Pheochromocytoma

Common Name(s)

Pheochromocytoma, Adrenal gland tumor

Pheochromocytomas are rare tumors of the adrenal glands, which are located right above the kidneys. Although they are usually not cancerous (benign), pheochromocytomas often cause the adrenal glands to make too many stress hormones called epinephrines and norepinephrines. This can lead to high blood pressure and cause symptoms such as severe headaches, irritability, sweating, rapid heart rate, nausea, vomiting, weight loss, weakness, chest pain, and a feeling of anxiety. Rarely, this kind of tumor occurs outside the adrenal gland, usually somewhere in the abdomen, and are called extra-adrenal pheochromocytomas or paragangliomas. Pheochromocytomas can occur in certain familial genetic syndromes.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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Pheo Para Alliance

To provide a resource to patients, healthcare providers and researchers that offers value. To "spread the word" about Pheochromocytoma and Paraganglioma and to help educate and provide knowledge that assists in the search for a cure...

Last Updated: 10 Feb 2015

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VHL Alliance

VHLA is dedicated to research, education, and support to improve awareness, diagnosis, treatment, and quality of life for those affected by VHL.

Last Updated: 5 Jan 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pheochromocytoma" for support, advocacy or research.

Logo
National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

View Details
Pheo Para Alliance

To provide a resource to patients, healthcare providers and researchers that offers value. To "spread the word" about Pheochromocytoma and Paraganglioma and to help educate and provide knowledge that assists in the search for a cure...

http://www.pheo-para-alliance.org

Last Updated: 10 Feb 2015

View Details
VHL Alliance

VHLA is dedicated to research, education, and support to improve awareness, diagnosis, treatment, and quality of life for those affected by VHL.

http://www.vhl.org

Last Updated: 5 Jan 2015

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pheochromocytoma" returned 555 free, full-text research articles on human participants. First 3 results:

Atrioventricular dissociation due to pheochromocytoma: a case report.
 

Author(s): N Mchirgui, I Rojbi, I Oueslati, K Khiari, H Baccar, R Nouira, Y Lakhoua, N Ben Abdallah

Journal: Tunis Med. 2014 Oct;92(10):645-6.

 

Last Updated: 11 Apr 2015

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[Pheochromocytoma during pregnancy: a diagnosis not to be missed].
 

Author(s): Chaouki Mrazguia, Sana Ghades, Mahira Regaieg, Nahed Khelifa, Sawssem Armi, Abedlaziz Falfoul

Journal: Tunis Med. 2014 Jun;92(6):422.

 

Last Updated: 6 Mar 2015

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Heterogeneous genetic background of the association of pheochromocytoma/paraganglioma and pituitary adenoma: results from a large patient cohort.
 

Author(s): Judit Dénes, Francesca Swords, Eleanor Rattenberry, Karen Stals, Martina Owens, Treena Cranston, Paraskevi Xekouki, Linda Moran, Ajith Kumar, Christopher Wassif, Naomi Fersht, Stephanie E Baldeweg, Damian Morris, Stafford Lightman, Amar Agha, Aled Rees, Joan Grieve, Michael Powell, Cesar Luiz Boguszewski, Pinaki Dutta, Rajesh V Thakker, Umasuthan Srirangalingam, Chris J Thompson, Maralyn Druce, Claire Higham, Julian Davis, Rosalind Eeles, Mark Stevenson, Brendan O'Sullivan, Phillipe Taniere, Kassiani Skordilis, Plamena Gabrovska, Anne Barlier, Susan M Webb, Anna Aulinas, William M Drake, John S Bevan, Cristina Preda, Nadezhda Dalantaeva, Antônio Ribeiro-Oliveira, Isabel Tena Garcia, Galina Yordanova, Violeta Iotova, Jane Evanson, Ashley B Grossman, Jacqueline Trouillas, Sian Ellard, Constantine A Stratakis, Eamonn R Maher, Federico Roncaroli, Márta Korbonits

Journal: J. Clin. Endocrinol. Metab.. 2015 Mar;100(3):E531-41.

 

Pituitary adenomas and pheochromocytomas/paragangliomas (pheo/PGL) can occur in the same patient or in the same family. Coexistence of the two diseases could be due to either a common pathogenic mechanism or a coincidence.

Last Updated: 21 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pheochromocytoma" returned 73 free, full-text review articles on human participants. First 3 results:

A probabilistic assessment of the diagnosis of paraganglioma/pheochromocytoma based on clinical criteria and biochemical/imaging findings.
 

Author(s): Ioannis Ilias, Georgios Meristoudis, Athanasios Notopoulos

Journal: Hell J Nucl Med. ;18(1):63-5.

 

Paragangliomas (PGL) and pheochromocytomas (P) are rare neural-crest-derived neoplasms. Very recently guidelines on diagnosis and treatment of PGL/P have been presented by the US Endocrine Society. In the following overview we assessed the implementation of these guidelines with probabilistic ...

Last Updated: 4 Apr 2015

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Coexistence of gastrointestinal stromal tumors (GISTs) and pheochromocytoma in three cases of neurofibromatosis type 1 (NF1) with a review of the literature.
 

Author(s): Ahmet Gorgel, Devrim Dolek Cetinkaya, Fusun Salgur, Mustafa Demirpence, Husnu Yilmaz, Ece Harman Karaman, Pelin Tutuncuoglu, Gonca Oruk, Mitat Bahceci, Aysegul Akder Sari, Aysegul Aksoy Altinboga, Irem Paker

Journal: Intern. Med.. 2014 ;53(16):1783-9.

 

It is well known that neurofibromatosis type 1 (NF1) is uncommonly associated with pheochromocytoma development and also, to a larger extent, with gastrointestinal stromal tumors (GISTs). We herein document three cases with the rare condition of NF1 coexisting with GIST and pheochromocytoma, ...

Last Updated: 18 Aug 2014

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A case of (123)I-MIBG scintigram-negative functioning pheochromocytoma: immunohistochemical and molecular analysis with review of literature.
 

Author(s): Aiko Kurisaki-Arakawa, Tsuyoshi Saito, Michiko Takahashi, Keiko Mitani, Takashi Yao

Journal:

 

A 70-year-old Japanese woman was referred to our hospital due to hyperhidrosis and rapid weight loss of 10 kg in a month. A lump measuring 26 mm in diameter was detected in the left adrenal gland by computed tomography. Biochemical tests showed high levels of serum and urinary norepinephrine ...

Last Updated: 14 Aug 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytoma
 

Status: Recruiting

Condition Summary: Paraganglioma; Pheochromocytoma

 

Last Updated: 14 Jul 2015

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Diagnosis of Pheochromocytoma
 

Status: Recruiting

Condition Summary: Pheochromocytoma

 

Last Updated: 26 Feb 2015

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Compassionate Use of 131I-MIBG for Patients With Malignant Pheochromocytoma
 

Status: Available

Condition Summary: Pheochromocytoma; Paraganglioma

 

Last Updated: 23 Dec 2014

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