Rheumatoid arthritis

Common Name(s)

Rheumatoid arthritis

Rheumatoid arthritis is a chronic inflammatory disorder that normally affects the small joints in your hands and feet. It is an autoimmune disease meaning your body’s immune system, which protects your health by attacking foreign substances such as bacteria and viruses, mistakenly attacks your joints causing inflammation or swelling, redness, warmth and pain. The severity of symptoms varies between individuals and may come and go. Symptoms may include tender, warm, and swollen joints, joint stiffness especially in the morning, firm bumps of tissue under the skin on your arms (rheumatoid nodules), fatigue, fever, and weight loss. Symptoms may get progressively worse and may affect your wrist, knee, ankle, elbow, hip and shoulder joints.

The reason the immune system attacks the joints is unknown, but doctors believe there is a genetic component along with environmental factors. Individuals with a family history, between the ages of 40 and 60, and female are at a higher risk of rheumatoid arthritis. Rheumatoid arthritis may increase your risk of developing osteoporosis, carpal tunnel syndrome, heart problems, and lung disease.

Rheumatoid arthritis can be difficult to diagnose in the beginning because there is no single blood test or physical finding to confirm the diagnosis. However, your doctor may perform a physical exam to check your joints, blood tests, and an x-rays to help diagnose. While there is currently no cure for rheumatoid arthritis, there are medications to ease the symptoms, reduce inflammation, and slow down the progression of the disease. If you or a family member has been diagnosed with rheumatoid arthritis, talk with your doctor to learn about the most current treatment options. Support groups are also good sources of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rheumatoid arthritis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

View Details
Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

View Details
US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

Last Updated: 24 Sep 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rheumatoid arthritis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

View Details
US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

http://www.uspainfoundation.org

Last Updated: 24 Sep 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rheumatoid arthritis" returned 11029 free, full-text research articles on human participants. First 3 results:

Effects of the oral Janus kinase inhibitor tofacitinib on patient-reported outcomes in patients with active rheumatoid arthritis: results of two Phase 2 randomised controlled trials.
 

Author(s): Gene V Wallenstein, Keith S Kanik, Bethanie Wilkinson, Stanley Cohen, Maurizio Cutolo, Roy Fleishmann, Mark C Genovese, Juan Gomez Reino, David Gruben, Joel Kremer, Sriram Krishnaswami, Eun Bong Lee, Virginia Pascual-Ramos, Vibeke Strand, Samuel H Zwillich

Journal: Clin. Exp. Rheumatol.. ;34(3):430-42.

 

Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Here we investigated the effects of tofacitinib on patient-reported outcomes (PRO) in patients with active RA.

Last Updated: 9 Jun 2016

Go To URL
Independent Candidate Serum Protein Biomarkers of Response to Adalimumab and to Infliximab in Rheumatoid Arthritis: An Exploratory Study.
 

Author(s): Ignacio Ortea, Bernd Roschitzki, Rosario López-Rodríguez, Eva G Tomero, Juan G Ovalles, Javier López-Longo, Inmaculada de la Torre, Isidoro González-Alvaro, Juan J Gómez-Reino, Antonio González

Journal:

 

Response to treatment of rheumatoid arthritis shows large inter-individual variability. This heterogeneity is observed with all the anti-rheumatic drugs, including the commonly used TNF inhibitors. It seems that drug-specific and target-specific factors lead individual patients to ...

Last Updated: 7 Apr 2016

Go To URL
Increased Reactive Oxygen Species Formation and Oxidative Stress in Rheumatoid Arthritis.
 

Author(s): Somaiya Mateen, Shagufta Moin, Abdul Qayyum Khan, Atif Zafar, Naureen Fatima

Journal:

 

Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder. Highly reactive oxygen free radicals are believed to be involved in the pathogenesis of the disease. In this study, RA patients were sub-grouped depending upon the presence or absence of rheumatoid factor, disease activity ...

Last Updated: 5 Apr 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rheumatoid arthritis" returned 1253 free, full-text review articles on human participants. First 3 results:

One year in review 2016: novelties in the treatment of rheumatoid arthritis.
 

Author(s): Andrea Calabrò, Anna Laura Caterino, Elena Elefante, Valentina Valentini, Antonio Vitale, Rosaria Talarico, Luca Cantarini, Bruno Frediani

Journal: Clin. Exp. Rheumatol.. ;34(3):357-72.

 

Rheumatoid arthritis (RA) is a chronic disease characterised by inflammation of the synovial tissue in joints, which can lead to joint destruction. The primary goal of the treatment is to control pain and inflammation, reduce joint damage and disability, and maintain or improve physical ...

Last Updated: 9 Jun 2016

Go To URL
[Immunological markers of rheumatoid arthritis].
 

Author(s): Agnieszka Matuszewska, Marta Madej, Piotr Wiland

Journal:

 

Rheumatoid arthritis (RA) is the most common connective tissue disease of autoimmune origin. The disease is characterized by chronic inflammation leading to bone erosions and organ involvement. RA is a progressive disease. It affects the quality of life, leading to disability and ...

Last Updated: 27 Apr 2016

Go To URL
The mechanism of action of tofacitinib - an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis.
 

Author(s): Jennifer A Hodge, Thomas T Kawabata, Sriram Krishnaswami, James D Clark, Jean-Baptiste Telliez, Martin E Dowty, Sujatha Menon, Manisha Lamba, Samuel Zwillich

Journal: Clin. Exp. Rheumatol.. ;34(2):318-28.

 

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterised by infiltration of immune cells into the affected synovium, release of inflammatory cytokines and degradative mediators, and subsequent joint damage. Both innate and adaptive arms of the immune response ...

Last Updated: 20 Apr 2016

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Targeting Synovitis in Early Rheumatoid Arthritis
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis; Polyarthritis

 

Last Updated: 9 Sep 2009

Go to URL
Health Outcomes in Rheumatoid Arthritis
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis

 

Last Updated: 28 Jun 2006

Go to URL