Allgrove syndrome

Common Name(s)

Allgrove syndrome, Triple A syndrome, Achalasia-Addisonianism-Alacrimia syndrome, Glucocorticoid deficiency with achalasia

Triple A syndrome is an inherited condition characterized by three specific features: achalasia, Addison disease, and alacrima (a reduced or absent ability to secrete tears). Most people with triple A syndrome have all three of these features, although some have only two. Affected individuals may also have dysautonomia, developmental delay, intellectual disability, speech problems, a small head size, muscle weakness, movement problems, peripheral neuropathy, and optic atrophy. Many of the neurological symptoms of triple A syndrome worsen over time. Triple A syndrome is caused by mutations in the AAAS gene and is inherited in an autosomal recessive pattern.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Allgrove syndrome" for support, advocacy or research.

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Allgrove syndrome" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

View Details

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Allgrove syndrome" returned 7 free, full-text research articles on human participants. First 3 results:

[Allgrove syndrome (triple A). Finding of a mutation not described in the AAAS gene].
 

Author(s): M Capataz Ledesma, P Méndez Pérez, R Rodríguez López, E Galán Gómez

Journal: An Pediatr (Barc). 2013 Feb;78(2):109-12.

 

Allgrove syndrome (triple A) is a rare autosomal recessive disease. The classic triad includes, congenital adrenal insufficiency due to ACTH resistance, achalasia of the cardia and alacrimia. Neurological abnormalities are associated with autonomic neuropathy, sensory and motor defects, ...

Last Updated: 6 Feb 2013

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Allgrove syndrome.
 

Author(s): Fatih Kilicli, Fettah Acibucu, Soner Senel, Hatice Sebila Dokmetas

Journal: Singapore Med J. 2012 May;53(5):e92-4.

 

Allgrove syndrome is a rare autosomal recessive disorder. It is also known as the 3A syndrome and characterised by the triad of achalasia, alacrima and adrenal insufficiency. The AAAS gene is encoded on chromosome 12q13. We report the case of a 23-year-old woman who presented at the ...

Last Updated: 15 May 2012

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The small, spastic, and furrowed tongue of Allgrove syndrome.
 

Author(s): Henry Houlden

Journal: Neurology. 2009 Apr;72(15):1366.

 

Last Updated: 14 Apr 2009

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Allgrove syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.