Rheumatoid arthritis

Common Name(s)

Rheumatoid arthritis

Rheumatoid arthritis is a chronic inflammatory disorder that normally affects the small joints in your hands and feet. It is an autoimmune disease meaning your body’s immune system, which protects your health by attacking foreign substances such as bacteria and viruses, mistakenly attacks your joints causing inflammation or swelling, redness, warmth and pain. The severity of symptoms varies between individuals and may come and go. Symptoms may include tender, warm, and swollen joints, joint stiffness especially in the morning, firm bumps of tissue under the skin on your arms (rheumatoid nodules), fatigue, fever, and weight loss. Symptoms may get progressively worse and may affect your wrist, knee, ankle, elbow, hip and shoulder joints.

The reason the immune system attacks the joints is unknown, but doctors believe there is a genetic component along with environmental factors. Individuals with a family history, between the ages of 40 and 60, and female are at a higher risk of rheumatoid arthritis. Rheumatoid arthritis may increase your risk of developing osteoporosis, carpal tunnel syndrome, heart problems, and lung disease.

Rheumatoid arthritis can be difficult to diagnose in the beginning because there is no single blood test or physical finding to confirm the diagnosis. However, your doctor may perform a physical exam to check your joints, blood tests, and an x-rays to help diagnose. While there is currently no cure for rheumatoid arthritis, there are medications to ease the symptoms, reduce inflammation, and slow down the progression of the disease. If you or a family member has been diagnosed with rheumatoid arthritis, talk with your doctor to learn about the most current treatment options. Support groups are also good sources of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rheumatoid arthritis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 16 Mar 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

Last Updated: 24 Sep 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Rheumatoid arthritis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 16 Mar 2015

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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US Pain Foundation

US Pain Foundation is created by people with pain for people with pain. As a 501 (c)3 non-profit organization dedicated to serving those who live with pain conditions and their care providers, U.S. Pain Foundation exists to help individuals find resources and inspiration.
Our mission is simple: to educate, connect, inform, advocate and empower those living with pain. In addition we work to educate the public on pain issues and to raise awareness on pain in America. We recognize and validate the 100 million Americans who battle pain every day by offering positive programs that empower and ed

http://www.uspainfoundation.org

Last Updated: 24 Sep 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Rheumatoid arthritis" returned 8897 free, full-text research articles on human participants. First 3 results:

Etanercept increases tumor necrosis factor-alpha level but not sFas level in patients with rheumatoid arthritis.
 

Author(s): Przemyslaw Kotyla, Katarzyna Jankiewicz-Ziobro, Aleksander Owczarek, Eugene J Kucharz

Journal: Isr. Med. Assoc. J.. 2015 Jan;17(1):14-8.

 

Targeted anti-tumor necrosis factor-alpha (TNFα) therapy in patients with rheumatoid arthritis (RA) has resulted in dramatic improvement in the disease course and prognosis. One of the features of RA is hyperplasia of synovial cells, particularly RA synovial fibroblasts (RA-SF), ...

Last Updated: 5 Mar 2015

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Etanercept tapering in rheumatoid arthritis.
 

Author(s): Paul Emery, Mohammed Hammoudeh, Bernard Combe

Journal: N. Engl. J. Med.. 2015 Jan;372(5):489-90.

 

Last Updated: 29 Jan 2015

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A phase IB clinical trial with Dekavil (F8-IL10), an immunoregulatory 'armed antibody' for the treatment of rheumatoid arthritis, used in combination wiIh methotrexate.
 

Author(s): M Galeazzi, L Bazzichi, G D Sebastiani, D Neri, E Garcia, N Ravenni, L Giovannoni, J Wilton, M Bardelli, C Baldi, E Selvi, A Iluliano, G Minisola, R Caporali, E Prisco, S Bombardieri

Journal: Isr. Med. Assoc. J.. 2014 Oct;16(10):666.

 

Last Updated: 2 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Rheumatoid arthritis" returned 1015 free, full-text review articles on human participants. First 3 results:

Putative approaches to bypass the citrulline-specific autoimmune response in rheumatoid arthritis.
 

Author(s): Smadar Gertel, Howard Amital

Journal: Isr. Med. Assoc. J.. 2014 Sep;16(9):587-90.

 

The major autoantigens in the inflamed synovium in rheumatoid arthritis (RA) are citrullinated peptides. Citrullinated peptides are employed in diagnostic kits for detection of anti-citrullinated protein antibodies (ACPA), a serological marker with high specificity and sensitivity ...

Last Updated: 29 Oct 2014

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Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis.
 

Author(s): Vasanth Konda Mohan, Nalini Ganesan, Rajasekhar Gopalakrishnan

Journal: J. Genet.. 2014 Aug;93(2):597-605.

 

Rheumatoid arthritis (RA) is a chronic autoimmune disorder of unknown aetiology resulting in inflammation of the synovium, cartilage and bone. The disease has a heterogeneous character, consisting of clinical subsets of anti-citrullinated protein antibody (ACPA)-positive and APCA-negative ...

Last Updated: 5 Sep 2014

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[An approach to bone and cartilage repair of rheumatoid arthritis by mesenchymal stem cells].
 

Author(s): Koshiro Sonomoto, Kunihiro Yamaoka, Yoshiya Tanaka

Journal: J. UOEH. 2014 Jun;36(2):141-6.

 

Rheumatoid arthritis (RA) is an autoimmune disease represented by chronic inflammation and following structural damage at the articular joints. Progression of the disease causes disability and subsequent early retirement or a care-requiring condition. Although new agents have the ...

Last Updated: 16 Jun 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Targeting Synovitis in Early Rheumatoid Arthritis
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis; Polyarthritis

 

Last Updated: 9 Sep 2009

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Patient Rheumatoid Arthritis Social Support Study
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis

 

Last Updated: 9 Jan 2014

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Health Outcomes in Rheumatoid Arthritis
 

Status: Recruiting

Condition Summary: Rheumatoid Arthritis

 

Last Updated: 28 Jun 2006

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