Prolidase deficiency

Common Name(s)

Prolidase deficiency

Prolidase deficiency is a rare disorder that affects multiple systems due to a defect on an enzyme that is related to the production of collagen (a strong protein found in bones, tissues, and skin).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Prolidase deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Prolidase deficiency" returned 13 free, full-text research articles on human participants. First 3 results:

Prolidase deficiency breaks tolerance to lupus-associated antigens.
 

Author(s): Biji T Kurien, Anil D'Sousa, Benjamin F Bruner, Timothy Gross, Judith A James, Ira N Targoff, Jacen S Maier-Moore, Isaac T W Harley, Heng Wang, R Hal Scofield

Journal: Int J Rheum Dis. 2013 Dec;16(6):674-80.

 

Prolidase deficiency is a rare autosomal recessive disease in which one of the last steps of collagen metabolism, cleavage of proline-containing dipeptides, is impaired. Only about 93 patients have been reported with about 10% also having systemic lupus erythematosus (SLE).

Last Updated: 2 Jan 2014

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[Effective therapy with a glycine-proline ointment in a patient with recurrent ulcers from prolidase deficiency].
 

Author(s): M P Ortega García, M A Cánoves Escolano, P Blasco Segura, M L García Melgares

Journal: Farm Hosp. ;30(5):304-8.

 

Prolidase deficiency is a rare disease. Lower leg recalcitrant ulcerations are the most characteristic symptoms.

Last Updated: 14 Dec 2006

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Molecular characterisation of six patients with prolidase deficiency: identification of the first small duplication in the prolidase gene and of a mutation generating symptomatic and asymptomatic outcomes within the same family.
 

Author(s): A Lupi, A Rossi, E Campari, F Pecora, A M Lund, N H Elcioglu, M Gultepe, M Di Rocco, G Cetta, A Forlino

Journal: J. Med. Genet.. 2006 Dec;43(12):e58.

 

Prolidase deficiency (PD) is a rare autosomal recessive connective tissue disorder caused by mutations in the prolidase gene. The PD patients show a wide range of clinical outcomes characterised mainly by intractable skin ulcers, mental retardation and recurrent respiratory infections. ...

Last Updated: 4 Dec 2006

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Prolidase deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.