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Werner's syndrome" returned 50 free, full-text research articles on human participants. First 3 results:

Endothelial cell study in a case of Werner's syndrome undergoing phacoemulsification and Yettrium-Aluminum-Garnet laser capsulotomy.
 

Author(s): Vasudha Kemmanu, Somshekar Nagappa, Kaushik Hegde, Naresh K Yadav, Bhujang K Shetty

Journal: Indian J Ophthalmol. ;60(6):570-2.

 

Werner's syndrome (WS) is a rare autosomal recessive disorder with multisystem manifestations of premature aging from the second decade of life. Cataract is one of the features of WS. Cataract surgery is complicated with postoperative wound dehiscence and bullous keratopathy when ...

Last Updated: 3 Dec 2012

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Werner's syndrome.
 

Author(s): Abid Keen, Iffat Hassan

Journal: Indian J Dermatol Venereol Leprol. ;78(3):380-1.

 

Last Updated: 8 May 2012

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Novel LMNA gene mutation in a patient with Atypical Werner's Syndrome.
 

Author(s): Yun Jeong Doh, Hee Kyoung Kim, Eui Dal Jung, Seung Hee Choi, Jung Guk Kim, Bo Wan Kim, In Kyu Lee

Journal: Korean J. Intern. Med.. 2009 Mar;24(1):68-72.

 

Hutchinson-Gilford progeria syndrome (HGPS) and Werner's syndrome are representative types of progeroid syndrome. LMNA (Lamin A/C) gene mutation with atypical Werner's syndrome have recently been reported. Atypical Werner's syndrome with the severe metabolic complications, the extent ...

Last Updated: 9 Mar 2009

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Werner's syndrome" returned 5 free, full-text review articles on human participants. First 3 results:

The Werner's Syndrome RecQ helicase/exonuclease at the nexus of cancer and aging.
 

Author(s): Stephen G Chun, David S Shaeffer, Peter K Bryant-Greenwood

Journal: Hawaii Med J. 2011 Mar;70(3):52-5.

 

Werner's Syndrome (WS) or adult-onset progeria is an autosomal recessive disorder of accelerated aging caused by mutations of the DNA RecQ helicase/exonuclease (WRN). WRN is an ATP-dependent helicase with 3' to 5' DNA exonuclease activity that regulates the replicative potential of ...

Last Updated: 2 Mar 2011

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A report of two cases of Werner's syndrome and review of the literature.
 

Author(s): K Yamamoto, A Imakiire, N Miyagawa, T Kasahara

Journal: J Orthop Surg (Hong Kong). 2003 Dec;11(2):224-33.

 

Two cases of Werner's syndrome are reported. The first case is that of a man with grey hair since his 20s, and alopecia since aged about 50 years. At the age of 53 years, Werner's syndrome was diagnosed, along with a malignant soft tissue tumour of the hand. The patient underwent ...

Last Updated: 16 Dec 2003

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Protecting genomic integrity during DNA replication: correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex.
 

Author(s): Annapaola Franchitto, Pietro Pichierri

Journal: Hum. Mol. Genet.. 2002 Oct;11(20):2447-53.

 

DNA replication is a critical step for cells because of the propensity of replication forks to stall, as a consequence either of endogenous DNA damage or of the propensity of repeated sequences to form tertiary structures, which can impede fork progression. Moreover, as a result of ...

Last Updated: 27 Sep 2002

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.