Protein S deficiency

Common Name(s)

Protein S deficiency

Protein S deficiency is a disorder that causes abnormal blood clotting. When someone bleeds, the blood begins a complicated series of rapid chemical reactions involving proteins called blood coagulation factors to stop the bleeding.  Other proteins in the blood, such as protein S, usually regulate these chemical reactions to prevent excessive clotting. When protein S is missing (deficient), clotting may not be regulated normally and affected individuals have an increased risk of forming a blood clot called a thrombosis.  People at risk to have protein S deficiency are those with an individual or family history of multiple blood clots in the veins.  Treatment may include taking medication known as blood thinners to decrease the chance of developing a blood clot.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Protein S deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Protein S deficiency" returned 133 free, full-text research articles on human participants. First 3 results:

Antithrombotic prophylaxis in a patient with nephrotic syndrome and congenital protein S deficiency.
 

Author(s): Andrea Artoni, Serena Maria Passamonti, Alberto Edefonti, Francesca Gianniello, Vittorio Civelli, Ida Martinelli

Journal:

 

Nephrotic syndrome confers an acquired prothrombotic phenotype due to the urinary loss of anticoagulant proteins.Patients with reactivation of nephrotic syndrome may develop thrombosis.

Last Updated: 1 Mar 2016

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Cerebral Vein Thrombosis Post CABG Precipitated by Malposition of Subclavian Central Catheter in Protein C & S Deficiency Patient.
 

Author(s): Feridoun Sabzi, Reza Faraji

Journal: Ethiop J Health Sci. 2015 Jul;25(3):283-8.

 

Cerebral venous thrombosis is an uncommon disorder in the general population. However, it has a higher frequency among patients younger than 40 years , patients with thrombophilia and patients that have foreign body such as catheter in their veins or arterial system.

Last Updated: 4 Dec 2015

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Hereditary protein S deficiency leads to ischemic stroke.
 

Author(s): Zhao-Hui Wang, Zhi-Jun Zhao, Kang Xu, Guo-Bing Sun, Lin Song, Hong-Xiang Yin, Xiao-Qi Chen

Journal: Mol Med Rep. 2015 Sep;12(3):3279-84.

 

Hereditary protein S (PS) deficiency is an independent risk factor for venous thromboembolism. However, the correlation between PS and arterial thrombotic disease, such as cerebral thrombosis, is not clear. The present study focused on the molecular mechanisms underlying ischemic ...

Last Updated: 16 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Protein S deficiency" returned 5 free, full-text review articles on human participants. First 3 results:

Acquired pial and dural arteriovenous fistulae following superior sagittal sinus thrombosis in patients with protein S deficiency: a report of two cases.
 

Author(s): Shunji Matsubara, Koichi Satoh, Junichiro Satomi, Toshio Shigekiyo, Tomoya Kinouchi, Hajimu Miyake, Shinji Nagahiro

Journal: Neurol. Med. Chir. (Tokyo). 2014 ;54(3):245-52.

 

Two patients with protein S deficiency with acquired multiple pial and dural arteriovenous fistulae (AVFs) following superior sagittal sinus (SSS) thrombosis are reported. Case 1 is a 38-year-old male with protein S deficiency who developed generalized seizure due to SSS thrombosis. ...

Last Updated: 17 Mar 2014

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[Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review].
 

Author(s): Fang Liu, Lanyan Zhu, Ping Chen, Zhihui Shi, Shaokun Liu

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Sep;38(9):971-6.

 

To explore the clinical manifestations, diagnosis and treatment of pulmonary thromboembolism associated with protein C (PC)/protein S (PS) deficiency. Two male patients 29 and 26 years old diagnosed with PC deficiency and/or PS deficiency were retrospectively analyzed and related ...

Last Updated: 27 Sep 2013

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Mesenteric venous thrombosis in protein S deficiency: case report and literature review.
 

Author(s): L L Lau, A H McMurray

Journal: Ulster Med J. 1999 May;68(1):33-5.

 

Last Updated: 4 Oct 1999

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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