Rheumatoid arthritis

Common Name(s)

Rheumatoid arthritis

Rheumatoid arthritis is a chronic inflammatory disorder that normally affects the small joints in your hands and feet. It is an autoimmune disease meaning your body’s immune system, which protects your health by attacking foreign substances such as bacteria and viruses, mistakenly attacks your joints causing inflammation or swelling, redness, warmth and pain. The severity of symptoms varies between individuals and may come and go. Symptoms may include tender, warm, and swollen joints, joint stiffness especially in the morning, firm bumps of tissue under the skin on your arms (rheumatoid nodules), fatigue, fever, and weight loss. Symptoms may get progressively worse and may affect your wrist, knee, ankle, elbow, hip and shoulder joints.

The reason the immune system attacks the joints is unknown, but doctors believe there is a genetic component along with environmental factors. Individuals with a family history, between the ages of 40 and 60, and female are at a higher risk of rheumatoid arthritis. Rheumatoid arthritis may increase your risk of developing osteoporosis, carpal tunnel syndrome, heart problems, and lung disease.

Rheumatoid arthritis can be difficult to diagnose in the beginning because there is no single blood test or physical finding to confirm the diagnosis. However, your doctor may perform a physical exam to check your joints, blood tests, and an x-rays to help diagnose. While there is currently no cure for rheumatoid arthritis, there are medications to ease the symptoms, reduce inflammation, and slow down the progression of the disease. If you or a family member has been diagnosed with rheumatoid arthritis, talk with your doctor to learn about the most current treatment options. Support groups are also good sources of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rheumatoid arthritis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

Last Updated: 24 Sep 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rheumatoid arthritis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

http://www.uspainfoundation.org

Last Updated: 24 Sep 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rheumatoid arthritis" returned 9112 free, full-text research articles on human participants. First 3 results:

Autoimmune hepatitis triggered by adalimumab and allergic reactions after various anti-TNFα therapy agents in a patient with rheumatoid arthritis.
 

Author(s): Jana Petríková, Peter Jarčuška, Marián Svajdler, Daniel Pella, Zelmíra Macejová

Journal: Isr. Med. Assoc. J.. 2015 Apr;17(4):256-8.

 

Last Updated: 4 Jun 2015

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Disease activity guided dose reduction and withdrawal of adalimumab or etanercept compared with usual care in rheumatoid arthritis: open label, randomised controlled, non-inferiority trial.
 

Author(s): Noortje van Herwaarden, Aatke van der Maas, Michiel J M Minten, Frank H J van den Hoogen, Wietske Kievit, Ronald F van Vollenhoven, Johannes W J Bijlsma, Bart J F van den Bemt, Alfons A den Broeder

Journal:

 

To evaluate whether a disease activity guided strategy of dose reduction of two tumour necrosis factor (TNF) inhibitors, adalimumab or etanercept, is non-inferior in maintaining disease control in patients with rheumatoid arthritis compared with usual care.

Last Updated: 10 Apr 2015

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Increased risk of depression in patients with rheumatoid arthritis: a seven-year population-based cohort study.
 

Author(s): Miao-Chiu Lin, How-Ran Guo, Ming-Chi Lu, Hanoch Livneh, Ning-Sheng Lai, Tzung-Yi Tsai

Journal: Clinics (Sao Paulo). 2015 Feb;70(2):91-6.

 

Rheumatoid arthritis (RA) is a costly and crippling autoimmune disease that can lead to the development of depression, contributing to suboptimal clinical outcomes. However, no longitudinal studies have identified an association between rheumatoid arthritis and subsequent depression. ...

Last Updated: 20 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rheumatoid arthritis" returned 1048 free, full-text review articles on human participants. First 3 results:

The supplementary therapeutic DMARD role of low-dose glucocorticoids in rheumatoid arthritis.
 

Author(s): Maurizio Cutolo, Cornelia M Spies, Frank Buttgereit, Sabrina Paolino, Carmen Pizzorni

Journal:

 

The management of rheumatoid arthritis (RA) is primarily based on the use of disease-modifying antirheumatic drugs (DMARDs), mainly comprising synthetic chemical compounds (that is, methotrexate or leflunomide) and biological agents (tumor necrosis factor inhibitors or abatacept). ...

Last Updated: 22 Jan 2015

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The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis.
 

Author(s): Camille Roubille, Vincent Richer, Tara Starnino, Collette McCourt, Alexandra McFarlane, Patrick Fleming, Stephanie Siu, John Kraft, Charles Lynde, Janet Pope, Wayne Gulliver, Stephanie Keeling, Jan Dutz, Louis Bessette, Robert Bissonnette, Boulos Haraoui

Journal: Ann. Rheum. Dis.. 2015 Mar;74(3):480-9.

 

The objective of this systematic literature review was to determine the association between cardiovascular events (CVEs) and antirheumatic drugs in rheumatoid arthritis (RA) and psoriatic arthritis (PsA)/psoriasis (Pso). Systematic searches were performed of MEDLINE, EMBASE and Cochrane ...

Last Updated: 6 Feb 2015

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Vagus nerve stimulation: a new bioelectronics approach to treat rheumatoid arthritis?
 

Author(s): F A Koopman, P R Schuurman, M J Vervoordeldonk, P P Tak

Journal: Best Pract Res Clin Rheumatol. 2014 Aug;28(4):625-35.

 

There has been a marked improvement in the treatment of rheumatoid arthritis (RA), but most patients do not achieve disease remission. Therefore, there is still a need for new treatments. By screening an adenoviral short hairpin RNA library, we discovered that knockdown of the nicotinic ...

Last Updated: 8 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Targeting Synovitis in Early Rheumatoid Arthritis
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis; Polyarthritis

 

Last Updated: 9 Sep 2009

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Patient Rheumatoid Arthritis Social Support Study
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis

 

Last Updated: 29 Jul 2015

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Health Outcomes in Rheumatoid Arthritis
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis

 

Last Updated: 28 Jun 2006

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