Osteoarthritis

Common Name(s)

Osteoarthritis

Osteoarthritis is one of the most common forms of arthritis. It is a chronic condition in which the material that cushions the joints, called cartilage, breaks down. This causes the bones to rub against each other, causing stiffness, pain and loss of joint movement. Common symptoms are sore or stiff joints, particularly the hips, knees, and lower back, but osteoarthritis may also affect the neck, small finger joints, the base of the thumb, ankle, and big toe. The pain may be moderate and come and go, without affecting the ability to perform daily tasks. Some people’s OA will never progress past this early stage. Others will have their OA get worse. The pain and stiffness of more severe osteoarthritis may make it difficult to walk, climb stairs, sleep, or perform other daily tasks.

About 27 million people in the United States have osteoarthritis. The cause is not fully understood and no cure exists but osteoarthritis treatments can slow the progression of the disease, relieve pain and improve joint function. Common risk factors include increasing age, obesity, previous joint injury, overuse of the joint, weak thigh muscles, and genetics.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteoarthritis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteoarthritis" returned 5287 free, full-text research articles on human participants. First 3 results:

Identification of key genes in rheumatoid arthritis and osteoarthritis based on bioinformatics analysis.
 

Author(s): Naiqiang Zhu, Jingyi Hou, Yuanhao Wu, Geng Li, Jinxin Liu, GuiYun Ma, Bin Chen, Youxin Song

Journal: Medicine (Baltimore). 2018 Jun;97(22):e10997.

 

Rheumatoid arthritis (RA) and osteoarthritis (OA) comprise the most common forms of arthritis. The aim of this study was to identify differentially expressed genes (DEGs) and associated biological processes between RA and OA using a bioinformatics approach to elucidate their potential ...

Last Updated: 31 Dec 1969

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High preoperative serum leptin level is an independent risk factor for deep vein thrombosis after total knee arthroplasty in osteoarthritis patients: A prospective and cross-sectional study.
 

Author(s): Wanli Lu, Sheng Zhou, Long Xue, Bingyang Dai, Liang Qiao, Dongyang Chen, Zhihong Xu, Yao Yao, Huajian Teng, Qing Jiang

Journal: Medicine (Baltimore). 2018 May;97(21):e10884.

 

It suggests that a high leptin level may increase the risk of venous thromboembolism (VTE) in animal studies. However, clinical studies in this field are still largely unexplored. Our objective was to evaluate the relationship between the preoperative serum leptin levels and postoperative ...

Last Updated: 31 Dec 1969

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Sinew acupuncture for knee osteoarthritis: study protocol for a randomized sham-controlled trial.
 

Author(s): Kwok Yin Au, Haiyong Chen, Wing Chung Lam, Chiu On Chong, Andrew Lau, Varut Vardhanabhuti, Kin Cheung Mak, Fei Jiang, Wing Yi Lam, Fung Man Wu, Hiu Ngok Chan, Yan Wah Ng, Bacon Fung-Leung Ng, Eric Tat-Chi Ziea, Lixing Lao

Journal:

 

Sinew acupuncture is a new modality of acupuncture in which needles are inserted into acupoints, ashi points or spasm points of sinew and muscles along the meridian sinew pathway. A previous observational study revealed that sinew acupuncture has immediate analgesic effects on various ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteoarthritis" returned 876 free, full-text review articles on human participants. First 3 results:

Function scores of different surgeries in the treatment of knee osteoarthritis: A PRISMA-compliant systematic review and network-meta analysis.
 

Author(s): Cheng-Yao Liu, Chuan-Dong Li, Liang Wang, Shan Ren, Fu-Bin Yu, Jin-Guang Li, Jiang-Xiong Ma, Xing-Long Ma

Journal: Medicine (Baltimore). 2018 May;97(21):e10828.

 

Osteoarthritis (OA) is the third most common diagnosis made by general practitioners in older patients. The aim of this study was to compare the function scores of different surgeries in the treatment of knee osteoarthritis (KOA).

Last Updated: 31 Dec 1969

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Challenges and controversies of complex interventions in osteoarthritis management: recognizing inappropriate and discordant care.
 

Author(s): Krysia S Dziedzic, Kelli D Allen

Journal: Rheumatology (Oxford). 2018 05;57(suppl_4):iv88-iv98.

 

A number of controversies and challenges exist for the management of OA in health care. This paper describes the challenges and gaps in OA care, particularly in relation to population health management, complex interventions and outcomes. It sets this in the context of competing health ...

Last Updated: 31 Dec 1969

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What is the evidence for a role for diet and nutrition in osteoarthritis?
 

Author(s): Sally Thomas, Heather Browne, Ali Mobasheri, Margaret P Rayman

Journal: Rheumatology (Oxford). 2018 05;57(suppl_4):iv61-iv74.

 

As current treatment options in OA are very limited, OA patients would benefit greatly from some ability to self-manage their condition. Since diet may potentially affect OA, we reviewed the literature on the relationship between nutrition and OA risk or progression, aiming to provide ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Feasibility of High Intensity Interval Training in Knee Osteoarthritis
 

Status: Recruiting

Condition Summary: Knee Osteoarthritis

 

Last Updated: 11 Dec 2017

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The Study to Evaluate Efficacy and Safety of Celecoxib Capsule in Hand Osteoarthritis Patients
 

Status: Recruiting

Condition Summary: Osteoarthritis Hand

 

Last Updated: 24 Feb 2017

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Clinical Trial of YYD302 (Phase3) for Treatment of Osteoarthritis of the Knee
 

Status: Recruiting

Condition Summary: Osteoarthritis, Knee

 

Last Updated: 17 Jun 2018

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