Psoriatic arthritis

Common Name(s)

Psoriatic arthritis

Psoriatic arthritis is joint inflammation and stiffness (arthritis) that affects people who have a condition that causes red, itchy, and scaly skin patches (psoriasis). Signs and symptoms of psoriatic arthritis are similar to other forms of arthritis and include stiff and painful joints. In addition, psoriatic arthritis can also cause finger and toe swelling, foot pain and lower back pain. Typically, psoriasis appears before joint problems. Psoriasis symptoms typically occur between the ages of 15 and 35 years and arthritis symptoms usually occur between the ages of 30 and 50. However, both conditions can occur at any age.

Psoriatic arthritis occurs when the body’s immune system attacks healthy cells and tissues. This abnormal immune response, which causes inflammation in your joints, may be due to a combination of genetic and environmental reasons. Risk factors for psoriatic arthritis include having psoriasis, being between the ages of 30 and 50, and having a family history of psoriatic arthritis. There are five types of psoriatic arthritis: distal interphalangeal (DIP), asymmetric oligoarticular, symmetric polyarthritis, spondylitis, and arthritis mutilans. The distal interphalangeal type predominantly affects the ends of fingers and toes. The symmetric polyarthritis form affects matching joints on opposite sides of the body (e.g. Right and left wrist), while the asymmetric oligoarticular type involves nonmatching joints of each side of the body. Spondylitis is inflammation in the joints between the vertebrae in the spine. Arthritis mutilans, which is the most severe and least common type of psoriatic arthritis, causes damage and loss of function of affected joints.

Your doctor may use a physical exam along with imaging and lab tests to diagnosis psoriatic arthritis. There is no cure, but treatment can help manage pain. Talk with a doctor if you have been diagnosed with psoriatic arthritis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriatic arthritis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

View Details
National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 26 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Psoriatic arthritis" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

View Details
National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 26 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

For scientists and medical professionals

Information about how to apply for National Psoriasis Foundation research grants and fellowships, our medical journal and other science-related materials for medical professionals.

Updated 15 Nov 2012

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Psoriatic arthritis" returned 607 free, full-text research articles on human participants. First 3 results:

Tofacitinib regulates synovial inflammation in psoriatic arthritis, inhibiting STAT activation and induction of negative feedback inhibitors.
 

Author(s): W Gao, T McGarry, C Orr, J McCormick, D J Veale, U Fearon

Journal: Ann. Rheum. Dis.. 2016 Jan;75(1):311-5.

 

Psoriatic arthritis (PsA) is a chronic inflammatory disease, characterised by synovitis and destruction of articular cartilage/bone. Janus-kinase and signal transducer and activator of transcription (JAK-STAT) signalling pathway is implicated in the pathogenesis of PsA.

Last Updated: 15 Dec 2015

Go To URL
Serum IL-6 and IL-23 Levels and Their Correlation with Angiogenic Cytokines and Disease Activity in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome.
 

Author(s): Hanna Przepiera-Będzak, Katarzyna Fischer, Marek Brzosko

Journal: Mediators Inflamm.. 2015 ;2015():785705.

 

To assess serum interleukin-6 (IL-6) and interleukin-23 (IL-23) and their correlation with angiogenic cytokines and disease activity in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and SAPHO syndrome.

Last Updated: 4 Sep 2015

Go To URL
Antinuclear Antibodies in Patients with Psoriatic Arthritis Treated or Not with Biologics.
 

Author(s): Florent Silvy, Daniel Bertin, Nathalie Bardin, Isabelle Auger, Marie-Caroline Guzian, Jean-Pierre Mattei, Sandrine Guis, Jean Roudier, Nathalie Balandraud

Journal:

 

With the emergence of biotherapies, accurate diagnosis in early arthritis is needed. At this time, there is no biological marker of psoriatic arthritis.

Last Updated: 3 Aug 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Psoriatic arthritis" returned 113 free, full-text review articles on human participants. First 3 results:

Apremilast in the treatment of psoriasis and psoriatic arthritis.
 

Author(s): M Gooderham, K Papp

Journal: Skin Therapy Lett.. ;20(5):1-6.

 

Phosphodiesterase 4 (PDE4) is a key enzyme in the regulation of immune responses of inflammatory diseases through degradation of the second messenger, cyclic adenosine 3',5'-monophosphate (cAMP). Apremilast, a selective PDE4 inhibitor, has been shown to reduce the production of pro-inflammatory ...

Last Updated: 19 Sep 2015

Go To URL
Identifying a novel locus for psoriatic arthritis.
 

Author(s): Ashley Budu-Aggrey, John Bowes, Anne Barton

Journal: Rheumatology (Oxford). 2016 Jan;55(1):25-32.

 

A number of studies have identified genetic risk loci for PsA, the majority of which also confer risk for psoriasis. The stronger heritability of PsA in comparison with psoriasis suggests that there should be risk loci that are specific for PsA. Identifying such loci could potentially ...

Last Updated: 15 Dec 2015

Go To URL
Treatment of psoriasis and psoriatic arthritis during pregnancy and breastfeeding.
 

Author(s): Patricia Shu Kurizky, Clarissa de Castro Ferreira, Lucas Souza Carmo Nogueira, Licia Maria Henrique da Mota

Journal: An Bras Dermatol. ;90(3):367-75.

 

Psoriasis is a chronic inflammatory disease that affects primarily the skin and joints, with a worldwide incidence of 2-3%. Fifty percent of patients are women, most still diagnosed during childbearing years. Currently,the estimate is that up to 107 thousand deliveries are performed ...

Last Updated: 3 Jul 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study in Participants With Psoriatic Arthritis Attending Dermatology Clinics
 

Status: Recruiting

Condition Summary: Psoriatic Arthritis

 

Last Updated: 13 May 2016

Go to URL
Psoriatic Arthritis Treat to Target vs. Usual Care
 

Status: Recruiting

Condition Summary: Psoriatic Arthritis (PsA)

 

Last Updated: 13 Nov 2013

Go to URL
Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic Arthritis
 

Status: Recruiting

Condition Summary: Psoriatic Arthritis

 

Last Updated: 4 May 2016

Go to URL