Parkinson disease 1

Common Name(s)

Parkinson disease 1

Parkinson disease is the second most common neurogenic disorder after Alzheimer disease (AD; {104300}), affecting approximately 1% of the population over age 50. Clinical manifestations include resting tremor, muscular rigidity, bradykinesia, and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia ({17:Polymeropoulos et al., 1996}). For a general phenotypic description and a discussion of genetic heterogeneity of Parkinson disease, see {168600}.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Parkinson disease 1" for support, advocacy or research.

National Parkinson Foundation

The National Parkinson Foundation is the only organization with a singular focus on improving the quality of Parkinson's care through research, education and outreach. We continue to bring help and hope to the estimated one million individuals in the US, four to six million worldwide, who are living with Parkinson's disease. NPF has funded more than $180 million in research and support services to improve the lives of people with PD. NPF programs touch more than one million people a year through our global network of Centers of Excellence, our US chapters, conferences, and online resources.

http://parkinson.org

Last Updated: 8 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Parkinson disease 1" for support, advocacy or research.

National Parkinson Foundation

The National Parkinson Foundation is the only organization with a singular focus on improving the quality of Parkinson's care through research, education and outreach. We continue to bring help and hope to the estimated one million individuals in the US, four to six million worldwide, who are living with Parkinson's disease. NPF has funded more than $180 million in research and support services to improve the lives of people with PD. NPF programs touch more than one million people a year through our global network of Centers of Excellence, our US chapters, conferences, and online resources.

http://parkinson.org

Last Updated: 8 Apr 2014

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General Support Organizations

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General Resources

Aware in Care

Aware in Care aims to help people with Parkinson’s disease get the best care possible during a hospital stay.

Updated 8 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Parkinson disease 1" returned 18 free, full-text research articles on human participants. First 3 results:

Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila.
 

Author(s): Saera Song, Seoyeon Jang, Jeehye Park, Sunhoe Bang, Sekyu Choi, Kyum-Yil Kwon, Xiaoxi Zhuang, Eunjoon Kim, Jongkyeong Chung

Journal: J. Biol. Chem.. 2013 Feb;288(8):5660-72.

 

Mutations in PINK1 (PTEN-induced putative kinase 1) are tightly linked to autosomal recessive Parkinson disease (PD). Although more than 50 mutations in PINK1 have been discovered, the role of these mutations in PD pathogenesis remains poorly understood. Here, we characterized 17 ...

Last Updated: 25 Feb 2013

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Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.
 

Author(s): Prachi Bajpai, Michelle C Sangar, Shilpee Singh, Weigang Tang, Seema Bansal, Goutam Chowdhury, Qian Cheng, Ji-Kang Fang, Martha V Martin, F Peter Guengerich, Narayan G Avadhani

Journal: J. Biol. Chem.. 2013 Feb;288(6):4436-51.

 

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxic side product formed in the chemical synthesis of desmethylprodine opioid analgesic, which induces Parkinson disease. Monoamine oxidase B, present in the mitochondrial outer membrane of glial cells, catalyzes the oxidation ...

Last Updated: 11 Feb 2013

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DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease.
 

Author(s): Xiangmin Lin, Travis J Cook, Cyrus P Zabetian, James B Leverenz, Elaine R Peskind, Shu-Ching Hu, Kevin C Cain, Catherine Pan, John Scott Edgar, David R Goodlett, Brad A Racette, Harvey Checkoway, Thomas J Montine, Min Shi, Jing Zhang

Journal: Sci Rep. 2012 ;2():954.

 

DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death, and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not change significantly in human ...

Last Updated: 12 Dec 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Parkinson disease 1" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A STUDY TO EVALUATE THE EFFICACY OF CJH1 (CLR4001) IN PARKINSON'S DISEASE
 

Status: Recruiting

Condition Summary: Parkinson's Disease

 

Last Updated: 12 Sep 2012

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Trodat 1 SPECT and Dopamine Polymorphism
 

Status: Not yet recruiting

Condition Summary: Parkinson Disease

 

Last Updated: 22 Jun 2011

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A Longitudinal Study in 1st Degree Relatives of Parkinson's Disease (PD) Patients
 

Status: Not yet recruiting

Condition Summary: Parkinson's Disease

 

Last Updated: 29 Dec 2011

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