Vitiligo

Common Name(s)

Vitiligo

Vitiligo is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. As a result, white patches appear on the skin in different parts of the body, and sometimes also on both the mucous membranes and the retina. The average age of onset is in the mid-20s.  It is generally considered to be an autoimmune disorder, and about 20-25 percent of people with vitiligo also have at least one other autoimmune disorder. In the absence of other conditions, vitiligo does not affect general health; however, concerns about appearance and ethnic identity are significant issues for many affected individuals. The exact cause of vitiligo is not known, but there are several different theories. There is strong evidence that people with vitiligo inherit a group of genes that make them susceptible to depigmentation. The main goal of treating vitiligo is to improve appearance; current treatment options include medication, surgery, and adjunctive therapies (used along with surgical or medical treatments).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vitiligo" for support, advocacy or research.

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American Vitiligo Research Foundation

American Vitiligo Research Foundation Inc. (AVRF) provides public awareness about vitiligo through dedicated work, education and counseling. We seek to make a difference worldwide to those afflicted by the disease, focusing on children and their families. We embrace diversity and encourage acceptance. The AVRF encourages higher ethical standards in research, and therefore supports finding a cure through alternatives to animal testing.

http://www.avrf.org/

Last Updated: 14 Jan 2013

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National Vitiligo Foundation Inc

Our mission is to educate and help the world to understand and accept people with Vitiligo with unquestionable love and respect; while also helping the medical professions find a cure.

http://www.mynvfi.org

Last Updated: 20 Mar 2013

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Vitiligo Research Foundation (VR Foundation)

Firmly committed to curing Vitiligo, the VR Foundation is a disease-specific non-profit organization funding and fast-tracking medical research globally. Our mission is to accelerate the end of suffering for millions of people who suffer from vitiligo through research, support and education.

http://vrfoundation.org

Last Updated: 9 Apr 2014

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Vitiligo Support International Inc.

Vitiligo Support International Inc. (VSI) is a patient driven 501 (c) (3) nonprofit organization, committed to supporting those affected by vitiligo, raising awareness, promoting research, and discussing effective treatments until a cure is found.

https://www.vitiligosupport.org/front_page.cfm

Last Updated: 30 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vitiligo" for support, advocacy or research.

Logo
American Vitiligo Research Foundation

American Vitiligo Research Foundation Inc. (AVRF) provides public awareness about vitiligo through dedicated work, education and counseling. We seek to make a difference worldwide to those afflicted by the disease, focusing on children and their families. We embrace diversity and encourage acceptance. The AVRF encourages higher ethical standards in research, and therefore supports finding a cure through alternatives to animal testing.

http://www.avrf.org/

Last Updated: 14 Jan 2013

View Details
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National Vitiligo Foundation Inc

Our mission is to educate and help the world to understand and accept people with Vitiligo with unquestionable love and respect; while also helping the medical professions find a cure.

http://www.mynvfi.org

Last Updated: 20 Mar 2013

View Details
Vitiligo Research Foundation (VR Foundation)

Firmly committed to curing Vitiligo, the VR Foundation is a disease-specific non-profit organization funding and fast-tracking medical research globally. Our mission is to accelerate the end of suffering for millions of people who suffer from vitiligo through research, support and education.

http://vrfoundation.org

Last Updated: 9 Apr 2014

View Details
Logo
Vitiligo Support International Inc.

Vitiligo Support International Inc. (VSI) is a patient driven 501 (c) (3) nonprofit organization, committed to supporting those affected by vitiligo, raising awareness, promoting research, and discussing effective treatments until a cure is found.

https://www.vitiligosupport.org/front_page.cfm

Last Updated: 30 Nov 2012

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General Support Organizations

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General Resources

Vitiligo Biobank

The Vitiligo BioBank is a non-profit, independent collection of biological samples and detailed associated data, designed to facilitate medical research into vitiligo, a devastating skin disease that is much neglected. Here at the Vitiligo Biob

Updated 18 Apr 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Vitiligo" returned 311 free, full-text research articles on human participants. First 3 results:

Major precipitating factors for stigma among stigmatized vitiligo and psoriasis patients with brown-black skin shades.
 

