Parkinson Disease

Common Name(s)

Parkinson Disease

Parkinson disease belongs to a group of conditions called movement disorders. The four main symptoms are tremor, or trembling in hands, arms, legs, jaw, or head; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance. These symptoms usually begin gradually and worsen with time.  As they become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks.  Not everyone with one or more of these symptoms has Parkinson disease, as the symptoms sometimes appear in other diseases as well.  Parkinson disease affects about 1 to 2 percent of people over the age of 60 years and the chance of developing Parkinson disease increases as we age. Although some Parkinson disease cases appear to be hereditary, and a few can be traced to specific genetic mutations, most cases are sporadic and occur in people with no apparent history of the disorder in their family.  Many researchers now believe that Parkinson disease results from a combination of genetic susceptibility and exposure to one or more environmental factors that trigger the disease.  
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Parkinson Disease" for support, advocacy or research.

Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

www.movementdisorders.org

Last Updated: 16 Jan 2013

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

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National Parkinson Foundation

The National Parkinson Foundation is the only organization with a singular focus on improving the quality of Parkinson's care through research, education and outreach. We continue to bring help and hope to the estimated one million individuals in the US, four to six million worldwide, who are living with Parkinson's disease. NPF has funded more than $180 million in research and support services to improve the lives of people with PD. NPF programs touch more than one million people a year through our global network of Centers of Excellence, our US chapters, conferences, and online resources.

http://parkinson.org

Last Updated: 8 Apr 2014

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Northwest Parkinson's Foundation

To establish optimal quality of life for the Northwest Parkinson's community through awareness, education, advocacy and care. The NWPF achieves our mission by supporting specialty care, producing and distributing free educational and support resources, raising awareness of Parkinson's disease and developing self-care tools that help improve the quality of life for patients, families and caregivers.

http://www.nwpf.org

Last Updated: 20 Feb 2013

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Parkinson's Disease Foundation, Inc.

The Parkinson's Disease Foundation (PDF) is a leading national presence in Parkinson's disease research, education and public advocacy. PDF is working for the nearly one million people in the US living with Parkinson's by funding promising scientific research and supporting people with Parkinson's, their families and caregivers through educational programs and support services. As of 2012, PDF had dedicated over $96 million to fund the work of leading scientists throughout the world and over $40 million to support national education and advocacy initiatives.

http://www.pdf.org

Last Updated: 11 Jan 2013

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The Bachmann-Strauss Dystonia & Parkinson Foundation

The Bachmann-Strauss Dystonia & Parkinson Foundation was established in 1995 to find better treatments and cures for the movement disorders dystonia and Parkinson's disease and to provide medical and patient information.

https://www.dystonia-parkinson.org

Last Updated: 15 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Parkinson Disease" for support, advocacy or research.

Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

www.movementdisorders.org

Last Updated: 16 Jan 2013

View Details
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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

View Details
National Parkinson Foundation

The National Parkinson Foundation is the only organization with a singular focus on improving the quality of Parkinson's care through research, education and outreach. We continue to bring help and hope to the estimated one million individuals in the US, four to six million worldwide, who are living with Parkinson's disease. NPF has funded more than $180 million in research and support services to improve the lives of people with PD. NPF programs touch more than one million people a year through our global network of Centers of Excellence, our US chapters, conferences, and online resources.

http://parkinson.org

Last Updated: 8 Apr 2014

View Details
Northwest Parkinson's Foundation

To establish optimal quality of life for the Northwest Parkinson's community through awareness, education, advocacy and care. The NWPF achieves our mission by supporting specialty care, producing and distributing free educational and support resources, raising awareness of Parkinson's disease and developing self-care tools that help improve the quality of life for patients, families and caregivers.

http://www.nwpf.org

Last Updated: 20 Feb 2013

View Details
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Parkinson's Disease Foundation, Inc.

The Parkinson's Disease Foundation (PDF) is a leading national presence in Parkinson's disease research, education and public advocacy. PDF is working for the nearly one million people in the US living with Parkinson's by funding promising scientific research and supporting people with Parkinson's, their families and caregivers through educational programs and support services. As of 2012, PDF had dedicated over $96 million to fund the work of leading scientists throughout the world and over $40 million to support national education and advocacy initiatives.

http://www.pdf.org

Last Updated: 11 Jan 2013

View Details
The Bachmann-Strauss Dystonia & Parkinson Foundation

The Bachmann-Strauss Dystonia & Parkinson Foundation was established in 1995 to find better treatments and cures for the movement disorders dystonia and Parkinson's disease and to provide medical and patient information.

https://www.dystonia-parkinson.org

Last Updated: 15 Feb 2013

View Details

 

General Support Organizations

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General Resources

Online Wellness Center

A website designed to inspire people with Parkinson’s and their loved ones to make positive personal changes that contribute to living their best with a chronic disease.

