Tourette Syndrome

Common Name(s)

Tourette Syndrome

Tourette syndrome is a disorder of the nervous system that causes a person to make repeated and uncontrolled (involuntary) movements and sounds (vocalizations) called tics. Tourette syndrome is named for Georges Gilles de la Tourette, who first described this disorder in 1885. There is strong evidence that Tourette syndrome is passed down through families, although the gene has not yet been found. The syndrome may be linked to problems in certain areas of the brain, and the chemical substances (dopamine, serotonin, and norepinephrine) that help nerve cells talk to one another. Tourette syndrome can be either severe or mild. It is estimated that about 1% of the population has Tourette syndrome. Many people with very mild tics may not be aware of them and never seek medical help.   Tourette syndrome is four times as likely to occur in boys as in girls.   Although Tourette syndrome can be a chronic condition with symptoms lasting a lifetime, most people with the condition experience their worst symptoms in their early teens, with improvement occurring in the late teens and continuing into adulthood.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Tourette Syndrome" for support, advocacy or research.

International OCD Foundation

Founded by a group of people with OCD in 1986, the International OCD Foundation (IOCDF) is an international not-for-profit organization made up of people with Obsessive Compulsive Disorder (OCD) and related disorders, as well as their families, friends, professionals and others. The mission and goals of the IOCDF are to: Educate the public and professionals about OCD in order to raise awareness and improve the quality of treatment provided; Support research into the cause of, and effective treatments for, OCD and related disorders; Improve access to resources for those with OCD and their fam

Last Updated: 19 Feb 2013

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

Last Updated: 5 May 2014

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 6 Apr 2015

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Pediatric Brain Foundation

Pediatric Brain Foundation's Mission is Three-fold: 1. Expedite scientific research to find treatments and cures for ALL of the more than 14 million children, in the U.S. alone, living with some form of neurological disorder 2. Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology 3. Educate the public and public officials on the critical importance of funding pediatric neurological research

Last Updated: 22 Apr 2015

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Tourette Syndrome Association, Inc.

Founded in 1972, TSA is the only national voluntary non-profit membership organization whose mission is to identify the cause, find the cure and control the effects of Tourette Syndrome through education, research and service.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Tourette Syndrome" for support, advocacy or research.

International OCD Foundation

Founded by a group of people with OCD in 1986, the International OCD Foundation (IOCDF) is an international not-for-profit organization made up of people with Obsessive Compulsive Disorder (OCD) and related disorders, as well as their families, friends, professionals and others. The mission and goals of the IOCDF are to: Educate the public and professionals about OCD in order to raise awareness and improve the quality of treatment provided; Support research into the cause of, and effective treatments for, OCD and related disorders; Improve access to resources for those with OCD and their fam

http://www.ocfoundation.org

Last Updated: 19 Feb 2013

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

http://www.movementdisorders.org/MDS.htm

Last Updated: 5 May 2014

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 6 Apr 2015

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Pediatric Brain Foundation

Pediatric Brain Foundation's Mission is Three-fold: 1. Expedite scientific research to find treatments and cures for ALL of the more than 14 million children, in the U.S. alone, living with some form of neurological disorder 2. Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology 3. Educate the public and public officials on the critical importance of funding pediatric neurological research

http://www.pediatricbrainfoundation.org

Last Updated: 22 Apr 2015

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Tourette Syndrome Association, Inc.

Founded in 1972, TSA is the only national voluntary non-profit membership organization whose mission is to identify the cause, find the cure and control the effects of Tourette Syndrome through education, research and service.

http://tsa-usa.org

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Tourette Syndrome" returned 200 free, full-text research articles on human participants. First 3 results:

[Treatment of Tourette syndrome by tomoxetine hydrochloride in older children].
 

Author(s): Ming-Xia Liu, Yi Zhou, Tong Xu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Nov;16(11):1162-4.

 

Last Updated: 21 Nov 2014

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Altered structural connectivity of cortico-striato-pallido-thalamic networks in Gilles de la Tourette syndrome.
 

Author(s): Yulia Worbe, Linda Marrakchi-Kacem, Sophie Lecomte, Romain Valabregue, Fabrice Poupon, Pamela Guevara, Alan Tucholka, Jean-François Mangin, Marie Vidailhet, Stephane Lehericy, Andreas Hartmann, Cyril Poupon

Journal: Brain. 2015 Feb;138(Pt 2):472-82.

 

Gilles de la Tourette syndrome is a childhood-onset syndrome characterized by the presence and persistence of motor and vocal tics. A dysfunction of cortico-striato-pallido-thalamo-cortical networks in this syndrome has been supported by convergent data from neuro-pathological, electrophysiological ...

Last Updated: 28 Jan 2015

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Meta-cognitions in tourette syndrome, tic disorders, and body-focused repetitive disorder.
 

Author(s): Kieron O'Connor, Marie-Ève St-Pierre-Delorme, Julie Leclerc, Marc Lavoie, Mélodie T Blais

Journal: Can J Psychiatry. 2014 Aug;59(8):417-25.

 

To explore if self-reported presence of thinking about tics or body-focused repetitive behaviours (BFRBs; gests) are direct triggers of tic or gest onset in 3 groups: Tourette syndrome (TS; n =18), persistent chronic tic disorders (TDs; n = 42), and a comparison group with BFRB (n = 36).

Last Updated: 27 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Tourette Syndrome" returned 29 free, full-text review articles on human participants. First 3 results:

Prenatal risk factors for Tourette Syndrome: a systematic review.
 

Author(s): Ting-Kuang Chao, Jing Hu, Tamara Pringsheim

Journal:

 

Tourette Syndrome (TS) appears to be an inherited disorder, although genetic abnormalities have been identified in less than 1% of patients, and the mode of inheritance is uncertain. Many studies have investigated environmental factors that might contribute to the onset and severity ...

Last Updated: 11 Feb 2014

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The effectiveness of habit reversal therapy in the treatment of Tourette syndrome and other chronic tic disorders: a systematic review.
 

Author(s): Neeladri Dutta, Andrea E Cavanna

Journal: Funct. Neurol.. ;28(1):7-12.

 

Tourette syndrome (TS) is a neurodevelopmental disorder characterized by multiple tics, which can require active intervention. It is recognized that behavioral techniques, especially habit reversal therapy (HRT), can offer an effective alternative or complement to pharmacotherapy ...

Last Updated: 4 Jun 2013

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Current controversies on the role of behavior therapy in Tourette syndrome.
 

Author(s): Lawrence Scahill, Douglas W Woods, Michael B Himle, Alan L Peterson, Sabine Wilhelm, John C Piacentini, Kevin McNaught, John T Walkup, Jonathan W Mink

Journal: Mov. Disord.. 2013 Aug;28(9):1179-83.

 

Comprehensive behavioral intervention for tics (CBIT) is a safe and effective treatment for managing the tics of Tourette syndrome (TS). In contrast to most current medications used for the treatment of tics, the efficacy of CBIT has been demonstrated in 2 relatively large, multisite ...

Last Updated: 4 Sep 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tourette Syndrome Deep Brain Stimulation
 

Status: Recruiting

Condition Summary: Tourette Syndrome

 

Last Updated: 22 Jan 2015

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MRI Study of Tic Remission in Tourette Syndrome
 

Status: Recruiting

Condition Summary: Tourette Syndrome

 

Last Updated: 1 Jun 2012

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Pilot Study for Use of Dysport in Treatment of Vocal Tics in Patients With Tourette's Syndrome
 

Status: Recruiting

Condition Summary: Tourette Syndrome; Chronic Vocal Tic

 

Last Updated: 9 Feb 2015

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