Author(s): Ramaswamy Premkumar, Bikash Kar, Pitchaimuthu Rajan, Joseph Richard

Journal: Indian J Dermatol Venereol Leprol. ;79(5):703-5.

 

Last Updated: 26 Aug 2013

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The psychosocial impact of vitiligo in Indian patients.
 

Author(s): Pooja Pahwa, Manju Mehta, Binod K Khaitan, Vinod K Sharma, M Ramam

Journal: Indian J Dermatol Venereol Leprol. ;79(5):679-85.

 

Vitiligo has a special significance in Indian patients both because depigmentation is obvious on darker skin and the enormous stigma associated with the disease in the culture.

Last Updated: 26 Aug 2013

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Tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with vitiligo.
 

Author(s): F Al-Harthi, A Zouman, M Arfin, M Tariq, A Al-Asmari

Journal:

 

Vitiligo is an acquired depigmentary disorder of the skin, characterized by multiple susceptibility loci and genetic heterogeneity. The etiology of vitiligo is unknown but several hypotheses, including an autoimmune origin, have been proposed. Tumor necrosis factor (TNF)-α, a pleiotropic ...

Last Updated: 25 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Vitiligo" returned 24 free, full-text review articles on human participants. First 3 results:

Vitiligo: interplay between oxidative stress and immune system.
 

Author(s): Naresh C Laddha, Mitesh Dwivedi, Mohmmad S Mansuri, Amina R Gani, Md Ansarullah, A V Ramachandran, Sarat Dalai, Rasheedunnisa Begum

Journal: Exp. Dermatol.. 2013 Apr;22(4):245-50.

 

Vitiligo is a multifactorial polygenic disorder with a complex pathogenesis, linked with both genetic and non-genetic factors. The precise modus operandi for vitiligo pathogenesis has remained elusive. Theories regarding loss of melanocytes are based on autoimmune, cytotoxic, oxidant-antioxidant ...

Last Updated: 26 Mar 2013

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In vitro research on vitiligo: strategies, principles, methodological options and common pitfalls.
 

Author(s): Maria Lucia Dell'anna, Muriel Cario-André, Barbara Bellei, Alain Taieb, Mauro Picardo

Journal: Exp. Dermatol.. 2012 Jul;21(7):490-6.

 

Understanding the cellular and molecular mechanisms leading to melanocyte loss in vitiligo is a mandatory step in improving the overall management of vitiligo patients. Until now, the study of vitiligo was characterised by a fragmented approach, and it is very hard to share and compare ...

Last Updated: 21 Jun 2012

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Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference.
 

Author(s): K Ezzedine, H W Lim, T Suzuki, I Katayama, I Hamzavi, C C E Lan, B K Goh, T Anbar, C Silva de Castro, A Y Lee, D Parsad, N van Geel, I C Le Poole, N Oiso, L Benzekri, R Spritz, Y Gauthier, S K Hann, M Picardo, A Taieb,

Journal: Pigment Cell Melanoma Res. 2012 May;25(3):E1-13.

 

During the 2011 International Pigment Cell Conference (IPCC), the Vitiligo European Taskforce (VETF) convened a consensus conference on issues of global importance for vitiligo clinical research. As suggested by an international panel of experts, the conference focused on four topics: ...

Last Updated: 18 Apr 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Punchgrafting Techniques for Vitiligo
 

Status: Recruiting

Condition Summary: Non-segmental Vitiligo; Segmental Vitiligo; Piebaldism

 

Last Updated: 20 Jun 2011

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Effect of Fluticasone Proprionate 0.05% on Narrow Band UV-B in Active Vitiligo
 

Status: Recruiting

Condition Summary: Patients With Active Non-segmental Vitiligo.; Evaluation of the Efficacy of UVB and Fluticason Proprionate 0.05%; Cream Compared to NB-UVB Alone in Patients With Non-segmental Vitiligo

 

Last Updated: 23 Nov 2010

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