Vitiligo

Common Name(s)

Vitiligo

Vitiligo is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. As a result, white patches appear on the skin in different parts of the body, and sometimes also on both the mucous membranes and the retina. The average age of onset is in the mid-20s.  It is generally considered to be an autoimmune disorder, and about 20-25 percent of people with vitiligo also have at least one other autoimmune disorder. In the absence of other conditions, vitiligo does not affect general health; however, concerns about appearance and ethnic identity are significant issues for many affected individuals. The exact cause of vitiligo is not known, but there are several different theories. There is strong evidence that people with vitiligo inherit a group of genes that make them susceptible to depigmentation. The main goal of treating vitiligo is to improve appearance; current treatment options include medication, surgery, and adjunctive therapies (used along with surgical or medical treatments).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vitiligo" for support, advocacy or research.

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American Vitiligo Research Foundation

American Vitiligo Research Foundation Inc. (AVRF) provides public awareness about vitiligo through dedicated work, education and counseling. We seek to make a difference worldwide to those afflicted by the disease, focusing on children and their families. We embrace diversity and encourage acceptance. The AVRF encourages higher ethical standards in research, and therefore supports finding a cure through alternatives to animal testing.

Last Updated: 14 Jan 2013

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National Vitiligo Foundation Inc

Our mission is to educate and help the world to understand and accept people with Vitiligo with unquestionable love and respect; while also helping the medical professions find a cure.

Last Updated: 20 Mar 2013

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Vitiligo Research Foundation (VR Foundation)

Firmly committed to curing Vitiligo, the VR Foundation is a disease-specific non-profit organization funding and fast-tracking medical research globally. Our mission is to accelerate the end of suffering for millions of people who suffer from vitiligo through research, support and education.

Last Updated: 21 Aug 2014

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Vitiligo Support International Inc.

Vitiligo Support International Inc. (VSI) is a patient driven 501 (c) (3) nonprofit organization, committed to supporting those affected by vitiligo, raising awareness, promoting research, and discussing effective treatments until a cure is found.

Last Updated: 30 Nov 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vitiligo" for support, advocacy or research.

Logo
American Vitiligo Research Foundation

American Vitiligo Research Foundation Inc. (AVRF) provides public awareness about vitiligo through dedicated work, education and counseling. We seek to make a difference worldwide to those afflicted by the disease, focusing on children and their families. We embrace diversity and encourage acceptance. The AVRF encourages higher ethical standards in research, and therefore supports finding a cure through alternatives to animal testing.

http://www.avrf.org/

Last Updated: 14 Jan 2013

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National Vitiligo Foundation Inc

Our mission is to educate and help the world to understand and accept people with Vitiligo with unquestionable love and respect; while also helping the medical professions find a cure.

http://www.mynvfi.org

Last Updated: 20 Mar 2013

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Vitiligo Research Foundation (VR Foundation)

Firmly committed to curing Vitiligo, the VR Foundation is a disease-specific non-profit organization funding and fast-tracking medical research globally. Our mission is to accelerate the end of suffering for millions of people who suffer from vitiligo through research, support and education.

http://vrfoundation.org

Last Updated: 21 Aug 2014

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Vitiligo Support International Inc.

Vitiligo Support International Inc. (VSI) is a patient driven 501 (c) (3) nonprofit organization, committed to supporting those affected by vitiligo, raising awareness, promoting research, and discussing effective treatments until a cure is found.

https://www.vitiligosupport.org/front_page.cfm

Last Updated: 30 Nov 2012

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General Support Organizations

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General Resources

Vitiligo Biobank

The Vitiligo BioBank is a non-profit, independent collection of biological samples and detailed associated data, designed to facilitate medical research into vitiligo, a devastating skin disease that is much neglected. Here at the Vitiligo Biob

Updated 18 Apr 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Vitiligo" returned 285 free, full-text research articles on human participants. First 3 results:

Segmental vitiligo after infliximab use for rheumatoid arthritis--a case report.
 

