Pheochromocytoma

Common Name(s)

Pheochromocytoma

Pheochromocytomas are rare tumors of the adrenal glands, which are located right above the kidneys. Although they are usually not cancerous (benign), pheochromocytomas often cause the adrenal glands to make too many stress hormones called epinephrines and norepinephrines. This can lead to high blood pressure and cause symptoms such as severe headaches, irritability, sweating, rapid heart rate, nausea, vomiting, weight loss, weakness, chest pain, and a feeling of anxiety. Rarely, this kind of tumor occurs outside the adrenal gland, usually somewhere in the abdomen, and are called extra-adrenal pheochromocytomas or paragangliomas. Pheochromocytomas can occur in certain familial genetic syndromes.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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VHL Family Alliance

Dedicated to improving diagnosis, treatment, and life quality for individuals and families affected by von Hippel-Lindau disease and funding research to uncover a cure.

Last Updated: 15 Oct 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

View Details
VHL Family Alliance

Dedicated to improving diagnosis, treatment, and life quality for individuals and families affected by von Hippel-Lindau disease and funding research to uncover a cure.

http://www.vhl.org

Last Updated: 15 Oct 2012

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pheochromocytoma" returned 535 free, full-text research articles on human participants. First 3 results:

Integrative genetic characterization and phenotype correlations in pheochromocytoma and paraganglioma tumours.
 

Author(s): Joakim Crona, Margareta Nordling, Rajani Maharjan, Dan Granberg, Peter Stålberg, Per Hellman, Peyman Björklund

Journal:

 

About 60% of Pheochromocytoma (PCC) and Paraganglioma (PGL) patients have either germline or somatic mutations in one of the 12 proposed disease causing genes; SDHA, SDHB, SDHC, SDHD, SDHAF2, VHL, EPAS1, RET, NF1, TMEM127, MAX and H-RAS. Selective screening for germline mutations ...

Last Updated: 27 Jan 2014

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[Evaluation of urinary metanephrines for the diagnosis of pheochromocytoma].
 

Author(s): A Bachali Belhadj, E Cherif Miladi, S Bahri, A Chaabane, H Lamouchi, K Khiari, N Khalfallah, S Ben Ammar

Journal: Tunis Med. 2013 Dec;91(12):724-8.

 

evaluate the assay of urinary metanephrines in diagnosis of pheochromocytoma (PH) and determine diagnostic cut-off values.

Last Updated: 24 Jan 2014

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Pheochromocytoma presenting as diabetes insipidus.
 

Author(s): Vandana Jain, Jaivinder Yadav, Amit Kumar Satapathy

Journal: Indian Pediatr. 2013 Nov;50(11):1056-7.

 

Pheochromocytomas are catecholamine producing tumors that classically present with the triad of sweating, palpitations and headache.

Last Updated: 2 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pheochromocytoma" returned 71 free, full-text review articles on human participants. First 3 results:

Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma.
 

Author(s): Eric Baudin, Mouhammed Amir Habra, Frederic Deschamps, Gilbert Cote, Frederic Dumont, Maria Cabanillas, J Arfi-Roufe, A Berdelou, Bryan Moon, Abir Al Ghuzlan, Shreyaskumar Patel, Sophie Leboulleux, Camilo Jimenez

Journal: Eur. J. Endocrinol.. 2014 Sep;171(3):R111-22.

 

Metastatic pheochromocytomas and paragangliomas (MPPs) present clinicians with three major challenges: scarcity, complexity of characterization, and heterogeneous behavior and prognosis. As with the treatment for all neuroendocrine tumors, the control of hormonal symptoms and tumor ...

Last Updated: 23 Jul 2014

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Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction.
 

Author(s): Ivana Jochmanová, Chunzhang Yang, Zhengping Zhuang, Karel Pacak

Journal: J. Natl. Cancer Inst.. 2013 Sep;105(17):1270-83.

 

Many solid tumors, including pheochromocytoma (PHEO) and paraganglioma (PGL), are characterized by a (pseudo)hypoxic signature. (Pseudo)hypoxia has been shown to promote both tumor progression and resistance to therapy. The major mediators of the transcriptional hypoxic response are ...

Last Updated: 4 Sep 2013

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Comparison of metaiodobenzylguanidine scintigraphy with positron emission tomography in the diagnostic work-up of pheochromocytoma and paraganglioma: a systematic review.
 

Author(s): V Rufini, G Treglia, P Castaldi, G Perotti, A Giordano

Journal: Q J Nucl Med Mol Imaging. 2013 Jun;57(2):122-33.

 

The aim of this paper was to systematically review published data about the comparison of radiolabelled metaiodobenzylguanidine (MIBG) scintigraphy and positron emission tomography (PET) with different radiopharmaceuticals in patients with pheochromocytoma and paraganglioma (Pheo/PGL).

Last Updated: 4 Jul 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diagnosis of Pheochromocytoma
 

Status: Recruiting

Condition Summary: Pheochromocytoma

 

Last Updated: 16 Oct 2014

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Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytoma
 

Status: Recruiting

Condition Summary: Paraganglioma; Pheochromocytoma

 

Last Updated: 18 Mar 2013

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RAD001 in Pheochromocytoma or Nonfunctioning Carcinoid
 

Status: Recruiting

Condition Summary: Pheochromocytoma; Extra-Adrenal Paraganglioma; Non-functioning Carcinoid

 

Last Updated: 28 Jun 2010

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