Rotor syndrome

Common Name(s)

Rotor syndrome

Rotor syndrome is a hereditary disorder of bilirubin metabolism. In Rotor syndrome there is an increase in the amount of bilirubin in the blood (hyperbilirubinemia). Rotor syndrome is characterized by jaundice, which is a yellowing of the skin and whites of the eyes. It is inherited in an autosomal recessive fashion. The underlying genetic defect has not been determined.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rotor syndrome" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rotor syndrome" returned 4 free, full-text research articles on human participants. First 3 results:

Loss of OATP1B3 function causes Rotor syndrome: implications for potential use of inhibitors in cancer.
 

Author(s): Elias Pratt, Tristan M Sissung, William D Figg

Journal: Cancer Biol. Ther.. 2012 Dec;13(14):1374-5.

 

There has been increasing recognition that organic anion transporter proteins (OATPs) play an important role in the biology of various cancers. De novo expression of OATPs has been identified in breast, colon, pancreatic, gastric and prostate cancer cells, among others. In patients ...

Last Updated: 9 Jan 2013

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Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.
 

Author(s): Evita van de Steeg, Viktor Stránecký, Hana Hartmannová, Lenka Nosková, Martin Hřebíček, Els Wagenaar, Anita van Esch, Dirk R de Waart, Ronald P J Oude Elferink, Kathryn E Kenworthy, Eva Sticová, Mohammad al-Edreesi, A S Knisely, Stanislav Kmoch, Milan Jirsa, Alfred H Schinkel

Journal: J. Clin. Invest.. 2012 Feb;122(2):519-28.

 

Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood, resulting in jaundice. The mechanistic basis of bilirubin excretion and hyperbilirubinemia syndromes ...

Last Updated: 1 Feb 2012

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[A case with Rotor syndrome in hyperbilirubinemic family].
 

Author(s): Min Kyu Jung, Myung Hwan Bae, Dae Jin Kim, Wan Suk Lee, Chang Min Cho, Won Young Tak, Young Oh Kweon

Journal: Korean J Gastroenterol. 2007 Apr;49(4):251-5.

 

Rotor syndrome is a rare, benign familial disorder characterized by chronic fluctuating, nonhemolytic and predominantly conjugated hyperbilirubinemia with normal hepatic histology. In contrast to Dubin-Johnson syndrome, there is no liver pigmentation in Rotor syndrome. A 36-year-old ...

Last Updated: 27 Apr 2007

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Reviews from the PubMed Database

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The terms "Rotor syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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