Updated 4 Dec 2012

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Aware in Care

Aware in Care aims to help people with Parkinson’s disease get the best care possible during a hospital stay.

Updated 8 Apr 2014

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Blogs

PDCommunity! Blog

NWPF staff answer your questions, share information and provide helpful links for quick access for all to benefit.

Updated 4 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Parkinson Disease" returned 543 free, full-text research articles on human participants. First 3 results:

Trigger medications and patient-related risk factors for Parkinson disease psychosis requiring anti-psychotic drugs: a retrospective cohort study.
 

Author(s): Hideyuki Sawada, Tomoko Oeda, Kenji Yamamoto, Atsushi Umemura, Satoshi Tomita, Ryutaro Hayashi, Masayuki Kohsaka, Takashi Kawamura

Journal:

 

Psychoses such as hallucinations are a frequent non-motor problem in patients with Parkinson disease (PD) and serious psychosis requires anti-psychotic medications that worsen Parkinsonism. Although psychosis could be associated with patient-related or biological factors such as cognition, ...

Last Updated: 6 Jan 2014

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Benefits of putaminal GDNF infusion in Parkinson disease are maintained after GDNF cessation.
 

Author(s): Nikunj K Patel, Nicola Pavese, Shazia Javed, Gary R Hotton, David J Brooks, Steven S Gill

Journal: Neurology. 2013 Sep;81(13):1176-8.

 

We previously reported clinical improvement, increase in putamen [(18)F]-dopa uptake on PET imaging, and neuropathologic evidence of sprouting of dopaminergic fibers following chronic intraputaminal delivery of glial cell line-derived neurotrophic factor (GDNF) in idiopathic Parkinson ...

Last Updated: 24 Sep 2013

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[Parkinson disease mortality rates in Chile].
 

Author(s): Pedro Chaná C, Magdalena Jiménez C, Violeta Díaz T, Carlos Juri

Journal: Rev Med Chil. 2013 Mar;141(3):327-31.

 

Parkinson disease (PD) is the second more common neurodegenerative disorder and determines a loss in quality of life, caregiver burden and increased mortality in those affected.

Last Updated: 31 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Parkinson Disease" returned 67 free, full-text review articles on human participants. First 3 results:

Parkinson disease: an update.
 

Author(s): John D Gazewood, D Roxanne Richards, Karl Clebak

Journal: Am Fam Physician. 2013 Feb;87(4):267-73.

 

Parkinson disease is a progressive neurologic disorder afflicting approximately 1 percent of Americans older than 60 years. The cardinal features of Parkinson disease are bradykinesia, rigidity, tremor, and postural instability. There are a number of neurologic conditions that mimic ...

Last Updated: 19 Feb 2013

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What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?
 

Author(s): Christopher J R Dunning, Sonia George, Patrik Brundin

Journal: Prion. ;7(1):92-7.

 

α-Synuclein is a key protein in Parkinson disease. Not only is it the major protein component of Lewy bodies, but it is implicated in several cellular processes that are disrupted in Parkinson disease. Misfolded α-synuclein has also been shown to spread from cell-to-cell and, in ...

Last Updated: 18 Feb 2013

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The pathology roadmap in Parkinson disease.
 

Author(s): D James Surmeier, David Sulzer

Journal: Prion. ;7(1):85-91.

 

An under-appreciated clue about pathogenesis in Parkinson disease (PD) is the distribution of pathology in the early and middle stages of the disease. This pathological 'roadmap' shows that in addition to dopaminergic neurons in the substantia nigra pars compacta (SNc), a significant ...

Last Updated: 18 Feb 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Connect.Parkinson: Connecting Individuals With Parkinson Disease to Specialists in Their Homes
 

Status: Recruiting

Condition Summary: Parkinson Disease

 

Last Updated: 25 Mar 2014

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Mindfulness Based Intervention (MBI) on the Quality of Life and Non-Motor Symptoms (NMS) of Persons With Parkinson's Disease (PD)
 

Status: Recruiting

Condition Summary: Parkinson's Disease; Non-Motor Symptoms of Parkinson's Disease

 

Last Updated: 20 May 2013

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Evaluation of Safety and Tolerability of Fetal Mesencephalic Dopamine Neuronal Precursor Cells for Parkinson's Disease
 

Status: Recruiting

Condition Summary: Idiopathic Parkinson Disease; Primary Parkinsonism

 

Last Updated: 21 May 2013

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