Pilomatrixoma

Common Name(s)

Pilomatrixoma

A pilomatrixoma is a benign (non-cancerous) skin tumor that typically occurs in the head and neck area. The tumor usually does not cause any symptoms, but it can be associated with pain. A pilomatrixoma often occurs during childhood but has been reported in individuals of all ages. It may be caused by a change (mutation) in the CTNNB1 gene. Pilomatrixomas have been reported to occur in multiple members of a family, although the pattern of inheritance has not been confirmed. Familial cases have been observed but the mode of inheritance has not been confirmed. Treatment focuses on surgical removal of the tumor. Pilomatrixomas usually occur in the absence of another condition but have been associated with some conditions including Gardner syndrome, myotonic dystrophy (especially when multiple pilomatrixomas are present), and sarcoidosis.  A few cases of malignant (cancerous) pilomatrixoma have been reported.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pilomatrixoma" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pilomatrixoma" returned 15 free, full-text research articles on human participants. First 3 results:

Immunohistochemical expression of podoplanin in so-called hard α-keratin-expressing tumors, including calcifying cystic odontogenic tumor, craniopharyngioma, and pilomatrixoma.
 

Author(s): Kentaro Kikuchi, Shigeru Ito, Harumi Inoue, Patricia González-Alva, Yuji Miyazaki, Hideaki Sakashita, Atsuo Yoshino, Yoichi Katayama, Tadashi Terui, Fumio Ide, Kaoru Kusama

Journal: J Oral Sci. 2012 ;54(2):165-75.

 

Podoplanin, a transmembrane sialomucin-like glycoprotein, is a specific marker of lymphatic vessels, and its expression is also considered to be associated with tumor invasion and tooth development. In this study, we examined the expression of podoplanin in calcifying cystic odontogenic ...

Last Updated: 13 Jul 2012

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[Pilomatrixoma: unusual clinical presentation].
 

Author(s): Marcela Concha R, María Magdalena Farías N, Alvaro Abarzúa A, Nicolás Droppelmann M, Sergio González B, Cristián García B, Ada Chicharro C

Journal: Arch Argent Pediatr. 2011 Dec;109(6):116-8.

 

Pilomatrixoma is a rare, benign neoplasm that is derived from hair matrix cells. It is more frequent during childhood, especially between the ages of 5 and 15 years. Pilomatrixoma is usually a hard, well circumscribed, solitary lesion, and can be located on any part of the body, except ...

Last Updated: 10 Jan 2012

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Pilomatrixoma misdiagnosed as round cell tumor on fine-needle aspiration cytology.
 

Author(s): L Agrawal, P Kaur, J Singh, N Singh

Journal: Indian J Cancer. ;47(4):483-5.

 

Last Updated: 6 Dec 2010

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pilomatrixoma" returned 1 free, full-text review articles on human participants. First 3 results:

Pilomatrixoma of the forearm: a case report.
 

Author(s): Michael V Birman, Jonathan B McHugh, Radford J Hayden, Peter J L Jebson

Journal: Iowa Orthop J. 2009 ;29():121-3.

 

Pilomatrixoma is a benign neoplasm derived from hair follicle matrix cells. Involvement of the upper extremities is relatively uncommon and can be mistaken for malignancy. We present the case of a 52-year-old woman with a pilomatrixoma of the forearm, and we review the literature ...

Last Updated: 10 Sep 2009

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Use of Otoscope as a Non-Invasive Tool for Diagnosis of Pilomatricoma
 

Status: Recruiting

Condition Summary: Pilomatrixoma

 

Last Updated: 17 Feb 2009

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Clinical Trial Comparing Tissue Adhesive Vs. Absorbable Suture Vs. Non-Absorbable Suture
 

Status: Recruiting

Condition Summary: Cyst of Face, Neck or Shoulder; Pilomatrixoma of Face, Neck or Shoulder

 

Last Updated: 15 Feb 2006

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