Primary hyperoxaluria type 1

Common Name(s)

Primary hyperoxaluria type 1

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary hyperoxaluria type 1" for support, advocacy or research.

Oxalosis & Hyperoxaluria Foundation

To seek the cause, improve the clinical treatment and discover the cure of hyperoxaluria and oxalate stone disease and enhance the quality of life of patients and their families.

Last Updated: 19 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary hyperoxaluria type 1" for support, advocacy or research.

Oxalosis & Hyperoxaluria Foundation

To seek the cause, improve the clinical treatment and discover the cure of hyperoxaluria and oxalate stone disease and enhance the quality of life of patients and their families.

http://www.ohf.org/

Last Updated: 19 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary hyperoxaluria type 1" returned 42 free, full-text research articles on human participants. First 3 results:

Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1.
 

Author(s): Chaitali Dutta, Nicole Avitahl-Curtis, Natalie Pursell, Marita Larsson Cohen, Benjamin Holmes, Rohan Diwanji, Wei Zhou, Luciano Apponi, Martin Koser, Bo Ying, Dongyu Chen, Xue Shui, Utsav Saxena, Wendy A Cyr, Anee Shah, Naim Nazef, Weimin Wang, Marc Abrams, Henryk Dudek, Eduardo Salido, Bob D Brown, Chengjung Lai

Journal: Mol. Ther.. 2016 Apr;24(4):770-8.

 

Primary hyperoxaluria type 1 (PH1) is an autosomal recessive, metabolic disorder caused by mutations of alanine-glyoxylate aminotransferase (AGT), a key hepatic enzyme in the detoxification of glyoxylate arising from multiple normal metabolic pathways to glycine. Accumulation of glyoxylate, ...

Last Updated: 16 Apr 2016

Go To URL
Helper-dependent adenoviral vectors for liver-directed gene therapy of primary hyperoxaluria type 1.
 

Author(s): R Castello, R Borzone, S D'Aria, P Annunziata, P Piccolo, N Brunetti-Pierri

Journal: Gene Ther.. 2016 Feb;23(2):129-34.

 

Primary hyperoxaluria type 1 (PH1) is an inborn error of liver metabolism due to deficiency of the peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT), which catalyzes conversion of glyoxylate into glycine. AGT deficiency results in overproduction of oxalate that ultimately ...

Last Updated: 4 Feb 2016

Go To URL
Left Lateral Sectionectomy of the Native Liver and Combined Living-Related Liver-Kidney Transplantation for Primary Hyperoxaluria Type 1.
 

Author(s): Guo-Yong Chen, Si-Dong Wei, Zhong-Wu Zou, Gao-Feng Tang, Jian-Jun Sun, Shao-Tang Zhou

Journal: Medicine (Baltimore). 2015 Aug;94(31):e1267.

 

Primary hyperoxaluria type I (PH1), the most severe form of primary hyperoxalurias, is a liver disease of the metabolic defect in glyoxylate detoxification that can be corrected by liver transplantation. A 21-year-old man presented to our center after 4 months of regular hemodialysis ...

Last Updated: 8 Aug 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary hyperoxaluria type 1" returned 4 free, full-text review articles on human participants. First 3 results:

Heart failure with mitral valve regurgitation due to primary hyperoxaluria type 1: case report with review of the literature.
 

Author(s): Luc Van Driessche, Annemieke Dhondt, Johan De Sutter

Journal: Acta Cardiol. 2007 Apr;62(2):202-6.

 

Primary hyperoxaluria type I (PH I) is a rare recessive autosomal disorder characterized by systemic calcium oxalate depositions, that results in renal failure and systemic oxalosis. We report a 38-year-old male with cardiac oxalosis, a severe complication of PHI, presenting with ...

Last Updated: 31 May 2007

Go To URL
Primary hyperoxaluria type 1: AGT mistargeting highlights the fundamental differences between the peroxisomal and mitochondrial protein import pathways.
 

Author(s): Christopher J Danpure

Journal: Biochim. Biophys. Acta. 2006 Dec;1763(12):1776-84.

 

Primary hyperoxaluria type 1 (PH1) is an atypical peroxisomal disorder, as befits a deficiency of alanine:glyoxylate aminotransferase (AGT), which is itself an atypical peroxisomal enzyme. PH1 is characterized by excessive synthesis and excretion of the metabolic end-product oxalate ...

Last Updated: 15 Dec 2006

Go To URL
Molecular etiology of primary hyperoxaluria type 1: new directions for treatment.
 

Author(s): Christopher J Danpure

Journal: Am. J. Nephrol.. ;25(3):303-10.

 

Primary hyperoxaluria type 1 (PH1) is a rare autosomal-recessive disorder caused by a deficiency of the liver-specific enzyme alanine:glyoxylate aminotransferase (AGT). AGT deficiency results in increased synthesis and excretion of the metabolic end-product oxalate and deposition ...

Last Updated: 12 Jul 2005

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of ALN-GO1 in Healthy Adult Subjects and Patients With Primary Hyperoxaluria Type 1
 

Status: Recruiting

Condition Summary: Primary Hyperoxaluria Type 1 (PH1)

 

Last Updated: 13 Feb 2017

Go to URL
Primary Hyperoxaluria Mutation Genotyping/Phenotyping
 

Status: Recruiting

Condition Summary: Primary Hyperoxaluria

 

Last Updated: 5 Jul 2016

Go to URL

Last Updated: 26 Sep 2016

Go to URL