Progressive supranuclear ophthalmoplegia

Common Name(s)

Progressive supranuclear ophthalmoplegia

Progressive supranuclear palsy (PSP) is the second most frequent cause of degenerative parkinsonism. In addition to parkinsonism, the clinical symptoms include early postural instability, supranuclear gaze palsy, and cognitive decline. Neuropathologically, the disorder is characterized by abundant neurofibrillary tangles, which differ in both distribution and composition from those associated with Alzheimer disease. In progressive supranuclear palsy, the tangles are primarily localized to subcortical regions and are found in both neurons and glia, whereas in Alzheimer disease they are more widespread, largely cortical, and limited to neurons. They also have different characteristics at the ultrastructural level ({1:Baker et al., 1999}). {15:Kertesz (2003)} suggested the term 'Pick complex' to represent the overlapping syndromes of frontotemporal dementia (FTD; {600274}), primary progressive aphasia (PPA), corticobasal degeneration (CBD), progressive supranuclear palsy, and FTD with motor neuron disease. He noted that frontotemporal dementia may also be referred to as 'clinical Pick disease,' and that the term 'Pick disease' ({172700}) should be restricted to the pathologic finding of Pick bodies. Genetic Heterogeneity of Progressive Supranuclear Palsy Other loci for PSP have been mapped to chromosome 1q31 (PSNP2; {609454}) and 11p12-p11 (PSNP3; {610898}). See also Parkinson-dementia syndrome, atypical progressive supranuclear palsy ({260540}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progressive supranuclear ophthalmoplegia" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progressive supranuclear ophthalmoplegia" returned 2 free, full-text research articles on human participants. First 3 results:

Eye movement recordings to investigate a supranuclear component in chronic progressive external ophthalmoplegia: a cross-sectional study.
 

Author(s): A E Ritchie, P G Griffiths, P F Chinnery, A W Davidson

Journal: Br J Ophthalmol. 2010 Sep;94(9):1165-8.

 

It has been postulated that eye movement disorders in chronic progressive external ophthalmoplegia (CPEO) have a neurological as well as a myopathic component to them.

Last Updated: 3 Sep 2010

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Exodeviated ophthalmoplegia in a patient with progressive supranuclear palsy.
 

Author(s): Chansok Kim, Ho Won Lee, Mee Young Park

Journal: J. Korean Med. Sci.. 2009 Oct;24(5):982-4.

 

We report a patient with progressive supranuclear palsy (PSP) with his serial photographs before the onset of ocular symptoms and after the onset with two year intervals. These photographs show his progressive eyeball deviations toward complete exotropia. There were no effective voluntary ...

Last Updated: 1 Oct 2009

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progressive supranuclear ophthalmoplegia" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Postural Instability in Progressive Supranuclear Palsy
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy; Parkinson's Disease

 

Last Updated: 23 Mar 2012

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Use of Lokomat in Patients With Progressive Supranuclear Palsy
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy

 

Last Updated: 4 Apr 2014

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Efficacy Study for Treatment of Dementia in Progressive Supranuclear Palsy
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy; Dementia

 

Last Updated: 14 Feb 2008

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