Pseudocholinesterase deficiency

Common Name(s)

Pseudocholinesterase deficiency, Deficiency of butyrylcholine esterase

Pseudocholinesterase deficiency is an enzyme abnormality that results in abnormally slow metabolic breakdown of choline ester drugs such as succinylcholine. This condition is recognized most often when respiratory paralysis unexpectedly persists for a prolonged period of time following administration of standard doses of succinylcholine. Pseudocholinesterase deficiency may be inherited or acquired.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pseudocholinesterase deficiency" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pseudocholinesterase deficiency" returned 2 free, full-text research articles on human participants. First 3 results:

[Congenital pseudocholinesterase deficiency].
 

Author(s): Remigiusz Gelo, Anna Jurek-Gelo, Ryszard Wardaszko, Andrzej KaƄski

Journal: Anestezjol Intens Ter. ;43(1):33-5.

 

Congenital pseudocholinesterase (pChe) deficiency is a rare genetic abnormality which may lead to prolonged duration of action of muscle relaxants that are hydrolysed by pChe. We describe two cases in which mivacurium resulted in neuromuscular block lasting several hours.

Last Updated: 26 Jul 2011

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Acquired pseudocholinesterase deficiency after high-dose cyclophosphamide.
 

Author(s): V Koseoglu, J Chiang, K W Chan

Journal: Bone Marrow Transplant.. 1999 Dec;24(12):1367-8.

 

Succinylcholine, a depolarizing neuromuscular blocking agent used in anesthesia is hydrolyzed in the plasma by the enzyme pseudocholinesterase (PSC). Conditions associated with reduced PSC activity lead to sustained action of succinylcholine and result in prolonged apnea. Cyclophosphamide ...

Last Updated: 23 Feb 2000

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Reviews from the PubMed Database

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The terms "Pseudocholinesterase deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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