Pseudocholinesterase deficiency

Common Name(s)

Pseudocholinesterase deficiency, Deficiency of butyrylcholine esterase

Pseudocholinesterase deficiency is a condition that causes increased sensitivity to certain muscle relaxant drugs used during general anesthesia, called choline esters. These drugs relax the muscles used for movement, including the muscles needed for breathing. They are normally broken down by the body within a few minutes of being given, at which time the muscles can move again. However, people with pseudocholinesterase deficiency may not be able to move or breathe on their own for a few hours after, therefore needing mechanical ventilation until the drugs are cleared from the body. Affected individuals may also have increased sensitivity to certain other drugs and to specific agricultural pesticides. Pseudocholinesterase deficiency can be inherited in an autosomal recessive manner and caused by mutations in the BCHE gene, or it can have non-genetic causes in which case it is called acquired pseudocholinesterase deficiency.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pseudocholinesterase deficiency" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pseudocholinesterase deficiency" returned 2 free, full-text research articles on human participants. First 3 results:

[Congenital pseudocholinesterase deficiency].
 

Author(s): Remigiusz Gelo, Anna Jurek-Gelo, Ryszard Wardaszko, Andrzej KaƄski

Journal: Anestezjol Intens Ter. ;43(1):33-5.

 

Congenital pseudocholinesterase (pChe) deficiency is a rare genetic abnormality which may lead to prolonged duration of action of muscle relaxants that are hydrolysed by pChe. We describe two cases in which mivacurium resulted in neuromuscular block lasting several hours.

Last Updated: 26 Jul 2011

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Acquired pseudocholinesterase deficiency after high-dose cyclophosphamide.
 

Author(s): V Koseoglu, J Chiang, K W Chan

Journal: Bone Marrow Transplant.. 1999 Dec;24(12):1367-8.

 

Succinylcholine, a depolarizing neuromuscular blocking agent used in anesthesia is hydrolyzed in the plasma by the enzyme pseudocholinesterase (PSC). Conditions associated with reduced PSC activity lead to sustained action of succinylcholine and result in prolonged apnea. Cyclophosphamide ...

Last Updated: 23 Feb 2000

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The terms "Pseudocholinesterase deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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