Author(s): Clarissa Luiza Dalla Bernardina Carvalho, Luciena Cegatto Martins Ortigosa

Journal: An Bras Dermatol. ;89(1):154-6.

 

The tumor necrosis factor alpha is a cytokine related to immune and inflammatory processes by acting on different parts of the body. It is secreted by several cell types including macrophages, lymphocytes, monocytes, neutrophils, dendritic cells, among others. Infliximab is a chimeric ...

Last Updated: 14 Mar 2014

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Feasibility, double-blind, randomised, placebo-controlled, multi-centre trial of hand-held NB-UVB phototherapy for the treatment of vitiligo at home (HI-Light trial: Home Intervention of Light therapy).
 

Author(s): Viktoria Eleftheriadou, Kim Thomas, Jane Ravenscroft, Maxine Whitton, Jonathan Batchelor, Hywel Williams

Journal:

 

Hand-held NB-UVB units are lightweight devices that may overcome the need to treat vitiligo in hospital-based phototherapy cabinets, allowing early treatment at home that may enhance the likelihood of successful repigmentation. The pilot Hi-Light trial examined the feasibility of ...

Last Updated: 14 Feb 2014

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Clinical epidemiological profile of vitiligo in children and adolescents.
 

Author(s): Flauberto de Sousa Marinho, Pablo Vitoriano Cirino, Nurimar C Fernandes

Journal: An Bras Dermatol. ;88(6):1026-8.

 

94 children and 25 adolescents, 42% male and 58% female, aged predominantly between six and ten years old (40%) were studied at the Martag√£o Gesteira Childcare and Pediatrics Institute (Rio de Janeiro Federal University) between 2005 and 2011. The prevalent clinical form of vitiligo ...

Last Updated: 29 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Vitiligo" returned 25 free, full-text review articles on human participants. First 3 results:

The role of vitamin D in melanogenesis with an emphasis on vitiligo.
 

Author(s): Khalid AlGhamdi, Ashok Kumar, Noura Moussa

Journal: Indian J Dermatol Venereol Leprol. ;79(6):750-8.

 

Vitiligo is a common pigmentary disorder caused by the destruction of functional melanocytes. Vitamin D is an essential hormone synthesized in the skin and is responsible for skin pigmentation. Low levels of vitamin D have been observed in vitiligo patients and in patients with other ...

Last Updated: 1 Nov 2013

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A central role for inducible heat-shock protein 70 in autoimmune vitiligo.
 

Author(s): Jeffrey A Mosenson, Jonathan M Eby, Claudia Hernandez, I Caroline Le Poole

Journal: Exp. Dermatol.. 2013 Sep;22(9):566-9.

 

Inducible heat-shock protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship ...

Last Updated: 16 Aug 2013

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Modern vitiligo genetics sheds new light on an ancient disease.
 

Author(s): Richard A Spritz

Journal: J. Dermatol.. 2013 May;40(5):310-8.

 

Vitiligo is a complex disorder in which autoimmune destruction of melanocytes results in white patches of skin and overlying hair. Over the past several years, extensive genetic studies have outlined a biological framework of vitiligo pathobiology that underscores its relationship ...

Last Updated: 14 May 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Punchgrafting Techniques for Vitiligo
 

Status: Recruiting

Condition Summary: Non-segmental Vitiligo; Segmental Vitiligo; Piebaldism

 

Last Updated: 20 Jun 2011

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Effect of Fluticasone Proprionate 0.05% on Narrow Band UV-B in Active Vitiligo
 

Status: Recruiting

Condition Summary: Patients With Active Non-segmental Vitiligo.; Evaluation of the Efficacy of UVB and Fluticason Proprionate 0.05%; Cream Compared to NB-UVB Alone in Patients With Non-segmental Vitiligo

 

Last Updated: 23 Nov 2010

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