Vitiligo

Common Name(s)

Vitiligo

Vitiligo is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. As a result, white patches appear on the skin in different parts of the body, and sometimes also on both the mucous membranes and the retina. The average age of onset is in the mid-20s.  It is generally considered to be an autoimmune disorder, and about 20-25 percent of people with vitiligo also have at least one other autoimmune disorder. In the absence of other conditions, vitiligo does not affect general health; however, concerns about appearance and ethnic identity are significant issues for many affected individuals. The exact cause of vitiligo is not known, but there are several different theories. There is strong evidence that people with vitiligo inherit a group of genes that make them susceptible to depigmentation. The main goal of treating vitiligo is to improve appearance; current treatment options include medication, surgery, and adjunctive therapies (used along with surgical or medical treatments).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vitiligo" for support, advocacy or research.

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American Vitiligo Research Foundation

American Vitiligo Research Foundation Inc. (AVRF) provides public awareness about vitiligo through dedicated work, education and counseling. We seek to make a difference worldwide to those afflicted by the disease, focusing on children and their families. We embrace diversity and encourage acceptance. The AVRF encourages higher ethical standards in research, and therefore supports finding a cure through alternatives to animal testing.

Last Updated: 14 Jan 2013

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National Vitiligo Foundation Inc

Our mission is to educate and help the world to understand and accept people with Vitiligo with unquestionable love and respect; while also helping the medical professions find a cure.

Last Updated: 20 Mar 2013

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Vitiligo Research Foundation (VR Foundation)

Firmly committed to curing Vitiligo, the VR Foundation is a disease-specific non-profit organization funding and fast-tracking medical research globally. Our mission is to accelerate the end of suffering for millions of people who suffer from vitiligo through research, support and education.

Last Updated: 21 Aug 2014

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Vitiligo Support International Inc.

Vitiligo Support International Inc. (VSI) is a patient driven 501 (c) (3) nonprofit organization, committed to supporting those affected by vitiligo, raising awareness, promoting research, and discussing effective treatments until a cure is found.

Last Updated: 30 Nov 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Vitiligo" for support, advocacy or research.

Logo
American Vitiligo Research Foundation

American Vitiligo Research Foundation Inc. (AVRF) provides public awareness about vitiligo through dedicated work, education and counseling. We seek to make a difference worldwide to those afflicted by the disease, focusing on children and their families. We embrace diversity and encourage acceptance. The AVRF encourages higher ethical standards in research, and therefore supports finding a cure through alternatives to animal testing.

http://www.avrf.org/

Last Updated: 14 Jan 2013

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National Vitiligo Foundation Inc

Our mission is to educate and help the world to understand and accept people with Vitiligo with unquestionable love and respect; while also helping the medical professions find a cure.

http://www.mynvfi.org

Last Updated: 20 Mar 2013

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Vitiligo Research Foundation (VR Foundation)

Firmly committed to curing Vitiligo, the VR Foundation is a disease-specific non-profit organization funding and fast-tracking medical research globally. Our mission is to accelerate the end of suffering for millions of people who suffer from vitiligo through research, support and education.

http://vrfoundation.org

Last Updated: 21 Aug 2014

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Vitiligo Support International Inc.

Vitiligo Support International Inc. (VSI) is a patient driven 501 (c) (3) nonprofit organization, committed to supporting those affected by vitiligo, raising awareness, promoting research, and discussing effective treatments until a cure is found.

https://www.vitiligosupport.org/front_page.cfm

Last Updated: 30 Nov 2012

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General Support Organizations

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General Resources

Vitiligo Biobank

The Vitiligo BioBank is a non-profit, independent collection of biological samples and detailed associated data, designed to facilitate medical research into vitiligo, a devastating skin disease that is much neglected. Here at the Vitiligo Biob

Updated 18 Apr 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Vitiligo" returned 278 free, full-text research articles on human participants. First 3 results:

Non-cultured melanocyte/keratinocyte transplantation for the treatment of stable vitiligo on the face: report of two cases.
 

Author(s): Mariana Gontijo Ramos, Daniel Gontijo Ramos, Gabriel Gontijo, Camila Gontijo Ramos, Tania Nely Rocha, Rafael Henrique Rocha

Journal: An Bras Dermatol. ;88(5):811-3.

 

There are many alternatives to treat vitiligo, including surgical procedures, which are recommended for patients resistant to other therapies. The melanocyte/keratinocyte transplantation consists in the separation of epidermal cells obtained from a donor site and spreading these cells ...

Last Updated: 31 Oct 2013

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Gefitinib-associated vitiligo: report in a man with parotid squamous cell carcinoma and review of drug-induced hypopigmentation.
 

Author(s): Sheila Z Jalalat, Philip R Cohen

Journal:

 

Gefitinib is a tyrosine kinase inhibitor that targets and inhibits epidermal growth factor receptors. It was initially used to treat non-small cell lung cancer but has increasingly been used for other solid tumors such as those in the breast, colorectal sites, and head and neck, as ...

Last Updated: 21 Oct 2013

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Palmar vitiligo associated with Graves' disease.
 

Author(s): Yosuke Sasaki, Mitsuyo Kinjo, Rita Lynn McGill, Hitoshi Miyasato

Journal: Intern. Med.. 2013 ;52(17):2001-2.

 

Last Updated: 2 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Vitiligo" returned 24 free, full-text review articles on human participants. First 3 results:

The role of vitamin D in melanogenesis with an emphasis on vitiligo.
 

Author(s): Khalid AlGhamdi, Ashok Kumar, Noura Moussa

Journal: Indian J Dermatol Venereol Leprol. ;79(6):750-8.

 

Vitiligo is a common pigmentary disorder caused by the destruction of functional melanocytes. Vitamin D is an essential hormone synthesized in the skin and is responsible for skin pigmentation. Low levels of vitamin D have been observed in vitiligo patients and in patients with other ...

Last Updated: 1 Nov 2013

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Modern vitiligo genetics sheds new light on an ancient disease.
 

Author(s): Richard A Spritz

Journal: J. Dermatol.. 2013 May;40(5):310-8.

 

Vitiligo is a complex disorder in which autoimmune destruction of melanocytes results in white patches of skin and overlying hair. Over the past several years, extensive genetic studies have outlined a biological framework of vitiligo pathobiology that underscores its relationship ...

Last Updated: 14 May 2013

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Vitiligo: interplay between oxidative stress and immune system.
 

Author(s): Naresh C Laddha, Mitesh Dwivedi, Mohmmad S Mansuri, Amina R Gani, Md Ansarullah, A V Ramachandran, Sarat Dalai, Rasheedunnisa Begum

Journal: Exp. Dermatol.. 2013 Apr;22(4):245-50.

 

Vitiligo is a multifactorial polygenic disorder with a complex pathogenesis, linked with both genetic and non-genetic factors. The precise modus operandi for vitiligo pathogenesis has remained elusive. Theories regarding loss of melanocytes are based on autoimmune, cytotoxic, oxidant-antioxidant ...

Last Updated: 26 Mar 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Punchgrafting Techniques for Vitiligo
 

Status: Recruiting

Condition Summary: Non-segmental Vitiligo; Segmental Vitiligo; Piebaldism

 

Last Updated: 20 Jun 2011

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Effect of Fluticasone Proprionate 0.05% on Narrow Band UV-B in Active Vitiligo
 

Status: Recruiting

Condition Summary: Patients With Active Non-segmental Vitiligo.; Evaluation of the Efficacy of UVB and Fluticason Proprionate 0.05%; Cream Compared to NB-UVB Alone in Patients With Non-segmental Vitiligo

 

Last Updated: 23 Nov 2010

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