Type 1 plasminogen deficiency

Common Name(s)

Type 1 plasminogen deficiency

Type 1 plasminogen deficiency is a genetic condition associated with chronic lesions in the pseudomembrane (tough, thick material) of the mucosa of the eye, mouth, nasopharynx, trachea, and female genital tract; decreased serum plasminogen activity; and decreased plasminogen antigen level. The lesions may be triggered by local injury and/or infection and often recur after removal of the lesion; they are caused by the deposition of fibrin (a protein involved in blood clotting) and by inflammation. The most common clinical finding is ligenous ('wood-like') conjunctivitis, a condition marked by redness and subsequent formation of pseudomembranes of part of the eye that progresses to white, yellow-white or red thick masses with a wood-like consistency that replace the normal mucosa. Hydrocephalus may be present at birth in a small number of individuals.  
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Type 1 plasminogen deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Type 1 plasminogen deficiency" returned 3 free, full-text research articles on human participants. First 3 results:

Plasminogen activator inhibitor type-1 deficiency does not influence the outcome of murine pneumococcal pneumonia.
 

Author(s): Anita W Rijneveld, Sandrine Florquin, Paul Bresser, Marcel Levi, Vivian De Waard, Roger Lijnen, Jaring S Van Der Zee, Peter Speelman, Peter Carmeliet, Tom Van Der Poll

Journal: Blood. 2003 Aug;102(3):934-9.

 

Urokinase-type plasminogen activator (uPA) and its receptor uPAR are components of the fibrinolytic system and are important for an adequate immune response to respiratory tract infection, in part through their role in the migration of inflammatory cells. PA inhibitor-1 (PAI-1) is ...

Last Updated: 18 Jul 2003

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Brief report: complete deficiency of plasminogen-activator inhibitor type 1 due to a frame-shift mutation.
 

Author(s): W P Fay, A D Shapiro, J L Shih, R R Schleef, D Ginsburg

Journal: N. Engl. J. Med.. 1992 Dec;327(24):1729-33.

 

Last Updated: 17 Dec 1992

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A lifelong bleeding disorder associated with a deficiency of plasminogen activator inhibitor type 1.
 

Author(s): J DiƩval, G Nguyen, S Gross, J Delobel, E K Kruithof

Journal: Blood. 1991 Feb;77(3):528-32.

 

A 36-year-old patient was investigated for a lifelong history of epistaxis and delayed bleeding after minor surgeries. Deficiencies or abnormalities of the coagulation system, of platelet function, or of factor XIII and alpha-2-antiplasmin were excluded. Consistently, however, over ...

Last Updated: 8 Mar 1991

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Reviews from the PubMed Database

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The terms "Type 1 plasminogen deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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