Wagner syndrome

Common Name(s)

Wagner syndrome

Wagner syndrome is a hereditary eye disease characterized by a central vitreous cavity which appears empty on slit-lamp examination. The condition was named after the Swiss ophthalmologist Hans Wagner, who described a family with this condition in 1938. Since then less than 50 families have been described. The first signs usually emerge during early adolescence, but onset may be as early as age 2. Wagner syndrome is caused by mutations in the VCAN gene.  It is inherited in an autosomal dominant manner.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wagner syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Wagner syndrome" returned 10 free, full-text research articles on human participants. First 3 results:

A family with Wagner syndrome with uveitis and a new versican mutation.
 

Author(s): Pierre-Raphaël Rothschild, Antoine P Brézin, Brigitte Nedelec, Cyril Burin des Roziers, Tiffany Ghiotti, Lucie Orhant, Mathieu Boimard, Sophie Valleix

Journal:

 

To report the clinical and molecular findings of a kindred with Wagner syndrome (WS) revealed by intraocular inflammatory features.

Last Updated: 31 Oct 2013

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Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes.
 

Author(s): Khanh-Nhat Tran-Viet, Vincent Soler, Valencia Quiette, Caldwell Powell, Tammy Yanovitch, Ravikanth Metlapally, Xiaoyan Luo, Nicholas Katsanis, Erica Nading, Terri L Young

Journal:

 

Stickler syndrome is an arthro-ophthalmopathy with phenotypic overlap with Wagner syndrome. The common Stickler syndrome type I is inherited as an autosomal dominant trait, with causal mutations in collagen type II alpha 1 (COL2A1). Wagner syndrome is associated with mutations in ...

Last Updated: 17 Apr 2013

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Novel VCAN mutations and evidence for unbalanced alternative splicing in the pathogenesis of Wagner syndrome.
 

Author(s): Barbara Kloeckener-Gruissem, John Neidhardt, István Magyar, Henri Plauchu, Jean-Christophe Zech, Laurette Morlé, Sheila M Palmer-Smith, Moira J Macdonald, Véronique Nas, Andrew E Fry, Wolfgang Berger

Journal: Eur. J. Hum. Genet.. 2013 Mar;21(3):352-6.

 

Wagner syndrome (WS) is an autosomal dominant vitreoretinopathy affecting various ocular features and is caused by mutations in the canonical splice sites of the VCAN gene, which encodes the large chondroitin sulfate proteoglycan, versican. We report the identification of novel splice ...

Last Updated: 14 Feb 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Wagner syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.