Rheumatoid arthritis

Common Name(s)

Rheumatoid arthritis

Rheumatoid arthritis is a chronic inflammatory disorder that normally affects the small joints in your hands and feet. It is an autoimmune disease meaning your body’s immune system, which protects your health by attacking foreign substances such as bacteria and viruses, mistakenly attacks your joints causing inflammation or swelling, redness, warmth and pain. The severity of symptoms varies between individuals and may come and go. Symptoms may include tender, warm, and swollen joints, joint stiffness especially in the morning, firm bumps of tissue under the skin on your arms (rheumatoid nodules), fatigue, fever, and weight loss. Symptoms may get progressively worse and may affect your wrist, knee, ankle, elbow, hip and shoulder joints.

The reason the immune system attacks the joints is unknown, but doctors believe there is a genetic component along with environmental factors. Individuals with a family history, between the ages of 40 and 60, and female are at a higher risk of rheumatoid arthritis. Rheumatoid arthritis may increase your risk of developing osteoporosis, carpal tunnel syndrome, heart problems, and lung disease.

Rheumatoid arthritis can be difficult to diagnose in the beginning because there is no single blood test or physical finding to confirm the diagnosis. However, your doctor may perform a physical exam to check your joints, blood tests, and an x-rays to help diagnose. While there is currently no cure for rheumatoid arthritis, there are medications to ease the symptoms, reduce inflammation, and slow down the progression of the disease. If you or a family member has been diagnosed with rheumatoid arthritis, talk with your doctor to learn about the most current treatment options. Support groups are also good sources of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rheumatoid arthritis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

Last Updated: 24 Sep 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rheumatoid arthritis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

http://www.uspainfoundation.org

Last Updated: 24 Sep 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rheumatoid arthritis" returned 11323 free, full-text research articles on human participants. First 3 results:

The -174G/C Interleukin-6 Gene Promoter Polymorphism as a Genetic Marker of Differences in Therapeutic Response to Methotrexate and Leflunomide in Rheumatoid Arthritis.
 

Author(s): A J Ruiz-Padilla, J I Gamez-Nava, A M Saldaña-Cruz, J D Murillo-Vazquez, M L Vazquez-Villegas, S A Zavaleta-Muñiz, B T Martín-Márquez, J M Ponce-Guarneros, N A Rodriguez Jimenez, A Flores-Chavez, F Sandoval-Garcia, J C Vasquez-Jimenez, E G Cardona-Muñoz, S E Totsuka-Sutto, L Gonzalez-Lopez

Journal: Biomed Res Int. 2016 ;2016():4193538.

 

Objective. To evaluate the association of -174G/C IL-6 polymorphism with failure in therapeutic response to methotrexate (MTX) or leflunomide (LEF). This prospective, observational cohort included 96 Mexican-Mestizo patients with moderate or severe rheumatoid arthritis (RA), initiating ...

Last Updated: 14 Oct 2016

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Coronary Artery Calcification Is Related to Inflammation in Rheumatoid Arthritis: A Long-Term Follow-Up Study.
 

Author(s): Bengt Wahlin, Thomas Meedt, Fredrik Jonsson, Michael Y Henein, Solveig Wållberg-Jonsson

Journal: Biomed Res Int. 2016 ;2016():1261582.

 

Objective. A long-term follow-up of patients with rheumatoid arthritis (RA) to evaluate factors related to coronary artery calcification (CAC). Methods. All 22 eligible patients (4 males/18 females, mean age 65 years, and RA-duration 30-36 years) from the original (baseline; n = 39) ...

Last Updated: 20 Sep 2016

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The Activity of JAK/STAT and NF-κB in Patients with Rheumatoid Arthritis.
 

Author(s): Jerzy Świerkot, Beata Nowak, Anna Czarny, Ewa Zaczyńska, Renata Sokolik, Marta Madej, Lucyna Korman, Agata Sebastian, Patryk Wojtala, Łukasz Lubiński, Piotr Wiland

Journal: Adv Clin Exp Med. ;25(4):709-17.

 

Research is still being conducted in order to determine the mechanisms responsible for the initiation of rheumatoid arthritis (RA) as well as for its persistence and progression.

Last Updated: 16 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rheumatoid arthritis" returned 1290 free, full-text review articles on human participants. First 3 results:

Cardiovascular risk assessment in patients with rheumatoid arthritis: The relevance of clinical, genetic and serological markers.
 

Author(s): Raquel López-Mejías, Santos Castañeda, Carlos González-Juanatey, Alfonso Corrales, Iván Ferraz-Amaro, Fernanda Genre, Sara Remuzgo-Martínez, Luis Rodriguez-Rodriguez, Ricardo Blanco, Javier Llorca, Javier Martín, Miguel A González-Gay

Journal: Autoimmun Rev. 2016 Nov;15(11):1013-1030.

 

Cardiovascular disease (CV) is the most common cause of premature mortality in patients with rheumatoid arthritis (RA). This is the result of an accelerated atherosclerotic process. Adequate CV risk stratification has special relevance in RA to identify patients at risk of CV disease. ...

Last Updated: 9 Aug 2016

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From TGN1412 to TAB08: the return of CD28 superagonist therapy to clinical development for the treatment of rheumatoid arthritis.
 

Author(s): Dmitry Tyrsin, Sergey Chuvpilo, Alexey Matskevich, Daniil Nemenov, Paula S Römer, Paula Tabares, Thomas Hünig

Journal: Clin. Exp. Rheumatol.. ;34(4 Suppl 98):45-8.

 

CD28 superagonists (CD28SA) are CD28-specific monoclonal antibodies which are able to activate T-cells without overt TCR engagement. In rodents, CD28SA efficiently activate regulatory T-cells and are therapeutically effective in multiple models of autoimmunity, inflammation and transplantation. ...

Last Updated: 2 Sep 2016

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Targeting GM-CSF in rheumatoid arthritis.
 

Author(s): Ali Berkant Avci, Eugen Feist, Gerd-Rüdiger Burmester

Journal: Clin. Exp. Rheumatol.. ;34(4 Suppl 98):39-44.

 

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is well-known as a haemopoietic growth factor. However, it is also essential in regulating functions of mature myeloid cells such as macrophages. Preclinical studies and observations of flares of arthritis in patients following ...

Last Updated: 2 Sep 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Discovering the Antecedents of Rheumatoid Arthritis Flare
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis

 

Last Updated: 6 Oct 2016

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The PRESS RA: Protein and Resistance Exercise Supplementation Study for Rheumatoid Arthritis
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis

 

Last Updated: 22 Dec 2015

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Rheumatoid Arthritis Patients and Porphyromonas Gingivalis
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis

 

Last Updated: 12 Jan 2017

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